Immacolata Castellano - Stazione Zoologica Anton Dohrn

Immacolata Castellano
Born in Sorrento (Naples) on 22/07/1976
Tel.: +39 081 5833276
Fax: +39 081 7641355
e-mail: [email protected]
Current Position: Post Doc.
Supervisor: Anna Palumbo
Appointed on project: Response to environmental stress in marine organisms: biological functions of
new genes and antioxidant molecules
Affiliation:
Section <BEOM >, Stazione Zoologica Anton Dohrn, Napoli (Italy)
Education/Training/Experience
Institute and Location
University Federico II, Naples
Stazione Zoologica A. Dohrn
Telethon Institute of Genetics
and Medicine, Naples
Department of Biochemistry and
Medical Biotechnology,
University Federico II, Naples
Institute of Protein
Biochemistry, CNR of Naples
Stazione Zoologica “Anton
Dohrn” of Naples (SZN).
Degree /
Function
Master
Year
Field of Study
1996-2001
Biological sciences
Fellow
2002
Ph.D.
2002-2006
Bioinformatics and
Molecular Biology
Biochemistry, Molecular
and Cellular Biology
Postdoc
2007-2010
Postdoc
2012-2014
Biochemistry and
Molecular Biology
Biochemistry and
Molecular Biology in
marine organisms
Appointments and awards
2005 - 2006: Teacher assistant (lecture in Biochemistry) for students at Faculty of Medicine, University
of Naples Federico II
2006: Travel Grant to participate to the EUROBIC8 Congress, Aveiro, Portugal
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Name Last Name - Curriculum vitae
2008: Travel Grant awarded by FEBS society to participate to 33° FEBS Congress and 11th
IUBMB Conference, Athens
2010: Travel Grant awarded by SIB society to participate to 35° FEBS Congress, 2010, Göteborg,
Sweden
2011: Travel Grant awarded by SIB society to participate 36° to FEBS Congress, Torino
2014: EMBO Travel Grant to participate “FEBS EMBO 2014”, Paris.
2014: First “Aldo Fasolo” Prize for young researchers awarded by SZN
Other matters relevant to scientific career
Member of the Italian Society of Biochemistry and Molecular Biology, SIB from 2008.
Reviewer for ISI-journals in Biochemistry and Molecular Biology: Molecular Biosystems,
Biochimie, BBA - Proteins and Proteomics, Process Biochemistry, Applied Microbiology
Biotechnology, Biomed Research International, International Journal of Biological
Macromolecules.
Publications
Author of 23 publications on ISI-journals, 1 book and 4 book chapters
List of publications of the last 10 years
Journal Papers
Castellano I, Ercolesi E, Romano G, Ianora A, Palumbo A (2015) “The diatom-derived aldehyde
decadienal affects life cycle transition in the ascidian Ciona intestinalis through nitric
oxide/ERK signaling” Open Biol. 5(3):140182. doi: 10.1098/rsob.140182.
Kumar A, Castellano I, Patti FP, Palumbo A, Buia MC (2015) “Nitric oxide in marine
photosynthetic organisms” Nitric Oxide. 47:34-39. doi: 10.1016/j.niox.2015.03.001. Review.
Migliaccio O, Castellano I, Cirino P, Romano G, Palumbo A (2015) “Maternal Exposure to
Cadmium and Manganese Impairs Reproduction and Progeny Fitness in the Sea Urchin
Paracentrotus lividus” PloS One. 10(6):e0131815doi: 10.1371/journal.pone.0131815.
Castellano I, Ercolesi E, Palumbo A (2014) "Nitric Oxide Affects ERK Signaling through Downregulation of MAP Kinase Phosphatase Levels during Larval Development of the Ascidian
Ciona intestinalis" PloS One. 9(7):e102907. 10.1371/journal.pone.0102907.
Migliaccio O, Castellano I, Romano G, Palumbo A (2014) “Stress response to cadmium and
manganese in Paracentrotus lividus developing embryos is mediated by nitric oxide”. Aquatic
Toxicology. 156C:125-134. doi: 10.1016/j.aquatox.2014.08.007.
Russo GL, Russo M, Castellano I, Napolitano A, Palumbo A (2014) “Ovothiol Isolated from Sea
Urchin Oocytes Induces Autophagy in Hep-G2 cell line” Marine Drugs. 12, 4069-4085;
doi:10.3390/md12074069.
Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
(2014) “Structural and denaturation studies of two mutants of a cold adapted superoxide
dismutase point to the importance of electrostatic interactions in protein stability” Biochim
Biophys Acta. 1844, 632-40. doi: 10.1016/j.bbapap.2014.01.007.
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Name Last Name - Curriculum vitae
Pica A, Russo Krauss I, Castellano I, La Cara F, Graziano G, Sica F, Merlino A (2013) “Effect of
NaCl on the conformational stability of the thermophilic γ-glutamyltranspeptidase from
Geobacillus thermodenitrificans: Implication for globular protein halotolerance” Biochim
Biophys Acta. 1834, 149-57 doi: 10.1016/j.bbapap.2012.09.014
Castellano I, Merlino A (2012) “γ-Glutamyltranspeptidases: sequence, structure, biochemical
properties, and biotechnological applications “ Cell Mol Life Sci. 69, 3381-94.
Pica A, Russo Krauss I, Castellano I, Rossi M, La Cara F, Graziano G, Sica F, Merlino A (2012)
“Exploring the unfolding mechanism of gamma-glutamyltranspeptidases: the case of the
thermophilic enzyme from Geobacillus thermodenitrificans” Biochim Biophys Acta 1824, 571577.
Castellano I, Di Salle A, Merlino A, Rossi M, La Cara F (2011) “Gene cloning and protein
expression of gamma-glutamyltranspeptidases from Thermus thermophilus and Deinococcus
radiodurans: comparison of molecular and structural properties with mesophilic” counterparts”
Extremophiles 15, 259-270.
Castellano I, Merlino A, Rossi M, La Cara F (2010) “Biochemical and structural properties of
gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: an enzyme specialized in
hydrolase activity”, Biochimie 92, 464-474.
Merlino A, Russo Krauss I, Castellano I, De Vendittis E, Rossi B, Conte M, Vergara A, Sica F
(2010) “Structure and flexibility in cold-adapted iron superoxide dismutases: The case of the
enzyme isolated from Pseudoalteromonas haloplanktis” Journal of Structural Biology 172, 34352.
De Vendittis A, Amato M, Mickniewicz A, Parlato G, De Angelis A, Castellano I, Rullo R,
Riccitiello F, Rengo S, Masullo M and De Vendittis E (2010) “Regulation of the properties of
superoxide dismutase from the dental pathogenic microorganism Streptococcus mutans by iron–
and manganese–bound cofactor”. Molecular BioSystems 6, 1973-82.
Cassano S, Agnese S, D’Amato V, Papale M, Garbi C, Castagnola P, Ruocco MR, Castellano I, De
Vendittis E, Santillo M, Amente S, Porcellini A, Avvedimento EV (2010) “ROS, Ki-Ras and
mitochondrial SOD co-operate in the NGF-induced differentation of PC12 cells”. Journal of
Biological Chemistry 285, 24141-53.
Cecere F, Iuliano A, Albano F, Zappelli C, Castellano I, Grimaldi P, Masullo M, De Vendittis E,
Ruocco MR (2010) “Involvement of the mitochondrial superoxide dismutase (SOD2) in the
apoptosis of the SH-SY5Y neuroblastoma cell line induced by diclofenac”. Journal of
Biomedicine and Biotechnology doi:10.1155/2010/801726.
Castellano I, Cecere F, De Vendittis A, Cotugno R, Chambery A, Di Maro A, Michniewicz A,
Parlato G, Masullo M, Avvedimento EV, De Vendittis E, Ruocco MR (2009) "Rat mitochondrial
manganese superoxide dismutase: amino acid positions involved in covalent modifications,
activity and heat stability", Biopolymers 91, 1215-1226.
Castellano I, Ruocco MR, Cecere F, Di Maro A, Chambery A, Michniewicz A, Parlato G, Masullo
M, De Vendittis E, (2008) “Glutathionylation of the iron superoxide dismutase from the
psychrophilic eubacterium Pseudoalteromonas haloplanktis”, Biochimica et Biophysica Acta
(BBA), 1784, 816-826.
De Vendittis E, Castellano I, Cotugno R, Ruocco MR, Raimo G, Masullo M, (2008) “Adaptation of
ubiquitous proteins from cold to hot environments involves continuous and small adjustments of
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Name Last Name - Curriculum vitae
avarage parameters related to amino acid composition” Journal of Theoretical Biology 250, 15671.
Merlino A, Krauss IR, Castellano I, De Vendittis E, Vergara A, Sica F, (2008) “Crystallization and
Preliminary X-ray Diffraction Studies of a Psychrophilic Iron Superoxide Dismutase from
Pseudoalteromonas haloplanktis” Protein & Peptide Letters, 15, 415-418.
De Vendittis E, Cotugno R, Castellano I et al, (2007) “Key enzyme systems controlling the
oxidative stress in the psychrophilic eubacterium Pseudoalteromonas haloplanktis”, Current
Topics in Peptide & Protein Research 8, 81-86.
Castellano I, Di Maro A, Ruocco MR, Chambery A, Parente A, Di Martino MT, Parlato G, Masullo
M, De Vendittis E, (2006) “Psychrophilic superoxide dismutase from Pseudoalteromonas
haloplanktis: biochemical characterization and identification of a highly reactive cysteine
residue”, Biochimie 88, 1377-1389.
Russo GL, Tosto M, Mupo A, Castellano I, Cuomo A, Tosto E, (2004), “Biochemical and
functional characterization of protein kinase CK2 in ascidian Ciona inestinalis oocytes at
fertilization. Cloning and sequence analysis of cDNA for alpha and beta subunits”, Journal of
Biological Chemistry 279, 33012-33023.
Books
Castellano I and Merlino A, (2013) “Gamma-Glutamyl Transpeptidases”, SpringerBriefs in
Biochemistry and Molecular Biology, DOI: 10.1007/978-3-0348-0682-4_1.
Chapters in Book
Migliaccio O, Castellano I, Romano G, Palumbo A (2014) “Response of Sea Urchin to
Environmental Stress” in “Sea Urchins: Habitat, Embryonic Development and Importance in
the Environment”, Nova Science Publishers, ISBN: 978-1-63321-550-4. Editors: Edgar
Raymond Banks.
Ruocco MR, Arcari P, Castellano I, Masullo M, Raimo G, De Vendittis E, (2004) In
“Biochemistry and Molecular Biology in the Thermophilic Archaeon Sulfolobus solfataricus”,
Research Signpost, Kerala, India, 81-103 ISBN, Editors: Farina B. and Faraone Mennella MR.
Raimo G, Arcari P, Cantiello P, Castellano I, De Vendittis E, Lamberti A, Longo O, Ruocco MR,
Masullo M (2004) In “Biochemistry and Molecular Biology in the Thermophilic Archaeon
Sulfolobus solfataricus”, Research Signpost, Kerala, India., 131- 149 ISBN, Editors: Farina B.
and Faraone Mennella MR.
.
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