clinical chemistry and laboratory medicine

CLINICAL
CHEMISTRY AND
LABORATORY
MEDICINE
Published in Association with the International Federation of Clinical Chemistry
and Laboratory Medicine and the European Federation of Clinical Chemistry and
Laboratory Medicine
CCLM is the official journal of the Association of Clinical Biochemists in Ireland (ACBI), the Belgian Society of Clinical Chemistry
(BVKC/SBCC), the German United Society for Clinical Chemistry and Laboratory Medicine (DGKL), the Hungarian Society of Laboratory Medicine (MLDT), the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC), the Korean Society of
Clinical Chemistry (KSCC), the Slovenian Association for Clinical Chemistry (SZKK), the Spanish Society for Clinical Biochemistry
and Molecular Pathology (SEQC), and the Turkish Biochemical Society (TBD).
EDITOR-IN-CHIEF
EDITORIAL BOARD
Mario Plebani
Padova, Italy
Marianne Abi Fadel
Beirut, Lebanon
Francisco V. Alvarez
Oviedo, Spain
Hassan M.E. Azzazy
Cairo, Egypt
Rossa Wai Kwun Chiu
Hong Kong, China
Eleftherios P. Diamandis,
Toronto, Canada
Arnold von Eckardstein
Zurich, Switzerland
Emmanuel Favaloro
Westmead, Australia
Debabrata Ghosh
New Delhi, India
Andrea Griesmacher
Innsbruck, Austria
Wolfgang Herrmann
Homburg/Saar, Germany
Johannes J.M.L. Hoffmann
Nuenen, Netherlands
Herbert Hooijkaas
Rotterdam, Netherlands
ASSOCIATE EDITORS
Giuseppe Lippi
Reviews Editor
Parma, Italy
Philippe Gillery
Reims, France
Steven Kazmierczak
Portland, USA
Karl J. Lackner
Mainz, Germany
Bohuslav Melichar
Olomouc, Czech Republic
John B. Whitfield
Brisbane, Australia
Kiyoshi Ichihara
Ube, Japan
Naziha Kaabachi
Tunis, Tunisia
János Kappelmayer,
Debrecen, Hungary
Jeong-Ho Kim
Seoul, Korea
Wolfgang Korte
St. Gallen, Switzerland
Christos Kroupis
Athens, Greece
Leslie Charles Lai
Kuala Lumpur, Malaysia
W.K. Christopher Lam
Taipa, Macau
Sylvain Lehmann
Montpellier, France
Janja Marc
Ljubljana, Slovenia
Eiji Miyoshi
Osaka, Japan
Tomris Özben
Antalya, Turkey
Vladimir Palicka
Hradec Králové,
Czech Republic
Mauro Panteghini
Milan, Italy
José M. Queraltó
Barcelona, Spain
Marileia Scartezini
Curitiba, Brazil
Gérard Siest,
Nancy, France
Ana-Maria Simundic
Zagreb, Croatia
Grazyna Sypniewska
Bydgoszcz, Poland
Gregory J. Tsongalis
Lebanon, USA
Pierre Wallemacq
Brussels, Belgium
Shengkai Yan
Beijing, China
Ian S. Young
Belfast, UK
MANAGING EDITOR
Heike Jahnke
Berlin, Germany
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ABSTRACTED/INDEXED IN Indexed in Academic OneFile (Gale/Cengage Learning); Analytical Abstracts; Biochemistry & Biophysics Citation Index;
Biological Abstracts; BIOSIS Previews; CAB Abstracts and Global Health; Chemical Abstracts and the CAS databases; Current Contents/Life Sciences;
CSA Illustrata – Natural Sciences; Elsevier BIOBASE/Current Awareness in Biological Sciences (CABS); EMBASE, the Excerpta Medica database;
EMBiology; Index Medicus/MEDLINE; ISI Custom Information Services; Journal Citation Reports/Science Edition; Science Citation Index; Science
Citation Index Expanded (SciSearch); and Scopus.
CCLM is the official journal of the Association of Clinical Biochemists in Ireland (ACBI), the Belgian Society of Clinical Chemistry (BVKC/SBCC), the
German United Society for Clinical Chemistry and Laboratory Medicine (DGKL), the Hungarian Society of Laboratory Medicine (MLDT), the Italian
Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC), the Korean Society of Clinical Chemistry (KSCC), the Slovenian Association
for Clinical Chemistry (SZKK), the Spanish Society for Clinical Biochemistry and Molecular Pathology (SEQC), and the Turkish Biochemical Society
(TBD).
The publisher, together with the authors and editors, has taken great pains to ensure that all information presented in this work (programs, applications,
amounts, dosages, etc.) reflects the standard of knowledge at the time of publication. Despite careful manuscript preparation and proof correction, errors
can nevertheless occur. Authors, editors and publisher disclaim all responsibility for any errors or omissions or liability for the results obtained from use of
the information, or parts thereof, contained in this work.
The citation of registered names, trade names, trademarks, etc. in this work does not imply, even in the absence of a specific statement, that such names
are exempt from laws and regulations protecting trademarks etc. and therefore free for general use.
ISSN 1434-6621 ∙ e-ISSN1437-4331 ∙ CODEN CCLMFW
All information regarding notes for contributors, subscriptions, Open access, back volumes and orders is available online at www.degruyter.com/cclm.
RESPONSIBLE EDITOR(S) Prof. Dr. Mario Plebani, Università di Padova, Dipartimento di Medicina di Laboratorio, Azienda Ospedaliera di
Padova, Via Nicolo Giustiniani 2, 35131 Padova, Italy. Tel.: +390 (0)49 821 2792, Fax: +390 (0)49 663 240, Email: [email protected]
JOURNAL MANAGER Heike Jahnke, De Gruyter, Genthiner Straße 13, 10785 Berlin, Germany, Tel.: +49 (0)30 260 05 – 220, Fax: +49 (0)30 260 05
– 325, Email: [email protected]
RESPONSIBLE FOR ADVERTISEMENTS Panagiota Herbrand, De Gruyter, Mies-van-der-Rohe-Straße 1, 80807 München, Germany, Tel.: +49 (0)89
769 02 – 394, Fax: +49 (0)89 769 02 – 350, Email: [email protected]
© 2012 Walter de Gruyter GmbH, Berlin/Boston
TYPESETTING Compuscript Ltd., Shannon, Ireland
PRINTING Franz X. Stückle Druck und Verlag e.K., Ettenheim
Printed in Germany
COVER ILLUSTRATION Research lab © Eisenhans. Permission to use the image on the cover granted by Fotolia LLC.
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Clin Chem Lab Med 2012;50(12):2065–2250, © 2012 by Walter De Gruyter • Berlin • Boston
CONTENTS
Editorials
Phlebotomy, stat testing and laboratory organization:
an intriguing relationship
Giuseppe Lippi, Ana-Maria Simundic and Mario
Plebani2065
Refers to article on p 2141
Human epididymis protein 4: the start of a postROMAn era?
Bohuslav Melichar2069
Refers to articles on pp 2127, 2171, 2181, 2189
Hyperhomocysteinemia in health and disease:
where we are now, and where do we go from here?
Giuseppe Lippi and Mario Plebani2075
Refers to article on p 2213
REVIEWS
The usefulness of cystatin C and related formulae
in pediatrics
Guido Filler, Shih-Han S. Huang and Abeer Yasin2081
The emerging role of biomarkers and bio-impedance
in evaluating hydration status in patients with acute
heart failure
Salvatore Di Somma, Silvia Navarin, Stefania Giordano,
Francesco Spadini, Giuseppe Lippi, Gianfranco Cervellin,
Bryan V. Dieffenbach and Alan S. Maisel2093
Biomarkers in primary open angle glaucoma
Haris Kokotas, Christos Kroupis, Dimitrios Chiras,
Maria Grigoriadou, Klea Lamnissou, Michael B. Petersen
and George Kitsos2107
MINI REVIEW
Identification of circulating microRNAs as
biomarkers in cancers: what have we got?
Yu Sun, Kuo Zhang, Gaowei Fan and Jinming Li2121
OPINION PAPER
HE4 in gynecological cancers: report of a European
investigators and experts meeting
Mario Plebani, on behalf of the HE4 Study Group2127
GUIDELINES AND RECOMMENDATIONS
Position paper on laboratory testing for patients
taking new oral anticoagulants. Consensus
document of FCSA, SIMeL, SIBioC and CISMEL
Armando Tripodi, Giancarlo Di Iorio, Giuseppe Lippi,
Sophie Testa and Cesare Manotti2137
GENERAL CLINICAL CHEMISTRY AND LABORATORY
MEDICINE
Reducing the number of clinical stat phlebotomy
orders: feasible or not?
Jolanda Scherrenburg, Dennis J. van de Wijngaart and
Pim M.W. Janssens2141
Calculating acid-base and oxygenation status
during COPD exacerbation using mathematically
arterialised venous blood
Stephen E. Rees, Beate A. Rychwicka-Kielek, Bjarne F.
Andersen, Rana Bibi, Jan F. Pedersen, Ulla M. Weinreich,
Lene B. Birket-Smith and Søren R. Kristensen2149
UrineCART, a machine learning method for
establishment of review rules based on UF-1000i
flow cytometry and dipstick or reflectance
photometer
Cao Yuan, Cheng Ming and Hu Chengjin2155
REFERENCE VALUES AND BIOLOGICAL VARIATIONS
Assessing seasonality in clinical research
Ton J. Cleophas and Aeilko H. Zwinderman 2163
CANCER DIAGNOSTICS
Identification of a novel in-frame deletion in
BRCA2 and analysis of variants of BRCA1/2 in
Italian patients affected with hereditary breast
and ovarian cancer
Maria Teresa Vietri, Anna Maria Molinari, Maria Laura
De Paola, Flavia Cantile, Morena Fasano and Michele
Cioffi2171
Human epididymis protein 4 (HE4) in benign and
malignant diseases
Linda Hertlein, Petra Stieber, Angela Kirschenhofer,
Sophie Fürst, Doris Mayr, Karin Hofmann, Katja
Krocker, Dorothea Nagel, Miriam Lenhard and
Alexander Burges2181
Human epididymis protein 4 as a serum marker
for diagnosis of endometrial carcinoma and
prediction of clinical outcome
Laura Zanotti, Eliana Bignotti, Stefano Calza, Elisabetta
Bandiera, Giuseppina Ruggeri, Claudio Galli, Germana
Tognon, Monica Ragnoli, Chiara Romani, Renata A. Tassi,
Luigi Caimi, Franco E. Odicino, Enrico Sartori, Sergio
Pecorelli and Antonella Ravaggi2189
A predictive equation to adjust for clinical
variables in soluble mesothelin-related protein
(SMRP) levels
Eun-Kee Park, Donald Wilson and Deborah H. Yates2199
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CARDIOVASCULAR DISEASES
Vitamin D deficiency parallels inflammation and
immune ­activation, the Ludwigshafen Risk and
Cardiovascular Health (LURIC) study
Christian Murr, Stefan Pilz, Tanja B. Grammer, Marcus
E. Kleber, Andreas Meinitzer, Bernhard O. Boehm,
Winfried März and Dietmar Fuchs2205
Plasma homocysteine and the risk of venous
thromboembolism: insights from the FIELD study
Markus Herrmann, Malcolm J. Whiting, Anne-Sophie
Veillard, Christian Ehnholm, David R. Sullivan and
Anthony C. Keech; for the FIELD study investigators 2213
LETTERS TO THE EDITOR
A two-base-pairs deletion in the albumin gene
causes a new case of analbuminemia
Gianluca Caridi, Monica Dagnino, Marco Di Duca,
Saikat Santra, Sarah Ball, Raashda A. Sulaiman,
Monica Campagnoli, Monica Galliano and Lorenzo
Minchiotti2221
Usefulness of an antiglycolytic granular mixture of
sodium fluoride and citrate for stabilizing plasma
homocysteine levels
Els Dumoulin, Tom Hornsby, Dimitri Hemelsoet, Joris
Delanghe and Veronique Stove2225
Phosphoethanolamine normal range in pediatric
urines for hypophosphatasia screening
Apolline Imbard, Corinne Alberti, Priscilla ArmoogumBoizeau, Chris Ottolenghi, Emilie Josserand, Odile Rigal
and Jean-François Benoist2231
Risk of false positive hepatitis C virus RNA due
to sample to sample carryover on an automated
hematology analyzer
Christine L. Schmotzer and Lan Zhou2235
Lack of commutability between a quality control
material and plasma samples in a troponin I
measurement system
Beatriz Candás-Estébanez, Ruth Cano-Corres, Dolors
Dot-Bach and José Valero-Politi 2237
Biological variation in pregnancy-associated
plasma protein-A in healthy men and non-pregnant
healthy women
Mustafa Serteser, Abdurrahman Coskun, Ibrahim Unsal
and Tamer C. Inal2239
Investigation of a slope discontinuity in a patients’
results distribution for D-dimer
Bryon P. Jackson, Laura J. McCloskey and Douglas F.
Stickle2243
Acknowledgment2247
Further insights on the relationship between
bilirubin and C-reactive protein
Giuseppe Lippi and Giovanni Targher 2229
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