21th NACFC, Anaheim 2007

21th Annual North American Cystic Fibrosis Conference
Anaheim, California
3-6 Ocotber, 2007
Poster e comunicazioni orali (*)
(Pediatric Pneumology 2007, Supplement 30)
Genetica – Biologia/fisiologia di CFTR – Nuove terapie
28 – Multivalent macromolecular CFTR inhibitors with nanomolar potency that occlude the CFTR
external pore.
SonaWane ND1, Zhao D1, Galietta L2, Zegarra-Moran O2, Verkman A1. 1Medicine, University of
California San Francisco, San Francisco, CA, USA; 2Genetica Molecolare, Istituto Giannina
Gaslini, Genova, Italy.
53 – Pharmacological stimulation of CFTR mutants carrying missensemutaions outside the
mucleotide binding domains.
Caputo A1, Caci E1, Arous N2, Hinzpeter A2, Pedemonte N1, Sondo E1, Zegarra-Moran O1, Fanen
P2, Galietta LJ1. 1Lab of Molecular Genetics, Istituto Giannina Gaslini, Genova, Italy; 2Inserm
U.841, Dpt Genetique-Hopital Henri Mondor, Creteil, France.
95* - Evaluation of the SCN-/H2O2/lactoperoxidase system as an antibacterial defense in human
airway epithelium..
Sondo E, Pedemonte N, Caci E, Bandettini R, Zegarra-Moran O, Galietta LJ. Istituto Giannina
Gaslini, Genova, Italy.
159 – Miglustat and DGJ reduce the inflammatory response to Pseudomonas aeruginosa, TNFalpha and IL-1beta in bronchial epithelial cells..
Dechecchi M1, Nicolis E1, Norez C2,1, Bezzerri V1, Tamanini A1, Quiri F1, Borgatti M3, Mancini L3,
Rizzotti P1, Beq F2, Gambari R3, Cabrini G1. 1Laboratory of Molecular Pathology, Laboratory of
Clinical Chemistry and Haematology, University Hospital of Verona, Verona, Italy; 2Institut de
Physiologie et Biologie Cellulaires CNRS, Universitè de Poitiers, Poitiers, France; 3Department of
Biochemistry and Molecular Biology, University of Ferrara, Italy.
162 – Medicinal plant extracts inhibit the induction of pro-inflammatory genes in bronchial
epithelial cells.
Lampronti I2, Dechecchi M1, Borgatti M2, Nicolis E1, Bezzerri V1, Mancini I2, Tamanini A1, Quiri
F1, Rizzotti P1, Cabrini G1, Gambari R2. 1Laboratory of Molecular Pathology, Laboratory of
Clinical Chemistry and Haematology, University Hospital of Verona, Verona, Italy; 2Department of
Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy.
163 – Modulation of expression of genes involved in leukocyte chemiotaxis by interfering with
nuclear transcription factors.
Bezzerri V1, Borgatti M2, Mancini I2, Nicolis E1, Dechecchi M1, Tamanini A1, Quiri F1, Lampronti
I2, Rizzotti P1, Gambari R2, Cabrini G1. 1Laboratory of Molecular Pathology, Laboratory of Clinical
Chemistry and Haematology, University Hospital of Verona, Verona, Italy; 2Department of
Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy.
204 – Molecular and clinical features associated with CFTR gene rearrangements in Italian
population: identification of a new duplication and recurrent deletions.
Costantino L1, Coviello D1, Paracchini V1, Porcaro L1, Capasso P1, Degiorgio D1, Padoan R2, Claut
R3, Costantini D3, Colombo C3, Seia M1. 1Molecular genetic laboratory, Fondazione Policlinico
Mangiagalli Regina Elena, Milano, Italy; 2Cystic Fibrosis Support Centre, Spedali Civili di Brescia,
Brescia, Italy; 3Cystic Fibrosis Centre, Fondazione Policlinico Mangiagalli Regina Elena, Milano,
Italy.
205 – Phenotypic heterogeneity in compound heterozygotes for the L997F sequence variant: the
two extremes of the spectrum?
Porcaro L1, Coviello D1, Costantino L1, Paracchini V1, Capasso P1, Degiorgio D1, Gagliardini R2,
Russo M3, Colombo C3, Seia M1. 1Molecular Genetics Laboratory, Fondazione IRCCS Policlinico
Mangiagalli Regina Elena, Milano, Italy; 2Cystic Fibrosis Centre, Ancona, Italy; 3Cystic Fibrosis
Centre, Fondazione IRCCS Policlinico Mangiagalli Regina Elena, Milano, Italy.
266 – Lentiviral vector-mediated expression of small hairpin RNA interference sequence inhibits
the epithelial sodium channel in functional models of human airway epithelium.
Copreni E1, Palmeri L1, Castellani S1, Tilesi F2, Ascenzioni F2, Conese M1. 1Institute for
Experimental Treatment of Cystic Fibrosis, H.S. Raffaele, Milano, Italy; 2Department of
Development and Cellular Biology, University of Rome “La Sapienza”, Rome, Italy.
268 – Evaluation of potentiators and correctors for the functional rescue of ΔF508 CFTR protein.
Pedemonte M1,2, Sondo E1, Galletta LJ1,2. 1Lab. Genetica Molecolare, Istituto Gaslini, Genova,
Italy; 2Centro Biotecnologie Avanzate, Genova, Italy.
269 – Azithromycin decrease glutathione-S-transferase T1 (GSTT1) and M1 (GSTM1) expression
and activity in cystic fibrosis airway epithelial cells.
Bergamini G1, Cigana C2, Sorio C1, Della Peruta M1, Assael BM2, Melotti P2. 1Pathology,
University of Medicine, Verona, Italy; 2Cystic Fibrosis Center, Azienda Ospedaliera di Verona,
Verona, Italy.
Microbiologia-Infezioni
340 – Relevance of oxygen limitation on Pseudomonas aeruginosa strains: effects on released
proteins expression.
Cigana C1, Bergamini G1, Mauri P2, Sorio C3, Di Silvestre D2, De Palma A2, Bennazzi L2, Bragonzi
A4, Assael BM1, Melotti P1. 1Cystic Fibrosis Center, Azienda Ospedaliera di Verona, Verona, Italy;
2
Institute for Biomedical Technologies, CNR, Milan, Italy; 3General Pathology, University of
Verona, Verona, Italy; 4Institute for Experimental Treatment of Cystic Fibrosis, H.S. Raffaele,
Milan, Italy..
347 – Definition of successful eradication therapy against the first P. aeruginosa colonization in
cystic fibrosis patients: are current criteria reliable?
Taccetti G, Braggion C, Ravenni N, Zavataro L, Neri A, Festini F, Campana S. Meyer Hospital,
University of Florence, CF Center of Tuscany, Florence, Italy.
352 – Commitment to chronic versus acute Pseudomonas aeruginosa infection in cystic fibrosis.
Paroni M1, Montanari S1, Nonis A2, Cramer R3, Tummler B3, Doering G4, Bragonzi A1. 1European
Institute for Cystic Fibrosis Research, Scientific Institute H.S. Raffaele, Milano, Italy; 2University
Centre of Statistics for Biomedical Sciences, Scientific Institute H.S. Raffaele, Milano, Italy;
3
Klinische Forschergruppe, Medizinische Hochschule, Hannover, Germany; 4Institute of Medical
Microbiology, Universitaetsklinikum Tuebingen, Tuebingen, Germany.
Pneumologia – Immunologia
405 – Parenteral single or multiple daily dose of tobramycin therapy for cystic fibrosis patients:
clinical outcome and drug serum levels.
Lori I1, Festini F1, Campana S1, Neri A1, Zavataro L1, Ciuti R2, Taccetti G1. 1Regional Cystic
Fibrosis Center of Tuscany, Meyer Pediatric Hopistal, Florence, Italy; 2Department of Laboratori
Diagnostics, Careggi Hospital, Florence, Italy.
406 – Audiometry and creatinine clearance in cystic fibrosis patients treated with intravenous
aminoglycosides. .
Braccini G, Boni V, Galici V, Trevisan F, Fanti F, Neri A, Festini F, Braggion C, Taccetti G.
Paediatrics, Department of Pediatrics, Tuscan Regional Cystic Fibrosis center, Meyer Children’s
Hospital, Florence, Italy.
Epidemiologia
459 – The Cairo Project (comparative analysis of international CF registries overwied): analysis
and review of the international scientific literature from the CF registries..
Mastella G, Baldo E, Forneris M, Furnari M, Lucidi V, Manunza D, Marinelli I, Messore B, Neri A,
Raia V, Salvatore D, Buzzetti R; CAIRO Group, Italian CF Research Fourndation, Verona, Italy.
461 – Epidemiology of community-acquired MRSA and Hospital-acquired MRSA in cystic fibrosis
patients: a national overview.
Cocchi P1, Cariani L2, Favari F2, Del Pezzo MA2, Lambiase A2, Fiscarelli E2, Giuffrè FV2, D’Aprile
A2, Manso E2, Doering G3, Taccetti G1, Campana S1. 1Department of Paediatrics, University of
Florence, Cystic Fibrosis Centre, Florence, Italy; 2Italian Cystic Fibrosis Microbiology Group,
Florence, Italy; 3Institute of Medical Microbiology and Hygiene, Tuebingen, Germany.
Miglioramento della Qualità
525 – Overfilling in current pancreatic enzyme preparations.
Anelli M, Foresti R, Peloso L, Ortensi G. medical Affaire, Eurand, Pessano con Bo, Italy.
Gastroenterologia/Nutrizione
Complicanze metaboliche
542 - Reduced insulin secretion during OGTT is tightly related to subsequent development of cystic
fibrosis related diabetes..
Battezzati A1,2, Battezzati P3, Costantini D2, Zazzeroni L2, Russo M2, Daccò V2, Colombo C2.
1
ICANS-DISTAM, University of Milan, Milano, Italy; 2CF Center, Fondazione IRCCS “Ospedale
Maggiore Policlinico, Mangiagalli, e Regina Elena”, Università degli Studi di Milano, Milano,
Italy; 3Dept of Medicine, Surgery and Dentistry, Università degli Studi di Milano, Milano, Italy.
Nutrizione
Nursing – Temi psicologici
548* – Emotional distress in parents of infants with CFTR_related disorders diagnosed through
neonatal screening.
Perobelli S1, D’Orazio C1, Assael B1, Tamanini A2, Castellani C1. 1Cystic Fibrosis Center, Verona,
Italy; 2Molecular Biology Laboratori, Verona, Italy.
Screening
Altro
*: Presentazione orale.