Emmanuele A. Jannini, Full Professor of Endocrinology
Transcript
Emmanuele A. Jannini, Full Professor of Endocrinology
EMMANUELE A. JANNINI, MD, OMRI, KSG, KHS Emmanuele A. Jannini, Full Professor of Endocrinology, Andrology and Sexual Medicine at the Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy, and head of the Laboratory of Molecular Endocrinology and Molecular Sexology at the University of L’Aquila, Italy, was born in Milan, Italy on April 22, 1960. Emmanuele A. Jannini has received various awards in the course of his career: the Valerio Monesi Fellowship for Research in Reproduction (1987), the Becton Dickinson Award of the Italian Society of Endocrinology (1992), the First Award of the European Academy of Andrology (2000), the prize for the best Special Issue of the Journal of Endocrinological Investigation (2004), and the XXV Ottorino Rossi Award from the “Mondino” Neurologic Insitute, Pavia (2014). For his scientific merits he has been elected Officer of the Order of the Merit of the Italian Republic (OMRI) and Officer of the Order of St Agatha (San Marino Republic). Furthermore, he has been elected Knight of the Order of St Gregory The Great (KSG) (Vatican City) and Knight of the Equestrian Order of the Holy Sepulchre of Jerusalem (KHS) (Vatican City). Prof. Jannini is currently President of the Italian Society of Andrology and Sexual Medicine, General Secretary of the Italian Society of Endocrinology, and Chairman of the Educational Committee of the European Academy of Andrology. Finally, he has served the European Medicines Agency, London, UK, as member of the Scientific Advisory Group for endocrinology and diabetes. He is also Associate Editor of the Journal of Endocrinological Investigation and Sexual Medicine Reviews, and a member of the Editorial Board of Andrology, Folia Biologica, and Endocrine. Prof. Jannini’s scientific activity is reflected in his >150 full papers published in peer-reviewed international journals (total impact factor: >600; cited >5000 times; H-index: 41). His main research interests are sexual medicine and andrology (erectile dysfunction and subcellular localization of type 5 phosphodiesterase; pathogenesis of premature ejaculation; functional anatomy of female orgasm) and endocrinology of reproduction and sexuality, particularly testosterone and thyroid physiopathology (the role of sexual activity in the control of the hypothalamus-pituitary-testiscular axis; molecular localization and the role of the nuclear TH receptor in the male genital tract). He conducts his research in endocrinology, andrology and sexual medicine both from a clinical and a basic perspective employing molecular, clinical and psychological tools. He is the editor of Italian and international textbooks of andrology and sexual medicine, published in different languages (English, Italian, Portuguese, Turkish, Japanese, Chinese). On the strength of his publications, he is listed as in the classification of Top Italian Scientists and is active in promoting education in sexual medicine and public sexual health worldwide. Prof. Jannini is a recipient of several public and private research grants. Emmanuele A. Jannini: Curriculum Vitae & Studiorum A) Books 1a) E.A. JANNINI: Il Fluido Sangue. Roma, Edizioni Universitarie Scientifiche, 1982. 2a) E.A. JANNINI: La Pressione Arteriosa: Strumenti e Misure. Roma, Edizioni Universitarie Scientifiche, 1986. 3a) E.A. JANNINI, C. MORETTI, A. FABBRI, L. GNESSI, A. ISIDORI: Neuroendocrinologia dello Stress. Sassari, Caleidoscopio, 1988. 4a) A. ISIDORI, E.A. JANNINI: Patologia organica del comportamento sessuale. In: P. INTROZZI (ed.): Trattato italiano di medicina interna. Firenze, USES, 1988, III vol, pp.1385-1433. 4a bis) Anche pubblicato in M. NEGRI (ed.): Recentia in medicina interna - Enciclopedia Medica Italiana. Firenze, USES, 1989, pp. 579-631. 5a) M. D'ARMIENTO, E.A. JANNINI: Thyroid hormone action. In F. Monaco, M.A. Satta, A. Shapiro, L. Troncone (eds.): Thyroid Disease. Boca Raton, CRC Press, 1993, pp. 145-154. 6a) E.A. JANNINI: Fisiologia del congresso sessuale. In E.E. Müller, A.E. Rigamonti: (eds.): La funzione sessuale. Milano, Pythagora Press, 2001, pp. 57-71. 7a) M. D’ARMIENTO, E.A. JANNINI: Embriologia, anatomia, fisiologia e semeiotica della tiroide. In G. Guarini, G. Fiorelli, A. Malliani, F. Violi, M. Volpe (eds.): Teodori 2000 – Trattato Italiano di Medicina Interna. VI Edizione, Roma, SEU, 2001. 8a) E.A. JANNINI: Voci Attrazione/seduzione; Corteggiamento; Disfunzioni sessuali; Eiaculazione precoce; Impotenza; Sessuologia (identità e ambiti di ricerca). In G. Russo (a cura di): Enciclopedia di Bioetica e Sessuologia. Messina, Elledici-CICVelar, 2004. 8a bis) Anche pubblicato in G. RUSSO (ed.): Biotetica medica. Torino Elledici, 2009, pp. 290-294. 2 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 9a) E.A. JANNINI, G. d’AMATI, A. LENZI: Histology and Immunohistochemical Studies of Female Genital Tissue. In I. Goldstein, C. Meston, S. Davis, A. Traish (eds.): Women's Sexual Function and Dysfunction: Study, Diagnosis and Treatment, London, Taylor and Francis, 2006, pp. 125-133. 10a) E.A. JANNINI, A. LENZI, G. WAGNER: Behavioural Therapy and Counselling. In W.B. Schill, F.H. Comhaire, T.B. Hargreave (Eds.) Andrology for the Clinician. Springer, Berlin, 2006, pp. 598-607. 11a) S.M. DI STASI, A. GIANNANTONI, E.A. JANNINI, G. VESPASIANI, L. STORTI, F. ATTISANI, R.L. STEPHEN: Topical therapy iontophoresis and electromotive drug administration. In L. A. Levine (ed.) Current Clinical Urology: Peyronie’s Disease: A Guide to Clinical Management. Humana Press Inc., Totowa, NJ, pp. 93-101, 2006. 12a) E.A. JANNINI, A. LENZI: Disturbi psicosessuali. In D. Marazziti (ed.) Psicofarmacologia clinica. Roma, Fioriti editore, 2006, 252-263. 13a) C. SIMONELLI, A. FABRIZI, A. LENZI, E.A. JANNINI: I disturbi del desiderio maschile e femminile. In C. Simonelli (ed.) L’approccio integrato. Milano, Francoangeli, 2006. 14a) E.A. JANNINI, A. LENZI: Couple therapy for premature ejaculation. In R.F. Kandeel, T. Lue, J.L. Pryor, R.S. Swerdloff (eds): Male sexual dysfunction: pathophysiology and treatment. Informa, New York. 2007, pp. 351-362. 15a) E.A. JANNINI, A. LENZI, M. MAGGI: Sessuologia medica: Trattato di Psicosessuologia e Medicina della Sessualità. Elsevier-Masson, Milano, 2007. 16a) E.A. JANNINI, G.L. GRAVINA, M. MAGGI, L. VIGNOZZI, L. LENZI Advances in the mechanism of ejaculation. I.A. ABDEL-HAMID (Ed), Advances In Sexual Medicine, Drug Discovery Issues. Research Signpost, Kerala, India, 2009, pp 27-46. 17a) R.E. NAPPI, F.ALBANI, M.R. STRADA, E.A. JANNINI: Impact of chemotherapy and hormone therapy on female sexual health cancer and sexual health. Curr Clin Urol, 2011, part 4, 525-534. 18b) E.A. JANNINI, C. MCMAHON, M.D. WALDINGER: Premature Ejaculation. Springer, Milan, 2012 3 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 19b) G. CORONA, E.A. JANNINI, M. MAGGI (eds.): Emotional, Physical, and Sexual Abuse. Impact in children and social minorities. Springer, Milan, 2014. B) Full papers 1b) F. GRASSI, L. MONACO, G. FRATAMICO, S. DOLCI, E.A. JANNINI, M. CONTI, F. EUSEBI, M. STEFANINI: Putative second messengers affect cell coupling in the seminiferous tubules. Cell Biol. Int. Rep., 10:631-639, 1986. 2b) S. DOLCI, C. MANNA, E.A. JANNINI, E. PICCIONE, N. PASETTO: ATP content and kinetics of acrosome reaction in human spermatozoa: influence of various culture media and incubation time. Andrologia, 20:169-172, 1988. 3b) S. ULISSE, L. GNESSI, A. FABBRI, E.A. JANNINI, C. MORETTI, V. BONIFACIO, A. DI LUCA, F. FRAIOLI, A. ISIDORI: Bombesin-like immunoreactivity in human seminal fluid. Ann. N. Y. Acad. Sci., 547:452-454, 1988. 4b) A. FABBRI, E.A. JANNINI, L. GNESSI, C. MORETTI, S. ULISSE, V. BONIFACIO, G. FRAJESE, A. ISIDORI: Evidence for low bioactive LH in male impotence: possible relationship with altered GnRH pulsatility. J. Clin. Endocrinol. Metab., 67:867-875, 1988. 5b) A. FABBRI, E.A. JANNINI, L. GNESSI, C. MORETTI, S. ULISSE, A. FRANZESE, R. LAZZARI, F. FRAIOLI, G. FRAJESE, A. ISIDORI: Endorphins in male impotence: evidence for naltrexone stimulation on erectile activity in patient therapy. Psychoneuroendocrinol., 14:103-111, 1989. 6b) A. FABBRI, E.A. JANNINI, L. GNESSI, S. ULISSE, C. MORETTI, A. ISIDORI: Neuroendocrine control of male reproductive function. The opioid system as a model of control at multiple sites. J. Steroid Biochem., 32:145-150, 1989. 7b) L. GNESSI, A. ISIDORI, M. BOLOTTI, S. ALTAMURA, S. ULISSE, E.A. JANNINI, A. FABBRI, G. SPERA: Identification of immunoreactive gastrinreleasing peptide related substances in adult rat Leydig cells. Endocrinology, 124:558560, 1989. 4 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 8b) L. GNESSI, S. ULISSE, A. FABBRI, E.A. JANNINI, V. BONIFACIO, C. MORETTI, G. SPERA, A. ISIDORI: Isolation of human seminal plasma peptide with bombesin-like activity. Fertil. Steril., 51:1034-1039, 1989. 9b) E.A. JANNINI, M. OLIVIERI, S. FRANCAVILLA, A. GULINO, E. ZIPARO, M. D'ARMIENTO: Ontogenesis of the nuclear 3,5,3'-triiodothyronine receptor in the rat testis. Endocrinology, 126:2521-2526, 1990. 10b) R. ROMANO, E.A. JANNINI, M. PEPE, A. GRIMALDI, M. OLIVIERI, P. SPENNATI, F. CAPPA, M. D'ARMIENTO: The effects of iodoprophylaxis on thyroid size during pregnancy. Am. J. Obstet. Gynecol., 164:482-485, 1991. 10b bis) R. ROMANO, E.A. JANNINI, M. PEPE, A. GRIMALDI, M. OLIVIERI, P. SPENNATI, F. CAPPA, M. D'ARMIENTO: The effect of iodoprophylaxis on thyroid size during pregnancy. In J.D. BAGDADE (ed.): Year book of Endocrinology 1992, St. Luis, Mosby Year Book, 1992. 11b) S. FRANCAVILLA, G. CORDESCHI, G. PROPERZI, L. DI CICCO, E.A. JANNINI, S. PALMERO, E. FUGASSA, B. LORAS, M. D'ARMIENTO: Effect of thyroid hormone on the pre- and post-natal development of the rat testis. J. Endocrinol., 129:35-42, 1991. 12b) E.A. JANNINI, T. MITSUHASHI, V.M. NIKODEM: Developmental expression of mRNAs from a rat c-erbA genomic locus. Biochem. Biophys. Res. Commun., 184:739745, 1992. 13b) S. ULISSE, E.A. JANNINI, M. PEPE, S. DE MATTEIS, M. D'ARMIENTO: Thyroid hormone stimulates glucose transport and GLUT1 mRNA in rat Sertoli cells. Mol. Cell. Endocrinol., 87:131-137, 1992. 14b) E.A. JANNINI, S. ULISSE, D. PIERSANTI, E. CAROSA, P. MUZI, J. LAZAR, M. D'ARMIENTO: Early thyroid hormone treatment in rats increases testis size and germ cell number. Endocrinology, 132:2726-2728, 1993. 15b) E.A. JANNINI, S. DOLCI, S. ULISSE, V.M. NIKODEM: Developmental regulation of the thyroid hormone receptor α1 mRNA expression in the rat testis. Mol. Endocrinol., 8:89-96, 1994. 5 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 16b) S. ULISSE, E.A. JANNINI, E. CAROSA, D. PIERSANTI, F.M. GRAZIANO, M. D'ARMIENTO: Inhibition of aromatase activity by Sertoli cells by thyroid hormone. J. Endocrinol., 140:431-436, 1994. 17b) E.A. JANNINI, S. ULISSE, S. CECCONI, L. CIRONI, R. COLONNA, M. D’ARMIENTO, A. SANTONI, M.G. CIFONE: Follicle-stimulating hormone-induced phospholipase A2 activity and eicosanoid generation in rat Sertoli cells. Biol. Reprod., 50:52-58, 1994. 18b) S. ULISSE, A.R. FARINA, D. PIERSANTI, A. TIBERIO, L. CAPPABIANCA, G. D’ORAZI, E.A. JANNINI, O. MALYKH, W.G. STETLER-STEVENSON, M. D’ARMIENTO, A. GULINO, A.R. MacKAY: Follicle-stimulating hormone increases the expression of tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 and induces TIMP-1 AP-1 site binding complex(es) in prepubertal rat Sertoli cells. Endocrinology, 135:2479-2487, 1994. 19b) E.A. JANNINI, S. ULISSE, M. D’ARMIENTO: Thyroid hormone and male gonadal function. Endocrine Rev.,16:443-459, 1995. 20b) E.A. JANNINI, S. ULISSE, M. D’ARMIENTO: Macroorchidism in juvenile hypothyroidism. J. Clin. Endocrinol. Metab., 80:2543-2544, 1995. letter 21b) L. GNESSI, A. EMIDI, E.A. JANNINI, E. CAROSA, S. BASCIANI, M. MARODER, M. ARIZZI, S. ULISSE, G. SPERA: Testicular development involves the spatiotemporal control of PDGF and PDGF receptors gene expression and action. J. Cell. Biol., 131:1105-1121, 1995. 22b) S. ULISSE, N. RUCCI, D. PIERSANTI, E. CAROSA, F.M. GRAZIANO, A. PAVAN, P. CEDDIA, M. ARIZZI, P. MUZI, L. GNESSI, M. D'ARMIENTO, E.A. JANNINI: Regulation by thyroid hormone of the expression of basement membrane components in rat prepubertal Sertoli cells. Endocrinology, 139:741-747, 1998. 23b) E. CAROSA, A. FANELLI, S. ULISSE, R. DI LAURO, E.J. RALL, E.A. JANNINI: Ciona intestinalis nuclear receptor 1: a new member of steroid/thyroid hormone receptor family. Proc. Natl. Acad. Sci. USA, 95:11152-11157, 1998. 24b) Z. KOSTROUCH, M. KOSTROUCHOVA, W. LOWE, E.A. JANNINI, J PIATIGORSKY, J.E. RALL: Retinoic acid X receptor in the diploblast, Tripedalia cystophora. Proc. Natl. Acad. Sci. USA, 95:13442-13447, 1998. 6 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 25b) E.A. JANNINI, E. SCREPONI, E. CAROSA, M. PEPE, F. LO GIUDICE, F. TRIMARCHI, S. BENVENGA: Lack of sexual activity from erectile dysfunction is associated with a reversible reduction in serum testosterone. Int. J. Androl., 22:385392, 1999. 26b) E.A. JANNINI, E. CAROSA, N. RUCCI, E. SCREPONI, M. D’ARMIENTO: Ontogeny and regulation of variant thyroid hormone receptor isoforms in developing rat testis. J. Endocrinol. Invest., 22:843-848, 1999. 27b) E.A. JANNINI, A. CRESCENZI, N. RUCCI, E. SCREPONI, E. CAROSA, A. DE MATTEIS, E. MACCHIA, G. D’AMATI, M. D’ARMIENTO: Ontogenetic pattern of thyroid hormone receptor expression in the human testis. J. Clin. Endocrinol. Metab., 85:3453-3457, 2000. 28b) D. CANALE, M. AGOSTINI, G. GIORGILLI, C. CAGLIERESI, G. SCARTABELLI, V. NARDINI, E.A. JANNINI, E. MARTINO, A. PINCHERA, E. MACCHIA: Thyroid hormone receptors in neonatal; prepubertal; and adult rat testis. J. Androl. 22:284-288, 2001. 29b) E. SCREPONI, E. CAROSA, S.M. DI STASI, M. PEPE, G. CARRUBA, E.A. JANNINI: Prevalence of chronic prostatitis in men with premature ejaculation. Urology, 58:198-201, 2001. 30b) E. CAROSA, S. BENVENGA, F. TRIMARCHI, A. LENZI, M. PEPE, C. SIMONELLI, E.A. JANNINI: Lack of sexual activity for erectile dysfunction causes a reversible reduction of LH bioavability. Int. J. Impotence Res., 14:93-99, 2002. (Editorial Comment by A. Morales: ibidem, p. 100). 31b) S. BASCIANI, S. MARIANI, M. ARIZZI, S. ULISSE, N. RUCCI, E. A. JANNINI, C. DELLA ROCCA, A. MANICONE, C. CARANI, G. SPERA, L. GNESSI: Expression of PDGF-A, PDGF-B, PDGFR-α and PDGFR-β during human testicular development and disease. J. Clin. Endocrinol. Metab., 87:2310-2319, 2002. 32b) G. d’AMATI, C.R.T. DI GIOIA, M. BOLOGNA, D. GIORDANO, M. GIORGI, S. DOLCI, E.A. JANNINI: Type 5 phosphodiesterase (PDE5) expression in human vagina. Urology, 60:191-195, 2002. 33b) E.A. JANNINI, C. SIMONELLI, A. LENZI: Disorders of ejaculation. J. Endocrinol. Invest., 25:1006-1019, 2002. 7 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 34b) E.A. JANNINI, C. SIMONELLI, A. LENZI: Sexological approach to ejaculatory disorders. Int. J Androl., 25:317-323, 2002. 35b) A. PINCHERA, E.A. JANNINI, A. LENZI: Research and academic education in medical sexology. J Endocrinol Invest, 26 (suppl.):13-14, 2003. 36b) A. LENZI, F. LOMBARDO, P. SALACONE, L. GANDINI, E.A. JANNINI: Stress, sexual dysfunctions, and male infertility. J Endocrinol Invest, 26 (suppl.):72-76, 2003. 37b) G. D’AMATI, C.R.T. DI GIOIA, L. PROIETTI PANNUNZI, D. PISTILLI, E. CAROSA, A. LENZI, E.A. JANNINI: Functional anatomy of the human vagina. J Endocrinol Invest, 26 (suppl.): 92-96, 2003. 38b) F. LOMBARDO, L. GANDINI, M. SANTULLI, E.A. JANNINI, F. DONDERO, A. LENZI: Endocrinological diagnosis in sexology. J Endocrinol Invest, 26 (suppl.):112114, 2003. 39b) E.A. JANNINI, A. LENZI: Introduction to the integrated model: medical, surgical and psychological therapies for the couple. J Endocrinol Invest, 26 (suppl.):128-131, 2003. 40b) S.M. DI STASI, A. GIANNANTONI, G. CAPELLI, E.A. JANNINI, G. VIRGILI, G. VESPASIANI: Transdermal electromotive administration of verapamil and dexamethasone for Peyronie’s disease. Br. J. Urol. Int., 91:825-829, 2003. 41b) E.A. JANNINI, A. LENZI, G. WAGNER: New perspectives in the pharmacotherapy of erectile dysfunction. Idrugs – The Investigational Drugs Journal, 6:1165-1172, 2003. 42b) A. CRESCENZI, M.F. GRAZIANO, E. CAROSA, E. PAPINI, N. RUCCI, F. NARDI, P. TRIMBOLI, F. PICCIRILLI, E.A. JANNINI, M. D’ARMIENTO: Localization and expression of thyroid hormone receptors in normal and neoplastic human thyroid. J. Endocrinol. Invest., 26:1008-1012, 2003. 43b) E.A. JANNINI, F. LOMBARDO, P. SALACONE, L. GANDINI, A. LENZI: Treatment of sexual dysfunctions secondary to male infertility with sildenafil citrate. Fertil. Steril., 81:705-707, 2003. 8 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 44b) S.M. DI STASI, A. GIANNANTONI, R.L. STEPHEN, G. CAPELLI, A. GIURIOLI, E. A. JANNINI, G. VESPASIANI: Prospective, randomized study using transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease. J. Urol., 171:1605-1608, 2004. 45b) A. MORELLI, S. FILIPPI, R. MANCINA, M. LUCONI, L. VIGNOZZI, M. MARINI, C. ORLANDO, G.B. VANNELLI, A. AVERSA, A. NATALI, G. FORTI, M. GIORGI, E.A. JANNINI, F. LEDDA, M. MAGGI: Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa. Endocrinology, 145: 2253–2263, 2004. 46b) E.A. JANNINI, F. LOMBARDO, P. SALACONE, L. GANDINI, A. LENZI: Phosphodiesterase Type 5 inhibitor therapy for sexual dysfunction induced in male infertility. Am. J. Urol. Rev., 2:451-456, 2004. (Editorial comment by B.R. Gilbert: ibidem, p. 457-460). 47b) E. CAROSA, P. MARTINI, F. BRANDETTI, S.M. DI STASI, F. LOMBARDO, A. LENZI, E.A. JANNINI: Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels. Clin. Endocrinol. 61, 382–386, 2004. 48b) A. BULTRINI, E. CAROSA, E.M. COLPI, G. POCCIA, R. IANNARELLI, D. LEMBO, A. LENZI, E.A. JANNINI: Possible correlation between type 1 diabetes mellitus and female sexual dysfunction: case report and literature review. J. Sex. Med., 1: 337–340, 2004. 49b) G. CORONA, L. PETRONE, E. MANNUCCI, E.A. JANNINI, R. MANSANI, A. MAGINI, R. GIOMMI, G. FORTI, M. MAGGI: Psyco-biological correlates of rapid ejaculation in patients attending to an Andrologic Unit for Sexual Dysfunctions. Eur. Urol., 46:615–622, 2004. 50b) F. LOMBARDO, P. SGRO’, L. GANDINI, F. DONDERO, E.A. JANNINI, A. LENZI: Can erectile dysfunction be due to the thermolabile variant of MTHFR? A case report. J. Endocrinol. Invest., 27:883-885, 2004. 51b) E. CAROSA, C. RADICO, N. GIANSANTE, S. ROSSI, F. D’ADAMO, S.M. DI STASI, A. LENZI, E.A. JANNINI: Ontogenetic profile and thyroid hormone regulation of type-1 and type-8 glucose transporters in rat Sertoli cells. Int. J. Androl. 28:99-106, 2005. 9 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 52b) E. CAROSA, R. VOLPE, P. MARTINI, F. BRANDETTI, S.M. DI STASI, F. LOMBARDO, P. SALACONE, P. SGRÒ, L. GANDINI, A. LENZI, E. A. JANNINI: Psychosocial issues of ART in aging male. J. Endocrinol. Invest. 28 (Suppl. to no. 3): 117-121, 2005. 53b) F. LOMBARDO, P. SGRO’, P. SALACONE, B. GILIO, L. GANDINI, F. DONDERO, E.A. JANNINI, A. LENZI: Androgens and fertility. J. Endocrinol. Invest. 28 (Suppl. to no. 3): 51-55, 2005. 54b) A. CELLERINO, E.A. JANNINI: Male reproductive physiology as a sexually selected handicap? Erectile dysfunction is correlated with general health and health prognosis and may have evolved as a marker of poor phenotypic quality. Medical Hypotheses, 65:179-18, 2005. 55b) E.A. JANNINI, A. LENZI: Ejaculatory disorders: epidemiology and current approaches to definition, classification and subtyping. W. J. Urol. 23:68-75, 2005. 56b) A. LENZI, E.A. JANNINI: The andrologist from medicine of reproduction to sexual medicine: the Italian experience. Int. J. Androl. (Supplement “Male Sexual and Erectile Dysfunction), 28 (supplement 2):9-13, 2005. 57b) F. LOMBARDO, L. GANDINI, E.A. JANNINI, P. SGRÒ, B. GILIO, L. TOSELLI, F. DONDERO, A. LENZI: Diagnosing erectile dysfunction: instruments for endocrine diagnosis Int. J. Androl. (Supplement “Male Sexual and Erectile Dysfunction), 28 (supplement 2):53-55, 2005. 58b) A. CELLERINO, E.A. JANNINI: Why humans need type 5 phosphodiesterase inhibitors. Int. J. Androl. (Supplement “Male Sexual and Erectile Dysfunction), 28 (supplement 2):14-7, 2005. 59b) E. CAROSA, F. LOMBARDO, P. MARTINI, F. BRANDETTI, E.A. JANNINI: How to use Tadalafil. Int. J. Androl. (Supplement “Male Sexual and Erectile Dysfunction), 28 (supplement 2):74-80, 2005. 60b) E.A. JANNINI, F. LOMBARDO, A. LENZI: Correlation between ejaculatory and erectile dysfunction. Int. J. Androl. (Supplement “Male Sexual and Erectile Dysfunction), 28 (supplement 2):40-5, 2005. 10 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 61b) C. CARANI, A.M. ISIDORI, A. GRANATA, E. CAROSA, M. MAGGI, A. LENZI, E.A. JANNINI: Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. J. Clin. Endocrinol. Metab., 90:6472-6479, 2005. 62b) A. BELMONTE, C. TICCONI, S. DOLCI, M. GIORGI, A. ZICARI, A. LENZI, E.A. JANNINI, E. PICCIONE: Regulation of phosphodiesterase 5 expression and activity in human pregnant and non-pregnant myometrial cells by human chorionic gonadotropin. 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Sociodemographic and clinical features of gender identity disorder: an italian multicentric evaluation. J Sex Med. 10:408-19, 2013 139 b) DI SIENA S, CAMPOLO F, ROSSI P, JANNINI EA, DOLCI S, PELLEGRINI M. UV and genotoxic stress induce atr relocalization in mouse spermatocytes. Int J Dev Biol. 57:281-7, 2013 140 b) BUISSON O, JANNINI EA. Pilot echographic study of the differences in clitoral involvement following clitoral or vaginal sexual stimulation. J Sex Med. 10:2734-40, 2013. 141 b) LIMONCIN E, CARTA R, GRAVINA GL, CAROSA E, CIOCCA G, DI SANTE S, ISIDORI AM, LENZI A, JANNINI EA. The sexual attraction toward disabilities: a preliminary internet-based study. Int J Impot Res. 26(2):51-4, 2014 142 b) ISIDORI AM, BUVAT J, CORONA G, GOLDSTEIN I, JANNINI EA, LENZI A, PORST H, SALONIA A, TRAISH AM, MAGGI M. A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment-a systematic review. 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Biomed Res Int. 2013:460546, 2013. 146 b) JANNINI EA, STERNBACH N, LIMONCIN E, CIOCCA G, GRAVINA GL, TRIPODI F, PETRUCCELLI I, KEIJZER S, ISHERWOOD G, WIEDEMANN B, SIMONELLI C. Health-related characteristics and unmet needs of men with erectile dysfunction: a survey in five european countries. J Sex Med. 11:40-50, 2014. 147 b) FISHER AD, CASTELLINI G, BANDINI E, CASALE H, FANNI E, BENNI L, FERRUCCIO N, MERIGGIOLA MC, MANIERI C, GUALERZI A, JANNINI E, OPPO A, RICCA V, MAGGI M, RELLINI AH. Cross-sex hormonal treatment and body uneasiness in individuals with gender dysphoria. J Sex Med. 11(3):709-19, 2014. 148 b) BODDI V, FISHER AD, MASEROLI E, RASTRELLI G, CORONA G, JANNINI E, RICCA V, MANNUCCI E, MAGGI M. Lack of sexual privacy affects psychological and marital domains of male sexual dysfunction. J Sex Med. 11(2):431-8, 2014 149 b) GRAVINA GL, MARAMPON F, SHERRIS D, VITTORINI F, DI CESARE E, TOMBOLINI V, LENZI A, JANNINI EA, FESTUCCIA C. TORC1/TORC2 inhibitor, palomid 529, enhances radiation response modulating crm1-mediated survivin function and delaying dna repair in prostate cancer models. Prostate. 74:85268, 2014. 150 b) CAROSA E, CASTRI A, FORCELLA C, SEBASTIANI G, DI SANTE S, GRAVINA GL, RONCHI P, CESARINI V, DOLCI S, DI STASI S, LENZI A, JANNINI EA. Platelet-derived growth factor regulation of type-5 phosphodiesterase in human and rat penile smooth muscle cells. J Sex Med. 11:1675-84, 2014. 151 b) ALTHOF SE, MCMAHON CG, WALDINGER MD, SEREFOGLU EC, SHINDEL AW, ADAIKAN PG, BECHER E, DEAN J, GIULIANO F, HELLSTROM WJ, GIRALDI A, GLINA S, INCROCCI L, JANNINI E, MCCABE M, PARISH S, ROWLAND D, SEGRAVES RT, SHARLIP I, TORRES LO. An update of the international society of sexual medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). J Sex Med. 11:1392-422, 2014. 21 Emmanuele A. 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Antitumor effects of saffron-derived carotenoids in prostate cancer cell models. Biomed Res Int. 2014:135048, 2014. 155 b) LIMONCIN E, GALLI D, CIOCCA G, GRAVINA GL, CAROSA E, MOLLAIOLI D, LENZI A, JANNINI EA. The psychosexual profile of sexual assistants: an internetbased explorative study. Plos One. 9:E98413, 2014. 155 b) ISIDORI AM, CORONA G, AVERSA A, GIANFRILLI D, JANNINI EA, FORESTA C, MAGGI M, LENZI A; SIAMS-ED STUDY GROUP. The SIAMS-ED TRIAL: a national, independent, multicentre study on cardiometabolic and hormonal impairment of men with erectile dysfunction treated with vardenafil. Int J Endocrinol. 2014:858715, 2014. 156 b) CIOCCA G, LIMONCIN E, CELLERINO A, FISHER AD, GRAVINA GL, CAROSA E, MOLLAIOLI D, VALENZANO DR, MENNUCCI A, BANDINI E, DI STASI SM, MAGGI M, LENZI A, JANNINI EA. Gender identity rather than sexual orientation impacts on facial preferences. J Sex Med. 11:2500-7, 2014 157 b) JANNINI EA, BUISSON O, RUBIO-CASILLAS A. Beyond the G-spot: clitourethrovaginal complex anatomy in female orgasm. Nat Rev Urol. 11:531-8, 2014 22 Emmanuele A. Jannini: Curriculum Vitae & Studiorum 158 b) CIOCCA G, LIMONCIN E, DI TOMMASO S, MOLLAIOLI D, GRAVINA GL, MARCOZZI A, TULLII A, CAROSA E, DI SANTE S, GIANFRILLI D, LENZI A, JANNINI EA. Attachment styles and sexual dysfunctions: a case-control study of female and male sexuality. Int J Impot Res. 2014 AUG 14. DOI: 10.1038/IJIR.2014.33. [epub ahead of print] 159 b) CARRELL DT, RAJPERT-DE MEYTS E, KRAUSZ C, JANNINI EA, LIU PY, GERTON GL, LA SALLE S, AMARAL A. The need of continuous focus on improved mentoring of trainees and young investigators in the field of andrology: highlights of current programs and opportunities for the future. Andrology. ;2:649-51, 2014. 160 b) CIOCCA G, CAROSA E, STORNELLI M, LIMONCIN E, GRAVINA GL, IANNARELLI R, SPERANDIO A, DI SANTE S, LENZI A, LAURO D, JANNINI EA. Post-traumatic stress disorder, coping strategies and type 2 diabetes: psychometric assessment after l'aquila earthquake. Acta Diabetol. 2014 NOV 19. [epub ahead of print] 161 b) SANSONE A, ROMANELLI F, JANNINI EA, LENZI A. Hormonal correlations of premature ejaculation. Endocrine. 2015 JAN 1. [epub ahead of print] 162 b) LIMONCIN E, CIOCCA G, GRAVINA GL, CAROSA E, MOLLAIOLI D, CELLERINO A, MENNUCCI A, DI SANTE S, LENZI A, JANNINI EA. Pregnant women’s preferences for men’s faces differ significantly from nonpregnant women. J Sex Med 2015 MAR [epub ahead of print] 163 b) JANNINI EA, BURRI A, JERN P, NOVELLI G. Genetics of human sexual behavior: where we are, where we are going. Sex Med Rev 2015 MAR [epub ahead of print] 23