Full CV - Istituto Italiano di Tecnologia

CURRICULUM VITAE OF DIEGO GHEZZI
Office address:
Istituto Italiano di Tecnologia
Department of Neuroscience and
Brain Technologies
Via Morego 30
16163 Genova, Italy
Telephone:
+39 010 71781 524
Fax:
+39 010 71781 230
eMail:
[email protected]
Date of birth:
November 7th, 1980
Place of birth:
Desio, Milano, Italy
Nationality:
Italian
EDUCATION AND TRAINING
2005 - 2008
Guest Ph.D. Student
Fondazione San Raffaele, DIBIT
Flavia Valtorta Laboratory
2006 - 2007
Guest Ph.D. Student
Ayanda Biosystems SA, EPFL, Lausanne CH
2005 - 2008
Ph.D. in Bioengineering – Grant Fondazione Istituto Italiano di Tecnologia
Politecnico di Milano, Department of Bioengineering
Thesis title: “Optical tools to stimulate in-vitro cultured neurons”
Supervisors Prof. Giancarlo Ferrigno and Prof. Flavia Valtorta
1999 - 2004
Master degree in Biomedical Engineering
Politecnico di Milano, Department of Bioengineering
Thesis title: “PhotoMEA: biosensore opto-elettronico per la rilevazione
dell’attività di reti di neuroni in vitro”
Supervisors Prof. Giancarlo Ferrigno and Prof. Sara Mantero
2004
Undergraduate student Stage (200hr)
Consortium for Research in Optical Processing and Switching (CoreCom)
Main activities and responsibilities: Development of optical technologies for
biomedical application
Supervisor Eng. Davide Piccinin
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RESEARCH EXPERIENCE
2010 - 2013
Senior Post-Doc
Fondazione Istituto Italiano di Tecnologia, Department of Neuroscience and
Brain Technologies
Supervisor Prof. Fabio Benfenati
2008 - 2010
Junior Post-Doc
Fondazione Istituto Italiano di Tecnologia, Department of Neuroscience and
Brain Technologies
Supervisor Prof. Fabio Benfenati
AWARDS
1. Winner of SmartCup Liguria 2013, Life Science section, September 27, 2013.
2. Best oral communication award at the 6th Meeting “Young Researchers in Physiology”, May 30 – June 1,
2012, Fondazione MediaTerraneo, Sestri Levante, Italy.
3. Travel stipend for attending the 8th IBRO World Congress of Neruoscience, July 14-18 2011 from
Federation of European Neuroscience Societies
4. 2007 INGENIO Research fellowship from Regione Lombardia, Protocol number A0000589
5. 2005-2008 3 years PhD fellowship from Fondazione Istituto Italiano di Tecnologia
6. Award for the best master thesis of the National Group of Bioengineering, 2005.
TEACHING EXPERIENCE
2007
Assistant of Prof. Giancarlo Ferrigno for course “Biosensors and
microtechnologies”, Master of Science Degree, Biomedical Engineering,
School of Engineering, Politecnico di Milano
2006 - 2007
Assistant of Prof. Antonio Pedotti for course “Laboratoy of electronic
technologies and biosensors”, Master of Science Degree, Biomedical
Engineering, School of Engineering, Politecnico di Milano
2006 - 2007
1 Lecture/year in the course “Neuroengineering”, Dr. Alessandra Pedrocchi,
Master of Science Degree, Biomedical Engineering, School of Engineering,
Politecnico di Milano
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2006 - 2007
1 Lecture/year in the course “Biotechnological applications and
bioreactors”, Prof. Sara Mantero, Master of Science Degree, Biomedical
Engineering, School of Engineering, Politecnico di Milano
TRAINING OF LABORATORY PERSONNEL
Dates
Name
Current Position
2005 - 2006
Laura Monti
M.Sc. Student
2005 - 2006
Massimo Alberti
M.Sc. Student
2005 - 2006
Lorenzo Guerrasio
M.Sc. Student
2006 - 2007
Giuseppe Pisani
Bachelor's degree
2007 - 2008
Daria Fazzi
M.Sc. Student
2006 - 2008
Jacopo Tessadori
M.Sc. Student
2006 - 2008
Emilia Biffi
M.Sc. / Ph.D. Student
2007
Silvano Furlan
Bachelor's degree
2007
Marta Gandolla
Bachelor's degree
2013
Daniele Ferrante
Bachelor's degree
2013 - Onwards
Paul Feyen
Ph.D. Student
2013 - Onwards
Duco Endeman
Post Doc
SHORT BIO AND RESEARCH INTERESTS
I studied Biomedical Engineering (1999 - 2004) at the Politecnico di Milano (Milano, Italy), and graduated
in 2004 discussing a thesis entitled: “PhotoMEA: an opto-electronic biosensor for monitoring in vitro
neuronal network activity” (Supervisors: Prof. Giancarlo Ferrigno and Prof. Sara Mantero) that was awarded
as best master thesis from the National Group of Bioengineering. My master thesis work lead to the
development of a novel opto-electronic interface to investigate the activity of in-vitro neuronal networks
(EP Patent 1,842,049; US Patent 11/878,528; WO Patent 2,006,079,919). This neuro-artificial interface
combined a traditional multi-electrode array (MEA) with multisite optical stimulations/recordings of the
neuronal activity, thus improving the usage of chip arrays to investigate the properties of in-vitro cultured
neuronal networks (Ghezzi et al., BioSystems 2007).
At the beginning of 2005, I was appointed at the Bioengineering Department (Politecnico di Milano) with a
Ph.D. fellowship, granted from Fondazione Istituto Italiano di Tecnologia (IIT). I obtained my Ph.D. in
Bioengineering in 2008, discussing a thesis entitled: “Optical tools to stimulate in-vitro cultured
neurons” (Supervisors Prof. Giancarlo Ferrigno and Prof. Flavia Valtorta). During the Ph.D. course, I worked
as a guest student in Prof. Flavia Valtorta laboratory (San Raffaele Scientific Institute, DIBIT, Milano, Italy),
pursuing investigations on neuronal optical stimulation using caged-compounds, and on the development of
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related interfaces (Ghezzi et al., Sensors 2008; Ghezzi et al., Journal of Neuroscience Methods 2008). Part
of my project was developed in collaboration with Ayanda Biosystems SA (EPFL, Lausanne, CH) where I
spent a useful research period. I also started a research project to develop a chamber for the long-term
stimulation and monitoring of electrical activity of in-vitro cultured neurons. The project was carried on by a
Ph.D. student, and was recently published (Biffi et al., Computational Intelligence and Neuroscience 2010;
Biffi et al., Biotechnology and Bioengineering 2012).
After the Ph.D., I joined the Neuroscience and Brain Technologies Department of IIT as Postdoctoral fellow
in the research group led by Prof. Fabio Benfenati. My main research line has been the development of an
organic retinal prosthesis to restore light sensitivity in cases of photoreceptor degeneration (Ghezzi et al.,
Nature Communications 2011; Ghezzi et al., Nature Photonics 2012). However, the multidisciplinary
scientific background that I developed during my scientific training also enabled me to participate in a
number of research collaborations:
1. The application of the high-density APS-MEA developed at IIT to acute brain slices for the spatial
analysis of plasticity events and epileptic paroxysms (Ferrea et al., Frontiers in Neural Circuits 2012),
for which I performed experiments comparing MEA recordings with voltage-sensitive dye imaging.
2. The evaluation of the effects of lithium as a cognitive enhancer in the Down syndrome (Contestabile et
al., The Journal of Clinical Investigation 2012), for which I performed the characterization of long-term
potentiation in the dentate gyrus of hippocampal slices.
3. The exploitation of optogenetic stimulation to investigate cross-modal interaction between primary
sensory areas (Iurilli G, Ghezzi D et al., Neuron 2012).
4. The development of a novel in-utero electroporation method for the specific expression of genes in
selected brain areas (Dal Maschio M*, Ghezzi D* et al., Nature Communications 2012, * first authors
with equal contribution).
My main expertise relates to optogenetics and optical stimulation combined to electrophysiology both invitro and in-vivo. My skills and competencies also include: (i) preparation of neuronal cell cultures, acute
brain slices and animals for in-vivo electrophysiology, (ii) in-vivo adult infection with lenti-viruses and
AAV-viruses in mice and rats, (iii) in-utero electroporation in rats, (iv) electrophysiological methods such as
micro-electrode arrays recordings, field recordings, tetrode arrays implant and patch-clamp recordings, (v)
voltage-sensitive, calcium-sensitive and 2-P imaging, (vi) fabrication of electronic and photonic devices,
(vii) design of electronic hardware for data management (such as amplifiers and DAQ systems), (viii)
development of software and firmware for system integration and signal processing, and (ix) managing of
various software for signal and imaging processing (e.g. MatLab, LabView and ImageJ)
I’m co-author of 12 peer-reviewed publications, 2 patents, 1 review, 1 book chapter, and 32 proceedings of
international congress. I supervised in the last 8 years: 9 master degree students, 2 PhD students and 1 Postdocs.
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I am/was also part of several European and National projects, including:
As Principal Investigator
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2013 “Development of polymer-based artificial photoreceptors to cure blindness caused by
photoreceptor degeneration”, San Paolo, Pending evaluation
-
2013 “Organic polymers for artificial retinal prosthesis”, Cariplo foundation, Pending evaluation
As Co-investigator
-
2012 “Development and application of opto-neural prosthetic devices as a therapeutic approach for
Retinitis pigmentosa”, Telethon grant # GGP12033
-
2012 “OLIMPIA: Training network on optoelectronics integrated with living systems for neuroscience
investigations and applications”, FP7-PEOPLE-2012-ITN: Marie Curie Initial Training Networks (ITN)
-
2011 “SI-CODE: Towards new Brain-Machine Interfaces: state-dependent information coding",
ICT-2011.9.1 - FET-Open: Challenging current thinking
-
2011 “FOCUS: Single molecule activation and computing", ICT-2009 8.7 - FETproactive 7: Molecular
Scale Devices and Systems
-
2006 “Development of new optical and MicroElectrode Array based devices for studying information
processing in patterned in vitro neuronal networks”, MIUR PRIN grant # 2006093522_002
During my activity I dedicated some effort in research outreach. I participated in the production of press
releases and TV spot (e.g. Bioscience Technology, Le Scienze Web News, MIT Technology Review, Forbes,
New Scientist, TG3 Liguria, TG Leonardo, Uno Mattina, and Superquark).
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PUBLICATIONS ON INTERNATIONAL JOURNALS
* These authors equally contributed to the work
1. D. Ghezzi, M.R. Antognazza, R. Maccarone, S. Bellani, E. Lanzarini, N. Martino, M. Mete, G. Pertile,
S. Bisti, G. Lanzani & F. Benfenati (2013) “A polymer optoelectronic interface restores light sensitivity
in blind rat retinas”, Nature Photonics, 7(5): 400-406. (IF 27.254)
2. A. Contestabile, B. Greco, D. Ghezzi, V. Tucci, F. Benfenati & L. Gasparini (2012) “Lithium rescues
hippocampal synaptic plasticity and memory in a mouse model of Down syndrome by restoring adult
neurogenesis”, The Journal of Clinical Investigation, 123(1): 348–361. (IF 12.812)
3. E. Ferrea, A. Maccione, L. Medrihan, T. Nieus, D. Ghezzi, P. Baldelli, F. Benfenati & L. Berdondini
(2012) “Large-scale, high-resolution electrophysiological imaging of field potentials in brain slices with
microelectronic multielectrode arrays”, Frontiers in Neural Circuits 6:80. (IF 3.333)
4. M. dal Maschio*, D. Ghezzi*, G. Bony*, A. Alabastri, G. Deidda, M. Brondi, S. Sulis Sato, R. Proietti
Zaccaria, E. Di Fabrizio, G.M. Ratto & L. Cancedda (2012) “High-performance and site-directed in
utero electroporation by a triple-electrode probe”, Nature Communications 3, 960. (IF 10.015)
5. E. Biffi, G. Regalia, D. Ghezzi, R. De Ceglia, A. Menegon, G. Ferrigno, G.B. Fiore & A. Pedrocchi
(2012) “A novel environmental chamber for neuronal network multisite recordings”, Biotechnology and
Bioengineering 109(10): 2553-2566. (IF 3.648)
6. G. Iurilli, D. Ghezzi*, U. Olcese*, G. Lassi, C. Nazzaro, R. Tonini, V. Tucci, F. Benfenati & P. Medini
(2012) “Sound-driven synaptic inhibition in primary visual cortex”, Neuron 73(4): 814-828. (IF 15.766)
7. D. Ghezzi*, M.R. Antognazza*, M. Dal Maschio, E. Lanzarini, F. Benfenati & G. Lanzani (2011) “A
hybrid bioorganic interface for neuronal photoactivation", Nature Communications 2, 166. (IF 10.015 )
8. E. Biffi, D. Ghezzi, A. Pedrocchi & G. Ferrigno (2010) “Development and Validation of a Spike
Detection and Classification Algorithm Aimed at Implementation on Hardware Devices", Computational
Intelligence and Neuroscience, 659050.
9. M.R. Antognazza, D. Ghezzi, D. Musitelli, M. Garbugli & G. Lanzani (2009) “A hybrid solid-liquid
polymer photodiode for the bioenvironment”, Applied Physics Letters 94, 243501. (IF 3.794)
10. D. Ghezzi*, R. M. Vazquez*, R. Osellame, F. Valtorta, A. Pedrocchi, G. Della Valle, R. Ramponi, G.
Ferrigno & G. Cerullo (2008) “Femtosecond laser microfabrication of an integrated device for optical
release and sensing of bioactive compounds”, Sensors 8, 6595-6604. (IF 1.953)
11. D. Ghezzi, A. Menegon, A. Pedrocchi, F. Valtorta & G. Ferrigno (2008) “A Micro-Electrode Array
device coupled to a laser-based system for the local stimulation of neurons by optical release of
glutamate”, Journal of Neuroscience Methods 175(1):70-78. (IF 2.114)
12. D. Ghezzi, A. Pedrocchi, A. Menegon, S. Mantero, F. Valtorta & G. Ferrigno (2007) “PhotoMEA: An
opto-electronic biosensor for monitoring in vitro neuronal network activity”, BioSystems 87(2-3):
150-155. (IF 1.581)
REVIEWS ON INTERNATIONAL JOURNALS
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1. N. Martino, D. Ghezzi, F. Benfenati, G. Lanzani & M.R. Antognazza (2013) “Organic Semiconductors
for Artificial Vision”, Journal of Material Chemistry B 1:3768-3780.
PATENTS
1. D. Ghezzi, F. Benfenati, G. Lanzani, M.R. Antognazza, G. Freddi, I. Donelli, M. Mete & G. Pertile,
“Dispositivo organico per la fotoinibizione di cellule eccitabili”. Priority number TO2013A000665.
2. D. Ghezzi, M.R. Antognazza, M. Dal Maschio, E. Lanzarini, F. Benfenati & G. Lanzani, “A hybrid
bioorganic interface for neuronal photoactivation, and retinal prosthetic device”. US Patent App.
13/351,046.
3. G. Ferrigno, S. Mantero, A. Pedrocchi, D. Ghezzi, “System and method for stimulating and surveying in
a non invasive manner of the electrical activity of at least a cell”. EP Patent 1,842,049; US Patent App.
11/878,528; WO Patent 2,006,079,919. Priority number MI2005000114.
BOOK CHAPTERS
1. D. Ghezzi, “Coupling MEA Recordings and Optical Stimulation: New Optoelectronic Biosensors”,
Optoelectronics - Devices and Applications, Padmanabhan Predeep (Ed.), ISBN: 978-953-307-576-1,
InTech.
EDITORIALS AND COMMENTS TO PAPERS
1. C. Kayser & R. Remedios (2012) “Suppressive Competition: How Sounds May Cheat Sight”, Previews
in Neuron 73(4): 627-629.
2. O. Graydon (2011) “Biophotonics: Neural optoelectronic interface”. News & Views in Nature Photonics
5: 138, 2011.
INVITED SEMINARS AND SYMPOSIA
1. May 24, 2013; D. Ghezzi, “Organic artificial photoreceptors to restore sight in blindness”, Invited
seminar; CNR, Institute of Neuroscience, Milano, Italy.
PROCEEDINGS OF INTERNATIONAL CONFERENCES
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1. J. Szczurkowska, M. Dal Maschio, A. W. Cwetsch, D. Ghezzi, G. Bony, A. Alabastri, R. Proietti
Zaccaria, E. Di Fabrizio, G. M. Ratto & L. Cancedda “Increased Performance in Genetic Manipulation
by Modeling the Dielectric Properties of the Rodent Brain”, Proceedings of IEEE-EMBC2013 35th
Annual International Conference of the IEEE Engineering in Medicine and Biology Society, July 3-7
2013, Osaka, Japan.
2. M. Mete, D. Ghezzi, M. R Antognazza, R. Maccarone, E. Lanzarini, N. Martino, G. Pertile, S. Bisti, G.
Lanzani & F. Benfenati, “A polymer-based interface restores light sensitivity in rat blind retinas”,
Abstracts of the ARVO Annual Meeting, Life-Changing Research, May 5-9 2013, Seattle, Washington,
United States of America.
3. G. Lanzani, M. R. Antognazza, E. Lanzarini, N. Martino, D. Ghezzi, & F. Benfenati, “Opto-neuronal
interfaces and the perspective toward artificial retina”, Proceedings of PHOTONICS2012 International
Conference on Fiber Optics and Photonics, December 9-12 2012, Madras, Chennai, Tamilnadu, India.
4. D. Ghezzi, E. Lanzarini, N. Martino, M. R. Antognazza, R. Maccarone, S. Bisti, M. Mete, G. Pertile, G.
Lanzani & F. Benfenati, “Organic electronics allows the photo-electric excitation of neuronal activity in
primary neuronal cultures and acute retinal explants”, Abstracts of the 42th Society for Neuroscience
Annual Meeting, October 13-17 2012, New Orleans, Louisiana, United States of America, 322.08
5. A. Contestabile, B. Greco, D. Ghezzi, V. Tucci, F. Benfenati & L. Gasparini, “A role for adult
neurogenesis in dentate synaptic plasticity deficits and memory impairment in Down syndrome”,
Abstracts of the 42th Society for Neuroscience Annual Meeting, October 13-17 2012, New Orleans,
Louisiana, United States of America, 720.08
6. M. Dal Maschio, D. Ghezzi, G. Bony, A. Alabastri, G. Deissa, M. Brondi, S. Sulis Sato, R. Proietti
Zaccaria, E. Di Fabrizio, G. M. Ratto & L. Cancedda, “High-performance and site-directed in
utero electroporation by a triple-electrode probe”, Abstracts of the 42th Society for Neuroscience Annual
Meeting, October 13-17 2012, New Orleans, Louisiana, United States of America, 109.02
7. F. Benfenati, D. Ghezzi, M.R. Antognazza, M. Dal Maschio, E. Lanzarini & G. Lanzani, “A hybrid bioorganic interface for neuronal photo-activation”, Proceedings of FENS2012 8th Forum of European
NeuroScience, July 14-18 2012, Barcelona, Sapin
8. L. Cancedda, M. dal Maschio, D. Ghezzi, G. Bony, A. Alabastri, G. Deidda, M. Brondi, S. Sulis Sato, R.
Proietti Zaccaria, G.M. Ratto & E. Di Fabrizio, “High-performance and site-directed in utero
electroporation by a triple-electrode probe”, Proceedings of FENS2012 8th Forum of European
NeuroScience, July 14-18 2012, Barcelona, Sapin
9. A. Contestabile, B. Greco, D. Ghezzi, V. Tucci, F. Benfenati & L. Gasparini, “A role for adult
neurogenesis in dentate synaptic plasticity deficits and memory impairment in Down syndrome”,
Proceedings of FENS2012 8th Forum of European NeuroScience, July 14-18 2012, Barcelona, Sapin
10. E. Ferrea, L. Medrihan, D. Ghezzi, T. Nieus, P. Baldelli, F. Benfenati & Maccione, “Electrophysiological
imaging of epileptic brain slices reveals pharmacologically confined functional changes”, Proceedings of
SIMEA2012 8th International Meeting on Substrate-Integrated Microelectrode Arrays, July 10 - July 13
2012, Reutlingen, Germany
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11. D. Ghezzi, M.R. Antognazza, M. Dal Maschio, E. Lanzarini, G. Lanzani, F. Benfenati, “A hybrid bioorganic interface for neuronal photo-activation", Abstracts of the 41th Society for Neuroscience Annual
Meeting, November 12-16 2011, Washington, District of Columbia, United States of America, 204.30
12. D. Ghezzi, M. Dal Maschio, G. Bony, G. Deidda, F. Benfenati, G. Ratto, L. Cancedda, “The threeelectrode device: A new frontier for the in utero electroporation", Abstracts of the 41th Society for
Neuroscience Annual Meeting, November 12-16 2011, Washington, District of Columbia, United States
of America, 618.12
13. E. Ferrea, L. Medrihan, A. Maccione, D. Ghezzi, P. Baldelli, F. Benfenati, L. Berdondini, “Validation of
a high-density microelectrode array for acute brain slice recordings", Abstracts of the 41th Society for
Neuroscience Annual Meeting, November 12-16 2011, Washington, District of Columbia, United States
of America, 520.10
14. D. Ghezzi, M.R. Antognazza, M. Dal Maschio, E. Lanzarini, G. Lanzani, F. Benfenati, “A hybrid bioorganic interface for neuronal photoactivation”, Abstracts of the 8th IBRO World Congress of
Neuroscience, July 14-18 2011, Firenze, Italy, B524
15. E. Ferrea, L. Medrihan, A. Maccione, P. Baldelli, D. Ghezzi, F. Benfenati, L. Berdondini, “Validation of
a high-density microelectrode array for acute brain slice recordings”, Abstracts of the 8th IBRO World
Congress of Neuroscience, July 14-18 2011, Firenze, Italy, B523
16. A. Contestabile, B. Greco, D. Ghezzi, V. Tucci, F. Benfenati, L. Gasparini, “Pro-neurogenesis therapy
rescues hippocampal-mediated learning and memory deficits in the ts65dn mouse model of Down
syndrome", Abstracts of the 40th Society for Neuroscience Annual Meeting, October 13-17 2010, San
Diego, California, United States of America, 870.27
17. G. Iurilli, D. Ghezzi, G. Lassi, V. Tucci, F. Benfenati, P. Medini, “Sound-driven modulation of sub- and
suprathreshold activity in mouse primary visual cortex", Abstracts of the 40th Society for Neuroscience
Annual Meeting, October 13-17 2010, San Diego, California, United States of America, 672.15
18. M. Dal Maschio, D. Ghezzi, H. Verstegen, F. Benfenati, “Targeted optogenetic stimulation to study the
computational properties in neuronal ensembles recorded by multi-electrode devices", Proceedings of
FENS2010 7th Forum of European NeuroScience, July 3-7 2010, Amsterdam, The Netherlands
19. A. Contestabile, B. Greco, D. Ghezzi, V. Tucci, F. Benfenati, L. Gasparini, “Neurogenesis as therapeutic
target to rescue hippocampal-mediated learning and memory deficits in a mouse model of Down
syndrome", Proceedings of FENS2010 7th Forum of European NeuroScience, July 3-7 2010, Amsterdam,
The Netherlands
20. D. Boido, E. Ferrea, D. Ghezzi, P. Farisello, P. Baldelli, F. Benfenati. “Characterization of a mice model
of human epilepsy with Multi-Electrode Arrays", Proceedings of SIMEA2010 7th International Meeting
on Substrate-Integrated Micro Electrode Arrays, June 29 - July 2 2010, Reutlingen, Germany
21. M. R. Antognazza, E. Lanzarini, D. Ghezzi, M. Dal Maschio, F. Benfenati, G. Lanzani, “New
Approaches towards Organic Photodetection and Bio-Integration”, Proceedings of ICSM2010 20th
International Conference on Science and Technology of Synthetic Metals, July 4-9 2010, Kyoto, Japan
22. M. R. Antognazza, E. Lanzarini, D. Ghezzi, M. Dal Maschio, F. Benfenati, G. Lanzani, “New
Approaches towards Organic Photodetection and Bio-Integration”, Proceedings of FPi9 9th International
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Symposium on Functional pi-electron Systems, May 23-28 2010, Atlanta, Georgia, United States of
America
23. M. R. Antognazza, E. Lanzarini, D. Ghezzi, M. Dal Maschio, F. Benfenati, G. Lanzani, “New
Approaches towards Organic Photodetection and Bio-Integration”, Proceedings of HOPV 2th
International Hybrid and Organic Photovoltaics Conference, May 23-27 2010, Assisi, Italy 2009
24. E. Biffi, D. Ghezzi, A. Pedrocchi, G. Fiore, G. Ferrigno, “A novel mea bioreactor measuring neural
network activity continuously over long periods to study synaptic plasticity and pharmacological
outcomes”, Abstracts of the 39th Society for Neuroscience Annual Meeting, October 17-21 2009,
Chicago, Illinois, United States of America, 390.18
25. E. Biffi, D. Ghezzi, A. Pedrocchi, G. Ferrigno, “Spike detection algorithm improvement, spike
waveforms projections with PCA and herarchical classification”, Proceedings of MEDSIP2008 4th IET
International Conference on Advances in Medical, Signal and Information Processing, July 14-16 2008,
Santa Margherita Ligure, Italy, W97-03
26. M. Heuschkel, D. Ghezzi, A. Menegon, A. Pedrocchi, S. Matero, S. Makohliso, F. Valtorta, G. Ferrigno,
“The OptoMEA platform: a new tool combining local chemical stimulation with distributed multielectrode array recordings”, Proceedings of SIMEA2008 6th International Meeting on SubstrateIntegrated Micro Electrode Arrays, July 8-11 2008, Reutlingen, Germany
27. D. Ghezzi, M. Heuschkel, A. Menegon, A. Pedrocchi, S. Mantero, S. Makohliso, F. Valtorta, G.
Ferrigno, “OptoMEA: a new tool for combining local optical activation of compounds with distributed
MEA recordings”, Abstracts of the 37th Society for Neuroscience Annual Meeting, November 3-10 2007,
San Diego, California, United States of America, 318.21
28. E. Biffi, D. Ghezzi, F. Esposti, A. Menegon, M. G. Signorini, F. Valtorta, G. Ferrigno, “A system for
automatic on-line time detection and classification of neural spikes based on a digital signal processor
and a FPGA controller”, Abstracts of the 37th Society for Neuroscience Annual Meeting, November 3-10
2007, San Diego, California, United States of America, 792.18
29. D. Ghezzi, A. Pedrocchi, A. Menegon, S. Mantero, F. Valtorta, G. Ferrigno, “A new optical tool to
combine optical and electrical analysis in neuronal drug screenin”, Proceedings of IDDST2007 BIT’s 5th
Anniversary Congress of International Drug Discovery Science and Technology, May 28 - June 5 2007,
Shanghai, China, pp 255
30. D. Ghezzi, A. Pedrocchi, A. Menegon, S. Mantero, F. Valtorta, G. Ferrigno, “PhotoMEA: a new optical
biosensor for the study of the functional properties of neuronal networks”, Proceedings of ICNT2006 3rd
International Congress of Nanotechnology, October 30 - November 2 2006, San Francisco, California,
United States of America, ICNT06-SYS-404
31. D. Ghezzi, A. Menegon, A. Pedrocchi, S. Mantero, F. Valtorta, G. Ferrigno, “PhotoMEA: development
of optical tools for the study of the functional properties of neuronal networks”, Abstracts of the 36th
Society for Neuroscience Annual Meeting, October 14-18 2006, Atlanta, Georgia, United States of
America, 513.8
32. D. Ghezzi, A. Menegon, A. Pedrocchi, S. Mantero, F. Valtorta, G. Ferrigno, “PhotoMEA: A New Step
Towards Total Optical Analysis of In Vitro Neuronal Networks”, Proceedings of ESDA2006 8th Biennial
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ASME Conference on Engineering Systems Design and Analysis, July 4-7 2006, Torino, Italy,
ESDA2006- 95218.
33. D. Ghezzi, A. Pedrocchi, A. Menegon, S. Mantero, F. Valtorta, G. Ferrigno, “PhotoMEA: A new optical
biosensor for neuronal networks analysis”, in Dynamical Principles for neuroscience and intelligent
biomimetic devices - Abstracts of the EPFL-LATSIS Symposium 2006, Auke Jan Ijspeert, Jonas Buchli,
Allen Selverston, Mikhail Rabinovich, Martin Hasler, Wulfram Gerstner, Aude Billard, Henry Markram
and Dario Floreano (Eds), EPFL, Lausanne, 2006, pp 83-84. ISBN 9782839901345
34. D. Ghezzi, A. Pedrocchi, A. Menegon, S. Mantero, F. Valtorta, G. Ferrigno, “PhotoMEA: An optoelectronic biosensor for monitoring in vitro neuronal networks activity”, Proceedings of IPCAT2005
Sixth International Workshop on Information Processing in Cells and Tissues, August 30 - September 1
2005, St William’s College, York, United Kingdom, pp 108-118
PROCEEDINGS OF NATIONAL CONFERENCES
1. D. Ghezzi, E. Lanzarini, N. Martino, M.R. Antognazza, R. Maccarone,, S. Bisti, G. Lanzani, F.
Benfenati, “Organic electronics allows the photo-electric excitation and inhibition of neuronal activity in
primary neuronal cultures and acute retinal explants”, Acta Physiologica 2012, Volume 206, Supplement
692 :P1.25. Proceedings of the 63rd National Congress of the Italian Physiological Society, September
21-23, 2012, Verona, Italy
2. D. Ghezzi, E. Lanzarini, N. Martino, R. Maccarone, M.R. Antognazza, S. Bisti, G. Lanzani, F.
Benfenati, “Organic electronics allows the photo-electric excitation and inhibition of neuronal activity in
primary neuronal cultures and acute retinal explants”, Proceedings of YRP2012 Annual Meeting of
Young Researchers in Physiology, May 30 – June 1, 2012, Sestri Levante, Italy
3. D. Ghezzi, A. Menegon, A. Pedrocchi, F. Benfenati, F. Valtorta, G. Ferrigno, “Development of a new
device to combine local optical stimulation and MEA recordings”, Proceedings of Primo Congresso
Nazionale di Bioingegneria, July 3-5, 2008, Pisa, Italy
PARTICIPATION TO INTERNATIONAL SUMMER SCHOOLS
1. 1st MCCS/EMBO Summer School “Lecture Course on Molecular and Cellular Cognition”, July 1-6,
2006, Fondazione Cini, Venezia, Italy
2. 4th European School of Neuro-IT and Neuroengineering “Dynamics, Computation and Learning in
Neural Systems”, June 13-17, 2006, Villa Giustiniani-Cambiaso, Genova, Italy
3. JRC Entrepreneurship Curriculum, May 19-21 and June 22-24, 2005, Joint Research Centre, Ispra, Italy
PARTICIPATION TO NATIONAL SUMMER SCHOOLS
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1. XXV Scuola Annuale di Bioingegneria “NEURO-ROBOTICA: neuroscienze e robotica per lo sviluppo
di macchine intelligenti”, September 25-28, 2006, Bressanone, Italy
2. XXIV Scuola Annuale di Bioingegneria “BIOMATERIALI: Dagli impianti protesici alla medicina
rigenerativa”, September 26-29, 2005, Bressanone, Italy
3. XXIII Scuola Annuale di Bioingegneria “Metodi avanzati di elaborazione di segnali biomedici”,
September 20-23, 2004, Bressanone, Italy
4. XXII Scuola Annuale di Bioingegneria “Bioingegneria della Postura e del Movimento”, September
22-25, 2003, Bressanone, Italy
SPOKEN LANGUAGES
Mother tongue
Italian
Other languages
English (Fluent in spoken and written English)
French (Reasonable understanding and speaking)
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