Curriculum Vitae - English version Prof. GIANFRANCO SINAGRA

Curriculum Vitae - English version
Prof. GIANFRANCO SINAGRA
Full Professor of Cardiology - MED 11
Head of Cardiovascular Department Azienda Ospedaliero-Universitaria “Ospedali
Riuniti” of Trieste
Director of Postgraduate School in Cardiovascular Disease - University of Trieste
Graduated in Medicine (summa cum Laude) at the University of Palermo.
Board of Cardiology (summa cum Laude) at the University of Trieste.
Fellow of the European Society of Cardiology, member of the ESC-Working Group on
Myocardial and Pericardial disease and ESC HF Association.
Since 1999, Chief of the Cardiology Division at University Hospital of Cattinara, Trieste.
Since 2009, Chief of Cardiovascular Department of Cardiology Azienda OspedalieroUniversitaria “Ospedali Riuniti” Trieste.
Since 2012 Deputy Director of the Medical, Surgical and Life Sciences Department of the
University of Trieste.
Since 2013, Delegate of the Rector of the University of Trieste for Scientific Research and
technology LS-ERC.
Since 2015, Member of the international committee for the guide and the integration of
healthcare system between Italy and Slovenia
Research fellow at the Department of Cardiologic Sciences of the St George’s Hospital of
London (1989), and the Wallenberg Laboratory for Cardiovascular Research of the
Sahlgrenska Hospital, Gothenburg University, Sweden (1991 and 1993).
Professional Activities
Direction of clinical research activities within the Cardiovascular Department and liaison
between clinical and basic research through the Direction of the CTC (Center for
Translational Cardiology) of the AOUTS.
Cardiology Institution is composed by 133 employees and generates over 2500 admission
per year; 1400 Invasive procedures; more than 50.000 Outpatient clinics and non-invasive
procedures.
Certified autonomy in analysis of Endomyocardial Biopsy through histopathology,
immunohistochemistry and molecular virology.
Advertising, direction and promotion of trans border healthcare cooperation and in the
development, update and implement of trans border protocols in the Emergency in
cardiology (Project e-Cardionet, Italy-Slovenia 2007-2013 and further updates).
Editorial and Scientific Activities
Associate Editor of the European Journal of Heart Failure; Member of editorial board for
Heart-BMJ, Nature and member of the International Scientific Board of the Journal of
Cardiovascular Medicine and Macedonian Journal of Medical Sciences. Member of the del
Scientific Committee of the Giornale Italiano di Cardiologia. Member of the End Point
Clinical Event Committee of the ValHeFT Trial. Member of the Steering Committee of the
BRING UP-ANMCO trial and of th Clinical Event end Point Committee of the studies
SENIOR and GISSI HF (Ist. Farmacologico Mario Negri Milano). Chairman of the CandHeart Trial.
Direction of the collaboration with IRCCS Burlo-Garofolo and with l’ICGEB.
Since 2009 direction of the Center of Translational Cardiology (CTC) which collaborates
with the University of Colorado, Denver, CO, USA, and the Mayo Clinic, Rochester, MN,
USA.
Direction of the research activities and collaboration to the following projects:
- International registries, in particular ESC registries, such as EORP HF Pilot and Long
Term, EORP AF General Pilot and Long term, EORP CMY Long Term, EORP PPCM and
EORP Pregnancy and Heart Disease;
- Multicentric clinical trials regarding Heart Failure Cardiomyopathies, Pulmonary
Hypertension, Devices and Ischemic heart disease.
Collaboration with the following institutions:
- University of Colorado, Denver, Health Science Center, Division of Cardiology;
L.Mestroni, MD, PhD;
- Indiana University School of Medicine, Indianapolis. M.Vatta PhD;
- Department of Cardiology, University of Cincinnati; Jeffrey Towbin PhD;
- International Centre for Genetic Engineering and Biotechnology, Trieste; M.Giacca, MD,
PhD;
- Pathology Department, University of Trieste; R Bussani, MD;
- IRCCS Burlo, Trieste; Department of Molecular Medicine; G. Severini PhD;
- Virginia Commonwealth University, Medicine Department; A. Abate, MD, PhD e VCU
Pauley Heart Center, Richmond, VA, USA;
- Mario Negri Institute for Pharmacological Research, Milan, - Department of
Cardiovascular research; R. Latini MD, PhD;
- University of Trieste – Department of Architecture and Engineering – Science and
Technology of Advanced Materials; Prof. Ing. O. Sbaizero
Research Projects:
- Project “Identification of a Gene for Autosomal Dominant Dilated Cardiomyopathy on
Chromosome 9”; National Institute of Health-USA, University of Colorado Cardiovascular
Institute;
- Project "FAMILIAL CARDIOMYOPATHY REGISTRY” (NIH 99-177) which attracted 1)
NIH RO1HL69071, RR00051 GCRC-1575 e UCHSC, SOM AEF; 2) Giant Gene Titin
(TTN) Involvement in Dilated Cardiomyopathy (Project NIH/NHLBI R95 – RS&G); 3)
Analysis of Altered SCN5A Ion Channel Function in the Etiology of Dilated
Cardiomyopathy (AHA 0615547Z);
- Project American Heart Association SWA 12GRNT11770055 "Whole Exome Sequencing
to Discover Dilated Cardiomyopathy Genes";
- Project Translational Research in Cardiology (CTC) funded by Fondazione Cassa di
Risparmio di Trieste and Fondazione Generali;
- Project of the Ministry of Health Finalized Research 2004: Molecular mechanisms of
adverse or positive ventricular post-MI remodeling;
- Project of the Ministry of Health Finalized Research: Italian Registry of Familial Dilated
Cardiomyopathy (RICAF), clinical and genetic basis for the optimized treatment;
- Project of the Ministry of Health Finalized Research 2008 ”Advanced Heart Failure: novel
technologies in diagnosis and treatment”;
- Project of the Ministry of Health Finalized Research: Dilated Cardiomyopathy and Glutendependent autoimmunity;
- Project Piano Operativo Regionale (POR) of the European Fund for the regional
development (FESR) 2007-13 ASSE 1 "innovation, research, technology and industrial
sharing – sustainment of industrial research projects with high systemic impact to the
development of research innovation and technologies network", Industrial research grant
regarding molecular Biomedicine;
Project E-cardionet, Territorial European Cooperation – Program for the trans border
cooperation Italy-Slovenia, 2007-2013;
Project NIH 1 R01 HL116906-01A1 “Genetics, Mechanisms and Clinical Phenotypes of
Arrhythmogenic Cardiomyopathy”;
Project FRA 1/2014-6/2016 (UniTS): “Novel strategies to improve outcomes in Myocardial
Infarction: role of metabolic and nutritional factors”;
Poject MIUR RF-2011-02348164 Biomedical finalized research “CARDIOriGEN MicroRNAs inducing cardiac regeneration - From discovery towards clinical application
CARDIOriGEN - MicroRNAs inducing cardiac regeneration”.
International Awards
- Leducq Award (2014, 5 years Project): Molecular Genetics, Pathogenesis and ProteinReplacement Therapy in Arrhythmogenic Cardiomyopathy.
Author of more than 400 publications, 226 published, in extenso, indexed international
journals.
Total Impact factor (ISI Web of Knowledge, Journal of Citation Reports) 843,041;
H-Index 39;
Actual H-index 26;
Total Citations 8288.
Academic Activities
Full professor of Cardiology at the University of Trieste for the following Courses: 1)
Medicine and Surgery 2) Medical Biotechnologies 3) Professional Education 4) Nursing
Graduating Inter-University Course of the University of Udine and Trieste 5) Postgraduate
School in Cardiovascular Disease, Anesthesia, General Surgery and Emergency surgery,
Medical Genetics, Geriatrics, Emergency Medicine, Internal Medicine, Nephrology,
Neurology, Pediatrics and Medical Imaging.
Supervisor for more than 100 graduation thesis and more than 80 fellowship
commencements in Cardiology, Internal Medicine, Medical Genetics and Nursing.
Scientific Board of the biannual course (since 1997) "Update in Cardiology – Heart Failure
and Cardiomyopathies”.
Member of the teaching body and of the working groups "Centro Regionale di Formazione
per l'Area delle Cure Primarie" (CEFORMED) and of the Agenzia Regionale Sanità FVG.
Invited speaker since 1990 to more than 500 national and international scientific meetings.
Trieste, 05.04.2016
Prof. Gianfranco SINAGRA