482 pubblicazioni scientifiche

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(1953)
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6. Bovet D, Longo VG et Silvestrini B. Les méthodes d'investigations
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11. Longo VG and Silvestrini B. Effects of adrenergic and cholinergic drugs injected
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13. Silvestrini B, Longo VG. Influenze sui potenziali stricnici corticali degli stati di
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14. Silvestrini B, Longo VG and Bovet D. Action of synchronizing and
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15. Bovet D, Kohn R, Marotta M and Silvestrini B. Some effects of histamine in the
normal and haemophilus pertussis vaccinated rat. Brit. J. Pharm. Chem. 1958; 13:74-83
16. Longo VG and Silvestrini B. Contribution a l'étude des rapports entre le potentiel
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17. Longo VG, Silvestrini B e Bovet D. Analisi elettroencefalografica delle proprieta'
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18. Silvestrini B. Antagonismo di alcune sostanze ad azione centrale nei confronti del
broncospasmo ottenuto mediante iniezione di serotonina nella cavia. Boll. Soc. Ital. Biol.
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19. Silvestrini B. Neuropharmacological study of the central effects of benactyzine and
hydroxyzine (cerebral electrical activity, alarm and flight reaction on hypothalamic
stimulation, central antagonism). Arch. Int. Pharmacodyn. 1958; 116:71-85
20. Silvestrini B, Kohn R. Azione del meprobamato sull'attivita' elettrica cerebrale del
coniglio e sulle reazioni di allarme e di fuga provocate dalla stimolazione elettrica dei
nuclei ipotalamici. Rend. Ist. Sup. Sanità 1958; 21:328-337
(1959)
21. Longo VG, Silvestrini B, Bovet D. An investigation of convulsant properties of the
5-7-diphenyl 1-3-diazamantan-6-olo. J. Pharmacol. Exp. Ther. 1959; 126:41-49
22. Maffii G, Silvestrini B, Bianchi G. Attivita' farmacologica di derivati betalattamici. Nota II. Azioni sistemiche del 3-metil-3-fenil-2-azetidinone e del 3-etil-3fenil-2-azetidinone. Il Farmaco (Ediz. Sci.) 1959; 14:269-287
2
23. Silvestrini B, Longo VG. Action of synchronizing and desynchronizing drugs on
strychnine-induced cortical spikes. Arch. Int. Pharmacodyn. 1959; 119:359-366
24. Silvestrini B, Maffii G. Rilievo dell'azione antitosse negli animali di laboratorio e
rapporti tra azione bechica ed altre proprieta' farmacologiche. Il Farmaco (Ediz. Sci.)
1959; 14:440-464
25. Silvestrini B, Maffii G. Effects of chlorpromazine, promazine, diethazine, reserpine,
hydroxyzine and morphine upon some mono-and polysynaptic motor reflexes. J. Pharm.
Pharmacol. 1959; 11:224-233
(1960)
26. Silvestrini B. Un antitosse-antinfiammatorio, l'Oxolamina (Perebron). Minerva Med.
1960; 51:4091-4094
27. Silvestrini B, Lefevre F, Gaffi A, Businco E, Scoponi M. Azioni di taluni
antistaminici sul comportamento e su particolari tipi di reazioni motorie del topo. Atti
del I Congr. Soc. Ital. Medicina del traffico, Sanremo, 1960: 857-860
28. Silvestrini B, Pozzatti C. Antitussive activity and other pharmacological properties
of six oxadiazoles. Arch. Int. Pharmacodyn. 1960; 129:249-263
(1961)
29. Bizzi L, Pozzatti C, Ballardin E, Silvestrini B. Esame farmacologico di alcuni
succinati e glutarati acidi di arilalchile. Boll. Chim. Farm. 1961; 100:855-863
30. Bizzi L, Pozzatti C, Silvestrini B. Primi dati farmacologici sul succinato acido di 1p.chlorofenilpentile (AF 425). Boll. Chim. Farm. 1961; 100:504-512,
31. Maffii G, Bianchi G, Schiatti P, Silvestrini B. Action of 5,5-diethyl-1,3-oxazine2,4-dione (dioxone) on respiration and circulation. Brit. J. Pharmacol. 1961; 16:231-243
32. Maffii G, Dezulian VM, Silvestrini B. A new analeptic 5,5-diethyl-1,3-oxazin-2,4dione (dioxone). J. Pharm. Pharmacol. 1961; 13:244-253
33. Maffii G, Silvestrini B. Rapporti tra struttura chimica ed attivita' farmacologica in
una serie di 1,3-ossazin-2,4-dioni e 1,3-ossazin-2,4-ditioni sostituiti. Il Farmaco (Ediz.
Sci.) 1961; 16:39-57
34. Palazzo G, Tavella M, Strani G, Silvestrini B. 1,2,4-oxadiazoles-IV. Synthesis and
pharmacological properties of a series of substituted aminoalkyl -1,2,4-oxadiazoles. J.
Med. Pharm. Chem. 1961; 4:351-367
35. Silvestrini B. Caratteristiche dell'Oxolamina. Boll. Chim. Farm. 1961; 100:869-872
36. Silvestrini B. Descrizione di una nuova molecola dotata di marcate proprieta' antiinfiammatorie ed antalgiche in paragone con alcuni farmaci noti. Minerva Med. 1961;
2:1282
3
37. Silvestrini B and Pozzatti C. Pharmacological properties of 3-phenyl-5-betadiethylaminoethyl-1,2,4-oxadiazole. Brit. J. Pharmacol. 1961; 16:209-217
(1962)
38. Palazzo G, Silvestrini B. Ricerche nel campo dell' 1,2,4-oxadiazolo. Nota VII.
Sintesi e proprieta' farmacologiche di derivati carbammici. Boll. Chim. Farm. 1962;
101:251-258,
39. Silvestrini B, Pozzatti C. Pharmacological study of 3-p-methoxylphenyl-5diethylaminoethyl-1,2,4 oxadiazole. Arzneim. Forsch. 1962; 12:539-543
(1963)
40. Catanese B, Palazzo G, Pozzatti C, Silvestrini B. Toxicologic studies on 1,2,4oxadiazole derivatives. Relationship between chemical structure and bladder irritation.
Exp. Molec. Path. 1963; Suppl. 2:28-40
41. Crepax P Silvestrini B. Experimental evaluation in laboratory animals of antiinflammatory analgesic drugs. Arch. Ital. Biol. 1963; 101:444-457
42. Fadiga F, Maffii G, Silvestrini B. Modificazioni provocate dal 5,5-dietil-1,3ossazin -2,4-dione (dietadione) nell'attivita' elettrica spontanea registrata dalla corteccia
cerebrale, dal talamo e dalla formazione reticolare mesencefalica. Boll. Soc. Ital. Biol.
Sper. 1963; 39:188-190
43. Maffii G, Silvestrini B, Banfi S. Antitussive activity of a new local anaesthetic
compound, Benzobutamide. Nature 1963; 199:916-917
44. Silvestrini B, Bignami A, Garau A, Pozzatti C. Toxicity studies of 3-phenyl-5beta-diethylaminoethyl -1,2,4-oxadiazole on mice, rats and dogs. Exp. Molec. Path.,
Suppl. 1963; 2:50-64
45. Silvestrini B, Catanese B, Garau A, Pozzatti C. Toxicity studies on 3-phenyl-5beta-diethylaminoethyl-1,2,4-oxadiazole. Vesical irritating activity of diethylamine and
other simple amines. Exp. Molec. Path. 1963; Suppl. 2:41-49
46. Silvestrini B and Pozzatti C. Pharmacological properties of 3-alpha-phenylpropyl-5
-beta-diethylaminoethyl-1,2,4-oxadiazole citrate. Arzneim. Forsch. 1963; 13:798-802
47. Silvestrini B, Pozzati C, Garau A. Proprietà farmacologiche di alcuni nuovi
analgesici di sintesi. Arch. Ital. Sci Farmacol. 1963; 13:260-261
(1964)
48. Bovet-Nitti F, Kohn R, Marotta M, Pinto Scognamiglio W, Silvestrini B.
Histamine-induced modification of neuromuscular blockade by lepto and pachycurares.
Arch. Int. Pharmacodyn. 1964; 149:308-317
4
49. Catanese B, Silvestrini B. Ricerche sul metabolismo del 5-beta-dietilamino-3-alfa fenilpropil-1,2,4-oxadiazolo. Boll. Chim. Farm. 1964; 103:447-450
50. Catanese B, Silvestrini B. Ricerche sulla motilità intestinale del topo studiata con
l'aiuto di un pigmento fotoluminescente. Boll. Chim. Farm. 1964; 103:727-735
51. Corsi G, Catanese B, Silvestrini B. Sintesi di derivati ossidrilati dell'Oxolamina e
indagini sul loro metabolismo e sulle loro proprieta' farmacologiche. Boll. Chim. Farm.
1964; 103:115-125
52. Silvestrini B, Catanese B, Corsi G and Ridolfi P. The urinary metabolites of 5-(2diethylaminoethyl)-3-phenyl-1,2,4-oxadiazole. J. Pharm. Pharmacol. 1964; 16:38-42
53. Silvestrini B, Garau A. Malformazioni fetali prodotte dalla talidomide nel topo.
Boll. Chim. Farm. 1964; 103:804-814
54. Silvestrini B. On “Doping”. Boll. Chim. Farm. 1964; 103:541-544
55. Silvestrini B. The pharmacology page. Boll Chim Farm, 1964; 103:385-388
(1965)
56. Falà F, Silvestrini B. Esame comparativo di alcuni sali della Benzidamina. Boll.
Chim. Farm. 1965; 104:705-709
57. Maffii G, Silvestrini B, Banfi S. Antitussive activity of medazonamide. Nature
1965; 205:914-915
58. Silvestrini B. Modificazioni dell'attività e del metabolismo dei farmaci in relazione
al fenomeno dell'induzione enzimatica. Boll. Chim. Farm. 1965; 104:275-283
59. Silvestrini B. E' utile o dannosa una regolamentazione ufficiale dello studio
tossicologico dei nuovi farmaci? Boll. Chim. Farm. 1965; 104:3-6
60. Silvestrini B. Contributi sperimentali all'ipotesi dei tumori intesi come malattia
sistemica. Boll. Chim. Farm. 1965; 104:400-408
61. Silvestrini B. Ricerca scientifica e industria farmaceutica. Clin. Europ. 1965; 2:121128
62. Silvestrini B. General implications from a study on the anti-inflammatory activity of
Benzydamine. In: Non-steroidal anti-inflammatory drugs. Eds.: Garattini S. and Dukes
M.N.G. Excerpta Med. Foundation, Amsterdam, 180-189, 1965
(1966)
63. Catanese B, Grasso A, Silvestrini B. Studies on the absorption and elimination of
Benzydamine in the mouse, rat, dog and man. Arzneim. Forsch. 1966; 16:1354-1357
5
64. Del Basso-Orsini P, Silvestrini B. Effects of some substances on the turbidimetric
response to heat of albumin and of serum and plasma of the rat. Ital. J. Biochem. 1966;
15:200-215
65. Palazzo G, Corsi G, Baiocchi L, Silvestrini B. Synthesis and pharmacological
properties of 1-substituted 3-dimethylaminoalkoxy-1H-indazoles. J. Med. Chem. 1966;
9:38-41
66. Silvestrini B. Methods for the study of anti-inflammatory drugs. In: Methods in drug
evaluation. 1966; Eds.: Mantegazza P., Piccinini. F. North-Holland Publishing
Company, Amsterdam, 46-61
67. Silvestrini B. Propiedades de la Benzidamina, un nuevo analgesico antiinflamatorio. Medicamenta 1966; 45:81-89
68. Silvestrini B. Un nuovo farmaco antiinfiammatorio: La Benzidamina. Boll. Chim.
Farm. 1966; 105:12-25
69. Silvestrini B. Prospettive dell'industria farmaceutica italiana alla luce dell'esperienza
americana. Boll. Chim. Farm. 1966; 105:477-480
70. Silvestrini B. La profilassi del tetano. Boll. Chim. Farm. 1966; 105:417-418
71. Silvestrini B. Problemi legati alla previsione in laboratorio delle proprietà
biologiche esplicate nell'uomo dai farmaci. Boll. Chim. Farm. 1966; 105:100-103
72. Silvestrini B. The place of Benzydamine in the therapy of inflammatory conditions.
Medicamenta 1966; 45:266-270
73. Silvestrini B, Catanese B, Del Basso P. Researches on the increase of liver weight
produced by some drugs. Biochem. Pharmacol. 1966; 15:249-254
74. Silvestrini B, Garau A, Pozzatti C and Cioli V. Pharmacological research on
Benzydamine. A new analgesic anti-inflammatory drug. Arzneim. Forsch. 1966; 16:5963
75. Silvestrini B, Garau A, Pozzatti C, Cioli V, Catanese B. Additional
pharmacological studies on Benzydamine. Arch. Int. Pharmacodyn. 1966; 163:61-69
76. Silvestrini B. Presentazione della Propaxolina (Toness). Minerva Med. 1966;
58:796-799
(1967)
77. Cioli V, Silvestrini B, Dordoni F. Evaluation of the potential of gastric ulceration
after administration of certain drugs. Exp. Molec. Pathol. 1967; 6:68-83
78. Silvestrini B. La circolare n. 54bis e la ricerca farmaceutica italiana. Boll. Chim.
Farm. 1967; 106:439-442
6
79. Silvestrini B, Catanese B, Cioli V, Burberi S, Scorza Barcellona P. Brewers
yeast-induced inflammation in rats: investigation on some humoral and functional
changes. Boll. Chim. Farm. 1967; 106:385-397
80. Silvestrini B, Lisciani R, Scorza Barcellona P. Anti-granuloma and thymolytic
activity of certain drugs. Europ. J. Pharmacol. 1967; 1:240-246
81. Silvestrini B, Scorza Barcellona P, Garau A, Catanese B. Toxicology of
Benzydamine. Toxicol. Appl. Pharmacol. 1967; 10:148-159
82. Silvestrini B. Inclusion of benzydamine (Tantum) in the therapy of inflammatory
states. Minerva Medica, 1967; 57(96):4067-4070
83. Silvestrini B. Drugs, cosmetics and beverages: meaning and gaps in various rules
governing their use. Boll Chim Farm, 1967; 106(1):1-5
84. Silvestrini B. The place of benzydamine in the therapy of inflammatory conditions.
Panminerva Medica 1967; 9(4): 135-139
(1968)
85. De Gregorio M, Silvestrini B. L'infiammazione. Considerazioni sulla patogenesi e
sulla terapia. Clin. Europ. 1968; 7:83-87
86. Lisciani R, Scorza Barcellona P, Silvestrini B. Researches on the topical activity
of Benzydamine. Europ. J. Pharmacol. 1968; 3:157-162
87. Piccinelli D, Silvestrini B. The analgesic activity of levallorphan. Brit. J.
Pharmacol. 1968; 34:686
88. Silvestrini B. Working hypotheses exploited in the pharmacological research of
some anti-inflammatory drugs. In: Inflammation. Eds.: Silvestrini B., Tura S., Spector
W.G.. Excerpta Med. Foundation, Amsterdam, 1968:26-36
89. Silvestrini B. Profilo farmacologico di un nuovo psicofarmaco. Acta Neurol. 1968;
23:13-15
90. Silvestrini B, Burberi S, Catanese B. Inflammatory responses in normal and
adrenalectomized rats during obstructive jaundice. Jap. J. Pharmacol. 1968; 18:421-429
91. Silvestrini B, Catanese B. Effects of free and protein bound phenylbutazone on
denaturation of plasma proteins. Arzneim. Forsch. 1968; 18:425-426
92. Silvestrini B, Cioli V, Burberi S, Catanese B. Pharmacological properties of AF
1161, a new psychotropic drug. Int. J. Neuropharmacol. 1968; 7:587-599
93. Silvestrini B, Tagliapietra L. Ricerche sperimentali sull'azione disinfettante della
Benzidamina. Boll. Chim. Farm. 1968; 107:353-361
7
(1969)
94. Burberi P, Burberi S, Silvestrini B. Experimental toxicological tests with
Benzydamine. Boll. Chim. Farm. 1969; 108:781-788
95. Cioli V, Scorza Barcellona P, Silvestrini B. Proposta di uno schema sperimentale
per valutare il potenziale effetto cancerogeno di farmaci ad impiego topico. Boll. Soc.
Ital. Biol. Sper. 1969; 45:857-860
96. Piccinelli D, Silvestrini B. Experimental research on the analgesic activity of
levallorphan. Pharmacol. Res. Commun. 1969; 1:100-107
97. Silvestrini B. Primary and secondary inflammation. Panminerva Med. 1969;
11:587-593
98. Silvestrini B, Catanese B and Lisciani R. A biochemical basis of the antiinflammatory activity of Bendazac (AF 983). In: Inflammation biochemistry and drug
interaction. Eds.: Bertelli A., Houck, J.C. Excerpta Med. Foundation, Amsterdam 1969;
283-288
99. Silvestrini B, Cioli V and Burberi S. Pharmacological properties of bendazac (AF
983) with particular reference to its topical action on some experimental inflammatory
processes. Arzneim. Forsch. 1969; 19:30-36
(1970)
100. Burberi P, Piccinelli D, Silvestrini B. Effects of systematically administered drugs
on intraocular pressure in rabbits. Arzneim. Forsch. 1970; 20:1143-1147
101. Catanese B, Lisciani R and Silvestrini B. Effects of ulcerogenic and antiulcer
drugs on gastric secretion in rats. Pharmacol. Res. Commun. 1970; 2:83-90
102. Silvestrini B. L'emploi d'agents anti-inflammatoires, particulierement l'Oxolamine
et la Benzydamine, dans les affections respiratoires. Brux. Med. 1970; 50:203-210
103. Silvestrini B, Burberi S, Catanese B, Cioli V, Lisciani R. Pharmacological
investigation of the anti-ulcer activity of Proxazole. In: Proc. Int. Symp. on Proxazole
and its applications in gastroenterology. 1970; Eds.: Barbara L., Esposito G. Edizioni
Minerva Medica, Torino:23-33
104. Silvestrini B, Catanese B, Lisciani R and Alessandroni A. Studies on the
mechanism of action of bendazac (AF 983). Arzneim. Forsch. 1970; 20:250-253
105. Silvestrini B, Cioli V. Anti-infiammatori e terapia delle infezioni. Atti della
Societa' Medica dei Castelli Romani e Prenestina. 1970; Vol. III:1-15
106. Silvestrini B, Quadri E. Investigations on the specificity of the so-called analgesic
activity of non-narcotic drugs. Europ. J. Pharmacol. 1970; 12:231-235
8
(1971)
107. Burberi S, Silvestrini B. Preventive action of Proxazole in experimentally induced
renal hypertension in rats. Jap. J. Pharmacol. 1971; 21:283-291
108. Cioli V, Scorza Barcellona P and Silvestrini B. Study of the potential
carcinogenicity of topical drug. Suggestions for a new experimental approach. Exp.
Molec. Path. 1971; 15:1-20
109. Cioli V, Silvestrini B. Comparative effects of heating and fasting in mice with
particular reference to development of sarcoma 180. Brit. J. Cancer. 1971; 25:149-157
110. De Feo G, Piccinelli D, Silvestrini B. Effetti di alcuni farmaci sulla motilita'
intestinale del topo normale e del topo trattato con tremorina. Farmaco Ediz. Sci. 1971;
26:123-130
111. Lisciani R, Scorza Barcellona P and Silvestrini B. Topical activity of Bendazac
on experimental burns. Japan. J. Pharmacol. 1971; 21:69-73
112. Silvestrini B. Significato degli antinfiammatori nella profilassi e terapia delle
affezioni respiratorie. G. Clin. Med. 1971; 52:48-61
(1972)
113. Catanese B, Lisciani R, Silvestrini B. Urinary metabolites of Benzydamine in
rats. Arzneim. Forsch. 1972 ; 22:882-884
(1973)
114. Silvestrini B. Denaturazione proteica e flogosi. Ann. Ital. Derm. Clin. Sper. 1973;
27:231-238
115. Silvestrini B. Benzidamina. In: Enciclopedia medica italiana, II Ed., Vol. II. Uses
Ediz. Scientifiche Firenze 1973:2202-2203
116. Silvestrini B. Aminofenazone. In.: Enciclopedia Medica Italiana, II Ed., Vol. I.
Uses Ediz. Scientifiche, Firenze 1973:1523-1525
117. Silvestrini B. Antinfiammatori. In.: Enciclopedia Medica Italiana, II Ed., Vol.II.
Uses Ediz. Scientifiche, Firenze 1973:350-359
118. Silvestrini B, Burberi S. Significati attuali della ricerca farmaceutica. Atti Conv.
"Prospettive del settore farmaceutico in Italia e sue dimensioni nel campo della ricerca
scientifica". Unione Interparlam. Studi Ric. Sci. Tecnol. - Roma, 11/12 Aprile, 27-33,
1973
119. Silvestrini B, Cioli V, Catanese B. Ricerca farmaceutica e Farmacopea. In:
Farmacopea ufficiale. Riflessi della sua applicazione sulla ricerca farmaceutica e sulla
produzione dei medicamenti. Rendiconti Conv. Roma, 17/12/73, Ist. Sup. Sanita' e
G.I.R.F., 55-65, 1973
9
120. Silvestrini B, Lisciani R. Pharmacology of Trazodone. Round table discussion.
Trazodone. A new psychotropic agent, Amsterdam, 1973. Curr. Ther. Res. 1973;
15:749-754
(1974)
121. Allori L, Silvestrini B. Due esempi tipici di medicina sperimentale e di
sperimentazione nell'uomo. Il Trazodone nelle sindromi cerebrali acute e l'AF 1312/TS
nel controllo della fertilita' maschile. Clin. Europ. 1974; 13:519-528
122. Scorza Barcellona P, Catanese B, Silvestrini B. Correlations between doses,
serum levels and embryotoxic effects of acetylsalicylic acid. In: Teratogenic activity of
psychotropic drugs, hallucinogens and ambiental pollutants. Eds.: Bertelli A., Donati L.,
Tuchmann H.. Duplessis-Pacini, Pisa, Italy, 1974:201-210
123. Silvestrini B, Catanese B, Cioli V. Aspects of protein stabilization connected with
the research of anti-rheumatic drugs. In: Future trends in inflammation. Eds. Velo G.P.,
Willoughby D.A., Giroud J.P. Piccin Medical Books, Padua and London 1974:193-202
(1975)
124. Silvestrini B. Dados psicofarmacologicos recentes sobre Trazodone.
Psychopharmacological data on Trazodone. A review. Folha Méd. 1975; 71:569-576
125. Allori L, Cioli V, Silvestrini B. Experimental and clinical data indicating a
potential use of Trazodone in acute stroke. Curr. Ther. Res. 1975; 18:410-416
126. Allori L, Silvestrini B. Orientamenti e prospettive nella terapia dell'arteriosclerosi.
Clin. Europ. 1975; 14:560-568
127. Burberi S, Catanese B, Cioli V, Coulston F, Lisciani R, Scorza Barcellona P,
Silvestrini B. Antispermatogenic activity of 1-p-Chlorobenzyl-1H -indazol-3-carboxylic
acid (AF 1312/TS) in rats. I. Trials of single and short-term administrations with study
of pharmacologic and toxicologic effects. Exp. Mol. Pathol. 1975; 23:288-307
128. Burberi S, Catanese B, Cioli V, Scorza Barcellona P, Silvestrini B.
Antispermatogenic activity of 1-p-Chlorobenzyl-1H- Indazol- 3-Carboxylic Acid (AF
1312/TS) in rats. II. A study of treatments of duration between 5 and 180 days. Exp.
Mol. Pathol. 1975; 23:308-320
129. Coulston F, Dougherty WJ, Lefevre R, Abraham R and Silvestrini B.
Reversible inhibition of spermatogenesis in rats and monkeys with a new class of
indazol-carboxylic acids. Exp. Mol. Pathol. 1975; 23:357-366
130. De Feo G, Piccinelli D, Putzolu S, Silvestrini B. Effects of topically instilled
drugs on intraocular pressure in rabbits. Arzneim. Forsch. 1975; 25:806-809
131. Silvestrini B. Farmaci del futuro. Medicamenti delle malattie mentali. Terzo
Programma - Eri/Ediz. RAI Radiotel. Ital. 1975:136-145
10
132. Silvestrini B. La ricerca nell'industria farmaceutica italiana. Clin. Europ. 1975;
14:126-133
133. Silvestrini B, Catanese B and Lisciani R. Pharmacology of Bendazac. In: New
trends in skin therapeutics. Non-steroid anti-inflammatory local treatment. Eds.: Fuga
G.C., De Gregorio M., Milbradt R. Leonardo Ediz. Sci., Roma, 1-9, 1975
(1976)
134. Allori L, Bernardi G, De Gregorio M, Silvestrini B. Aspetti di farmacoterapia
dell'ictus e delle cerebropatie vascolari croniche. Clin. Europ. 1976; 15:432-446
135. Catanese B, Rossi A, Silvestrini B and Toschi G. Effect of Bendazac and
phenylbutazone on polymerization of bovine serum albumin. Pharmacol. Res. Commun.
1976; 8:549-555
136. Corsi G, Palazzo G, Germani C, Barcellona P and Silvestrini B. I-Halobenzyl1H-indazole-3-carboxylic acids. A new class of antispermatogenic agents. J. Med.
Chem. 1976; 19:778-783
137. De Feo G, Piccinelli D, Silvestrini B. Indagini sulla tonometria oculare per
identazione nel coniglio. Boll. Chim. Farm. 1976; 115:329-334
138. Silvestrini B. Pharmacological profile of Trazodone. In: Therapy in psychosomatic
medicine. Ed.: Antonelli F. Ediz. Luigi Pozzi, Roma 1976:7-20
139. Silvestrini B, Lisciani R. Experimental data suggesting an adrenergic mechanism
in the production of parkinsonian symptoms. Curr. Ther. Res. 1976; 20:716-724
(1977)
140. Catanese B, Baldini A, Burberi S, Silvestrini B, Coulston F. Study of rat serum
concentrations of 1-[(4-clorophenyl) methyl]-1H-Indazole-3-Carboxylic acid, new
antispermatogenic agent. Toxicol. Appl. Pharmacol. 1977; 42:11-18
141. Coulston F, Silvestrini B. Reversible inhibition of spermatogenesis in rats and
monkeys with a new class of indazole-carboxylic acids. In: La ricerca scientifica nell'
industria farmaceutica in Italia. Ediz. Ferro, Milano 1977:1045-1052
142. Gatti GL, Silvestrini B. Trazodone, a new approach to psychopharmacology.
Recent experimental data. Anales del V Congr. Latino Americano de Farmacologia y
Terapeutica, Lima (Peru) 1974. Un. Nac. Mayor de San Marcos, Lima, 209-213, 1977
143. Scorza Barcellona P, Catanese B, Cioli V and Silvestrini B. A critical evaluation
of the correlation between blood levels and antispermatogenic effects of AF 1312/TS in
rats. In: Clinical Toxicology. Eds.: W.A.M. Duncan, B.J. Leonard. Excerpta Med.,
Amsterdam-Oxford 1977; 13:195-197
11
144. Scorza Barcellona P, Cioli V, Burberi S, Silvestrini B. Effects of 1-pchlorobenzyl-1H-indazol-3-carboxylic acid (AF 1312/TS) on the fertility of rats. J.
Reprod. Fert. 1977; 50:159-161
145. Silvestrini B. Antinfiammatori non steroidei ed epatopatie. In: Progressi in
epatologia. Eds.: C. Cascirni, L. Capocaccia-Capozzi, Roma 1977:233-239
146. Silvestrini B, Baiocchi L, Germani C. L'esperienza dell'Istituto di Ricerca F.
Angelini. In: Atti Simp. Int. La ricerca scientifica nell'industria farmaceutica in Italia.
Ediz. Ferro, Milano 1977:85-108
147. Silvestrini B, Cioli V, Catanese B. The concept of primary and secondary
inflammation under some theoretical and applied aspects. Anales del V Cong. Latino
americano de Farmacologia y Terapeutica, Lima (Peru), 1974. Un. Nac. Mayor de San
Marcos, Lima, 12-16, 1977
(1978)
148. Catanese B, Cioli V, De Martino C, Silvestrini B. A comparative study of serum
and testicular concentrations of AF 1312/TS (or 1-[(4-chlorophenyl) methyl]-1Hindazole-3-carboxylic acid and diclondazolic acid or 1-[(2,4-dichloro phenyl)methyl]1H-indazole-3 -carboxylic acid) in rats. Pharmacol. Res. Commun. 1978; 10:261-269
149. Lisciani R, Baldini A, De Feo G, Silvestrini B. Pharmacological investigations on
Etoperidone a new psychotropic agent. Arzneim. Forsch. 1978; 28:417-423
150. Silvestrini B. Esperienze derivanti dallo studio di una nuova classe di farmaci
antispermatogenici. XIX Congr. Soc. Ital. Farmacol. 1st joint meeting Yugoslav and
Italian Pharmacologists, Ancona, Italia 1978:91
151. Silvestrini B. Trazodone a new approach to the therapy of depression. In:
Depression and the role of Trazodone in antidepressant therapy. Eds.: G. Morozov, J.
Saarma, B. Silvestrini. Ediz. Luigi Pozzi, Roma, 1978:1-10
152. Silvestrini B. Considerazioni sui rapporti tra pianificazione delle nascite e ricerca
scientifica. Boll. Soc. Torricelliana, Faenza, 1978; 29:1-13
153. Silvestrini B, Cioli V. Rassegna critica delle proprieta' farmacologiche della
Benzidamina ed osservazioni sui suoi impieghi ginecologici. Clin. Europ. 1978; 16:3-16
154. Silvestrini B, De Gregorio M. Osservazioni relative agli impieghi topici della
Benzidamina in odontoiatria. Paradontol. Stomatol. 1978; 17:63-75
155. Silvestrini B, De Martino C, Cioli V, Campana A, Malorni W, Scorza
Barcellona P. Antispermatogenic activity of diclondazolic acid in rats. Proc. Serono
Symp. "Recent Progress in Andrology", L'Aquila, 1977. Eds.: A. Fabbrini, E.
Steinberger. Academic Press, New York 1978; 14:453-457
12
(1979)
156. Caputo A, Floridi A, Paggi MG, Marcante ML, De Martino C, Silvestrini B.
Control of cell differentiation and cancer cells by Lonidamine. Chemioter. Oncol. 1979;
3:276-281
157. Caputo A, Silvestrini B. Lo studio della spermatogenesi come modello
sperimentale per la ricerca di nuovi agenti antitumorali. In: Atti del V Congresso
Nazionale di Oncologia. Ediz. Nuove Ricerche, Ancona, 1979:235-241
158. De Martino C, Floridi A, Marcante ML, Malorni W, Scorza Barcellona P,
Bellocci M, Silvestrini B. Morphological, histochemical and biochemical studies on
germ cell mithochondria of normal rats. Cell Tissue Res. 1979; 196:1-22
159. Floridi A, De Martino C, Marcante ML, Scorza Barcellona P, Silvestrini B.
Morphological and biochemical modification of rat germ cell mitochondria induced by
new antispermatogenic compounds. Ultramicroscopy 1979; 5:417-418
160. Marcante ML, Floridi A, De Martino C, Scorza Barcellona P, Malorni W,
Silvestrini B. Effects of 1-p. Chlorobenzyl-1H-indazol-3-carboxylic (AF 1312/TS) and
Lonidamine (AF 1890) on rat Sertoli cells. Ultramicroscopy 1979; 5:418-419
161. Silvestrini B. Ibuprofen e analoghi. In: Enciclopedia Med. Italiana, II Ediz., Vol.
VII. Uses Ediz. Sci., Firenze 1979:1106-1107
162. Silvestrini B. Trazodone, a new therapeutic and theoretical approach to depression.
Activ. Nerv. Sup. 1979; 21:301-303
163. Silvestrini B, De Martino C. Antinfiammatori e processi infettivi. Osservazioni
sperimentali e prospettive per la ricerca farmacologica. G. Ital. Chemioter. 1979;
26:111-120
164. Silvestrini B, Lisciani R. Antinfiammatori di uso topico in dermatologia. Criteri
informatori e prospettive della ricerca sperimentale. G. Ital. Dermatol. Minerva
Dermatol. 1979; 114:197-203
(1980)
165. Paggi MG, Floridi A, Marcante ML, De Martino C, Bellocci M, Caputo A,
Silvestrini B. Effect of Lonidamine on the energy metabolism of tumor cells. In: 4th Int.
Symp. on the prevention and detection of cancer. London (U.K.) 1980
166. Silvestrini B. Necessità di nuovi indirizzi per la ricerca sperimentale di agenti
antitumorali. In: Broncopneumatie sociali e cancro broncopolmonare. Eds.: T. Battelli,
M. Bonsignori. Ediz. Nuove Ricerche, Ancona, Italia 1980:157-163
167. Silvestrini B. Introductory remarks on Trazodone and its position in the treatment
of psychiatric diseases. In: Trazodone, a new broad-spectrum antidepressant. Eds.: S.
Gershon, K. Rickels, B. Silvestrini. Excerpta Med. Amsterdam, 1980:1-7
13
168. Silvestrini B, Natali PG, Catanese B, Barillari G, Cordiali-Fei P. Occurrence of
globulin-like migrating blood albumins or GLIMBAL, in pathological rat and human
sera. Can. J. Biochem. 1980; 58:89-92
(1981)
169. Costa Tiozzo R, Buffa P, Silvestrini B. Biochemical lesions induced in isolated
rat liver mitochondria by 1-(2,4-dichlorobenzyl)1H-indazole -3-carboxylic acid (DICA).
In: Abstracts of Symposia and posters of 14th FEBS Meeting, Edinburg, 1981. Poster
Abstract Th-J-46B
170. Floridi A, De Martino C, Marcante ML, Apollonj C, Scorza Barcellona P,
Silvestrini B. Morphological and biochemical modifications of rat germ cell
mitochondria induced by new antispermatogenic compounds. Studies in vivo and in
vitro. Exp. Mol. Pathol. 1981; 35:314-331
171. Floridi A, Paggi MG, D'Atri S, De Martino C, Marcante ML, Silvestrini B and
Caputo A. Effect of Lonidamine on the energy metabolism of Ehrlich ascites tumor
cells. Cancer Research 1981; 41:4661-4666
172. Floridi A, Paggi MG, Marcante ML, Silvestrini B, Caputo A, De Martino C.
Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells. JNCI
1981; 66:497-499
173. Paggi MG, Floridi A, De Martino C, Nista A, Marcante ML, Caputo A,
Silvestrini B. Inhibition of lactate production by Lonidamine in human tumors. Curr.
Chemother. Immunother., 1344-1345, 1981. Proc. 12th International Congress of
Chemiotherapy. Florence (Italy) July, 1981
174. Silvestrini B. Basic and applied research in the study of indazole carboxylic acids.
In: Lonidamine: A new pharmacological approach to the study and control of
spermatogenesis and tumors. Eds.: B. Silvestrini, A. Caputo. Chemotherapy 1981; 27
(2):9-20
175. Silvestrini B. Gli antidepressivi. C.I.S.U. (Centro Informazione Stampa
Universitaria) 1981:39-51
176. Silvestrini B, Lisciani R. Pharmakologische moglichkeiten bei der erforschung
von antidepressiva. In : Depressive Syndrome. Chronischer alkoholismus. Eds.: H.
Lechner, J. Kugler, D. Fontanari. Fortschr. Ther. Excerpta Med., Amsterdam 1981:39-50
177. Silvestrini B, Lisciani R, De Gregorio M. Trazodone. In: Pharmacological and
biochemical properties of drug substances. Ed.: M.E. Goldgerg. American Pharm.
Assoc. Acad. Pharm. Sci. 1981; 3:94-119
(1982)
178. Caputo A, Battelli T, Marcante ML, Gallo M, Floridi A, Silvestrini B, De
Martino C. Therapeutical implications of the effect of Lonidamine on cancer cell
14
membrane. Eds.: T. Galeotti et al. Elsevier Biomedical Press Membranes in Tumor
Growth, 591-595, 1982
179. Catanese B, Barillari G, Iorio E, Silvestrini B., A comparative study of the oral
absorption in man of Bendazac and its lysine salt. Boll. Chim. Farm. 1982; 121:87-90
180. Testa M, Iuliano G, Silvestrini B. Pilot study of Bendazac for treatment of
cataract. The Lancet 1, April 10 1982:849-850
181. De Maio D, Scieghi G, Riva C, Silvestrini B. Preliminary clinical experiences
with dapiprazole. 13th C.I.N.P. Congr., Jerusalem (Israel), June 20-25, 1982
182. De Martino C, Marolla A, Nista A, Malorni W, Natali PG, Floridi A, Marcante
ML, Silvestrini B. Inhibitory effect of Lonidamine on aerobic glycolysis of human
leukemic cells. Caryologia 1982; 35:115-116
183. Floridi A, D'Atri S, Paggi MG, Marcante ML, De Martino C, Silvestrini B,
Caputo A, Lehninger A. Binding of Lonidamine to Ehrlich ascites tumor and liver
mitochondria. In: Membranes in tumor growth. Eds.: T. Galeotti et al. Elsevier
Biomedical Press 1982:559-565
184. Kim JH, Kim SH, Alfieri A, Young CW, Silvestrini B. Lonidamine: a
hyperthermic sensitizer of HeLa cells in culture and of the Meth-A tumor in vivo. In:
Proc. 73rd Ann. Meet. Amer. Ass. for Cancer Res. 1982; 23
185. Lisciani R, Baldini A, Silvestrini B. General pharmacological properties of
Dapiprazole, a potential psychotropic agent. Arzneim. Forsch. 1982; 32:674-678
186. Scorza Barcellona P, Campana A, Silvestrini B, De Martino C. The
embryotoxicity of a new class of antispermatogenic agents: the 3-Indazole-Carboxylic
acids. Arch. Toxicol., Suppl. 1982; 5:197-201
187. Silvestrini B. Trazodone. A new type of antidepressant: a discussion of
pharmacological data and their clinical implications. Adv. Biochem. Psychopharmacol,
1982; 31:327-340
188. Silvestrini B. Trazodone. Uma nova aproximaçao farmacologica. Medico
Policlinico 1982; 90:4-7/ - 91:7-9
189. Silvestrini B, Bonomi L, Lisciani R, Perfetti S, Bellucci R, Massa F, Baldini A.
Effects of Dapiprazole on pupillary size and intraocular pressure in rabbits. Arzneim.
Forsch. 1982; 32:678-681
190. Silvestrini B, Cioli V, De Martino C, Scorza Barcellona P. 3-IndazoleCarboxylic Acids as male antifertility agents: a survey of preclinical and clinical studies.
Arch. Androl. 1982; 9:11-12
191. Silvestrini B, Lisciani R, Baldini A, De Sanctis AJ. Psychopharmacological
profile of Dapiprazole a new potential antipsychotic agent. Arzneim. Forsch. 1982;
32:668-673
15
192. Silvestrini B, Valeri P, Palmery M. Pharmacological and Biochemical
observation on Dapiprazole. XXI Congr. Soc. Ital. Farmacologia, Napoli (Italia), giugno
1982
193. Floridi A, D'Atri S, De Martino C, Paggi MG, Marcante ML, Menichini R,
Silvestrini B, Caputo A. Effect of antispermatogenic compounds (Gossypol and
Lonidamine) on the energy metabolism of tumor cells. 13th Intern. Cancer Congress,
Seattle (Washington), 8 - 15 September, 1982
(1983)
194. Bonomi L, Michieletto S, Marchini G, De Feo G, Valeri P, Silvestrini B. Effects
of ocular instillations of Dapiprazole on pupil motility. Curr. Ther. Res. 1982; 34:469474
195. Floridi A, D'Atri S, Menichini R, Marcante ML, Nista A, Silvestrini B, Caputo
A, De Martino C. The effect of the association of Gossypol and Lonidamine on the
energy metabolism of Ehrlich ascites tumor cells. Exp. Mol. Pathol. 1982; 38:322-335
196. Floridi A, Nista A, Paggi MG, Marcante ML, Bellocci M, De Martino C,
Silvestrini B, Caputo A. The combined effect of hyperthermia and Lonidamine on the
energy metabolism of Ehrlich ascites tumor cells. XIII Int. Cong. Chemother., Vienna
(Austria), 28 Aug - 2 Sept., 1-4, 1983
197. Silvestrini B. Uso ed abuso degli psicofarmaci. In: Educazione Sanitaria.
O.E.M.F., 139-146, Milano, 1983
198. Silvestrini B, Catanese B, Barillari G, Iorio E, Valeri P. Basic data supporting
the use of the L-lysine salt of Bendazac in cataract. Int. J. Tiss. Reac. 1983; 5:217-225
199. Silvestrini B, Hahn GM, Cioli V, De Martino C. Effects of Lonidamine alone or
combined with hyperthermia in some experimental cell and tumour systems. Br. J.
Cancer 1982; 47:221-231
200. Zupi G, Natali PG, Balduzzi MA, Greco C, Di Filippo F, Silvestrini B, Caputo
A. Cytotoxic effect of Lonidamine combined with hyperthermia on human melanoma
cells in vitro. Relevance of time - Sequence schedules of treatment. 13th Int. Congr.
Chemiotherapy, Vienna (Austria), 28 Aug - 2 Sept., 1983
(1984)
201. Battelli T, Manocchi P, Giustini L, Mattioli R, Ginnetti A, De Gregorio M, De
Martino C, Silvestrini B. A long-term clinical experience with Lonidamine. In:
Lonidamine. Proceedings of the IInd International Symposium, Vancouver, 1982. Eds.:
B. Silvestrini, P.R. Band, A. Caputo, C.W. Young. Oncology 1984; 41(suppl. 1):39-47
202. Caputo A, Silvestrini B. Lonidamine, a new approach to cancer therapy. In:
Lonidamine. Proceeding IInd Int. Symp., Vancouver, 1982. Eds.: B. Silvestrini, P.R.
Band, A. Caputo, C.W. Young. Oncology 1984; 41(1):2-6,
16
203. Cioli V, Corradino C, De Martino C, Pasquini P, Rossi V, Silvestrini B.
Pharmacological investigations on Lonidamine. Arzneim. Forsch. 1984; 34:455-460
204. Cioli V, Corradino C, Mazzanti G and Silvestrini B. General pharmacological
investigations on bendazac lysine. Farmaco (Ediz. Sci.) 1984; 39:437-454
205. De Feo G, Mazzanti G, Piccinelli D, Silvestrini B, Stefancich G and Artico M.
A pharmacological study of benzodiazepine derivatives devoid of anticonvulsant
activity. In: XXII Cong. Soc. It. Farmacol., Bologna, 10-13 Ott., 1984
206. Floridi A, D'Atri S, Bellocci M, Marcante ML, Paggi MG, Silvestrini B,
Caputo A, De Martino C. The effect of Gossypol and Lonidamine on electron transport
in Ehrlich ascites tumor mitochondria. Exp. Mol. Pathol. 1984; 40:246-261
207. Hahn G, van Kersen I and Silvestrini B. Inhibition of the recovery from
potentially lethal damage by lonidamine. Br. J. Cancer 1984; 50:657-660
208. Kim JH, Alfieri A, Kim SH, Young CW, Silvestrini B. Radiosensitization of
Meth-A Fibrosarcoma in mice by lonidamine. Oncology 1984; 41(1):36-38
209. Kim JH, Kim SH, Alfieri A, Young CW, Silvestrini B. Lonidamine. A
hyperthermic sensitizer of HeLa cells in culture and of the meth-a tumor in vivo. In:
Lonidamine. Proceedings IInd Int. Symp., Vancouver, 1982. Eds.: B. Silvestrini, P.R.
Band, A. Caputo, C.W. Young. Oncology 1984; 41(1):30-35
210. Laudonio N, Candiloro A, Zupi G, Greco C, Silvestrini B and Caputo A.
Effetto citotossico della lonidamina in combinazione con farmaci antineoplastici su linee
tumorali umane. Atti II Riun. Naz. Oncol. Sper. Clin. 1984; n. 13
211. Mazzanti G, Piccinelli D and Silvestrini B. Investigations on the antiinflammatory action of progesterone. In: XXII Congresso Soc. It. Farmacol., Bologna,
10-13 Ott., 1984
212. Scorza Barcellona P, Campana A, Rossi V, Corradino C and Silvestrini B. A
comparative study of acute toxicity of drugs used during anticancer therapy in healthy
and tumor-bearing mice. Arch. Toxicol. 1984; 7:90-93
213. Silvestrini B. Problemi etici della sperimentazione clinica dei farmaci. Atti
Convegno Int. Sper. Clin. Farmaci. Documento S.I.S.F., 20:33-34
214. Silvestrini B, Palazzo G and De Gregorio M. Lonidamine and related
compounds. Progr. Med. Chem. 1984; 21:111-135
215. Silvestrini B, Sternieri E and De Gregorio M. New perspectives in the treatment
of drug abuse with antidepressants. Clin. Neuropharmacol. 1984; 7(1):258-259
216. Silvestrini B, Valeri P. Trazodone, a new avenue in the treatment of depression.
In: The role of Trazodone in antidepressant therapy. Safety and clinical efficacy. Eds.:
B. Silvestrini, J.P. Feighner, T. Silverstone. Psychopathology 1984; 17(2):3-14
17
217. Valeri P, Bonomi L, Ciranni G, Piccinelli D and Silvestrini B. Penetration and
distribution of bendazac lysine in the eye. In: XXII Cong. Soc. It. Farmacol., Bologna,
10-13 Ott, 1984
(1985)
218. Bertelli A and Silvestrini B. Current trends in the research of antiinflammatory
agents. Int. J. Tiss. Reac. 1985; 7:169-173
219. Floridi A, Alexandre A, Paggi MG, Pellegrini L, Marcante ML, Silvestrini B.,
Caputo A and Lehninger AL. Mechanisms of mitochondrial swelling induced by
lonidamine. In: Cell Membrane and Cancer 1985. Eds.: Galeotti et al. Elsevier Science
Publishers, 217-221,
220. Floridi A, Delpino A, Nista A, Feriozzi R, Marcante ML, Silvestrini B and
Caputo A. Effect of lonidamine on protein synthesis in neoplastic cells. Exp. Mol.
Pathol. 1985; 42:293-305
221. Caputo A, Greco C, Pisano L, Di Filippo F, Cavaliere R, Silvestrini B and Zupi
G. Cytotoxic effects of lonidamine in combination with anticancer agents in human
tumour cell lines. In: 14th Int. Congr. Chemiother. Osaka, 1985
222. Nista A, De Martino C, Malorni W, Marcante ML, Silvestrini B and Aristide
F. Effect of lonidamine on the aerobic glycolysis of normal and phytohemagglutin in
stimulated human peripheral blood lymphocytes. Exp. Mol. Pathol. 1985; 42:194-205
223. Scorza Barcellona P, Campana A, Caranti S and Silvestrini B. Further
toxicological investigations on the new anticancer agent lonidamine. In: 2nd Int. Conf.
Progr. Cancer, San Remo, 68, 1985
224. Silvestrini B. Animal models for the study of atypical anti-infiammatory agents.
Agents and Actions 1985; 17:329-337
225. Silvestrini B. Rationale for the development of trazodone. Speculations and facts.
Proc. IVth World Congr. Biol. Psychiatry, Philadelphia (U.S.A), Sept. 8-13, 1985
226. Silvestrini B, Piccinelli D, Valeri P, Palmery M, Bolle P, Tita B. Sindrome di
astinenza e dapiprazolo. I Congr. Sottoprog. C.N.R. Tossicodip., Firenze, 26 - 28 Sett.,
1985
227. Silvestrini B, Scorza Barcellona P. 1H-Indazole-3-Carboxilic Acid and male
contraception. Int. Symp. Genet. Fertil. Regulation, Twin Symposia, Nairobi (Kenia),
Sept. 22- 25, 1985
228. Silvestrini B and Valeri P. Trazodone - a distinctive pharmacological profile. In:
Psychiatry. The State of the Art. 3: 167-171. Ed.: Pichot et al. Plenum Publishing
Corporation, 1985
229 Valeri P, Palmery M, Tita B and Silvestrini B. Investigation on the ocular
pharmacokinetics of bendazac in rabbit. Exp. Mol. Pathol. 1985; 43:283-287
18
(1986)
230. Zupi G, Grego C, Laudonio N, Benassi M, Silvestrini B, Caputo A. In vitro and
In Vivo Potentiation by lonidamine of Antitumor Effect of adriamcycin. Anticancer Res.
1986; 6:1245-1250
231. Silvestrini B, Valeri P. A comparative biochemical and pharmacological study of
Trazodone and Dapiprazole. In: Modulation of central and peripheral transmitter
function
Eds.: G. Biggio, P.F. Spano, G. Toffano, G.L. Gessa. Fidia Res. Ser., Livina Press,
Springer Verlag, Berlin. Symp. Neurosci. 1986; 3:435-442
232. Cioli V, Corradino C, Crook D, De Martino C, James RW, Rossi V, Scorza
Barcellona P and Silvestrini B. Endocrine and antispermatogenic effects of lonidamine
in male rats of different ages. Adv. Contra. Delv. Syst. 1986; 2:212-230
233. Silvestrini B. Trazodone and the mental pain hypothesis of depression.
Neuropsychobiology 1986; 15:2-9
234. Floridi A, Bagnato A, Bianchi C, Paggi MG, Nista A, Silvestrini B, Caputo A.
Kinetics of inhibition of mitochondrial respiration by antineoplastic agent lonidamine. J.
Exp. Clin. Cancer Res. 1986; 5(3):273-280
235. Silvestrini B. An operative subclassification of Orphan Drug. Rendiconti della
Accademia Nazionale delle Scienze detta dei XL. Memorie di Scienze Fisiche e
Naturali. Serie V, 1986; 10:103-106
236. Delpino A, Nista A, Marcante ML, Ferrini U, Silvestrini B, Caputo A and
Floridi A. Induction of Stress Proteins by Lonidamine in Human and Murine Melanoma
Cells. Exp. Mol. Pathol. 1986; 44:197-206
237. Silvestrini B. Etica e profitto dei medicamenti.Tratto da “Chiesa e Salute nel
Mondo”. Dolentium Hominum 1986; 1:38-40
238. Silvestrini B, Valeri P, Palmery M, Piccinelli D. Sindrome di astinenza e
dapiprazolo. C.N.R. Medicina Preventiva e Riabilitativa. Roma, 17-21 marzo 1986
239. Valeri P, Palmery M, Silvestrini B, Bolle P. Diversita' negli aggiustamenti di
sistemi recettoriali cerebrali a somministrazioni ripetute di antidepressivi. XXIII Congr.
Naz. Soc. Ital. Farmacol., Sanremo, 6-8 Ott., 1986
(1987)
240. Silvestrini B. La terapia dell'ictus in fase acuta. Prospettive farmacologiche alla
luce delle conoscenze attuali. Atti e memorie della Società Medica del Lazio 1987;
3:143-149
241. Musci G, Silvestrini B. Mechanism of the scavenger-like activity of bendazac.
Drugs Expl. Clin. Res. 1987; XIII (5):289-292
19
242. Paggi MG, Zupi G, Fanciulli M, Del Carlo C, Giorno S, Laudonio N,
Silvestrini B, Caputo A, Floridi A. Effect of Lonidamine on the Utilization of 14CLabeled Glucose by Human Astrocytoma Cells. Exp. Mol. Pathol. 1987; 47:154-165
243. De Martino, C, Malorni, W, Accinni, L, Rosati F, Mista A, Formisano G,
Silvestrini B, Arancia G. Cell Membrane Changes induced by Lonidamine in Human
Erythrocytes and T LyMphocytes, and Ehrlich Ascites Tumor Cells. Exp. Mol. Pathol.
1987; 46:15-30
244. Silvestrini B. Benzydamine, an unique model of anti-inflammatory activity. Int. J.
Tiss. Reac 1987; IX(2):87-91
245 Silvestrini B. Sperimentazione farmacologica e strategia di ricerca. Fed. Med. 1987;
40(2):149-152
246. De Martino C, Battelli T, Quintarelli G, Silvestrini B, Vecchi A, De Gregorio
M, Bellocci M, Mattioli R, Ginnetti A, Accinni L. Importanza dell'indagine
ultrastrutturale di cellule neoplastiche nei versamenti pleuro-peritoneali per la
diagnostica citologica e per i saggi preclinici dei farmaci. In: I nuovi Farmaci (nella
terapia dei Tumori). Eds.: T. Battelli, P.R. Band, A. Giannetti, K. Sikora, B. Silvestrini.
Ed.: Monduzzi, Bologna, 1987; 6:33-74
247. Silvestrini B. Problems in the experimental research for anticataract agents. A
critical overview. Acta XXV Concilium Opthalmologicum. Proceedings of the XXVth
International Congress of Ophthalmology. Rome, May 4-10, 1986. Kugler & Ghedini,
Amsterdam, Berkeley, Milano, 2510-2516, 1987
248. Valeri P, Palmery M, Martinelli B and Silvestrini B. Acute interaction between
morphine and dapiprazole. First Joint Meeting of the Italian and Dutch Pharmacol. Soc..
Florence, 10-13 may, 1987
249. Silvestrini B. Lonidamina storia di una scoperta farmacologica. In. I nuovi farmaci
(nella terapia dei tumori). Eds.: T. Battelli, P.R. Band, A. Giannetti, K. Sikora, B.
Silvestrini. Ed.: Monduzzi, Bologna, 1987; 6:75-79
250. Silvestrini B. Rationale for bendazac. In: Recent developments in the
Pharmacological Treatment of Cataract. Eds.: F. D'Ermo, F. Ponte, A.M. Laties. Ed.:
Kugler Publ. & Ghedini Ed. Milano 1987:1-9
251. Silvestrini B. L'innovazione medica al servizio dell'uomo. Dolentium Hominum
1987; 4:34-39
252. Bagnato A, Bianchi C, Caputo A, Silvestrini B, Floridi A. Enhancing effect of
Lonidamine on the Inhibition of Mitochondrial respiration by Adriamycin. Anticancer
Res. 1987; 7:799-802
253. Floridi A, Bianchi C, Bagnato A, Gambacurta A, Paggi MG, Silvestrini B,
Caputo A. Lonidamine-induced Outer Membrane Permeability and Susceptibility of
Mitochondria to Inhibition by Adriamycin. Anticancer Res. 1987; 7:1149-1152
20
(1988)
254. Silvestrini B. Preliminary considerations on the medical treatment of cataract. In:
Ophthalmology today. Eds: L.N. Ferraz de Oliveira. Ed.: Elsevier Science Publisher
B.V., Amsterdam, 1988:715-722
255. Silvestrini B. Benzydamine: a preclinical overview. In: Benzydamine topical
therapy in gynecology. Eds: A.R. Genazzani, B. Silvestrini. Ed.: The Parthenon
Publishing Groups Lt., Carnforth, 1988:11-19
256. Silvestrini B. Pharmacological viewpoints on the senescence of the eye. Intern.
Ass. Cataract Rel. Res. 1988; 1:34-37
257. Silvestrini B. Beyond the limits of typical antidepressants. Psychopharmacology
1988; 95:S1-S2
258. Silvestrini B. Preclinical profile of trazodone. Psychopharmacology 1988; 96:S1S4
259. Valeri, P, Palmery M, Silvestrini B. Binding profile of trazodone and dapiprazole
to some brain receptors. Drugs Exptl. Clin. Res. 1988; 14(1):53-58
260. Silvestrini B, Palmery M, Severini C. Effect of D-Lysergic Acid Diethylamine on
Serotonin, Adrenalin and Dopamine evoked Aorta contractions. Pharm. Res. Comm.
1988; 20(5):435-436
261. Silvestrini, B. Lonidamine, the prototype of energolytic antitumor agents.
Pharmacol. Res. Comm. 1988; 20 suppl. II :362
262. Silvestrini, B. Recent story and prospectives of antidepressant therapy. In: The
Modes of Depression: psychobiology and psychodynamics. Eds: L. Ravizza, E.
Genazzani,R. Torta, C. Eva. Ed.: Publ. Libreria Cortina, Torino, Italia 1988:127-131
263. Paggi, MG, Fanciulli M, Perrotti N, Floridi A, Zeuli M, Silvestrini B and
Caputo A. The Role of Mitochondrial Hexokinase in Neoplastic Phenotype and its
Sensitivity to Lonidaminea. Annals of the N. Y. Academy of Sciences 1988; 551:358-360
264. Floridi A, Bagnato A, Bianchi C, Fanciulli M, Silvestrini B and Caputo A.
Lonidamine-Induced Membrane Permeability and the Effect of Adriamycin on the
Energy Metabolism of Ehrlich Ascites Tumor Cells. Annals of the N.Y. Academy of
Sciences 1988; 551:270-272
265. Tita B, Bolle P, Martinoli L, Mazzanti G, Silvestrini B. A comparative study of
Atropa belladonna and atropine on an animal model of urinary retention. Pharmacol.
Res. Comm. 1988 ; 20(5) :55-58
266. Valeri P, Pimpinella G, Palmery M, Mazzanti G, Martinelli B, de Feo G,
Silvestrini B. Role of adrenergic system on withdrawal behavior in mice to a single dose
of morphine. Pharmacol. Res. Comm. 1988; 20(II):390
21
267. Silvestrini B, Valeri P. Ocular penetration and effects of aspirin and bendazac.
Facts and speculations. 8th Intern. Congress of Eye Research. Proceedings of the Intern.
Society for Eye Research 1988; V:90
268. Scorza Barcellona P, Caranti S, Campana A and Silvestrini B. Pretreatment
with bendazac attenuates retinal damage induced by intense light in rats. 8th Intern.
Congress of Eye Research. Proceedings of the Intern. Society for Eye Research 1988;
V:90
269. Silvestrini B. Trazodone. Enciclopedia Medica Italiana - Uses Ediz. Scientif.
Firenze 1988; 15:390-391
270. Tita B, Bolle P, Mazzanti G and Silvestrini B. A method for the pharmacological
study of micturition in the intact, non anaesthetized animal. Pharmacol. Res. Comm.
1988; 20(2):383
(1989)
271. Silvestrini, B. Lonidamine, a new approach to cancer treatment. In: Advances
management malignancies. Eds.: A. Sagripanti, A. Carpi, B. Grassi. Ed: Monduzzi,
Firenze, Italia 1989:337-344
272. Silvestrini B. Lonidamine: a new pharmacological way for overcoming
radioresistance. In: Resistance to Antitumor Agents. Laboratory and Clinical Studies.
Eds.: M. Ghione, L. Rausa. Ed. Harwood Academic Publishers, New York 1989:245258
273. Silvestrini, B. Trazodone: From the Mental Pain to the "Dys-Stress" Hypothesis of
Depression. Clin. Neuropharmacol. 1989; 12(suppl. 1):S4-S10
274. Silvestrini, B.
12(suppl. 1):S58-S59
Concluding
Remarks.
Clin.
Neuropharmacol.
1989;
275. Silvestrini, B. Riflessioni sul significato biologico della senescenza. Dolentium
Hominum 1989; 10:56-59
276. Citro G, Galati R, Verdina A, Castiglione S, Silvestrini B, Caputo A, Floridi A.
Immunochemical determination of lonidamine in rat tissues and blood serum.
Anticancer Res. 1989; 9:811-816
277. Ciancarelli-Tozzi MG, Silvestrini B, Finazzi-Agro A. Photosensitized
haemolysis of human erythrocytes is reduced by bendazac. Drugs Exptl. Clin. Res.
1989; 15(5):219-222
278. Silvestrini B, Guglielmotti A, Saso L, Cheng CY. Changes in Concanavalin Areactive Proteins in Inflammatory Disorders. Clin. Chem. 1989; 35:2207-2211
279. Mazzanti G and Silvestrini B. Reflections on Scientific and Normative Bases of
Current Phytotherapy. Atti del Congr. Intern. sulle Piante Medicinali. Memorie di
Scienze Fisiche e Naturali. Rendiconti dell'Accademia Nazionale delle Scienze detta dei
XL, serie V vol. XIII parte II, 1989; 107:249-255
22
280. Silvestrini B. The two phytotherapies and the laws governing them. Memorie di
Scienze Fisiche e Naturali. Atti del congr. Intern. sulle Piante Medicinali. Rendiconti
dell'Accademia Nazionale delle Scienze detta dei XL, serie V vol. XIII parte II, 1989;
107:421-423
281. Silvestrini B. Towards a pharmacology of protein denaturation. 19th meeting
Federation European Biochemical Societies, Rome, July, 2-7 1989
282. Silvestrini B. Background for the use of trazodone in special forms of depression.
VIII World Congress of Psychiatry, Athens (Greece), October 12-19 1989
283. Bolle P, Tita B, Martinoli L, Silvestrini B. Studio comparativo dell'Atropa
belladonna e dei suoi principali alcaloidi sulla minzione del topo intatto e non
anestetizzato. Annali dell'Universita' di Ferrara. Atti del V Congresso della Soc. Ital.
Farmacognosia, 16-18 ottobre 1989
284. Silvestrini B. Anomalie della risposta di stress e trazodone. In: Meeting
Internazionale di Cardiologia e Neurologia. (Selecta Neurologica) Eds. I. Richichi, G.
Nappi. Ed. Cluster Press, Roma, 479, 1989
285. Palmery M, Leone MG, Mazzanti G, Morrone LA, Tita B e Silvestrini B.
Effetto facilitante di Passiflora incarnata L. sulla risposta dell'aorta isolata all'adrenalina,
noradrenalina e serotonina. Annali dell'Universita' di Ferrara. Atti del V Congresso della
Soc. Ital. Farmacognosia, 16-18 ottobre 1989
(1990)
286. Silvestrini B, Guglielmotti A, Saso L, Milanese A, Melanitou E, Grima J,
Cheng CY. Development of an Enzyme-Linked Immunosorbent Assay with a
Monoclonal Antibody Prepared against α1-Antitrypsin for Diagnostic Screening of
Inflammatory Disorders. Clin. Chem. 1990; 36/2:277-282
287. Cheng YC, Grima J, Stahler MS, Guglielmotti A, Silvestrini B, Bardin CW.
Sertoli Cell Synthesizes and Secretes a protease Inhibitor, α2-Macroglobulin.
Biochemistry 1990; 29:1063-1068
288. Silvestrini B. Farmaci antitumorali della seconda generazione. Nuovi antitumorali.
Fed.Med. 1990; 53:569-572
289. Silvestrini B. The Paradoxical Stress Response: A Possible Common Basis for
Depression and Other Conditions. J. Clin. Psychiatry 1990; 51:6-8
290. Silvestrini B. La lonidamina, un nuovo indirizzo nel trattamento dei tumori. Eur.
Rev. Med. Pharmacol. Sci. (Verduci Ed.) 1990; 12:205-210
291. Silvestrini B. Farmaci dell'occhio: Recenti acquisizioni e prospettive. Eur. Rev.
Med. Pharmacol. Sci. (Verduci Ed.) 1990; 12:81-9
292. Silvestrini B, Valeri P. Pharmacological aspects of aging lens and cataract, with
particular reference to aspirin and bendazac. In: the Senile Cataract. Proceedings of the
23
4th IACRR Int. Congress, Milano, Oct. 28-30, 1988. Ed. F. Ponte and G. Giuffre',
Medical Books, Palermo, 1990
293. Silvestrini B, Palmery M, Basta F, Valeri P. Dual action of amphetamine on the
rabbit aortic strips. Pharmacol. Res. 1990; 22(suppl. 2) :460
294. De Feo G, Lisciani R, Orticelli G, Del Vecchio A, Mazzanti G and Silvestrini B.
Short term tolerance to lethal effects of total body hyperthermia in mice. XIth Int.
Congress of Pharmacology. Eur. J. Pharmacol. 1990; 183:237-238
295. Palmery M, Leone MG, Moffa M, Pimpinella G and Silvestrini B. Facilitating
effect of Harmaline on the aortic response to Dopamine. Satellite Meeting of the XIth
International Congress of Pharmacology. Como, 8-11 luglio 1990
296. Bolle P, Tita B, Mazzanti G, Martinelli B, Silvestrini B. Un modello
sperimentale per lo studio farmacologico della minzione. Eur. Rev. Med. Pharmacol.
Sci. (Verduci Ed.) 1990; 12:201-204
297. Bonomi L, Silvestrini B, Catanese B, Baravelli S, Panei M. Penetrazione del
bendazac nell'umore acqueo dell'uomo, dopo applicazione topica di bendazac lisina
collirio. Risultati preliminari. In: Farmacologia oculare attualita' e prospettive. Atti del II
Congr. Naz. Farmacologia Oculare. Catania, 12-14 ottobre 1990. Ed. Filippo Drago,
Cappelli ed., 377-382, 1990
298. Silvestrini B. Riflessioni di un biologo sulla senescenza. In: Manuale Merck di
geriatria. II ed. italiana. Stampa Medica Srl, S. Donato Milanese (MI) 1990; 103:14231427
(1991)
299. Silvestrini B and Silvestrini M. Drugs and abnormalities of stress response. In:
Stress and related disorders: from adaption to dysfunction. Eds.: Genazzani, A.R.,
Nappi, G., Petraglia, F. Martignoni, E. Ed.: The Parthenon Publishing Group, Carnorth,
U.K., 1991
300. Silvestrini B. Le prospettive della psicofarmacologia come mezzo di restauro della
mente. Dolentium Hominum 1991; 16:135-138
301. Silvestrini B. Lonidamine: An Overview. Seminars in Oncology 1991; 18(2-suppl.
4):2-6
302. Stahler MS, Schlegel P, Bardin CW, Silvestrini B and Cheng Y. alfa2Macroglobulin is not an Acute-Phase Protein in the Rat Testis. Endocrinology 1991;
128:2805-2814
303. Silvestrini B., Cataract, Protein Denaturation and Pathological Aging. Proceedings
of the 5th IACRR International Congress. Roma, November 17-19 1989. Ed.: Ponte F.
and Giuffrè G. Ed., Medical Books 1991, Palermo
24
304. Silvestrini B, Palmery M, Basta F and Valeri P. Facilitating effect of
amphetamine on the response of rabbit aortic strips to adrenaline, dopamine and
serotonin. J. Neural. Transm. Gen. Sect. 1991; 86:51-59
305. Scorza Barcellona P, Campana A, Caranti S, D'Onofrio E, Silvestrini B.
Pretreatment with bendazac attenuates retinal damage induced by intense light in rats.
Pharm. Res. 1991; 24(1):105-112
306. Silvestrini B. Radicali liberi, denaturazione proteica ed interventi farmacologici.
In: "Radicali liberi e patologia oculare" suppl. n. 3 - Anno 2 del Bollettino di
Farmacologia Oulare. Ed. F. Drago e A. Reibaldi, 23-26, 1991
307. Silvestrini B. Peculiarità del controllo neurovegetativo delle funzioni oculari. In:
Glaucoma argomenti controversi. Minerva Oftalmologica 1991; 33(3):211-216
308. Silvestrini B, Bombardieri S, Caranti S, Cheng CY, D'Ascanio A, Guglielmotti
A, Milanese C, Saso L, Tirri G, Valentini G. The use of a monoclonal antibody
against alfa 1-antitrypsin in diagnostic screening of inflammatory disorders. Int. Journ.
of Immunotherapy, 1991; VII(4):197-204
309. Silvestrini B. Physiopathological and pharmacological aspects of the stress
response. In: Biological Psychiatry vol. 1, Eds. Racagni G., Brunello N., Fukuda T. Ed.:
Excerpta Medica, London 1991:152-156
310. Silvestrini B. Drugs Affecting the Serotonergic System. In: Headache and
Depression: Serotonin Pathways as a Common Clue. Eds.: G. Nappi, G. Bono, G.
Sandrini, E. Martignoni, G. Micieli. Ed.: Raven Press, New York 1991:219-224
311. Silvestrini B. Correlati psicopatologici delle risposte di stress ortodosse e
paradosse. Prevenzione cardiovascolare, num. straord., pag. 31, 1991. Atti del II Congr.
Intern. di Cardioneurologia. L'Aquila 28-31 agosto 1991
312. Silvestrini B. Basic Physiopathological Aspects. Biol. Psychiatry 1991; 29:11S35S. Abs. of the 5th World Congress of Biological Psychiatry, Florence (Italy), June 914, 1991
(1992)
313. Silvestrini B. Gli psicofarmaci: da uso terapeutico a rischio d'abuso. Dolentium
Hominum 1992; 19:92-96
314. Palmery M, Leone MG, Pimpinella G, Silvestrini B. Facilitating effect of
harmaline on the aortic response to dopamine. Pharmacol. Res. 1992; 25(suppl. 1):7-8
315. Leone MG, Silvestrini B, Palmery M and Cheng YC. Identification of multiple
biological factors in rabbit serum that modulate dopamine-mediated aortic constriction.
Biochem. Int. 1992; 26(6):1079-1090
316. Silvestrini B, Palmery M, Tita B. Sympathetic discharge and blood pressure.
Functional Neurol. 1992; 7(3):45-50
25
317. Li AHY, Saso L, Cazzolla N, Zwain I, Marshall A, Guglielmotti A, Silvestrini
B and Cheng CY. Differential expression of α2-Macroglobulin mRNA in the rat testis,
brain, and liver in response to acute inflammation. Annual Meeting of the Endocrine
Soc., San Antonio, Texas, June 24-27, 1992
318. Saso L, Silvestrini B, Guglielmotti A, Lahita RG and Cheng CY. Abnormal
glycosilation of selected glycoproteins during chronic inflammatory conditions can be
reversed by bindarit, 2-[(1-benzyl-indazol-3-yl)methoxy]-2-methyl propionic acid.
National Meeting American Association for Clinical Chemistry, Chicago, July 19-13,
1992
319. De Feo G, Giacomelli S, Lisciani R, Panzironi C and Silvestrini B. Further
investigations on the tolerance to the lethal effects of total body hyperthermia in mice.
Pharmacol. Res. 1992; 26(suppl. 1):95
320. Silvestrini B, Palmery M, Basta F, Leone MG and Cheng CY. Identification of
novel biological factors that facilitate the aortic response to dopamine. Pharmacol. Res.
1992; 26(suppl. 1):166
321. Silvestrini B, Tita B, Bolle P, Faccendini P and Bello U. Adrenergic blocking
agents and adrenal sympathetic discharge. Pharmacol. Res. 1992; 26(suppl. 1):166
322. Leone MG, Silvestrini B, Palmery M and Cheng CY. A study on multiple
biological factors in rabbit serum that modulate dopamine-mediated aortic constriction.
Pharmacol. Res. 1992; 26(suppl. 1):167
323. De Feo G, Lisciani R, Giacomelli S, Bucci MG and Silvestrini B. An animal
model for the pharmacological study of the negative feed-back controll of intraocular
pressure. Pharmacol. Res. 1992; 26(suppl. 1):167
324. Tita B, Bello U, Faccendini P, Bolle P and Silvestrini B. Different effects of
autonomic drugs on the bladder function of female and male rats. Pharmacol. Res. 1992;
26(suppl. 1):197
325. Saso L, Silvestrini B, Zwain IH, Mo MY and Cheng CY. Changes of
cerebrospinal fluid proteins in the rat during acute inflammation. Pharmacol. Res. 1992;
26(suppl. 1):237
326. Cioli V, Durando L, Braghiroli L, Mazzanti G and Silvestrini B. Effects of
selected blocking α-1 agents on analgesic tolerance to morphine. Pharmacol. Res. 1992;
26(suppl. 1):313
327. Saso L, Silvestrini B, Zwain I, Guglielmotti A, Luparini MR, Cioli V and
Cheng CY. Abnormal Glycosylation of Hemopexin in Arthritic Rats Can Be Blocked
by Bindarit. J. Rheumatol. 1992; 19(12):1859-1867
328. Cioli V, Ciarniello MG, Guglielmotti A, Luparini MR, Durando L, Martinelli
B, Catanese B, Fava L and Silvestrini B. A new protein antidenaturant agent, Bindarit,
reduces secondary Phase of adjuvant Arthritis in Rats. J. Rheumatol. 1992; 19(11):173542
26
329. Cheng CY, Zwain I, Cazzolla N, Saso L, Mo M-y, Guglielmotti A, Silvestrini B
and Bardin W. Purification of proteins and peptides on SMARTTM System. Science
Tools 1992; 36(1):1-5
330. Tita B, Bello U, Faccendini P, Bolle P and Silvestrini B. Further investigations
on sex-related responses of trigone and proximal urethra in anesthetized rats. VI Congr.
Soc. Ital. Neuroscienze, Modena, 1-4 dicembre 1992. Neurosciences Letters 1992;
Suppl. 43:S110
(1993)
331. Tita B, Bello U, Faccendini P, Bolle P e Silvestrini. Studio preliminare degli
effetti del dapiprazolo su trigono ed uretra di ratto anestetizzato. III Congr. Naz. Soc.
Ital. per la verifica e lo sviluppo dei farmaci post-registrazione. Roma, 29.-30 gennaio,
1993
332. Tita B, Bello U, Bolle P, Faccendini P, Silvestrini B. A physiopharmacological
study of sympathetic innervation in micturition. Pharmacol. Res. 1993; 27(suppl. 1):4950
333. Silvestrini B, Basta F, Leone MG, Palmery M, Cheng Y. Serotonin does not
account for all the serum contracting and facilitating effects on aortic strips. Pharmacol.
Res. 1993; 27(suppl. 1):77- 78
334. Palmery M., Pimpinella G., Saso L., Silvestrini B. Facilitating effect of
amphetamine and harmaline on blood pressure response to biogenic amines in rats.
Pharmacol. Res. 1993; 27(suppl. 1):75-76
335. Guglielmotti A, Silvestrini B, Saso L, Zwain I and Cheng CY. Chronic
inflammatory response in the rat can be blocked by bindarit. Biochem. and Mol. Biol.
Int. 1993; 29(4):747-756
336. Silvestrini B. Biotecnologie e progresso farmaco-terapeutico. Federazione Medica
1993; 6:5-7
337. Saso L, Silvestrini B, Lahita R and Cheng CY. Changes of immunoreactivity in
alfa1-antitrypsin in patients with autoimmune diseases. Inflammation 1993; 17(3):383400
338. Saso L, Silvestrini B, Guglielmotti A, Lahita R and Cheng CY. Abnormal
glycosylation of alfa2-macroglobulin, a non-acute-phase protein, in patients with
autoimmune diseases. Inflammation 1993; 17(4):465-479
339. Saso L, Silvestrini B and Cheng CY. The Use of High-Performance
Electrophoresis chromatography for the Micropurification of Cerebrospinal Fluid
Proteins in the rat. Analyt. Biochem. 1993; 212:315-324
340. Leone MG, Saso L, Del Vecchio A, Mo M, Silvestrini B and Cheng CY.
Micropurification of Two Human Cerebrospinal Fluid proteins by High Performance
Electrophoresis Chromatography. J. Neurochem. 1993; 61:533-540
27
341. Cheng CY, Calcagno K, Tio S and Silvestrini B. Identification and purification
of a tissue inhibitor of metalloproteinases-2 (TIMP-2) from Sertoli cell-enriched culture
medium. The American Society for Cell Biology, Bethesda, 6 Aug. 1993
342. Zwain IH, Grima J, Silvestrini B and Cheng CY. Biosynthesis of clusterin by rat
astrocytes and its differential regulation by cytokines. The American Society for Cell
Biology, Bethesda, 6 Aug. 1993
343. de Feo G, Clemente M, Bardosova B, Ponzianelli A, Lisciani R, Silvestrini B,
Giuliano M. Effects of short and long lasting variations of blood pressure on intraocular
pressure. Riunione Monotematica Nazionale di Farmacologia Oculare, Roma, 30
novembre 1993
344. Leone MG, Giacomelli S, Giuliano M, Cheng CY, Silvestrini B. Identificazione
e purificazione di diverse proteine nell’umor acqueo mediante HPLC. Riunione
Monotematica Nazionale Farmacologia Oculare, Società Italiana di Farmacologia,
Roma, 30 Novembre 1993
345. Silvestrini B. Daniel Bovet, the teacher. Annali ISS, 1993; 29(1):41-44
(1994)
346. Li HYA, Zwain IH, Pineau C, Cazzolla N, Saso L, Silvestrini B, Bardin CW
and Cheng CY. Response of alfa2-macroglobulin messenger ribonucleic acid
expression to acute inflammation in the testis is different from the response in the liver
and brain. Biology Reprod. 1994; 50:1287-1296
347. Silvestrini B. Ricerca e sperimentazione preclinica dei nuovi farmaci in psichiatria:
limiti delle ipotesi farmacocentriche e dei modelli sperimentali su esse basati. In: La
sperimentazione dei nuovi farmaci in psichiatria. Eds: M. Maj, G. Racagni. Masson,
Milano 1994, 29-35
348. Mathur PP, Mo MY, Panzironi C, Silvestrini B, Bardin CW, Grima J and
Cheng CY. Rat testicular testibumin is identical to sulfated glycoprotein-1 (SGP-1)
whose mRNA expression in the testis is age- but not germ cell-dependent. Biochem.
Mol. Biol. Int. 1994; 34(5):1063-1071
349. Cheng CY, Panzironi C, Saso L, e Silvestrini B. La glicosilazione proteica, un
possibile fattore patogenetico, e bersaglio di effetti farmacologici, nelle malattie
autoimmunitarie. Giornata monotematica della Società Italiana di Farmacologia:
“Farmacologia della Flogosi ed Immunomodulazione”, Perugia, 10 giugno 1994
350. Silvestrini B. La rete dei comitati di etica. In: Comitati di Etica e
Farmacovigilanza. Eds.: V. Berté, A.A. Bignamini. Ed. Health Srl, Bologna 1994:17-23
351. Palmery M, Leone MG, Panzironi C and Silvestrini B. Duplice azione della
mescalina sul preparato di aorta di coniglio. VII Congr. Naz. Soc. Ital. Farmacogn.,
Bologna, 30 giugno-2 luglio, 1994
28
352. Bolle P, Palmery M, Leone MG, Martinoli L and Silvestrini B. Effects of
amphetamine on adrenergic response in rabbit urethral strips. XXVII Congr. Naz. Soc.
Ital. Farmacol., Torino, 25-29 settembre, 1994
353. Saso L, Valentini G, Panzironi C, Braghiroli L, and Silvestrini B. Protective
action of some biological agents against albumin heat-induced denaturation. XXVII
Congresso Nazionale della Società Italiana di Farmacologia. Torino, 25-29 settembre,
1994
354. Saso L, Mazzanti G, Valentini G, Cheng CY and Silvestrini B. Effects of some
urine components on calcium oxalate precipitation. XXVII Congresso Nazionale della
Società Italiana di Farmacologia. Torino, 25-29 settembre, 1994
355. De Feo G, Lisciani R, Di Pasquale C, Ponzianelli A, Silvestrini B. Further
studies on the mechanism of thermotolerance in mice. Conferenza CNR P.F. ACRO, La
Ricerca Oncologica in Italia, Roma, 9-10 giugno 1994
356. Silvestrini B, Palmery M, Tolu L, Basta F, Leone MG and Cheng Y. Facilins, a
novel class of biological factors that facilitate the aortic response to dopamine and other
biogenic amines. J. Neural Transm. 1994; 95:77-93
(1995)
357. Silvestrini B. Obiettivi e limiti della ricerca biologica in medicina. Dolentium
Hominun, 1995; 28:112-115
358. Saso L, Casini ML, Valentini G, Alcaro S and Silvestrini B. Effect of selected
substances on heat induced aggregation of albumin examined by HPLC and
polyacrylamide gel electrophoresis. Pharmacol. Res. 1995; 31(suppl. 1):214
359. Saso L, Posta S, Valentini G, Guglielmi R, Paris L and Silvestrini B. Influence
of selected endogenous and exogenous compounds on calcium oxalate precipitation.
Pharmacol. Res. 31(suppl. 1):355
360. Silvestrini B, Faccendini P, Bolle P, Tita B. Differential action of propranolol on
the release and direct effect of epinephrine. Pharmacol. Res. 1995; 31(suppl. 1):328
361. Iurlo M, Nomikos GG, Hertel P, Gherardini G, Palmery M, Leone MG,
Silvestrini B. Effetti della somministrazione sistemica di armina nel rilascio in vivo
della dopamina e dei suoi metaboliti nell'area ventro-striatale del ratto attraverso la
tecnica della microdialisi. VI Congresso della Società Italiana di Neuroscienze. Milano
25-28 giugno 1995
362. Giacomelli S, Palmery M, Bolle P, Romanelli L, Silvestrini B. Effetto della
dietilamide dell'acido lisergico (LSD) sulla inibizione della secrezione di prolattina in
29
vitro mediata dalla dopamina. VI Congresso della Società Italiana di Neuroscienze.
Milano, 25-28 giugno 1995 ; 1995
363. Li AHY, Silvestrini B, Leone MG, Giacomelli S and Cheng CY. Cerebrin-50, a
human cerebrospinal fluid protein whose mRNA is present in multiple tissues but
predominantly expressed in the lymphoblastoid cells and the brain. Biochem. Mol. Biol.
Int. 1995; 35(1):135-144
364. Palmery M, Leone MG, Iurlo M, Luzi A, Silvestrini B. Effetti di alcune sostanze
psicotogeniche sul preparato di striscia aorta di coniglio. In: Farmacognosia: moderni
sviluppi di una scienza antica. Patron, Bologna 1995:151-156
365. Mazzanti G, Braghiroli L, Scarpati ML e Silvestrini B. Persea Indica: un
esempio di apparente tossicomania nell'animale selvatico. Acta Technologiae et Legis
Medicamenti 1995; 6(suppl. 3):464-466
(1996)
366. Giacomelli S, Leone MG, Grima J, Silvestrini B, Cheng CY. Astrocytes
synthesize and secrete prostaglandin D synthetase in vitro. Biochemica et Biophysic Acta
1996; 1310:269-276
367. Silvestrini B. Il rispetto della vita nella ricerca biomedica. Dolentium Hominum
1996; 31:159-162
368. Cheng CY, Giacomelli S, Leone MG, Palmery M, Silvestrini B. A factor(s) from
rabbit serum inhibits prolactin secretion in vitro.3dt Joint Meeting of French and Italian
Pharmacological Societies Capri May 23-26 1996
369. Saso L, Braghiroli L, Mangiafico S, Tommasino P e Silvestrini B. Un nuovo
metodo per la valutazione dell’effetto barriera di polisaccaridi vegetali. VIII Congresso
Nazionale della Società Italiana di Farmacognosia; Napoli, 9-14 giugno 1996
370. Saso L, Panzironi C, Braghiroli L, Valentini G, Casini ML, Mattei E, de Feo
G, Mazzanti e Silvestrini B. Implicazioni farmacologiche della stabilizzazione
dell’albumina sierica da parte di sostanze endogene ed esogene. Atti del XXII Congresso
Internazionale della Società Farmaceutica del Mediterraneo Latino, 47-50, 1996
371. Saso L, Valentini G, Casini ML, Mattei E, Braghiroli L, Mazzanti G e
Silvestrini B. Valutazione in vitro dell’inibizione della precipitazione dell’ossalato di
calcio da parte di diversi componenti urinari fisiologici. XXII Congresso Internazionale
della Società Farmaceutica del Mediterraneo Latino. Montpellier, 19-22 settembre 1996
372. Silvestrini B. Borse di studio. In: Il Neurologo italiano. Hippocrates Ed. MedicoScientifiche Srl, Milano, 1996:700-702
373. Saso L, Braghiroli L, Mangiafico S, Tommasino P and Silvestrini B. Evaluation
of the barrier properties of demulcents of vegetable origin with a new method in vitro.
Phytother Res 1996; 10:S50
30
374. Silvestrini B, Saso L, Cheng CY. La glicosilazione proteica come elemento
patogenetico e bersaglio terapeutico nelle malattie autoimmunitarie. Reumatismo1996;
48:129-133
375. Braghiroli L, Silvestrini B, Zhu LJ, Moo-Young A and Cheng CY.
Identification of paracrine factor(s) released by germ cells (GC) that modulate Sertoli
cell (SC) α2 –Macroglobulin (α2-MG) production. 6th Internation Congress on Cell
Biology & 36th Amercian Society for Cell Biology Anuual Meeting. San Francisco, CA,
December 11, 1996
(1997)
376. Iurlo M, Nomikos GG, Leone MG, Schilstroem B, Gherardini G, Palmery M,
Silvestrini B, Svensson TH. Harmine increases extracellular dopamine concentrations
in the ventral striatum of freely moving rats. I Seminario Nazionale per Dottorandi in
farmacologia e Scienze affini, Siena, Certosa di Pontignano, 3-5 febbraio 1997.
(Abstract)
377. Silvestrini B, Cheng CY. Pharmacology of the lacrimal secretion. Simposio
Internazionale La Sindrome dell’“occhio secco” - Roma, 14-15 febbraio 1997
378. Cheng CY and Silvestrini B. New Micromethodologies applicable to the study of
tears composition. Simposio Internazionale La Sindrome dell’“occhio secco” - Roma,
14-15 febbraio 1997
379. Saso L, Tommasino P, Valentini G, Panzironi C, Mattei E, Casini ML and
Silvestrini B. In vitro evaluation of the barrier properties of hyaluronic acid. . Simposio
Internazionale La Sindrome dell’“occhio secco” - Roma, 14-15 febbraio 1997
380. Saso L, Tommasino P, Bonanni G, Castellacci C, Santini L, Valentini G and
Silvestrini B. Interaction between hyaluronic acid and mucin evaluated by gel
permeation chromatograpy. Simposio Internazionale La Sindrome dell’“occhio secco” –
Roma 14-15 febbraio 1997
381. Bisogno P e Silvestrini B. Il rispetto della vita. In: Bioetica: le ragioni della vita e
della scienza. Franco Angeli, Milano 1997
382. Silvestrini B. E’ utile la vivisezione? In: Bioetica: le ragioni della vita e della
scienza. FrancoAngeli, Milano 1997
383. Silvestrini B. Le aberrazioni nell’ordine naturale delle cose. Dolentium Hominum,
1997; 34:77-80
384. Silvestrini B. I farmaci naturali. Acta Phytother. 1997; 2:4-7
31
385. Monastra G, Silvestrini B and Bruni A. Cholesterylphosphoryl-L-serine inhibits
tumor necrosis factor release in vivo and in vitro. XXVIII Congresso Nazionale SIF,
Bari 30 aprile-3 maggio 1997
386. Monastra G, Zatta A and Silvestrini B. Protective activity of benzydamine
hyaluronate against hypotonic haemolysis. XXVIII Congresso Nazionale SIF, Bari 30
aprile-3 maggio 1997
387. Bolle P, Tucci P, Tita B and Silvestrini B. Indomethacin alters the effects of
isoproterenol on rabbit isolated detrusor strips. XXVIII Congresso Nazionale SIF, Bari
30 aprile-3 maggio 1997
388. Iurlo M, Nomikos GG, Leone MG, Schilstrom B, Gherardini G, Palmery M,
Silvestrini B and Svensson TH. Harmine: modulatory effects on in vivo release of
dopamine in the rat ventral striatum area. XXVIII Congresso Nazionale SIF, Bari 30
aprile-3 maggio 1997
389. Silvestrini B. Le dosi terapeutiche delle vitamine. X Symposium Internazionale di
Vitaminologia “Le azioni protettive delle vitamine”. Roma, 15.5.97
390. Ferrari G, Minozzi MC, Zanellato AM and Silvestrini B. GM1, like IGF-I and
GDNF, prevents neuronal apoptosis. Satellite Symposium to the Combined Meeting of
the International & American Societies for Neurochemistry. New York, July 13-16,
1997
391. Mathur PP, Grima J, Mo MY, Zhu LJ, Aravindan GR, Calcagno K, O’Bryan
M, Chung S, Mruk D, Lee WM, Silvestrini B and Cheng CY. Differential expression
of multiple cathepsin mRNAs in the rat testits during maturation and following
lonidamine induced tissue restructuring. Biochem. Mol. Biol. Int. 1997; 42:217-233
392. Giacomelli S, Cheng CY, Leone MG, Palmery M and Silvestrini B.
Identification, purification, and partial characterization of a factor from rabbit serum that
inhibits prolactin secretion by pituitary cells cultured in vitro. Biochem. Mol. Biol. Int.
1997; 42:1199-1213
393. Sorrentino C, Mo MY, Silvestrini B and Cheng CY. Prostaglandin D2
synthetase: its cellular distribution and hormonal regulation in the male reproductive
tract. 30th Annual Meeting Society for the Study of Reproduction (agosto1997)
394. Silvestrini B. The document on vaccination of the National Committee for
Bioethics of Italy. Euroconference on: Ethical, Legal, and Social aspects of vaccine
research and vaccination policies. Rome, Italy – June 12-14, 1997
395. Mruk D, Zhu LJ, Silvestrini B, Lee WM and Cheng CY. Interactions of
proteases and protease inhibitors in Sertoli-germ cell cocultures preceding the formation
of specialized Sertoli-germ cell junctions in vitro. J Androl. 1997; 18:612-622
32
396. Panzironi C, Silvestrini B, Mo MY, Lahita RG, Mruk D and Cheng CY. An
increase in the carbohydrate moiety of α2-macroglobulin is associated with systemic
lupus erythematosus (SLE). Biochem. Mol. Biol. Int. 1997; 43(6):1305-1322
(1998)
397. Mruk D, Mo MY, Grima J, Silvestrini B, Lee WM and Cheng CY. Sertolin is a
novel Sertoli cell product: its cDNA cloning, tissue distribution,, and regulation.
American Society of Andrology, 23rd Annual Meeting, Hyatt Regency, Long Beach,
CA, March 27-29, 1998
398. Saso L, Valentini G, Casini ML, Mattei E, Panzironi C and Silvestrini B.
Development of a turbidimetric assay to study the effect of urinary components of
calcium oxalate precipitation. Urol Int 1998; 60:47-52
399. Silvestrini B. La Facoltà di Farmacia nella Società che cambia. Leader for Chemist
1998; 3:4-10
400. Giacomelli S, Palmery M, Romanelli L, Cheng CY and Silvestrini B. Lysergic
acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it
potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro. Life Sciences
1998; 63(3):215-222
401. Chung SSW, Mo M-y, Silvestrini B, Lee WM and Cheng CY. Rat testicular Ncadherin: its complementary Deoxyribonucleic Acid cloning and regulation.
Endocrinology 1998; 139(4):1853-1862
402. Saso L, Casini ML, Valentini G, Mattei E, Panzironi C and Silvestrini B.
Development of an HPLC assay to study the effect of Endogenous and Exogenous
substances on heat-induced aggregation of human serum albumin. Clin. Chem. Lab.
Med. 1998; 36(3):155-162
403. Braghiroli L, Silvestrini B, Sorrentino S, Grima J, Mruk D and Cheng CY.
Regulation of α2-macroglobulin expression in rat Sertoli cells and hepatocytes by germ
cells in vitro. Biol. Reprod. 1998; 59:111-123
404. Mruk D, Cheng CH, Cheng YH, Mo MY, Grima J, Silvestrini B, Lee WL and
Cheng CY. Rat Testicular extracellular superoxide dismutase: its purification, cellular
distribution, and regulation. Biol. Reprod. 1998; 59:298-308
405. Sorrentino C, Silvestrini B, Braghiroli L, Chung SSW, Giacomelli S, Leone
MG, Xie YB, Sui YP, Mo MY and Cheng CY. Rat Prostaglandin D2 synthetase: its
tissue distribution, Changes during maturation, and regulation in the testis and
epididymis. Biol. Reprod. 1998; 59:843-853
33
406. Scazzocchio F, Silvestrini B, Salvatore G, Mazzanti G. Azione battericida di
alcuni olii essenziali. 9° Congresso Nazionale della Società Italiana di Fitochimica.
Cetraro (CS), 27-30 maggio 1998
407. Bucci MG, Centofanti M, Pescosolido N, Rosa R, Romanelli L, Silvestrini B.
Valutazione dell’effetto dei farmaci anti-glaucomatosi sull’ipertensione oculare indotta
da prolungata chiusura palpebrale. 1° Incontro Nazionale della Sezione di Farmacologia
Clinica. Matera, 29-31 maggio 1998
408. Silvestrini B. La voce del cuore e quella della ragione. Orizzonte medico, 1998;
4:14-15
409. Silvestrini B. Aspetti medici della droga. Definizioni, droga e malattia, riflessioni
etiche. Convegno Ecclesiale: Solidali per la vita. Dolentium Hominum 1998; 38:40-43
410. Chung SSW, Zhu LJ, Mo M-Y, Silvestrini B, Lee MW and Cheng CY.
Evidence for cross-talk between Sertoli and germ cells using selected cathepsins as
markers. J. Androl. 1998; 19:686-703
411. Saso L, Valentini G, Giardino AM, Spadaro A, Riccieri V, Zoppini A and
Silvestrini B. Changes of glycosylation of serum proteins in psoriatic arthritis, studied
by enzyme-linked lectin assay (Ella), using Concanavalin A. Biochem. and Mol. Biol.
Int. 1998; 46:867-876
412. Saso L, Leone MG, Sorrentino C, Giacomelli S, Silvestrini B, Grima J, Li
JCH, Samy E, Mruk D and Cheng CY. Quantification of prostaglandin D synthetase
in cerebrospinal fluid: a potential marker for brain tumor. Biochem. and Mol. Biol. Int.
1998; 46:643-656
413. Silvestrini B, Valeri P, Romanelli L, Saettone MF e Chetoni P. Principi di
farmacologia generale di interesse oftalmologico. In: Farmacologia oculare. Eds. F.
Drago – N. Orzalesi. UTET, Torino, 1998
414. Saso L, Valentini G, Leone MG, Grippa E, Silvestrini B. Development of an in
vitro Assay for the screening of substances capable of dissolving calcium oxalate
crystals. Urol Int 1998; 61:210-214
415. Saso L, Valentini G, Grippa E, Leone MG and Silvestrini B., Effect of selected
substances on heat-induced aggregation of albumin, IgG and lysozyme. Res. Commun.
Mol. Pathol. Pharmacol. 1998; 102, 15-28
416. Ferrari G, Minozzi MC, Zanellato AM, Silvestrini B. GM1, like IGF-I and
GDNF, prevents neuronal apoptosis. Ann N Y Acad Sci. Jun 19 1998; 845:408
417. Quaglia MG, Farina A, Silvestrini B, Desideri N, Porra R, Bossu E, Palmery
M. Racemate or pure enantiomer: a strategy for more adequate use of chiral drug
therapy. Rapp. ISTISAN 98/13, 8-11,1998
34
(1999)
418. Silvestrini B. Vittorie drogate. Newton 1999; 1:120-126
419. Saso L, Tommasino P, Grippa E, Leone MG and Silvestrini B. Micromethods
for the analysis of tear proteins in pharmacological studies. Res. Comm. in Mol. Pathol.
and Pharm. 1999; 103:149-168
420. Podestà E, Silvestrini B, Botrè C. Alternative methods to animal testing: the role
of biosensors. II Workshop Sensori Chimici e Biosensori. Roma, 18-19 Marzo 1999
421. Saso L, Bonanni G, Grippa E, Gatto MT, Leone MG and Silvestrini B.
Interaction of hyaluronic acid with mucin, evaluated by gel permeation chromatography.
Res. Comm. in Mol. Pathol. and Pharm. 1999; 104:277-284
422. Saso L, Valentini G, Casini ML, Mattei E, Braghiroli L, Mazzanti G,
Panzironi C, Grippa E and Silvestrini B.. Inhibition of Protein Denaturation by Fatty
Acids, Bile Salts and Other Natural Substances: A New Hypothesis for the Mechanism
of Action of Fish Oil in Rheumatic Diseases. Jpn. J. Pharmacol. 1999; 79:89-99
423. Silvestrini B. Nuove biotecnologie e responsabilità morale. Atti del III Convegno
Internazionale Multidisciplinare: La Bioetica e la sfida delle società complesse:
informazione, trapianti, sistemi sanitari e clonazione. Biesse Grafica, Roma, 1999
424. Silvestrini B. The document on vaccination of the national committee for bioethics
of Italy. Arch. Clin. Bioet. suppl. Bioet. Clin. II 1999; 1:67-69
425. Cheng CY, Mo MY, Mruk D, Lee WM and Silvestrini B. TEMO is a novel
testicular gene to study Sertoli-germ cell interactions: its cDNA cloning and regulation.
10th World Congress on Human reproduction. Salvador, Bahia (Brazil) May, 4-8, 1999
426. Grima J, Silvestrini B, Cheng CY. Testin, a sensitive marker to monitor the
integrity of Sertoli-germ cell junctions, can be used to screen potential male
contraceptives. 10th World Congress on Human reproduction. Salvador, Bahia (Brazil)
May, 4-8, 1999
427. Silvestrini B. Aspetti etico-normativi del doping: il punto di vista del farmacologo.
Convegno l’Etica e lo Sport. Roma, 18 maggio 1999
428. Silvestrini B. Il ruolo della farmacologia in vitaminologia. XIV Congresso
Nazionale di Vitaminologia. Roma, 20 maggio 1999
429. Palmery M e Silvestrini B. Psicofarmaci ed occhio. Congresso Farmacologia
Oculare 1999. Belgirate (Lago Maggiore, 18-20 giugno 1999)
430. Leone MG, Abdel-Haq H, Tita B, Giacomelli S, Saso L, Cheng CY and
Silvestrini B. Effect of Lonidamine on Lipocalin-type prostaglandin D synthase levels
in rat testis and epididymis. Pharmacol. Res. 1999; 39(suppl., 95) (Abstract book XXIX National Congress of the Italian Pharmacological Society, Florence June 20-23)
431. Palmery M e Silvestrini B. Veleni animali e vegetali sul territorio italiano.
Trattato di Medicina Legale e Scienze Affini. Casa Editrice Dott. Antonio Milani, 1999;
IV:209-235
35
432. Cazzolla N, Saso L, Grima J, Leone MG, Grippa E, Cheng CY and Silvestrini
B. Development of an enzyme-linked immunosorbent assay, using a monoclonal
antibody against α2-macroglobulin, for the diagnosis of systemic lupus erythematosus.
Clinical Biochem. 1999; 32(4):249-255
433. Leone MG, Saso L, Cheng CY, Silvestrini B. Micropurification of β- and γcrystallins from rabbit aqueous humor. Int. J. Biol. Macromol. 1999; 26:167-171
434. Saso L, Leone MG, Mo M-Y, Grippa E, Cheng CY and Silvestrini B.
Differential changes in α2-macroglobulin and hemopexin in brain and liver in response
to acute inflammation. Biochemistry (Moscow) 1999; 64(7):839-844
435. Saso L, Valentini G, Leone MG, Grippa E, Guglielmi R, Paris L, Cantore G
and Silvestrini B. Changes in Concanavalin A-Reactive Proteins in Neurological
Disorders. J. Clin. Lab. Anal. 1999; 13:158-165
436. Grippa E, Valla R, Battinelli L, Mazzanti G, Saso L and Silvestrini B.
Inhibition of Candida rugosa lipase by berberine and structurally related alkaloids,
evaluated by high-performance liquid chromatoghraphy. Biosci. Biotechnol. Biochem.
1999; 63(9):1557-1562
437. Saso L, Valentini G, Mattei E, Panzironi C, Casini ML, Grippa E and
Silvestrini B. Stabilization of rat serum proteins following oral administration of fish
oil. Arch. Pharm. Res. 1999; 22(5):485-490
438. Silvestrini B. La sperimentazione animale. In: Frontiere della Vita, vol. IV, Parte
III Bioetica, Sezione IV Etica e interventi sul vivente. Istituto della Enciclopedia
Italiana, Roma, 1999
439. Saso L, Valentini G, Riccieri V, Spadaro A, Zoppini A, Silvestrini B. Changes
of glycosylation of serum proteins in Sjogren's syndrome: correlation with interleukin-6
and soluble interleukin-2 receptor. IUBMB Life. Oct 1999; 48 (4):385-390
(2000)
440. Silvestrini B. Cure alternative: cosa dice la scienza. Newton, 2000; IV(2):77-84
441. Palmery M, Abdel-Haq H, Antonini A, Cometa MF, Silvestrini B. Facilitating
and direct effects of ecstasy and MDA on rabbit aortic strips. Abstract. XII Congresso
Nazional della Società Italiana di Tossicologia. Bologna, 23-26 Febbraio 2000.
442. Samy ET, Li JCH, Grima J, Lee WM, Silvestrini B and Cheng CY. Sertoli Cell
Prostaglandin D2 Synthetase is a Multifunctional Molecule: its Expression and
Regulation. Endocrinology 2000; 141(2):710-721
443. Abdel-Haq H, Giacomelli S, Palmery M, Leone MG, Saso L and Silvestrini B.
Aflatoxins inhibit prolactin secretion by rat pituitary cells in culture. Drug and Chemical
Toxicol. 2000; 23(2):381-386
36
444. Abdel-Haq H, Palmery M, Leone MG, Saso L and Silvestrini B. Stimulation of
Guinea Pig isolated atria by Aflatoxins. Toxicol. in Vitro 2000; 14:193-197
445. Abdel-Haq H, Palmery M, Leone MG, Saso L and Silvestrini B. Relaxant
effects of Aflatoxins on isolated Guinea Pig trachea. Toxicol. Sci. 2000; 55:162-170
446. Grippa E, Pavone F, Gatto MT, Petrucci R, Marrosu G, Silvestrini B, Saso L.
In vitro evaluation of antioxidant activity by electrophoresis and high performance liquid
chromatography. Biochim. et Biophys. Acta 2000; 25109:1-7
447. Li JCH, Samy ET, Grima J, Chung SSW, Mruk D, Lee WM, Silvestrini B and
Cheng CY. Rat Testicular Myotubularin, a Protein Tyrosine Phosphatase Expressed by
Sertoli and Germ Cells, Is a Potential Marker for Studying Cell-Cell Interactions in the
Rat Testis. J. Cell. Physiol. 2000; 185:366-385
448. Saso L, Grippa E, Gatto MT, Leone MG and Silvestrini B. Inhibition of HeatInduced Aggregation of β- and γ-Crystallin by α-Crystallin Evaluated by Gel Permeation
HPLC. Biochemistry (Moscow) 2000; 65(2):250-255
449. Saso L, Silvestrini B. Problemi etici della sperimentazione sull’uomo con
particolare riguardo al consensoinformato. Minerva Medica 2000; 91:255-65
450. Silvestrini B. Ricerca Farmacologia: Passato e Futuro. Raphael, dicembre 2000, 48
451. Abdel-Haq H, Cometa MF, Palmery M, Leone MG, Silvestrini B and Saso L.
Relaxant effects of Hydrastis canadensis L. and its major alkaloids on guinea pig
isolated trachea. Pharmacol. Toxicol. 2000; 7,218-222
452. Leone MG, Grippa E, Guidolin D, Tita B, Abdel-Haq H, Gatto MT, Bordi F,
Cheng CY, Silvestrini B, and Saso L. Effects of lonidamine on testicular and
epididymal proteins in the rat. Reprod. Toxicol. 2000; 14:257-263
453. Saso L, Tommasino P, Italiano G, Grippa E, Leone MG, Gatto MT and
Silvestrini B., Changes of acute-phase proteins in streptozotocin-induced diabetic rats.
Physiol Res. 2000; 49:403-409
454. Gong XD, Wong YL, Leung GP, Cheng CY, Silvestrini B, Wong PY.
Lonidamine and analogue AF2785 block the cyclic adenosine 3', 5'-monophosphateactivated chloride current and chloride secretion in the rat epididymis. Biol Reprod. Sep
2000; 63(3):833-838
455. Saso L, Silvestrini B. Nephrolithiasis. Recenti Prog Med. Jul-Aug 2000; 91(78):388-95
456. Silvestrini B. Medicine alternative: le due facce del problema. L’arco di Giano,
2000; 26:129-137
37
(2001)
457. Saso L, Silvestrini B. Antidenaturant drugs for cataract and other condensation
diseases. Medical Hypotheses 2001; 56(1):114-120
458. Grima J, Silvestrini B and Cheng CY. Reversibile Inhibition of Spermatogenesis
in Rats Using a New Male Contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3carbohydrazide. Biol. Reprod. 2001; 64:1500-1508
459. Cheng CY, Silvestrini B, Grima J, Mo MY, Zhu LJ, Johansson E, Saso L,
Leone MG, Palmery M and Mruk D. Two new male contraceptives exert their effects
by depleting germ cells prematurely from the testis. Biology of Reproduction 2001;
65:449-461
460. Saso L, Grippa E, Gatto MT and Silvestrini B. Inhibition of calcium oxalate
precipitation by bile salts. Int. J. Urol. 2001; 8:124-127
461. Saso L, Valentini G, Casini ML, Grippa E, Gatto MT, Leone MG and
Silvestrini B. Inhibition of Heat-induced Denaturation of Albumin by Nonsteroidal
Antiinflammatory Drugs (NSAIDs): Pharmacological Implications. Arch. Pharm. Res.
2001; 24 (2):150-158
462. Silvestrini B. Biotecnologie e ricerca. Atti del Convegno Biotecnologie,
clonazione, trapianti, procreazione medicalmente assistita: la bioetica alle frontiere della
vita. Consiglio Nazionale delle Ricerche, 81-84, Roma (2001)
463. Iurlo M, Leone MG, Schilstrom B, Linnèr L, Nomikos GG, Hertel P,
Silvestrini B, Svensson TH. Effects of harmine on dopamine output and metabolism in
rat striatum: role of monoamine oxidase-A inhibition. Psychopharmacology 2001;
159:98-104
464. Grippa E, Gatto MT, Leone MG, Tita B, Adbel-Haq H, Vitalone A, Silvestrini
B and Saso L. Analysis of lonidamine in rat serum and testis by high performance
liquid chromatography. Biomed. Chromatogr 2001; 15:1-8
465. Riccieri V, Spadaro A, Saso L, Valentini G, Taccari E and Silvestrini B.
Immunohistologic markers of immune activation and changes of glycosylation of serum
proteins in primary Sjogren's syndrome. Clin. Exp. Rheumatol. 2001; 19:53-58
466. Podestà E, Silvestrini B, Botrè C, Botrè F. Toxicity testing in environmental
monitoring: the role of enzymatic biosensors. Annali dell’Istituto Superiore di Sanità.
Ann. Ist. Super. Sanità 2001; 37(4):607-613
467. Leone MG, Adbel-Haq H, Gennaro G, Amici S, Conte D, Romanelli F, Latini
M, Fillo S, Isidori A, Saso L and Silvestrini B. Changes of lipocalin type
prostaglandin D-synthase in the seminal plasma of subfertile man. Res Commun Mol
Pathol Pharmacol 2001; 110:17-25
38
468. Costa LG, Guizzetti M, Lu H, Bordi F, Vitalone A, Tita B, Palmery M, Valeri
P, Silvestrini B. Intracellular signal transduction pathways as targets for neurotoxicants.
Toxicology. Mar 7 2001; 160(1-3):19-26
(2002)
469. Bonanomi M, Lucente G, Silvestrini B. Male fertility: core chemical structure in
pharmacological research. Contraception 2002; 65:317-320
470. Mruk DD, Silvestrini B, Mo M, Cheng CY., Antioxidant superoxide dismutase a review: its function, regulation in the testis, and role in male fertility. Contraception
2002; 65(4):305-11
471. Cheng CY, Mo M, Grima J, Saso L, Tita B, Mruk D, Silvestrini B. Indazole
carboxylic acids in male contraception. Contraception 2002; 65(4):265-8
472. Silvestrini B. L’ingegneria genetica in medicina: una riflessione in chiave
biologica. Atti del Convegno OGM. Scienza, normativa ed etica, Consiglio Nazionale
delle Ricerche, 143-153, Roma (2002)
473. Silvestrini B. Tossicomanie: definizioni e classificazioni, Annali dell’Istituto
Superiore di Sanità, 2002; 38(3):211-215
474. Silvestrini B. I confini fra medicina convenzionale e “non convenzionale”, Atti del
Convegno Etica della Salute e “Terapie non Convenzionali”, Centro Interuniversitario di
Ricerca Bioetica, Quaderno n. 1, 151-170, Giannini Editore, Napoli (2002)
475. Silvestrini B. La sperimentazione sul vivente: una riflessione in chiave etica.
Kéiron, 2002; 11:10-23
(2003)
476. Silvestrini B. Presupposti etico-scientifici della sperimentazione animale. Atti del
convegno L'etica della sperimentazione animale, Università di Pisa, pag. 33-46. Ed.
ETS, 2003
477. Silvestrini B. L’ingegneria genetica in medicina: una riflessione in chiave
naturalistica, in L’Eldorado della nuova biologia. Clonazione, animali transgenici,
cellule staminali, Franco Angeli 2003:107-120
478. Silvestrini B. Medicina alternativa e medicina scientifica: aspetti etici. Bollettino
Ordine Medici di Padova 2003; 6:27-31
(2004)
479. Silvestrini B. Tabagismo: i rischi delle dipendenze. Pianeta Adolescenti, Sinnos
Editrice 2004:52-64
39
(2005)
480. Silvestrini B, Silvestrini M. Funzione Sessuale Maschile, in Trattato di
Andrologia, a cura di M. Porena e G.F. Meschini Fabris, Ed. UTET Scienze Mediche,
2005:367-370
481. Cheng CY, Mruk D, Silvestrini B, Bonanomi M, Wong C-H, Siu MKY, Lee
NPY, Lui W-Y, Mo M-Y. AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3carbohydrazide] is a potential male contraceptive: a review of recent data. Contraception
2005; 72:251-261
482. Silvestrini B. La medicina che guarda a Darwin, Janus 2005; 20:118-124
(2006)
483. Mruk DD, Wong CH, Silvestrini B, Cheng CY. A male contraceptive targeting
germ cell adhesion. Nature Med. 2006; 12(11):1323-1327
(2008)
484 Mruk DD, Silvestrini B, Cheng CY. Anchoring junctions as drug targets: role
in contraceptive development. Pharmacological Rev 2008; 60(2):146-180
485 Silvestrini B, Arpino M, Ferrante M, Musicco M, Santilli G. Healthy Growth
chart project. Part I, Medicina dello Sport 2008; 61(2):197-206
486. Silvestrini B. Medicine non convenzionali: un problema bioetico. Nuntium 2008;
34:15-19
(2009)
487. Hu G-X, Hu L-F, Yang D-Z, Li J-W, Chen G-R, Chen B-B, Mruk DD,
Bonanomi M, Silvestrini B, Cheng CY, Ge R-S. Adjudin targeting rabbit germ cell
adhesion as a male contraceptive: a pharmacokinetic study. J Androl 2009; 30(1):87-93
488. Silvestrini B, Arpino M, Ferrante M, Musicco M, Santilli G. Healthy Growth
chart project. Part 2. A pilot study on sports and juvenile obesity. Medicina dello Sport
2009; 62(3):273-284
489. Silvestrini B. Prefazione di Scienza & Etica, Percorsi di comunicazione e
formazione. A cura di R. Azzaro Pulvirenti. FrancoAngeli Ed 2009:7-16
40
(2010)
490. Silvestrini B, Arpino M, Ferrante M, Musicco M, Santilli G. Il Progetto
“Carta del Benessere” – Rassegna critica dei risultati di uno studio pilota. Scuola dello
Sport 2010; 29(84):3-10
(2011)
491. Cheng CY, Wong EWP, Lie PPY, Li MWM, Su L, Siu ER, Yan HHN, Mannu
J, Mathur PP, Bonanomi M, Silvestrini B and Mruk DD. Environmental toxicants
and
male
reproductive
function.
Spermatogenesis,
2011;
1(1):2-13
492. Cheng CY, Wong EWP, Lie PPY, Li MWM, Mruk DD, Yan HHN, Mok K-W,
Mannu J, Mathur PP, Lui W-y, Lee WM, Bonanomi M and Silvestrini B.
Regulation of blood-testis barrier dynamics
by desmosome, gap junction,
hemidesmosome and polarity proteins. An unexpected turn of events. Spermatogenesis,
2011; 1(2):105-115
493. Cheng CY, Lie PPY, Wong EWP, Mruk DD and Silvestrini B. Adjudin disrupts
spermatogenesis via the action of some unlikely partners. Spermatogenesis, 2011;
1(4):1-7
494. Musicco M, Azzaro Pulvirenti R, Gainotti S, Petrini C, Riccio C and
Silvestrini B. A study of the Healthy Growth Charter in socially disadvantaged children.
Ann Ist Super Sanità 2011; 47(4):417-423
(2012)
495. Mok K-W, Mruk DD, Silvestrini B and Cheng CY. rpS6 Regulates Blood-Testis
Barrier Dynamics By Affecting F-Actin Organization and Protein Recruitment..
Endocrinology, 2012; 153(10):5036–5048
496. Su L, Mruk DD, Lie PPY, Silvestrini B and Cheng CY. A peptide derived from
laminin-c3 reversibly impairs spermatogenesis in rats. NatureCommun, 2012
497. Mok KW, Lie PP, Mruk DD, Mannu J, Mathur PP, Silvestrini B, Cheng CY.
The apical ectoplasmic specialization-blood-testis barrier functional axis is a novel
target for male contraception. Adv Exp Med Biol. 2012; 763:334-55
498. Su L, Jenardhanan P, Mruk DD, Mathur PP, Cheng YH, Mok KW, Bonanomi
M, Silvestrini B, Cheng CY. Role of P-glycoprotein at the blood-testis barrier on
adjudin distribution in the testis: a revisit of recent data. Adv Exp Med Biol. 2012;
763:318-33
41
(2013)
499. Xie QR, Liu Y, Shao J, Yang J, Liu T, Zhang T, Wang B, Mruk DD,
Silvestrini B, Cheng CY and Xia W. Male contraceptive Adjudin is a potential anticancer drug. Biochemical Pharmacology , 2013; 85:345–355
500. Shao J, Liu T, Xie QR, Zhang T, Yu H, Wang B, Ying W, Mruk DD,
Silvestrini B, Cheng CY and Xia W. Adjudin attenuates lipopolysaccharide (LPS)and ischemia-induced microglial activation. Journal of Neuroimmunology , 2013;
254:83–90
501. Qian X, Cheng Y-h, Jenardhanan P, Mruk DD, Mathur PP, Xia W, Silvestrini
B and Cheng CY. Adjudin disrupts spermatogenesis by targeting drug transporters.
Lesson from the breast cancer resistance protein (BCRP). Spermatogenesis, 2013
502. Silvestrini B. Immunokinetics: a new approach to vaccines. A working hypothesis.
Annali dell’Istituto Superiore di Sanità. Ann. Ist. Super. Sanità 2013; 49(3):306-308
503. Ferrante M, Musicco M, Riccio C e Silvestrini B. Anche la salute è un talento:
“La carta del benessere”. Mettere a frutto i talenti, Collana Prometheus, 2013
(2014)
504. Xiao X, Mruk DD, Tang EI, Wong CKC, Lee WM, John CM, Turek J,
Silvestrini B and Cheng CY. Environmental toxicants perturb human Sertoli cell
adhesive function via changes in F-actin organization mediated by actin regulatory
proteins. Human Reproduction, 2014; 29(6):1279-1291
(2015)
505. Yan Ho Cheng, Pranitha Jenardhanan, Premendu P. Mathur, Xiaojing Qian,
Weiliang Xia, Bruno Silvestrini and Chuen Yan Cheng. Interaction of Oligomeric
Breast Cancer Resistant Protein (BCRP) with Adjudin: A Male Contraceptive with AntiCancer Activity. Current Molecular Pharmacology, 2014, 7, 147-153
Atti di Convegni e Congressi
•
•
•
Inflammation. Aethopathogenetic, Clinical and Therapeutic Problems. An
International Symposium. Bologna 7-8 Novembre 1967. Editors B. Silvestrini e
S. Tura. Co-editor W.G. Spector. Excerpta Medica (1967)
Inflammation Biochemistry and Drug Interaction. Proceeding of an International
Symposium, Como, Italy, 11-13 October 1968. Excerpta Medica Foundation
(1969)
“Trazodone, a new psychotropic drug”. Second International Congress of
Psychosomatic Medicine, Amsterdam, 1973. Curr. Ther. Res., 15, 108 (1973)
42
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Modern Problems of Pharmacopsychiatry – Trazodone. Proceedings of the First
International Symposium, Montreal, 1973 , Karger Eds. (1974)
Depression and the role of trazodone in antidepressant therapy. Symposium
organized by Ministry of Health of the USSR, Serbsky Central Research Institute
of Forensic Psychiatry and F. Angelini Research Institute, Italy. Moscow, 1977.
Eds. G. Morozov, J. Saarma, B. Silvestrini (1978)
Trazodone, a new broad-spectrum antidepressant. Proceedings of a Symposium,
11th Congres of C.I.N.P., Austria, 1978. Excerpta Medica (1980)
Lonidamine: a new pharmacological approach to the study and control of
spermatogenesis and tumors. Chemotherapy, 27, Suppl. 2 (1981)
Lonidamine. Proceedings of the IInd International Symposium, Vancouver,
1982. Oncology 41, Suppl. 1 (1984)
Benzydamine: a new therapeutic concept for the treatment of inflammation”.
Proceedings of a Symposium, 1st World Conference of Inflammation,
Analgesics, Immunomodulators. Venice, 1984
Trasformazione della Società contemporanea ed occupazione giovanile”.
Quaderni del CNR, La Roccia ed. (1985).
Trazodone: An antidepressant with adrenolytic activity”. 16th C.I.N.P. Congress,
Munich, 1988. Clinical Neuropharmacology, 12 (1989)
Scienza e tecnologia per la pace nel Medio Oriente, Roma, 20-21 Giugno 1994.
Prometheus, FrancoAngeli ed, 1995
I giovani nella società che cambia. Ruolo della scienza nella formazione e nel
lavoro, 1996. Prometheus, FrancoAngeli ed, 1995
Le piante medicinali in Farmacia”, Roma, 19 Ottobre 1995. Prometheus,
FrancoAngeli ed, 1995
Scienza e tecnologia per la pace in Medio Oriente. Prometheus, FrancoAngeli ed,
1996
Pharmacological approaches to male fertility: from contraception to the treatment
of sterility”, Roma, 4-5 Dicembre 2000. Contraception, 2001
Fertilità maschile: dalla contraccezione alla terapia”, Università “La Sapienza”,
Roma, 24-25 Ottobre 2003. In stampa su Contraception
Mettere a Frutto i Talenti. FrancoAngeli Ed., 2013
Books
Silvestrini B.
Valutazione sperimentale delle principali attività farmacologiche.
Ediz. Bulzoni, Roma (1969)
Silvestrini B., Feighner J.P. and Silverstone T. (eds.)
The role of trazodone in antidepressant therapy: safety and clinical efficacy.
Psychopathology 17, Suppl. 2 (1984)
Silvestrini B., Tura S. (eds.) and Spector W.G. (co-ed)
Inflammation-Aetiopathogenetic, clinical and therapeutic problems.
Excerpta Medica Foundation (1986)
43
Silvestrini B.
Malati di droga.
Sperling & Kupfer, Milano (1995)
5 Edizioni, attualmente esaurito. Può essere scaricato gratuitamente, anche nella
traduzione inglese, da www.noopolis.eu
Giarelli G., Roberti di Sarsina P., Silvestrini B.
Le medicine non convenzionali in Italia – Storia, problemi e prospettive di integrazione.
Franco Angeli, Milano, 2007
Silvestrini B.
Medicina naturale, analisi, riflessioni, prospettive.
FrancoAngeli, Milano, 2007
Silvestrini B.
Malati di droga
Edizioni RED, 2009
Silvestrini B.
Il farmaco moderno. Un patto esemplare fra uomo e natura.
Carocci Ed., 2014
Lavori in press, submitted e in preparation
Chung SSW, Zhu LJ, Mo MY, Silvestrini B, Lee WM and Cheng CY. The
localization of multiple cathepsin mRNAs in staged seminiferous epithelium by in situ
hybridization is consistent with their role in germ cell migration. Endocrinology
(submitted)
Li JCH, Gradoni L, Silvestrini B, Cheng CY. Characterization of a trypanosomal
variable surface glycoprotein (VSG) T122. (In press)
Li JCH, Samy ET, Grima J, Chung SSW, Mruk D, Lee WM, Silvestrini B and
Cheng CY. Rat Myotubularin (rMTM) is a Sertoli cell product to monitor cell-cell,
interactions in the testis. Biol. Reprod. (In press)
Hong-yu Zhou1, Guo-xin Hu1, Jun-wei Li1,Lu-feng Hu1, Guo-rong Chen2, Dolores
D. Mruk3, Bruno Silvestrini4, C. Yan Cheng3, Ren-shan Ge1,3
Effects of Adjudin on spermatogenesis of male beagle dogs
1. Department of Pharmacology, Wenzhou Medical College, Wenzhou, China 325000;
2. Department of Pathology, Wenzhou Medical College, Wenzhou, China, 325000.
3. Population Council, NewYork, NY 10021, United States. 4. The Noopolis Fdn,
Rome, Italy.
44
Xiao X, Mruk DD, Jenardhanan P, Mannu J, Mathur PP, Lee WM, Silvestrini B,
Cheng Y-ho and Cheng CY. Nonreceptor Protein Kinases c-Src, c-Yes, and FAK are
biomarkers for Male Contraceptive Research. (In Press)
Silvestrini B. Appunti sugli aspetti legali e deontologici del “conflitto d’interessi”. (In
Press)
45
Brevetti
(limitatamente, tra gli oltre 200 brevetti facilmente reperibili sul sito internet
http:://it.espacenet.com, a quelli concessi negli USA).
1. G. Palazzo, B. Silvestrini, U.S. Patent n. 3,141,019: 1,2,4-oxadiazoles and
processes for producing the same, 1964.
2. G. Palazzo, B. Silvestrini, U.S. Patent n. 3,409,668: Substituted anthranilamides
and process for the preparation thereof, 1968.
3. G. Palazzo, B. Silvestrini, U.S. Patent n. 3,381,009: Triazole: -4,3-a -pyridines,
1968.
4. G. Palazzo, B. Silvestrini, U.S. Patent n. 3,502,668: 2-phenyl-5-tertiaryamino
alkyl-1,3,4-oxadiazoles, 1970.
5. G. Palazzo, B. Silvestrini, U.S. Patent n. 3,895,026: Substituted 1-benzyl-1Hindazole-3-carboxylic acids and derivatives thereof, 1975.
6. B. Silvestrini, U.S. Patent n. 4,131,675: Use of combinations of L-DOPA with
trazodone and L-DOPA with etoperidone in parkinsonism, 1978.
7. B. Silvestrini, U.S. Patent n. 4,132,791: Use of etoperidone in Parkinsonism and
in other extrapyramidal syndromes characterized by tremors, 1979.
8. B. Silvestrini, U.S. Patent n. 4,154,832:
cerebral syndromes (strokes), 1979.
Novel treatment for acute organic
9. L. Baiocchi, B. Silvestrini, U.S. Patent n. 4,134,989: Guaiacol p.isobutyl
hydratropate, 1979.
10. B. Silvestrini, U.S. Patent n. 4,162,318: Use of trazodone and etoperidone in
Parkinsonism and in other extrapyramidal syndromes characterized by tremors,
1979.
11. B. Silvestrini, U.S. Patent n. 4,282,237: 1-benzyl-1H-indazole-3-carboxilic acids
for interrupting pregnancy in mammals, 1981.
12. B. Silvestrini, L. Baiocchi, U.S. Patent n. 4,252,721: Cicloalkyltriazoles and
process for obtaining same, 1981.
13. L. Baiocchi, B. Silvestrini, U.S. Patent n. 4,264,618: Basic Thio-idazoles, 1981.
14. B. Silvestrini, L. Baiocchi, U.S. Patent n. 4,307,095: Method of treating
schizophrenia with cycloalkltriazoles, 1981.
46
15. B. Silvestrini, L. Baiocchi, U.S. Patent n. 4,307,096: Method of treating
glaucoma with cycloalkltriazoles, 1981.
16. B. Silvestrini, L. Baiocchi, U.S. Patent n. 4,325,952:
abstinence syndrome with cycloalkyltriazoles, 1982.
Method of treating
17. B. Silvestrini, L. Baiocchi, U.S. Patent n. 4,402,956: 2-[3-[4-chloro-4fluorophenil]-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one,
1983.
18. B. Silvestrini, L. Baiocchi, U.S. Patent n. 4,352,813: (1-benzyl-1H-indazol-3yl)oxy acetic acid salt with L-lysine, 1982.
19. B. Silvestrini, L. Baiocchi, U.S. Patent n. 4,451,477: Bendazac treatment of
cataract, 1984.
20. B. Silvestrini, U.S. Patent N. 4,554,288: Use of bendazac and its salts in the
treatment of retinitis pigmentosa, 1985.
21. B. Silvestrini, U.S. Patent n. 4,749,684: Method for increasing hair growth, 1988
22. B. Silvestrini, U.S. Patent n. 4,906,632: Method of preventing myocardial
infarction and acute cerebral ischemia, 1990.
23. B. Silvestrini, Y. Cheng, U.S. Patent Application n. 311,650: Serum proteins
related to autoimmune disease (filed 1989).
24. B. Silvestrini, U.S. Patent Application n. 456,190: Use of lonidamine in cancer
(filed 1989).
25. B. Silvestrini, U.S. Patent Application n. 362,755: Method for inhibiting the
development of tolerance in the analgesic treatment witrh morphine (filed 1989).
26. L. Baiocchi, B. Silvestrini, US Patent Application n. 470,118:: Ethers of 1benzyl-3-hydroxymethyl-indazole with aliphatic 2-hydroxyacids (filed 1990).
27. B. Silvestrini, U.S. Patent Application n. 362,755: Pharmaceutical composition
for topical ophthalmic use having improved local tolerability (filed 1990).
28. B. Silvestrini, Yan Cheng. U.S. Patent n. 5,047,509 (Date of Patent Sep. 10,
1991): Abnormally glycosilated variants of alfa 2-macroglobulin.
29. B. Silvestrini, U.S. Patent n. 5,041,446: Method for inhibiting the development
of tolerance in the analgesic treatment with morphine, 1991.
47
30. L. Baiocchi, B. Silvestrini, U.S. Patent n. 4,999,367: Ethers of 1-benzil-3hidroxymethyl-indazole with aliphatic 2-hidroxyacids, compositions and use,
1991.
31. B. Silvestrini, U.S. Patent n. 5,093,348: Pharmaceutical composition for topical
ophthalmic use having improved local tolerability, 1992.
32. L. Baiocchi B. Silvestrini U.S. Patent n. 5,112,986: 1-benzyl-hydroxymethylindazole compounds and derivatives, 1992.
33. B. Silvestrini, Y. Cheng U.S. Patent n. 5,258,312 - Serum proteins used to detect
autoimmune disease, 1993.
34. B. Silvestrini, Y. Cheng U.S. Patent n. 5,284,750 - Serum proteins related to
autoimmune disease, 1994.
35. B. Silvestrini, Y. Cheng U.S. Patent n.: 6,001,865: 3-substituted 1-benzyl-1Hindazole derivatives as antifertility agents, 1999
36. B. Silvestrini, C. Buratto and A. Buratto. U.S. Patent n. 6,269,554 B1: Combined
pronation and supination control plantar insert for shoes 2001
37. B. Silvestrini and G. Kirshner. US Patent n. 6,224,857 B1: Pharmaceutical
preparations comprised of salts of hyaluronic acid with local anaesthetics. 2001.
48