Giovanni Migliaccio - EMA

Curriculum vitae
PERSONAL INFORMATION
Giovanni Migliaccio
WORK EXPERIENCE
June 1984–February 1993
Researcher
Istituto Superiore di Sanità (Italy)
Execution of research project, supervision of technicians
Planning of independent research activities
Data analysis
Manuscript preparation and submission
February 1993–January 1998
Senior Researcher
Istituto Superiore di Sanità (Italy)
Execution of research project, supervision of technicians
Planning of independent research activities
Data analysis
Manuscript preparation and submission
Direction of a section
January 1998–Present
Director of Research
Istituto Superiore di Sanità (Italy)
Planning of independent research activities
Data analysis
Manuscript preparation and submission
Direction of a section
January 2012–Present
Scientific Director
EATRIS (Netherlands)
- SELECTION AND MANAGEMENT OF SCIENTIFIC SERVICES
- DESIGN OF SCIENTIFIC STRATEGIC PROJECTS
EDUCATION AND TRAINING
September 1972–June 1977
Laurea Sperimentale in Scienze Biologiche
Università Federico II (Napoli) (Italy)
Basic and advanced Biological sciences with 36 different course
Inclusion of two year experimental design for the thesis with final dissertation awarded cum laude
June 1986–December 1988
Post Doctoral Fellow
University of Washington, Seattle WA (United States)
Growth factors in Hematopoiesis
Stem cells
January 1989–September 1993
Associate Member
New York Blood Center (United States)
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Curriculum vitae
Giovanni Migliaccio
Hematopoiesis; Stem cells commitment, Synthetic growth media
ADDITIONAL INFORMATION
Expertise
Experimental Hematology with specialization in growth factor control of stem cell self-renewal and
differentiation.
Hemoglobin gene regulation
Cell therapies and Tissue engineering
Clinical trial authorization
Good Laboratory practices
Publications
[1] L. Varricchio, C. Dell'Aversana, A. Nebbioso, G. Migliaccio, L. Altucci, A. Mai, G. Grazzini, J.J.
Bieker, A.R. Migliaccio, Identification of NuRSERY, a new functional HDAC complex composed by
HDAC5, GATA1, EKLF and pERK present in human erythroid cells, Int J Biochem Cell Biol, 50 (2014)
112-122.
[2] G.A. van Dongen, A.E. Ussi, F.H. de Man, G. Migliaccio, EATRIS, a European initiative to boost
translational biomedical research, Am J Nucl Med Mol Imaging, 3 (2013) 166-174.
[3] G. Migliaccio, C. Pintus, Role of the EU Framework in Regulation of Stem Cell-Based Products,
Adv Biochem Eng Biotechnol, 130 (2013) 287-299.
[4] G. Migliaccio, F.H. de Man, A.E. Ussi, Therapeutics: Boost to translational medicine in Europe,
Nature, 497 (2013) 565.
[5] L. Varricchio, C. Dell'Aversana, A. Nebbioso, G. Migliaccio, L. Altucci, J.J. Bieker, A.R.F. Migliaccio,
Identification of a New Functional HDAC Complex Composed by HDAC5, GATA1 and EKLF in
Human Erythroid Cells, Blood, 120 (2012).
[6] L. Varricchio, E. Masselli, E. Alfani, A. Battistini, G. Migliaccio, A.M. Vannucchi, W. Zhang, D.
Rondelli, J. Godbold, B. Ghinassi, C. Whitsett, R. Hoffman, A.R. Migliaccio, The dominant negative β
isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from
polycythemia vera patients, Blood, 118 (2011) 425-436.
[7] G. Migliaccio, F. Masiello, V. Tirelli, M. Sanchez, L. Varricchio, C. Whitsett, A.R. Migliaccio, Under
HEMA conditions, self-replication of human erythroblasts is limited by autophagic death, Blood Cells
Mol Dis, 47 (2011) 182-197.
[8] G. Migliaccio, F. Capone, Il farmaco di origine biologica in: C. Tomino (Ed.) Alla ricerca del farmaco
perduto Medi Service, Milano, 2011, pp. 131-160.
[9] A.R. Migliaccio, C. Whitsett, G. Migliaccio, Red Blood Cells from Stem Cells, in: A. Mozzarelli, S.
Bettati (Eds.) Chemistry and Biochemistry of Oxygen Therapeutics, John Wiley & Sons, Ltd., New
York, 2011, pp. 257-271.
[10] B. Ghinassi, L. Ferro, F. Masiello, V. Tirelli, M. Sanchez, G. Migliaccio, C. Whitsett, S. Kachala, I.
Riviere, M. Sadelain, A.R. Migliaccio, Recovery and Biodistribution of Ex Vivo Expanded Human
Erythroblasts Injected into NOD/SCID/IL2Rgamma mice, Stem Cells Int, 2011 (2011) 673752.
[11] F. Capone, L. Lombardini, S. Pupella, G. Grazzini, A.N. Costa, G. Migliaccio, Cord blood stem cell
banking: a snapshot of the Italian situation, Transfusion, 51 (2011) 1985-1994.
[12] R. Botta, G. Migliaccio, Cell-based treatments: advanced therapies and transplants, Transplant
Proc, 43 (2011) 338-340.
[13] F. Belardelli, P. Rizza, F. Moretti, C. Carella, M.C. Galli, G. Migliaccio, Translational research on
advanced therapies, Ann Ist Super Sanità, 47 (2011) 72-78.
[14] C.K. Schneider, P. Salmikangas, B. Jilma, B. Flamion, L.R. Todorova, A. Paphitou, I. Haunerova,
T. Maimets, J.H. Trouvin, E. Flory, A. Tsiftsoglou, B. Sarkadi, K. Gudmundsson, M. O'Donovan, G.
Migliaccio, J. Ancans, R. Maciulaitis, J.L. Robert, A. Samuel, J.H. Ovelgonne, M. Hystad, A.M. Fal,
B.S. Lima, A.S. Moraru, P. Turcani, R. Zorec, S. Ruiz, L. Akerblom, G. Narayanan, A. Kent, F.
Bignami, J.G. Dickson, D. Niederwieser, M.A. Figuerola-Santos, I.G. Reischl, C. Beuneu, R. Georgiev,
M. Vassiliou, A. Pychova, M. Clausen, T. Methuen, S. Lucas, M. Schussler-Lenz, V. Kokkas, Z. Buzas,
N. MacAleenan, M.C. Galli, A. Line, J. Gulbinovic, G. Berchem, M. Fraczek, M. Menezes-Ferreira, N.
Vilceanu, M. Hrubisko, P. Marinko, M. Timon, W. Cheng, G.A. Crosbie, N. Meade, M.L. di Paola, T.
VandenDriessche, P. Ljungman, L. D'Apote, O. Oliver-Diaz, I. Buttel, P. Celis, Challenges with
advanced therapy medicinal products and how to meet them, Nat Rev Drug Discov, 9 (2010) 195201.
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Giovanni Migliaccio
[15] G. Migliaccio, M. Sanchez, F. Masiello, V. Tirelli, L. Varricchio, C. Whitsett, A.R. Migliaccio,
Humanized culture medium for clinical expansion of human erythroblasts, Cell Transplant, 19 (2010)
453-469.
[16] G. Migliaccio, A.R. Migliaccio, Getting personal with B19 parvovirus, Blood, 115 (2010) 922-923.
[17] G. Migliaccio, C. Carella, Toward a European harmonisation of the requirements for the first
clinical use of Advanced Therapy Medicinal Products (ATMPs): Preclinical requirements for cell based
medicinal products, Pharmaceuticals Policy and Law, Volume 12 (2010) 35-40.
[18] G.T. Kozma, F. Martelli, M. Verrucci, L. Gutierrez, G. Migliaccio, M. Sanchez, E. Alfani, S.
Philipsen, A.R. Migliaccio, Dynamic regulation of Gata1 expression during the maturation of
conventional dendritic cells, Exp Hematol, 38 (2010) 489-503 e481.
[19] B. Ghinassi, F. Martelli, M. Verrucci, E. D'Amore, G. Migliaccio, A.M. Vannucchi, R. Hoffman, A.R.
Migliaccio, Evidence for organ-specific stem cell microenvironments, Journal of Cellular Physiology,
223 (2010) 460-470.
[20] E. Stellacci, A. Di Noia, A. Di Baldassarre, G. Migliaccio, A. Battistini, A.R. Migliaccio, Interaction
between the glucocorticoid and erythropoietin receptors in human erythroid cells, Exp Hematol, 37
(2009) 559-572.
[21] A.R. Migliaccio, C. Whitsett, G. Migliaccio, Erythroid cells in vitro: from developmental biology to
blood transfusion products, Curr Opin Hematol, 16 (2009) 259-268.
[22] A.R. Migliaccio, F. Martelli, M. Verrucci, G. Migliaccio, A.M. Vannucchi, H. Ni, M. Xu, Y. Jiang, B.
Nakamoto, T. Papayannopoulou, R. Hoffman, Altered SDF-1/CXCR4 axis in patients with primary
myelofibrosis and in the Gata1 low mouse model of the disease, Exp Hematol, 36 (2008) 158-171.
[23] F. Martelli, B. Ghinassi, R. Lorenzini, A.M. Vannucchi, R.A. Rana, M. Nishikawa, S. Partamian, G.
Migliaccio, A.R. Migliaccio, Thrombopoietin Inhibits Murine Mast Cell Differentiation, Stem Cells, 26
(2008) 912-919.
[24] A. Mai, K. Jelicic, D. Rotili, A. Di Noia, E. Alfani, S. Valente, L. Altucci, A. Nebbioso, S. Massa, R.
Galanello, G. Brosch, A.R. Migliaccio, G. Migliaccio, Identification of two new synthetic histone
deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and
patients with thalassemia, Mol Pharmacol, 72 (2007) 1111-1123.
[25] B. Ghinassi, M. Verrucci, K. Jelicic, A. Di Noia, G. Migliaccio, A.R. Migliaccio, Interleukin-3 and
erythropoietin cooperate in the regulation of the expression of erythroid-specific transcription factors
during erythroid differentiation, Exp Hematol, 35 (2007) 735-747.
[26] B. Ghinassi, M. Sanchez, F. Martelli, G. Amabile, A.M. Vannucchi, G. Migliaccio, S.H. Orkin, A.R.
Migliaccio, The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the
common megakaryocytic-erythroid progenitor, Blood, 109 (2007) 1460-1471.
[27] A. Di Baldassarre, M. Di Rico, A. Di Noia, T. Bonfini, A. Iacone, M. Marchisio, S. Miscia, E. Alfani,
A.R. Migliaccio, G. Stamatoyannopoulos, G. Migliaccio, Protein kinase Calpha is differentially
activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the
control of the (A)gamma globin-promoter in cellular models of hemoglobin switching, J.Cell.Biochem.,
101 (2007) 411-424.
[28] M. Sanchez, I.L. Weissman, M. Pallavicini, M. Valeri, P. Guglielmelli, A.M. Vannucchi, G.
Migliaccio, A.R. Migliaccio, Differential amplification of murine bipotent megakaryocytic/erythroid
progenitor and precursor cells during recovery from acute and chronic erythroid stress, Stem Cells, 24
(2006) 337-348.
[29] A.M. Vannucchi, L. Bianchi, F. Paoletti, A. Pancrazzi, E. Torre, M. Nishikawa, M. Zingariello, A. Di
Baldassarre, R.A. Rana, R. Lorenzini, E. Alfani, G. Migliaccio, A.R. Migliaccio, A pathobiologic
pathway linking thrombopoietin, GATA-1, and TGF-{beta}1 in the development of myelofibrosis, Blood,
105 (2005) 3493-3501.
[30] G. Migliaccio, A. Di Baldassarre, C. Di Rico, A. Di Noia, B. Nakamoto, H. Cao, E. Skarpidi, A.R.
Migliaccio, Spontaneous switch from Agamma- to beta-globin promoter activity in a stable transfected
dual reporter vector, Blood Cells Mol Dis, 34 (2005) 174-180.
[31] A.R. Migliaccio, E. Alfani, V. Di Giacomo, M. Cieri, G. Migliaccio, Ex vivo amplification of T cells
from human cord blood, Pathol Biol (Paris), 53 (2005) 151-158.
[32] F. Martelli, B. Ghinassi, B. Panetta, E. Alfani, V. Gatta, A. Pancrazzi, C. Bogani, A.M. Vannucchi,
F. Paoletti, G. Migliaccio, A.R. Migliaccio, Variegation of the phenotype induced by the Gata1low
mutation in mice of different genetic backgrounds, Blood, 106 (2005) 4102-4113.
[33] V. di Giacomo, A. Matteucci, E. Stellacci, A. Battistini, A. Di Baldassarre, S. Capitani, E. Alfani,
A.R. Migliaccio, L. Cocco, G. Migliaccio, Expression of signal transduction proteins during the
differentiation of primary human erythroblasts, Journal of Cellular Physiology, 202 (2005) 831-838.
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Curriculum vitae
Giovanni Migliaccio
[34] G. Amabile, A. Di Noia, E. Alfani, A.M. Vannucchi, M. Sanchez, D. Bosco, A.R. Migliaccio, G.
Migliaccio, Isolation of TPO-dependent subclones from the multipotent 32D cell line, Blood Cells Mol
Dis, 35 (2005) 241-252.
[35] A.M. Vannucchi, L. Bianchi, F. Paoletti, V. Di Giacomo, G. Migliaccio, A.R. Migliaccio, Impaired
GATA-1 expression and myelofibrosis in an animal model, Pathol Biol (Paris), 52 (2004) 275-279.
[36] G. Migliaccio, G. Novelli, E. Cancellieri, Le nuove frontiere della ricerca clinica, in: C. Tomino (Ed.)
Manuale tecnico-pratico sulla sperimentazione clinica dei medicinali, Critical Medicine Publishing
Editore, Roma, 2004, pp. 335-389.
[37] M. Sanchez, E. Alfani, A.R. Migliaccio, T. Bonfini, G. Migliaccio, Amplification of T cells from
human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7 and
interleukin-2, Bone Marrow Transplant, 31 (2003) 713-723.
[38] A.R. Migliaccio, R.A. Rana, M. Sanchez, R. Lorenzini, L. Centurione, L. Bianchi, A.M. Vannucchi,
G. Migliaccio, S.H. Orkin, GATA-1 as a regulator of mast cell differentiation revealed by the phenotype
of the GATA-1low mouse mutant, J Exp Med, 197 (2003) 281-296.
[39] A.R. Migliaccio, R. Lorenzini, A.M. Vannucchi, G.J. Spangrude, G. Migliaccio, Robust levels of
long-term multilineage reconstitution in the absence of stem cell self-replication in W/Wv mice
transplanted with purified stem cells, J Hematother Stem Cell Res, 12 (2003) 409-424.
[40] A.M. Vannucchi, L. Bianchi, C. Cellai, F. Paoletti, R.A. Rana, R. Lorenzini, G. Migliaccio, A.R.
Migliaccio, Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA1(low) mice), Blood, 100 (2002) 1123-1132.
[41] G. Migliaccio, R. Di Pietro, V. di Giacomo, A. Di Baldassarre, A.R. Migliaccio, L. Maccioni, R.
Galanello, T. Papayannopoulou, In vitro mass production of human erythroid cells from the blood of
normal donors and of thalassemic patients, Blood Cells Mol Dis, 28 (2002) 169-180.
[42] A.R. Migliaccio, G. Migliaccio, A. Di Baldassarre, K. Eddleman, Circulating hematopoietic
progenitor cells in a fetus with alpha thalassemia: comparison with the cells circulating in normal and
non-thalassemic anemia fetuses and implications for in utero transplantations, Bone Marrow
Transplant, 30 (2002) 75-80.
[43] A.R. Migliaccio, S. Campisi, G. Migliaccio, Standardization of progenitor cell assay for cord blood
banking, Ann Ist Super Sanità, 37 (2001) 595-600.
[44] A.M. Vannucchi, F. Paoletti, S. Linari, C. Cellai, R. Caporale, P.R. Ferrini, M. Sanchez, G.
Migliaccio, A.R. Migliaccio, Identification and characterization of a bipotent (erythroid and
megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice, Blood, 95 (2000)
2559-2568.
[45] A.R. Migliaccio, C. Bengra, J. Ling, W. Pi, C. Li, S. Zeng, M. Keskintepe, B. Whitney, M. Sanchez,
G. Migliaccio, D. Tuan, Stable and unstable transgene integration sites in the human genome:
extinction of the Green Fluorescent Protein transgene in K562 cells, Gene, 256 (2000) 197-214.
[46] L. Forte, G. Migliaccio, M. Sanchez, A.R. Migliaccio, A.M. Passarelli, S. Amadori, Effects of cell
banking manipulations on ex vivo amplification of umbilical cord blood, Ann Ist Super Sanità, 36
(2000) 333-342.
[47] C. Carta, S. Campisi, G. Migliaccio, A.R. Migliaccio, Erythropoietin-dependent suppression of the
expression of the beta subunits of the interleukin-3 receptor during erythroid differentiation, Blood Cells
Molecules & Diseases, 26 (2000) 467-478.
[48] E. Alfani, A.R. Migliaccio, M. Sanchez, A.M. Passarelli, G. Migliaccio, Characterization of the T cell
receptor repertoire of neonatal T cells by RT-PCR and single strand conformation polymorphism
analysis, Bone Marrow Transplant, 26 (2000) 83-89.
[49] A.R. Migliaccio, C. Carta, G. Migliaccio, In vivo expansion of purified hematopoietic stem cells
transplanted in nonablated W/Wv mice, Exp.Hematol., 27 (1999) 1655-1666.
[50] R. Cancedda, P. Chistolini, G. Cossu, M. De LUca, M. Marazzi, F. Mavilio, G. Migliaccio, C. Pini,
A. Sargentini, Linee guida per l'ingegneria dei tessuti e la terapia cellulare., Notiziario dell'Istituto
Superiore di Sanità, 12 (1999) 1-8.
[51] A. Bassini, G. Zauli, G. Migliaccio, A.R. Migliaccio, M. Pascuccio, S. Pierpaoli, L. Guidotti, S.
Capitani, M. Vitale, Lineage-restricted expression of protein kinase C isoforms in hematopoiesis,
Blood, 93 (1999) 1178-1188.
[52] A.R. Migliaccio, G. Migliaccio, The making of an erythroid cell. Molecular control of hematopoiesis.
[Review] [223 refs], Biotherapy, 10 (1998) 251-268.
[53] H. Kurata, G.C. Mancini, G. Alespeiti, A.R. Migliaccio, G. Migliaccio, Stem cell factor induces
proliferation and differentiation of fetal progenitor cells in the mouse, Br J Haematol, 101 (1998) 676687.
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Giovanni Migliaccio
[54] E. Moroni, L. Cairns, S. Ottolenghi, B. Giglioni, E. Ashihara, G. Migliaccio, A.R. Migliaccio,
Expression in hematopoietic cells of GATA-1 transcripts from the alternative "testis" promoter during
development and cell differentiation, Biochem.Biophys.Res.Commun., 231 (1997) 299-304.
[55] A.R. Migliaccio, G. Migliaccio, Erythroid cells, in: N.G. Testa, B. Lord, M. Dexter (Eds.)
Hematopoietic lineages in Health and Disease, Marcell Dekker, inc1997, pp. 107-128.
[56] M. Cianfriglia, M.C. Galli, G. Migliaccio, A. Care', U. Testa, E. Proietti, Linee guida per l'avvio degli
studi clinici di fase I/II con cellule umane viventi per la terapia cellulare somatica, Notiziario dell'Istituto
Superiore di Sanità, 10 (1997) 1-8.
[57] E. Ashihara, A.M. Vannucchi, G. Migliaccio, A.R. Migliaccio, Growth factor receptor expression
during in vitro differentiation of partially purified populations containing murine stem cells, Journal of
Cellular Physiology, 171 (1997) 343-356.
[58] G. Migliaccio, M.C. Galli, Le interleuchine,Atti del VII Congresso dell'Ordine dei Biologi1996, pp.
385-409.
[59] G. Migliaccio, M. Baiocchi, N. Hamel, K. Eddleman, A.R. Migliaccio, Circulating progenitor cells in
human ontogenesis: response to growth factors and replating potential, Journal of Hematotherapy, 5
(1996) 161-170.
[60] G. Migliaccio, M. Baiocchi, J.W. Adamson, A.R. Migliaccio, Isolation and biological
characterization of two classes of blast-cell colony-forming cells from normal murine marrow, Blood,
87 (1996) 4091-4099.
[61] A.R. Migliaccio, A.M. Vannucchi, G. Migliaccio, Molecular control of erythroid differentiation.
[Review] [270 refs], International Journal of Hematology, 64 (1996) 1-29.
[62] A.R. Migliaccio, G. Migliaccio, P. Rubinstein, J.W. Adamson, Standardization of assays for
progenitor cells in placental/umbilical cord blood, Haematologica, 81 (1996) 170.
[63] A.R. Migliaccio, G. Migliaccio, E. Ashihara, E. Moroni, B. Giglioni, S. Ottolenghi, Erythroid-specific
activation of the distal (testis) promoter of GATA1 during differentiation of purified normal murine
hematopoietic stem cells, Acta Haematol, 95 (1996) 229-235.
[64] A.R. Migliaccio, G. Alespeiti, E. Burderi, G. Migliaccio, Extensive self-replication capacity of
isolated hematopoietic stem cells in non-myeloablated W/Wv mice, Blood, (1996).
[65] H. Kurata, G.C. Mancini, G. Migliaccio, A.R. Migliaccio, Hematopoietic progenitor cells purified
from the murine fetal liver proliferate in serum-deprived cultures stimulated with stem cell factor (SCF)
alone,Blood, 1996.
[66] K.A. Eddleman, F.A. Chervenak, P. George-Siegel, G. Migliaccio, A.R. Migliaccio, Circulating
hematopoietic stem cell populations in human fetuses: implications for fetal gene therapy and
alterations with in utero red cell transfusion, Fetal Diagnosis & Therapy, 11 (1996) 231-240.
[67] G. Alespeiti, F. Kajumo, R. Tanosaki, G. Migliaccio, A.R. Migliaccio, Bone Marrow reconstitution in
non-myeloablated W/Wv mice, Exp.Hematol., (1996).
[68] D. Ashany, K.B. Elkon, G. Migliaccio, A.R. Migliaccio, Functional characterization of lymphoid cells
generated in serum-deprived culture stimulated with stem cell factor and interleukin 7 from normal and
autoimmune mice, Journal of Cellular Physiology, 164 (1995) 562-570.
[69] G. Migliaccio, A.R. Migliaccio, Serum-deprived cultures of primary haemopoietic cells, in: R.I.
Freshney, I.B. Pragnell, M.G. Freshney (Eds.) Culture of haemopoietic cells, Wiley-Liss, 1994, pp. 8198.
[70] G. Migliaccio, G.C. Mancini, Y.J. Jiang, E. Ashihara, D. Sotiropoulos, A.R. Migliaccio, J.W.
Adamson, Purified murine stem cells: their colonization potential and the expression of hemopoietic
growth factor receptor genes during in vitro differentiation, J.Cell.Biochem., 18b (1994) 184.
[71] G. Migliaccio, M. Baiocchi, Y.J. Jiang, D. Sotiropoulos, A.R. Migliaccio, 5-Azacytine (5-AzaC)
reactivates the erythroid potential in a myeloid restricted murine cell line, Exp.Hematol., suppl. (1994).
[72] A.R. Migliaccio, G. Migliaccio, J.W. Adamson, Expansion of human neonatal progenitor cells in
vitro under serum-deprived conditions, Blood Cells, 20 (1994) 424-428.
[73] A.R. Migliaccio, Y.J. Jiang, R. Winardi, G. Migliaccio, J.W. Adamson, Coordinate regulation of the
a-chain of the IL-3 receptor (aIL- 3) and Id gene expression during erythroid differentiation,
Exp.Hematol., 22 (1994) 722.
[74] A.R. Migliaccio, Y. Jiang, G. Migliaccio, S. Nicolis, S. Crotta, A. Ronchi, S. Ottolenghi, J.W.
Adamson, GATA-1-independent regulation of the expression of the erythropoietin receptor (EPO-R)
gene in a human EPO-dependent cell line, UT-7 EPO, Ann.NY Acad.Sci., 718 (1994) 359-361.
[75] A.R. Migliaccio, M. Baiocchi, B. Durand, K. Eddleman, G. Migliaccio, J.W. Adamson, Stem cell
factor and the amplification of progenitor cells from CD34+ cord blood cells, Blood Cells, 20 (1994)
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129-138.
[76] B. Durand, G. Migliaccio, N.S. Yee, K. Eddleman, T. Huima-Byron, A.R. Migliaccio, J.W.
Adamson, Long-term generation of human mast cells in serum-free cultures of CD34+ cord blood
cells stimulated with stem cell factor and interleukin-3, Blood, 84 (1994) 3667-3674.
[77] B. Durand, A.R. Migliaccio, J.W. Adamson, G. Migliaccio, Long-term culture of human mast cells
from neonatal CD34+ cells stimulated with stem cell factor (SCF) and interleukin-3 (IL-3), in: N.
Abraham, R.K. Shadduck, A.S. Levine, F. Takaku (Eds.) Molecular Biology of Haematopoiesis. Vol 3,
Intercept, Andover, 1994, pp. 191-200.
[78] C. Barron, A.R. Migliaccio, G. Migliaccio, Y. Jiang, J.W. Adamson, S. Ottolenghi, Alternatively
spliced mRNAs encoding soluble isoforms of the erythropoietin receptor in murine cell lines and bone
marrow, Gene, 147 (1994) 263-268.
[79] E. Ashihara, A.R. Migliaccio, Y.J. Jiang, D. Sotiropoulos, J.W. Adamson, G. Migliaccio, Expression
of hematopoietic growth factor (GF) receptor genes in purified murine stem cells during in vitro
differentiation, Exp.Hematol., 22 (1994) 748.
[80] J.W. Adamson, G. Migliaccio, C.E. Stevens, P. Rubinstein, Placental/umbilical cord blood as a
source of stem and progenitor cells for marrow reconstitution in man, in: N. Abraham, R.K. Shadduck,
A.S. Levine, F. Takaku (Eds.) Molecular Biology of Haematopoiesis. Vol 3, Intercept, Andover, 1994,
pp. 211-214.
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Migliaccio, Dependence for the proliferative response to erythropoietin on an established erythroid
differentiation program in a human hematopoietic cell line, UT-7, Exp.Hematol., 21 (1993) 665-670.
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(Ed.) The human yolk sac and yolk sac tumor, Heidelberg, Springer-Verlag, 1993, pp. 70-83.
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of the murine "W phenotype" in long-term cultures of human cord blood cells by c-kit antisense
oligomers, Journal of Cellular Physiology, 157 (1993) 158-163.
[85] A.R. Migliaccio, G. Migliaccio, B. Durand, G.C. Mancini, J.W. Adamson, The generation of colonyforming cells (CFC) and the expansion of hematopoiesis in cultures of human cord blood cells is
dependent on the presence of stem cell factor (SCF), Cytotechnology, 11 (1993) 107-113.
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Adamson, Transcriptional and posttranscriptional regulation of the expression of the erythropoietin
receptor gene in human erythropoietin-responsive cell lines, Blood, 82 (1993) 3760-3769.
[87] A.R. Migliaccio, M. Baiocchi, B. Durand, K. Eddleman, G. Migliaccio, J.W. Adamson, Aspects of
the biology of the neonatal hematopoietic stem cell, Stem Cells, 11 Suppl 2 (1993) 56-64.
[88] M.C. Galli, P.J. Giardina, A.R. Migliaccio, G. Migliaccio, The biology of stem cell factor, a new
hematopoietic growth factor involved in stem cell regulation. [Review] [43 refs], International Journal of
Clinical & Laboratory Research, 23 (1993) 70-77.
[89] B. Durand, B. Samal, A.R. Migliaccio, G. Migliaccio, J.W. Adamson, Macrophage inhibitory
protein 1 (MIP-1a) and leukemia inhibitori factor (LIF) increase the number of colony-forming cells
(CFC) in long-term cultures of human CD34+ cord blood cells, in: M. Guigon (Ed.) The negative
regulation of Hematopoiesis, Colloque INSERM/John Libbey Eurotext Ltd1993, pp. 155-157.
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colony-forming cells (CFC) from CD34+ human umbilical cord blood cells, Leuk Lymphoma, 11 (1993)
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[91] G. Migliaccio, A.R. Migliaccio, M.L. Druzin, P.J.V. Giardina, K.M. Zsebo, J.W. Adamson, The effect
of the recombinant human stem cell factor (SCF) on cord blood progenitor cell growth and the
generation of colony forming cells (CFC) from pre-CFC in liquid culture, in: N. Abraham, G.
Konwalinka, P. Marks, L. Sachs, M. Tavassoli (Eds.) Molecular Biology of Haematopoiesis. Vol 2,
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generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the presence of
recombinant human stem cell factor, Blood, 79 (1992) 2620-2627.
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Ottolenghi, J.W. Adamson, Molecular mechanism underlying the erythroid specificity of the cellular
response to erythropoietin (Epo), in: N. Abraham, G. Konwalinka, P. Marks, L. Sachs, M. Tavassoli
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(Eds.) Molecular Biology of Haematopoiesis. Vol 2, Intercept, Andover, 1992, pp. 93-107.
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of marrow stromal cell cultures from normal or aplastic anemia donors, Journal of Cellular Physiology,
152 (1992) 199-206.
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G. Migliaccio, Studies of erythroid nuclear factor, in: G. Stamatoyannopoulos, A.W. Nienhuis (Eds.)
The regulation of the hemoglobin switching, The John Hopkins University Press, Baltimore, 1991, pp.
358-364.
[96] G. Migliaccio, A.R. Migliaccio, J. Valinsky, K. Langley, K. Zsebo, J.W. Visser, J.W. Adamson, Stem
cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells, Proc
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[97] G. Migliaccio, A.R. Migliaccio, M.L. Druzin, P.J. Giardina, K.M. Zsebo, J.W. Adamson, Effects of
recombinant human stem cell factor (SCF) on the growth of human progenitor cells in vitro, Journal of
Cellular Physiology, 148 (1991) 503-509.
[98] G. Migliaccio, A.R. Migliaccio, J.W. Adamson, In vitro differentiation and proliferation of human
hematopoietic progenitors: the effects of interleukins 1 and 6 are indirectly mediated by production of
granulocyte-macrophage colony-stimulating factor and interleukin 3, Exp.Hematol., 19 (1991) 3-10.
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Adamson, Erythropoietin-responsiveness during erythroid differentiation is acquired through posttranscriptional regulation of the expression of the erythropoietin receptor gene, in: G.
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Adamson, Response to erythropoietin in erythroid subclones of the factor-dependent cell line 32D is
determined by translocation of the erythropoietin receptor to the cell surface, Proceedings of the
National Academy of Sciences USA, 88 (1991) 11086-11090.
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studies in vitro under serum-deprived conditions. [Review] [88 refs], Exp.Hematol., 18 (1990) 10491055.
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of hematopoietic growth factors released by stromal cells from normal donors or transplanted patients
[see comments], Blood, 75 (1990) 305-312.
[103] A.R. Migliaccio, G. Migliaccio, The control of proliferation and differentiation of early erythroid
progenitors. [Review] [53 refs], Biotherapy, 2 (1990) 299-303.
[104] A.R. Migliaccio, G. Migliaccio, Il ruolo del GM-CSF nella regolazione dell'ematopoiesi,
Biotechnology Report, (1990).
[105] A. Migliaccio, G. Migliaccio, D. Dale, W. Hammond, Hematopoietic progenitors in cyclic
neutropenia: effect of granulocyte colony-stimulating factor in vivo, Blood, 75 (1990) 1951-1959.
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Papayannopoulou, Influence of recombinant hematopoietins and of fetal bovine serum on the globin
synthetic pattern of human BFUe, Blood, 76 (1990) 1150-1157.
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Migliaccio, Progressive inactivation of the expression of an erythroid transcriptional factor in GM- and
G-CSF-dependent myeloid cell lines, Nucleic Acids Research, 18 (1990) 6863-6869.
[108] G. Migliaccio, A.R. Migliaccio, B.L. Kreider, G. Rovera, J.W. Adamson, Selection of lineagerestricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell
line 32D, Journal of Cell Biology, 109 (1989) 833-841.
[109] G. Migliaccio, A.R. Migliaccio, K. Kaushansky, J.W. Adamson, Regulation of differentiation of
murine progenitor cells derived from blast cell colonies under serum-deprived conditions,
Exp.Hematol., 17 (1989) 110-115.
[110] G. Migliaccio, A. Migliaccio, S. Ruscetti, J. Adamson, The growth of Rauscher erythroleukemia
cells is mediated by autocrine production of a factor with biological activity similar to interleukin- 3,
Blood, 73 (1989) 1770-1777.
[111] A.R. Migliaccio, G. Migliaccio, Y. Shimada, J.W. Adamson, Direct effects of IL-4 on the in vitro
differentiation and proliferation of hematopoietic progenitor cells, Biotechnol Ther, 1 (1989) 347-360.
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granulocyte/macrophage and erythroid progenitors: comparative analysis of the influence of
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recombinant human erythropoietin, G-CSF, GM-CSF, and IL-3 in serum-supplemented and serumdeprived cultures, Blood, 72 (1988) 248-256.
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induction of hematopoietic stem cell proliferation and erythroid burst colony formation, Blood, 72
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[114] A.R. Migliaccio, G. Migliaccio, Human embryonic hemopoiesis: control mechanisms underlying
progenitor differentiation in vitro, Dev Biol, 125 (1988) 127-134.
[115] A. Migliaccio, G. Migliaccio, J. Adamson, Effect of recombinant hematopoietic growth factors on
proliferation of human marrow progenitor cells in serum-deprived liquid culture, Blood, 72 (1988)
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[116] G. Migliaccio, A.R. Migliaccio, Cloning of human erythroid progenitors (BFU-E) in the absence of
fetal bovine serum, Br J Haematol, 67 (1987) 129-133.
[117] G. Migliaccio, A.R. Migliaccio, Early hemopoietic differentiation: the action of multi-CSF is
complemented by lineage specific growth factors, Ann.NY Acad.Sci., 511 (1987) 39-49.
[118] A. Migliaccio, M. Bruno, G. Migliaccio, Evidence for direct action of human biosynthetic
(recombinant) GM-CSF on erythroid progenitors in serum-free culture, Blood, 70 (1987) 1867-1871.
[119] G. Migliaccio, A.R. Migliaccio, G. Russo, C. Peschle, Embryionic-fetal hematopoiesis in humans.
Kinetics of hematopoietic progenitors in yolk-sac, liver and blood and initial characterization of their in
vitro growth factor requirements, Cell Biol Int Rep, 10 (1986) 479.
[120] G. Migliaccio, A.R. Migliaccio, S. Petti, F. Mavilio, G. Russo, D. Lazzaro, U. Testa, M. Marinucci,
C. Peschle, Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the
yolk sac----liver transition, J Clin Invest, 78 (1986) 51-60.
[121] A.R. Migliaccio, G. Migliaccio, D. Ferrero, G. Russo, C. Peschle, Colony-inhibiting factor (CIL)
from T-cell lines suppresses the prolferation of adult but not embryionic fetal hemopoietic progenitors,
in: R. Baserga, P. Foa, D. Metcalf, E.E. Polli (Eds.) Biological regulation of cell proliferation, Raven
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[122] A.R. Migliaccio, G. Migliaccio, M. Bruno, G. Mastroberardino, C. Peschle, La differenziazione
emopoietica: aspetti ontogenetici e citogenetici, in: G. Prodi, L. Alberghina, M.I. Colnaghi, P.M.
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Mastroberardino, C. Peschle, Bromodeoxyuridine treatment of normal adult erythroid colonies: an in
vitro model for reactivation of human fetal globin genes, Blood, 68 (1986) 1036-1041.
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Marinucci, Erythropoietic development and hemoglobin switching in human embryos: cellular and
molecular aspects, Prog Clin Biol Res, 191 (1985) 383-396.
[125] C. Peschle, F. Mavilio, A. Care, G. Migliaccio, A.R. Migliaccio, G. Salvo, P. Samoggia, S. Petti, R.
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Mastroberardino, M. Presta, A.M. Gianni, P. Comi, et al., Embryonic----Fetal Hb switch in humans:
studies on erythroid bursts generated by embryonic progenitors from yolk sac and liver, Proc Natl
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C. Peschle, Human embryionic hemopoiesis: Kinetics of erythroid progenitors in yolk sac, liver and
circulating blood, in: C. Peschle, C. Rizzoli (Eds.) New trends in experimental hematology.
Oncogenes, Stem cells, Bone Marrow transplantation, Serono Symposia, Roma, 1984, pp. 77-82.
[128] G. Migliaccio, L. Avitabile, A.R. Migliaccio, S. Petti, R. Guerriero, G. Mastroberardino, G. Saglio,
A. De Capua, A. Baldini, P. Markelaj, S. Amadori, F. Mandelli, C. Peschle, A new human
erythroleukemic line: initial characterization and hemin-induced erythroid differentiation, in: S.A.
Aaronson, L. Frati, R. Verna (Eds.) Genetic and phenotypic markers of tumors, Plenum Press, New
York, 1984, pp. 323-331.
[129] M. Gabbianelli, M. Sargiacomo, L. Avitabile, T. Improta, E. Rocca, U. Testa, G. Migliaccio, M.
Tomasi, C. Peschle, Use of reconstitute Sendai virus envelopes to transform Friend leukemia cels in
suspension cultures, in: C. Peschle, C. Rizzoli (Eds.) New trends in experimental hematology,
Oncogenes, Stem cells, Bone Marrow Transplantation, Serono Symposia, Roma, 1984, pp. 433-437.
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Improta, G. Mastroberardino, C. Peschle, Reactivation of human fetal globin genes in adult erythroid
burst follwing bromodeoxy uridine treatment, in: C. Peschle, C. Rizzoli (Eds.) New Trend in
experimental Hematology. oncogenes, Stem cells, Bone Marrow Transplantation, Serono Symposia,
Roma, 1984, pp. 413-419.
[131] A. Care', F. Mavilio, G. Migliaccio, A.R. Migliaccio, A. Rocca, G. Salvo, P. Samoggia, S. Petti, R.
Guerriero, M. Marinucci, D. Lazzaro, G. Russo, G. Mastroberardino, C. Peschle, Embryionic fetal
hemoglobin switching in human embryios, in: C. Peschle, C. Rizzoli (Eds.) New trends in experimental
hematology, Oncogenes, Stem cells, Bone Marrow Transplantation, Serono Symposia, Roma, 1984,
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[132] C. Peschle, A.R. Migliaccio, G. Migliaccio, G. Russo, G. Mastroberardino, S. Ottolenghi, B.
Giglioni, P. Comi, A.M. Gianni, M. Presta, et al., Cellular and molecular mechanisms of the human
embryonic leads to fetal hemoglobin switch, Prog Clin Biol Res, 134 (1983) 411-419.
[133] A.R. Migliaccio, G. Migliaccio, M. Gabbianelli, R. Guerriero, R. Del Sordo, G.B. Rossi, G.
Mastroberardino, C. Peschle, Differential release of hemopoietins (GM-CSF,BPA) by selected murine
T-lymphocyte cell lines, in: U. Torelli, G.P. Bagnara, M.A. Brunelli, C. Castaldini, A.U. Di Prisco (Eds.)
Frontiers in experimental hematology, Serono Symposia, Roma, 1983, pp. 115-118.
[134] F. Mavilio, A. Giampaolo, M. Marinucci, G. Migliaccio, A. Care', G. Mastroberardino, C. Peschle,
DNA methylation and globin gene expression in human ontogenetic development, in: U. Torelli, G.P.
Bagnara, M.A. Brunelli, C. Castaldini, A.U. Di Prisco (Eds.) Frontiers in experimental hematology,
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[135] F. Mavilio, A. Giampaolo, A. Care, G. Migliaccio, M. Calandrini, G. Russo, G.L. Pagliardi, G.
Mastroberardino, M. Marinucci, C. Peschle, Molecular mechanisms of human hemoglobin switching:
selective undermethylation and expression of globin genes in embryonic, fetal, and adult
erythroblasts, Proceedings of the National Academy of Sciences USA, 80 (1983) 6907-6911.
[136] G. Mastroberardino, G. Migliaccio, A.R. Migliaccio, A. Covelli, C. Peschle, Modulation of the
kinetics of erythroid progenitors in hemopoietic microenvironment: possible role of PGE, in: U. Torelli,
G.P. Bagnara, M.A. Brunelli, C. Castaldini, A.U. Di Prisco (Eds.) Frontiers in experimental hematology,
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[137] C. Peschle, G. Colletta, A. Covelli, R. Ciccariello, G. Migliaccio, G.B. Rossi, The erythropoietic
component of the Friend virus erythroleukemias: role of the hormone(s) ans SFFV genome, in: R.
Revoltella, G. Pontieri, G. Rovera, C. Basilico, R. Gallo, J. Subak-Sharpe (Eds.) Expression of
differentiated function in cancer cells, Raven Press, New York, 1982, pp. 311-322.
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Ciccariello, C. Peschle, Cellular mechanism for regulation of Hb synthesis, in: R. Revoltella, G.
Pontieri, G. Rovera, C. Basilico, R. Gallo, J. Subak-Sharpe (Eds.) Expression of differentiated function
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B. Giglioni, M.L. Pozzoli, P. Comi, Regulation of Hb synthesis in ontogenesis and erythropoietic
differentiation. In vitro studies on fetal liver, cord blood, adult blood or marrow, and in HPFH patients,
in: G. Stamatoyannopoulos, A.W. Nienhuis (Eds.) Hemoglobin in development and differentiation,
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Mastroberardino, Identification and characterization of three classes of erythroid progenitors in human
fetal liver, Blood, 58 (1981) 565-572.
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Proliferation and differentiation of stem and progenitor cells in long-term cultures: studies in normal
and á-thalassemic subjects, in: F. Gavosto (Ed.) Hemolymphopoiesis: normal and pathological cell
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[142] A.R. Migliaccio, G. Migliaccio, R. Ciccariello, G. Russo, G. Mastroberardino, C. Peschle,
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comparative studies on fetal liver vs adult marrow, and fetal-neonatal vs adult blood, in: F. Gavosto
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[143] F. Lettieri, G.B. Rossi, R. Ciccariello, G. Migliaccio, A. Covelli, L. Gioia, C. Peschle, FLV
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independence from hemopoietic hormones, in: F. Gavosto (Ed.) Hemolymphopoiesis: normal and
pathological cell differentiation, Editrice Esculapio, Torino, 1981, pp. 33-36.
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Peschle, Clonogenic growth of murine and human erythromonocytic progenitors in serum-free
cultures, in: F. Gavosto (Ed.) Hemolymphopoiesis: normal and pathological cell differentiation, Editrice
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[146] G.B. Rossi, A.R. Migliaccio, G. Migliaccio, F. Lettieri, M. Di Rosa, C. Peschle, G.
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Modulation of in vitro hemopoiesis by PGE and cAMP: species dependent influences on erythroid
precursors, in: G.B. Rossi (Ed.) In vivo and in vitro erythropoiesis: The Friend system, Amsterdam,
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[154] C. Peschle, P. Barba, C. Cillo, M.C. Magli, G. Migliaccio, F. Pizzella, I.A. Rappaport, Testosterone
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C. Peschle, Modulazione dei precursori eritroidi murini da prostaglandine E: possibile effettore
dell'AMPciclico, in: M.A. Brunelli (Ed.) Emolinfopoiesi: fattori di regolazione e meccanismi di crescita,
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globiniche in "bursts" eritroidi derivati da sangue cordonale ed adulto, in: M.A. Brunelli (Ed.)
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eritroblastopenie pure,Atti del XXVI Congresso Nazionale della Societ… Italiana di Ematologia, Torino
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Curriculum vitae
Giovanni Migliaccio
1977, Tipografia Viscontea, Pavia, 1977, pp. 128-140.
Projects
Head of the project “Identification of lineage specific regulatory sequences in the hematopoietic
system” Progetto Finalizzato Ingegneria Genetica, CNR
1992-1995
Head of the project "Ex-vivo amplification of human B- and T- cells for supportive or genetic
immunization of HIV positive subjects"; Progetto Nazionale AIDS
1994-1998
Head of the project “Large scale production of human hemopoietic progenitors and cells in vitro”
Primo Progetto di Ricerca “Sangue”, Fondi Art. 12 bis, comma 6, D.Lgs.229/99 del Ministero della
Sanità
1996-1997
Partner of the CEE ERBBIO4CT960646 Contract “Bioreactor Production of Human Hemopoietic
Cells” Progetto BIOTEC- CEE
1997-1999
Head of Section in the Project “Studies for the optimization of the organ and tissue transplants.” Fondi
Art. 12 bis, comma 6, D.Lgs.229/99 del Ministero della Sanità
1999-2000
Head of the Project “The plasticity of post-natal hemopoietic stem cells” Fondi Art. 12 bis, comma 6,
D.Lgs.229/99 del Ministero della Sanità
2002-2003
Head of Unit “Optimization of the ex-vivo expansion of human hematopoietic stem and progenitor
cells” Progetti FIRB, Ministero della Istruzione, Università e Ricerca.
2002-2005
Head of Unit “Role and function of TRAIL receptors in the erythroid differentiation” Progetti FIRB,
Ministero della Istruzione, Università e Ricerca.
2007-2010
PI of the project “Italian Network of Oncology BioBanks (RIBBO) for Alliance against Cancer (ACC)
Special Program for Oncology Research 2006
2007-2008
Head of Unit for the project “Italian Network for Clinical trials and GMP structures for Tumours
Biotherapies” for Alliance against Cancer (ACC) Special Program for Oncology Research 2006
2007-2009
Head of Unit for the project “Integrated Oncology Program – Theme 4: “Cellular Pharmaceuticals,
vaccines and innovative biotherapies against cancer”
2007-2009
Memberships
Head of the Section of Cellular Physiology, Cell Biology Laboratory, Istituto Superiore di Sanità, Rome
– Italy 1995 to 2004
Expert of the Good Laboratory Practices on Cell Culture for the Health Ministry 1997 to 2011
Member of the drafting group for the guidelines on Cell Therapy for the Istituto Superiore di Sanità
1997
Member of the drafting group for the guidelines on Cell Therapy of the Bioethical Committee of the
Cabinet of the Prime Minister 1999
Member of the drafting group for the Cell Therapy Guidelines for EMEA, London UK
1999 to 2000
Member of the Sub-Committee on Clinical Experimentation of the Italian Medicines Agency (AIFA )
from 2001
Head of the drafting group for the Guidelines on Cell Therapy for the Istituto Superiore di Sanità 2003
Member of the Cell Therapy Group of the European Pharmacopeia 2003 to 2004
Member of the Cell Product Working Party of the European Medicines
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Curriculum vitae
Giovanni Migliaccio
Agency (EMEA, London UK) 2005-2012
Member of the commission for the authorization of Phase I clinical studies on Innovative Medicinal
Products, Istituto Superiore di Sanità 2005-2014
Head of the section “Gene and Cell therapy” Istituto Superiore di Sanità from 2004
Member of the Committee for Orphan Disease’s Clinical Trial funding, AIFA 2006-2008
Member of the Committee “Stem Cells from Umbilical Cord Blood” Health Ministry, Rome Italy 2007
Advanced Medicinal Product’s Expert for the Consiglio Superiore di Sanità, Rome, Italy from 2008
Member of the Committee for the Advanced Therapies (CAT), EMEA London 2009-2011
Chair of the Cell Therapy Working Group for the EDQM (European Pharmacopeia)
From 2010
Scientific Director for EATRIS From 2011
Other Relevant Information
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