20th Annual North American Cystic Fibrosis Conference Denver

20th Annual North American Cystic Fibrosis Conference
Denver, Colorado
2-5 November, 2006
Poster e comunicazioni orali (*)
Genetica – Biologia/fisiologia di CFTR – Nuove terapie
71 – Role of NBD mutations on the putative binding site of CFTR potentiators.
Zagarra-Moran O1, Monteverde M1, Pincin C2, Galietta LJ1, Moran O2. 1Laboratorio di Genetica
Molecolare, Istituto Giannina Gaslini, Genova,Italy; 2Istituto di Biofisica, Consiglio Nazionale delle
Ricerche, Genova, Italy.
118 – Thiocyanate transport mechanisms in human bronchial epithelial cells.
Pedemonte N, Caci E, Sondo E, Caputo A, Ravazzolo R, Zagarra-Moran O, Galietta LJ:
Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genova, Italy.
144* - Selective modulation of P. aeruginosa-dependent induction of interleukin-8 by transcription
factor decoy oligonucleotides in CF bronchial epithelial cells.
Bezzerri V1, Borgatti M2, Mancini I2, Nicolis E1, Dechecchi M1, Tamanini A1, Quiri F1, Lampronti
I2, Gambari R2, Cabrini G1. 1Laboratory of Molecular Pathology, CF Center, University Hospital of
Verona, Verona, Italy; 2Department of Biochemistry and Molecular Biology, University of Ferrara,
Ferrara, Italy.
152 – The inflammatory response of CF airway cells to Pseudomonas aeruginosa is reduced by
benzo(C)quinolizinium compound MPB-47.
Dechecchi M1, Nicolis E1, Tamanini A1, Bezzerri V1, Giri M3, Mettey Y2, Assael B1, Becq F2,
Cabrini G1. 1Laboratory of Molecular Pathology, CF Center, University Hospital of Verona,
Verona, Italy; 2Institute de Physiologie et Biologie Cellulaires CNRS, Universitè de Poitiers,
Poitiers, France; 3Medical Physics Dept, University Hospital of Verona, Verona, Italy.
167 – Pseudomonas aeruginosa-dependent induction of transcription factor SP1 in a CF bronchial
epithelial cell line.
Bezzerri V1, Borgatti M2, Mancini I2, Nicolis E1, Dechecchi M1, Quiri F1, Lampronti I2, Cabrini G1,
Gambari R2.1Laboratory of Molecular Pathology, CF Center, University Hospital of Verona,
Verona, Italy; 2Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara,
Italy.
192 – TG15 T5 allele in clinically discordant monozygotic twins with cystic fibrosis.
Picci L2, Cameran M2, Pradal U1, Scarpa M2, Melotti P1, Assael BM1, Castellani C1. 1Cystic
Fibrosis Center Verona, Verona, Italy; 2Pediatrics Department, Padua, Italy.
210 – Molecular analysis with DHPLC technique and research of great deletions in patients with
cystic fibrosis.
Repetto T1, Torricelli F2, Minuti B2, Pelo E2, Romolini C2, Giuntini R1. 1Cystic Fibrosis Regional
Center, Meyer Hospital, Florence, Italy; 2Department of Genetics, Careggi Hospital, Florence, Italy.
212 – Screening of rearrangements in the CFTR gene in Italian population.
Seia M1, Capasso P1, Degiorgio D1, Coviello D1, Travi M1, Colombo C2, Costantini D2, Padoan R3,
Porcaro L1. 1Molecular Genetic Laboratory, Fondazione Policlinico Mangiagalli Regina Elena,
Milano, Italy; 2CF Center, Fondazione Policlinico Mangiagalli Regina Elena, Milano, Italy; 3CF
Service, A.O.Spedali Civili di Brescia, Brescia, Italy.
270 – Homing of bone marrow-derived stem cells in a murine model of airway epithelial damage
caused by Pseudomonas aeruginosa.
Rejman I, Conese M. Institute for Experimental Treatment of Cystic Fibrosis, H.S. Raffaele,
Milano, Italy.
275 – Structure-activity relationship of 1,4-dihydropyridines as activators of mutant CFTR
channels.
Pedemonte N1, Giampieri M2, Boido D3, Nieddu E2, Zagarra-Moran O1, Mazzei M2, Galietta LJ1. 1
Lab. di Genetica Molecolare, Istituto Giannina Gaslini, Genova; 2Dip. Sci. Far. Università di
Genova, Genova, Italy; 3Istituto di Biofisica, CNR, Genova, Italy.
282 – Azithromycin reduces tumor necrosis factor alpha expression in CF airway epithelial cells.
Cigana C, Assael BM, Melotti P. Cystic Fibrosis Center, Azienda Ospedaliera di Verona, Verona,
Italy.
285 – Novel generation lentiviral vectors: evaluation of inflammatory potential in human
respiratory epithelial cells.
Copreni E1, Nicolis E2, Tamanini A2, Bezzerri V2, Castellani S1, Palmieri L1, Conese M1, Cabrini
G2. 1Institute for Experimental Treatment of Cystic Fibrosis, H.S. Raffaele, Milano, Italy;
2
Laboratory of Molecular pathology, CF Center, University Hospital of Verona, Verona, Italy.
286 – Efficiency and persistence of a VSV-G pseudotyped lentiviral vector mediated gene transfer
into the murine airways hold promise for gene therapy of cystic fibrosis.
Copreni E, Castellani S, Palmieri L, Conese M. Institute for Experimental Treatment of Cystic
Fibrosis, H.S. Raffaele, Milano, Italy.
Microbiologia-Infezioni
305* - Evaluation of a cultural method for the isolation of mycobacterium abscessus and
mycobacterium chelonae in sputum of cystic fibrosis patients.
Cariani L1, Marchi M1, Costantini D1, Clarizia G2, Russo MC1, Torresani E2, Colombo C1,
Garlaschi ML2. 1Regional Center of Cystic Fibrosis, Milano, IRCCS Ospedale Maggiore
Policlinico, Mangiagalli e Regina Elena, Milan, Italy; 2Department of Microbiology, IRCCS,
Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
310* - Cost versus benefit of Pseudomonas aeruginosa hypermutation in the absence or presence of
antibiotic treatment.
Montanari S1, Oliver A2, Cariani L3, Conese M1, Tummler B4, Doering G5, Bragonzi A1. 1Institute
for Experimental Treatment of CF; Milan, Italy; 2Hospital San Durata, Palma de Mallorca, Spain,
3
Ospedale Maggiore Policlinico, Milano, Italy; 4Medizinische Hochschule, Hannover, Germany;
5
Universitaetsklinikum Tuebingen, Tuebingen, Germany.
318 – Pathogenicity of Pseudomonas aeruginosa clonal strains isolated from CF patients in a
murine model of chronic pulmonary infection.
Paroni M1, Montanari S1, Tummler B2, Conese M1, Doering G3, Bragonzi A1. 1Institute for
Experimental Treatment of CF, Milano, Italy; 2Medizinische Hochschule, Hannover, Germany;
3
Universitaetsklinikum Tuebingen, Tuebingen, Germany.
328 – Anti-Pseudomonas aeruginosa IgA and IgG antibodies in the serum of cystic fibrosis patients
prior to bacterial isolation.
Taccetti G1, Ruffo M1, Lori I1, Neri A1, Ravenni N1, Costantini D2, Russo M2, Festini F1, Campana
S1. 1CF Center of Florence, Florence, Italy; 2CF Center of Milan, Milan, Italy.
Pneumologia – Immunologia
359 – Rapid growing mycobacteria in sputum of cystic fibrosis patients.
Costantini D1, Cariani L1, Russo MC1, Claut L1, Faelli N1, Daccò V1, Marchi M1, Garlaschi M2,
Colombo C1. 1Pediatrics, CF Center, IRCCS Ospedale Maggiore Policlinico, Milan, Italy;
2
Microbiology, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
393 – Bronchodilator response assessed with interrupter resistance (Rint) in young children with
cystic fibrosis.
Lombardi E1, Ettumi K1, Orlandini D1, Taccetti G2, Repetto T2, Sly P3. 1Meyer Children’s
University Hospital, Allergy and Pulmonology Center, Florence, Italy; 2Meyer Hospital, University
of Florence, CF Center of Tuscany, Florence, Italy; 3Princess Margaret Hospital for Children,
Telethon Institute for Child Health Research, Perth, WA, Australia.
402* - Effects of a combined strength and aerobic training in adults with cystic fibrosis (CF) and
severe lung disease.
Tartali C1, Donà M1, Lanza M2, Zamboni M3, Borruso A1, Cornacchia M1, Cappelletti L1, Assael
B1, Braggion C1. 1Cystic Fibrosis Center, Ospedale Civile Maggiore, Verona, Italy; 2Faculty of
Human Motor Science, University, Verona, Italy; 3Geriatric Department, Ospedale Civile
Maggiore, Verona, Italy.
Epidemiologia
433 – A national overview of MRSA epidemiology: emergence of an epidemic clone.
Piluso A1, Cariani L2, Favari F3, Del Pezzo M4, Lambiase A4, Fiscarelli E5, Gioffrè VF6, d’Aprile
A7, Manso E8, Taccetti G1, Campana S1. 1Department of Pediatrics, Cystic Fibrosis Center, Meyer
Hospital, Florence, Italy; 2Cystic Fibrosis Center, Milan, Italy; 3Ospedale Civile Maggiore, Verona,
Italy; 4University “Federico II”, Naples, Italy; 5Ospedale Bambin Gesù, Rome, Italy; 6Ospedale di
Soverato, Soverato, Italy; 7Ospedale G. Tatarella, Cerignola, Italy; 8Ospedale Umberto I, Ancona,
Italy.
437 – Gender difference in cystic fibrosis. Analysis from the Italian CF Registry (ICFR).
Viviani L1, Bossi A1, Assael BM2, Italian C3. 1Istituto di Statistica Medica e Biometria, University
of Milan, Milan, Italy; 2Cystic Fibrosis Centre, Verona, Italy; 3Italian CF Centres, Italy.
Miglioramento della Qualità
446* - Can telemonitoring improve quality of life in CF patients? An RCT protocol to assess the
effectiveness of a telemedicine intervention.
Viviani L1, Bossi A1, Milani S1, Gagliardini R2, Grzincich G3, Quattrucci S4, Bella S5, Padoan R6.
1
Istituto di Statistica Medica e Biometria, Università degli Studi, Milano, Italy; 2Ospedale dei
Bambini G. Salesi, Ancona, Italy; 3Clinica Pediatrica dell’Università, Parma, Italy; 4Clinica
Pediatrica Università “La Sapienza”, Roma, Italy; 5Ospedale Bambino Gesù, Roma, Italy; 6Spedali
Civili, Brescia, Italy.
Gastroenterologia/Nutrizione
Complicanze metaboliche
511* - Contribution of defects in insulin sensitivity and beta-cell function to the changes over time
in the glucose tolerance of cystic fibrosis patients.
Battezzati A1,2, Mari A3, Costantini D2, Zazzeroni L2, Russo M2, Colombo C2. 1ICANS-DISTAM,
University of Milan, Milano, Italy; 2CF Center, Fondazione IRCCS “Ospedale Maggiore
Policlinico, Mangiagalli, e Regina Elena”, University of Milan, Milano, Italy; 3Metabolic Modeling
Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy.
516 – Longitudinal evaluation of height growth in patients with cystic fibrosis in relation to lung
disease severity.
Assael BM1, Casazza G2, Iansa P1, Milani S2. 1Center for Cystic Fibrosis, Azienda Ospedaliera di
Verona, Verona, Italy; 2Department od Statistics, University of Milano, Milano, Italy.
517 – Insulin glargine in patients with glucide intolerance in cystic fibrosis: pilot study.
Minicucci L1, Casciaro R1, De Alessandri A1, Haupt M1, Furnari M2, Bella S3, Lombardo M4,
Haupt R5, Lorini R1. 1Department of Pediatrics, University of Genoa, G. Gaslini Children’s
Hospital, Genoa, Italy; 2Cystic Fibrosis Regional Center, Children Hospital “Di Cristina” ARNAS,
Palermo, Italy; 3Department of Pediatric Medicine, Children’s Hospital and Research Institute
Bambino Gesù, Rome, Italy; 4Department of Pediatrics, Paediatric Gastroenterology Unit.
University of Messina, Messina, Italy; 5Epidemiology and Biostatistics Section, Scientific
Directorate, G. Gaslini Children’s Hispital, Genoa, Italy.
Nutrizione
Nursing – Temi psicologici
536 – Before finding out: newborn screening programme and anxiety of the parents.
Catastini P, Zavataro L, Festini F, Magni S, Repetto T. Pediatric Meyer Hospital, Florence, Italy.
543 – Perception of pain related to venipunture in children with cystic fibrosis compared to nonaffected children.
Festini F1, Neri S1, Bastiani C2, Caprilli S2. 1Department of Pediatrics, Section of Science of Al lied
Health Professions, University of Florence, Florence, Italy; 2Pain Therapy Unit, Meyer
PediatricHospital, Florence, Italy.
550 – Being parent with cystic fibrosis (CF): a chance, a choice, a hope.
Pizzamiglio G, Monti M, Blasi F, Tursia P. U.O. Broncopneumologia, Fondazione Ospedale
Maggiore Policlinico, Mangiagalli, Regina Elena IRCCS, Milano, Italy.
Screening
Altro
*: Presentazione orale.