Humoral cross reactivity between α-synuclein and herpes simplex

Herpes simplex 1 está presente mais nos pacientes com doença de Parkinson do que nos
controles – mimetiza a alfa-sinucleína
Humoral cross reactivity between α-synuclein and herpes
simplex-1 epitope in Parkinson's disease, a triggering role in
the disease?
Caggiu E1, Paulus K2, Arru G3, Piredda R2, Sechi GP2, Sechi LA4.
J Neuroimmunol. 2016 Feb 15;291:110-4. doi: 10.1016/j.jneuroim.2016.01.007. Epub 2016 Jan
9.
Author information
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1
Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di
Sassari, Italy.
2
Dipartimento di Medicina Clinica e Sperimentale, Università di Sassari, Viale San
Pietro 43b, 07100 Sassari, Italy.
3
Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di
Sassari, Italy; Dipartimento di Medicina Clinica e Sperimentale, Università di Sassari,
Viale San Pietro 43b, 07100 Sassari, Italy.
4
Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di
Sassari, Italy. Electronic address: [email protected].
Abstract
Environmental factors are implicated in the development of Parkinson's disease (PD). We have
investigated on the role of molecular mimicry between HSV1 and α-synuclein that could
foster the progression of PD. The antibody response against homologous peptides in PD
patients and healthy controls was evaluated, showing that these antibodies are highly
prevalent among PD patients to healthy controls.
The competitive assay demonstrated cross-reactivity between HSV1 and human αsynuclein peptides. The results may suggest the hypothesis of the involvement of HSV1 in
stimulating the immune cells against the neurons of the substantia nigra as a consequence of
the cross reactivity.
Copyright © 2016 Elsevier B.V. All rights reserved.
KEYWORDS:
Autoimmunity; Cross-reactivity; HSV1; Parkinson's disease; α-Synuclein
PMID:
26857504