Curriculum vitae

Curriculum Vitae
PERSONAL INFORMATION
Tarcisio Not
Tarcisio Not
+39 040 3785 472
[email protected]
Sex Male| Date of birth 19 September 1951 | Nationality Italian
WORK EXPERIENCE
1985-1991 Researcher: Department of Pediatrics of Trieste University and Institute for Maternal and Child
Health - IRCCS Burlo Garofolo Trieste.
1991-2014 Assistant Professor of Paediatrics: Trieste University and Institute for Maternal and Child
IRCCS Burlo Garofolo Trieste.
Health -
1995-2000 Visiting Research Scientist: Department of Pediatrics, Division of Gastroenterology and
Nutrition, University of Maryland. Coordinator of the first celiac disease screening programs in USA.
2008-Present Head of the Immune-Laboratories of Institute for Maternal and Child
Garofolo Trieste.
Health - IRCCS Burlo
2014-Present Professor of Paediatrics: Department of Pediatrics of Trieste University and Institute for
Maternal and Child Health - IRCCS Burlo Garofolo Trieste.
EDUCATION AND TRAINING
1983- Medical Doctor: School of Medicine of Trieste University
1984-1989 Resident: Department of Pediatrics of Trieste University and Institute for Maternal and Child
Health - IRCCS Burlo Garofolo Trieste.
PERSONAL SKILLS
Mother tongue(s)
Italian
Other language(s)
English
UNDERSTANDING
SPEAKING
WRITING
Listening
Reading
Spoken interaction
Spoken production
B1
B2
B2
B2
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Curriculum Vitae
© European Union, 2002-2013 | http://europass.cedefop.europa.eu
Tarcisio Not
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Curriculum Vitae
Keynote Speaker
Invited Lecturer 2005-2014
Organisational / managerial skills
Tarcisio Not
- 16th Annual Pediatric Gastroenterology Course at University College of
London, London. Celiac disease.
(November 2005)
- Workshop su diagnosi di celiachia. UO di gastroenterologia pediatrica.
Policlinico Università di Messina (Settembre 2005)
- Active case finding, in the screening of celiac disease. Hospital for Children,
Novi Sad (Serbia), (October, 2006)
- Attualità di laboratorio sulla malattia celiaca. ASL 20 Verona (Ottobre
2006).
- Working group in prolamin and toxicity. Area Science Park, Trieste,
(October 2006)
- Anti-ttg rapidi e screening della celiachia. Giornate di Medico e Bambino,
Alessandria (Aprile 2006)
- Nuovi aspetti della celiachia. IRCCS Burlo Garofolo, Area Science Park,
Trieste (Gennaio 2006)
- GastroPed Incontri di Gastroenterologia Pediatrica. Ospedale Meyer,
Firenze (Febbraio 2007)
- Innovative Medicine Exploring Joint Italy-Qatar Opportunities. Early
diagnosis for better quality of life in chronic diseases. Doha (Qatar) (June
2007)
- Celiac diseases here and overseas. . IRCCS Burlo Garofolo, Area Science
Park, Trieste (January 2008).
- 5th CBM Summer School Personalized Medicine. CBM, Area Science Park
(July 2009)
- The gut in rheumatic disease. Celiac disease and autoimmunity:the tip of an
iceberg. Annual European Congress of Rheumatology. Copenhagen (Jume
2009)
- Epidemiologia della celiachia. ASL Brescia. Brescia (Novembre 2009)
- Nexus Meetings. Exploring new directions for difficult patients in
Gastroenterology, Venice(June 2009)
- Celiac disease and autoimmunity. 7th International Congress on
Autoimmunity. Ljubljana (Slovenia) (May 2010).
- Corso Avanzato di Celiachia. VI° up-date in gastroenterologia. Azienda
Universitaria Ospedaliera di Udine. Udine (Ottobre 2010)
-Celiachia: vecchie conoscenze e novità dalla ricerca. IRCAD Università
degli Studi del Piemonte Orientale. Novara (Maggio 2011)
- Diete Speciali e Autocontrollo. ASL 1 Triestina. Dipartimento di
Prevenzione. Corsi (settembre 2008-2014)
- Associazione Italiana Celiachia. La celiachia: conoscere il camaleonte.
Genova (Novembre 2013)
- Coeliac Disease and IBD: inside and outside the gut. How not to spoil the
intestinal biopsy. University of Trieste and IRCCS Burlo Garofolo (January
2014)
- New developments in coeliac disease. Gluten dependent clinical condition
discovered by the intestinal anti-TG deposits. School of Medicine University
of Maribor (Republic of Slovenia) September 2014.
▪ Currently responsible for a team of 5 researchers for innovative diagnosis in the field of
gastrointestinal autoimmune disorders.
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Curriculum Vitae
Tarcisio Not
Direction of competitive projects:
- MIUR-2001068143_004 “Correlazione tra fattoti genetici e marcatori sierologici di autoimmunità e il
danno mucosale dell’intolleranza al glutine”, fondo di € 36669;
- MIUR-2004060237_003 “Ruolo del glutine nella risposta auto-anticorpale mucosale, in soggetti a rischio
di malattia celiaca”, fondo di € 70000;
- Ricerca Finalizzata Ministero della Salute BS7. 2002-2004 “Storia naturale dell’intolleranza al glutine
non diagnosticata nella popolazione di un paese della regione del FVG” fondo di € 326000;
- Ricerca Finalizzata Ministero della Salute 72/04 “Caratterizzazione della risposta immune glutinedipendente della mucosa intestinale nelle fasi precoci del diabete tipo 1” fondo di € 46000.
- Regione Friuli Venezia Giulia L.R.19,2000, Progetto “Formazione del personale sanitario locale ad approcci
clinici efficaci e semplificati nell’assistenza pediatrica in un paese povero; formazione del personale alla
diagnostica per immagini mediante utilizzo di tecnologia digitale con trasmissione delle immagini a distanza per
teleconsulto; e-learning ” 2009, fondo €33000.
- Progetto Telethon E1141/2000 Phage antibody librarires from coeliac disease patients, fondo di € 90000.
- MIUR-2008B3WM2R, “Ruolo dell'anti-idiotipo anti-transglutaminasi nella patogenesi della malattia
celiaca” fondo € 84000;
- Ricerca Finalizzata Ministero della Salute 2008 “Dilatative cardiomyopathy and gluten dependent
autoimmunity” fondo 283000 €
- Ricerca Finalizzata Ministero della Salute 2011 “Anti-idiotypic network to anti transglutaminase antibodies in the
pathogenesis of celiac disease”, fondo 155.000 €
- Transregional Network for Innovation and Technology to Improve health care (www.trans2 care.eu) 2011-2013
“Clinical and technological innovations on celiac disease diagnosis and treatment”, fondo 175.000 €.
- Focus in CD, Central Europe 2016-2019, fondo 244.000 €
- XVII EXECUTIVE PROGRAMME OF SCIENTIFIC AND TECHNOLOGICAL CO-OPERATION
BETWEEN THE REPUBLIC OF HUNGARY AND THE REPUBLIC OF ITALY FOR THE YEARS 2008–
2010. LS/17 “Intestinal gluten-dependent immune response in the early stages of celiac disease in subjects at risk
for genetic gluten intolerance”, fondo 15000 €
- Regione Friuli Venezia Giulia (L.R.19,2000), Progetto “Formazione del personale sanitario locale ad
approcci efficaci e semplificati nell’assistenza pediatrica in un paese povero” 2008, fondo 31.779 €.
- Regione Friuli Venezia Giulia (L.R.19,2000), Progetto “Formazione del personale sanitario locale ad
approcci clinici efficaci e semplificati nell’assistenza pediatrica in un paese povero; formazione del
personale alla diagnostica per immagini mediante utilizzo di tecnologia digitale con trasmissione delle
immagini a distanza per teleconsulto; e-learning ” 2009, fondo 33000 €.
© European Union, 2002-2013 | http://europass.cedefop.europa.eu
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Curriculum Vitae
Tarcisio Not
30/104 selected publications
1. Not T, Ventura A, Peticarari S, Basile S, Torre G, Dragovic D. A new, rapid, noninvasive screening
test for celiac disease. J Pediatr. 1993;123:425-7.
2. Not T, Horvath K, Hill ID, Partanen J, Hammed A, Magazzu G, Fasano A. Celiac disease risk in the
USA: high prevalence of antiendomysium antibodies in healthy blood donors.Scand J
Gastroenterol. 1998;33:494-8
3. Baldas V, Tommasini A, Trevisiol C, Berti I, Fasano A, Sblattero D, Bradbury A, Marzari R,
Barillari G, Ventura A, Not T. Development of a novel rapid non-invasive screening test for coeliac
disease. Gut. 2000;47:628-31.
4. Ventura A, Neri E, Ughi C, Leopaldi A, Città A, Not T. Gluten-dependent diabetes-related and
thyroid-related autoantibodies in patients with celiac disease. J Pediatr. 2000;137:263-5
5. Sblattero D, Berti I, Trevisiol C, Marzari R, Tommasini A, Bradbury A, Fasano A, Ventura A, Not
T. Human recombinant tissue transglutaminase ELISA: an innovative diagnostic assay for celiac
disease. Am J Gastroenterol. 2000;95:1253-7.
6. Fasano A, Not T, Wang W, Uzzau S, Berti I, Tommasini A, Goldblum S. Zonulin, a newly
discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet. 2000
29;355:1518-9.
7. M. Hadjivassiliou, S. Boscolo, G.A.B. Davies-Jones, R.A. Grunewald, T. Not, D.S. Sanders, J.E.
Simpson, E. Tongiorgi, C.A. Williamson, and N.M. Woodroofe The humoral response in the
pathogenesis of gluten ataxia. Neurology 2002; 58: 1221.
8. C Esposito, F Paparo, I Caputo, M Rossi, M Maglio, D Sblattero, T Not, R Porta, S Auricchio, R Marzari,
and R Troncone. Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase
activity both in vitro and in situ. Gut 2002;2:177-181
9. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti R, Drago S, Elitsur Y, Green P, Guandalini S, Hill
I, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman S, Murray J, Horvath K.
Prevalence of celiac disease in at-risk and not-at-risk groups in the United States. Arch Intern Med
2003;163:286-292.
10. Not T, Faleschini E, Tommasini A, Repetto A, Pasotti M, Baldas V, Spanò A, Sblattero D, Marzari
R, Campana C, Gavazzi A, Tavazzi L, Biagi F, Corazza G, Ventura A, Arbustini E. Celiac disease
in patients with sporadic and inherited cardiomyopathies and in their relatives. Eur Heart J
2003;24:1455-1461.
11. Tommasini A, Not T, Kiren V, Baldas V, Santon D, Trevisiol C, Berti I, Neri E, Gerarduzzi T,
Bruno I, Lenhardt A, Zamuner E, Spanò A, Crovella S, Martellossi S, Torre G, Sblattero D, Marzari
R, Bradbury A, Tamburlini G, Ventura A. Mass screening for coeliac disease using anti-human
transglutaminase antibody assay. Arch Dis Child 2004;89:512-515
12. Sblattero D, Ventura A, Tommasini A, Cattin L, Martelossi S, Florian F, Marzari R, Bradbury A,
Not T. Cryptic gluten intollerance in type 1 diabetes: identifying suitable candidates for gluten-free
diet. Gut 2006;55:133-134
13. Nemec G, Ventura A, Martelossi S, Di Leo G, Baldas V, Tommasini A, Ferrara F, Taddio A, Città
A, Sblattero D, Marzari R, Not T. Looking for celiac disease: diagnostic accuracy of two rapid
commercial assays. Am J Gastroenterol 2006;101:1597-1600
14. Lotta L. E. Koskinen, Elisabet Einarsdottir, Emma Dukes, Graham A. R. Heap, Patrick Dubois, Ilma R.
Korponay-Szabo, Katri Kaukinen, Kalle Kurppa, Fabiana Ziberna, Serena Vatta, Tarcisio Not, Alessandro
Ventura, Pertti Sistonen, Róza Ádány, Zsuzsa Pocsai, György Széles, Markku Mäki, Juha Kere, Cisca
Wijmenga, David A. van Heel, and Päivi Saavalainen ASSOCIATION STUDY OF THE IL18RAP LOCUS
IN THREE EUROPEAN POPULATIONS WITH COELIAC DISEASE Human Molecular Genetics
2009;18:1148-55
15. Katri Haimila, Elisabet Einarsdottir, Andrea de Kauwe, Lotta LE Koskinen, Qiang Pan-Hammarström,
Tanja Kaartinen, Kalle Kurppa, Fabiana Ziberna, Tarcisio Not, Serena Vatta, Alessandro Ventura, Ilma
Korponay-Szabo, Róza Ádány, Zsuzsa Pocsai, György Széles, Emma Dukes, Katri Kaukinen, Markku Mäki,
Sinikka Koskinen, Jukka Partanen, Lennart Hammarström, Päivi Saavalainen. The shared CTLA4-ICOS risk
locus in celiac disease, IgA deficiency and common variable immunodeficiency. Genes and Immunity
© European Union, 2002-2013 | http://europass.cedefop.europa.eu
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2009;10:151-61.
Curriculum Vitae
Tarcisio Not
16.Luigina De Leo, Nicola Di Toro, Giuliana Decorti, Noelia Malusà, Alessandro Ventura, Tarcisio Not.
Fasting increases tobramycin oral absorption in mice. Antimicrob. Agents Chemother. 2010;54:1644-6
17. Fortunato Ferrara, Sara Quaglia, Ivana Caputo, Carla Esposito, Marilena Lepretti, Serena Pastore,
Rita Giorgi, Stefano Martelossi, Gianna Dal Molin, Nicola Di Toro, Alessandro Ventura, Tarcisio
Not Anti-transglutaminase antibodies in non-celiac children suffering from infectious diseases. Clin
Exp Immunol 2010;159:217-23
18. Simeon E. Goldblum, Usha Rai, Amit Tripathi, Manjusha Thakar,T Watts, Luigina De Leo, Nicola Di
Toro, Tarcisio Not, Rithwik Ramachandran, Morley Hollenberg, Alessio Fasano. The Active Zot Domain (aa
288-293) Increases ZO-1 and Nuclear Myosin 1βSerine/Threonine Phosphorylation, Alters Interaction
Between ZO-1 and its Binding Partners, and Induces Tight Junction Disassembly through PAR2 Activation.
FASEB Journal 2011;25:144-58
19. Anna Bellini, Chiara Zanchi, Stefano Martelossi, Grazia Di Leo, Tarcisio Not, Alessandro Ventura.
Compliance to the Gluten-free Diet: the Role of the Locus of Control in Celiac Disease. J Pediatr
2011; 158:463-466
20. Not T, Ziberna F, Vatta S, Quaglia S, Martelossi S, Villanacci V, Marzari R, Florian F, Vecchiet M,
Sulic AM, Ferrara F, Bradbury A, Sblattero D, Ventura A. Cryptic genetic gluten intolerance
revealed by intestinal antitransglutaminase antibodies and response to gluten-free diet. Gut
2011;60:1487-93
21. Lumana Kawanda1, Ivan Capobianco2, Meta Starc, Daniel Felipe, Davide Zanon, Egidio Barbi, Nadine
Munkela, Verónica Rodrigues, Lúis Malundo and Tarcisio Not. Sedation with intranasal midazolam of
Angolan children undergoing invasive procedures. Acta Paediatr. 2012;101:e296-8
22. Massa O, Alessio M, Russo L, Nardo G, Bonetto V, Bertuzzi F, Paladini A, Iafusco D, Patera P, Federici G,
Not T, Tiberti C, Bonfanti R, Barbetti F. Serological Proteome Analysis (SERPA) as a tool for the
identification of new candidate autoantigens in type 1 diabetes. J Proteomics. 2013 Mar 14;82C:263-273.
23. Sara D'Angelo, Flavio Mignone, Cecilia Deantonio, Roberto Di Niro , Roberta Bordoni, Roberto Marzari,
Gianluca De Bellis,Tarcisio Not, Fortunato Ferrara, Andrew BradburyClaudio Santoro, Daniele Sblattero
Profiling celiac disease antibody reperto ire. Clin Immunol 2013;148:99-109
24. Floriana Zennaro, Joaquim Antonio Oliveira Gomes, Armando Casalino, Magda Lonardi, Meta Starc,
Pierpaolo Paoletti, Daniele Gobbo, Chiara Giusto, Tarcisio Not, Marzia Lazzerini. Digital Radiology to
Improve the Quality of Care in Countries with Limited Resources: A Feasibility Study from Angola Plos One
2013;8: e73939
25. Singh P, Wadhwa N, Chaturvedi MK, Bhatia V, Saini S, Tandon N, Makharia GK, Maki M, Not T,
Phillips A, Bhatnagar S. Validation of point-of-care testing for coeliac disease in children in a tertiary hospital
in north India. Arch Dis Child. 2014;99:1004-8.
26. Sara Quaglia, Luigina De Leo, Fabiana Ziberna, Serena Vatta, Vincenzo Villanacci,Marilena Granzotto,
Vincenzo Petix, Stefano Martelossi, Grazia Di Leo, Lucio Torelli and Tarcisio Not. Intestinal-mucosa antitransglutaminase antibody assays to test for genetic gluten intolerance Cellular & Molecular Immunology
2014; doi:10.1038/cmi.2014.32
27. Luigina De Leo, Sara Quaglia, Fabiana Ziberna, Serena Vatta, Stefano Martelossi, Massimo Maschio, and
Tarcisio Not Serum Anti-Tissue Transglutaminase Antibodies Detected during Febrile Illness May Not Be
Produced by the Intestinal Mucosa J Pediatr 2015;166:761-3
28. Inna Sareneva , Lotta L.E. Koskinen, Ilma R. Korponay-Szabo, Katri Kaukinen, Kalle Kurppa, Fabiana
Ziberna, Serena Vatta, Tarcisio Not, Alessandro Ventura, Róza Ádány, Zsuzsa Pocsai, György Széles,
Markku Mäki, Päivi Saavalainen, Elisabet Einarsdottir. LINKAGE AND ASSOCIATION STUDY OF FCγR
POLYMORPHISMS IN CELIAC DISEASE. Tissue Antigens 2009;73,54-58
29. Sara D'Angelo, Flavio Mignone, Cecilia Deantonio, Roberto Di Niro , Roberta Bordoni, Roberto Marzari,
Gianluca De Bellis,Tarcisio Not, Fortunato Ferrara, Andrew BradburyClaudio Santoro, Daniele Sblattero.
Profiling celiac disease antibody reperto ire. Clin Immunol 2013;148:99-109.
© European Union, 2002-2013 | http://europass.cedefop.europa.eu
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Curriculum Vitae
Tarcisio Not
30. R. Pillon, F. Ziberna, L. Badina, A. Ventura, G. Longo, S. Quaglia, L. De Leo, S. Vatta,
S. Martelossi, G. Patano, T. Not, I. Berti. Prevalence of celiac disease in patients with severe food allergy.
Allergy 2015; DOI: 10.1111/all.12692.
Bibliometric data since 2016: HI 30, Total citations: 4521 (www.scopus.com)
Trieste 20 ottobre 2016
Prof. Tarcisio Not
© European Union, 2002-2013 | http://europass.cedefop.europa.eu
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