MARIO PESCATORI

Mario Pescatori, PhD.
Erasmus MC, Department of Surgery,
Lab. Of Experimental Surgical Oncology
Rotterdam, The Nederlands.
[email protected]
[email protected]
Personal data:
Place and date of birth:
-Roma, March 24th, 1964.
Address:
-Rusthoflaan 96A, 3034XP Rotterdam, NL
cell. +31629399723 (NL)
Education:
B.S., Biological sciences.
University "La Sapienza", Rome, March 1993.
Thesis: “Molecular Cloning of a cDNA encoding a protein component of the venom of the spider
Latrodectus tredecimguttatus copurifying with the -latrotoxin”.
Doctorate, Molecular and Cellular Biology.
University "Tor Vergata", Rome, May 1999.
Thesis: “Humanised, chimeric antibodies with -latrotoxin-neutralizing properties: recombinant
immunoglobulin as anti-venom therapeutics”
Research activity:
- Erasmus Medical Center, Rotterdam, NL.
Dept. of Experimental Surgical Oncology.
Research Scientist/ Bioinformatician
October 2011 - to date
- Health e-genomics, Rotterdam, NL.
Chief Scientific Officer (CSO) & co-founder
November 2013 - to date
- Crosslinks BV, Rotterdam NL
Bioinformatician/Data Analyst
2009 – January 2013
-Università Cattolica del sacro Cuore, Roma, IT.
Istituto di Anatomia Umana e Biologia Cellulare.
Visiting Scientist
March 2010 – march 2013
- Erasmus Medical Center, Rotterdam, NL.
Dept. of Bioinformatics, Rotterdam , NL.
Research Scientist.
November 2007 – June 2011
- PortoConteRicerche, srl, Alghero, IT
Head of gene expression unit/ Bioinformatician
2009 - 2010
- SHARDNA spa, Cagliari, IT.
Research Scientist/Bioinformatician.
2007 - 2008
-Università Cattolica del sacro Cuore, Roma, IT.
Instituto di Neurologia,
Research Scientist.
2000 - 2007
- CNR, Institute of Cell Biology, Rome, IT.
Research Scientist.
1998 - 1999
- University Tor Vergata, Rome, IT.
PhD student
1995 - 1999
- UCLA, School of Medicine, Department of Molecular and
Medical Pharmacology, Los Angeles, CA, USA.
Postdoctoral Fellow
1993 - 1995
- CNR, Institute of Cell Biology, Rome, IT.
Graduate Student
1990 – 1993
Teaching and visiting activity:
-Università degli Studi di Sassari, Sassari, IT.
Dip. Di Clinica e Patologia Veterinaria
(Technologies & data Analysis for Gene Expression Studies)
Contractor Professor
October 2010 - to date
-Università degli Studi di Sassari, Sassari, IT.
Dep. of Biomedical Sciences,
Clinical Biochemistry
Visiting Professor
October 2013 – December 2013
-Università degli Studi di Sassari, Sassari, IT.
Dep. of Surgery, Microsurgery and Medicine,
Inst of Dermatology
Visiting Professor
January 2013 – April 2013
-Università degli Studi di Sassari, Sassari, IT.
Dep. of Biomedical Sciences,
Clinical Biochemistry
Visiting Professor
October 2012 – December 2012
-Università degli Studi di Sassari, Sassari, IT.
Dip. Di Clinica e Patologia Veterinaria
Visiting Professor
-Don Gnocchi ONLUS, Rome, IT.
Consultant
October 2011 – April 2012
2006 - 2010
Research Articles:
34. Marei HE, Althani A, Afifi N, Abd-Elmaksoud A, Bernardini C, Michetti F, Barba M, Pescatori
M, Maira G, Paldino E, Manni L, Casalbore P, Cenciarelli C. Over-Expression of hNGF in Adult
Human Olfactory Bulb Neural Stem Cells Promotes Cell Growth and Oligodendrocytic Differentiation.
PLoS One. 2013 Dec 19;8(12):e82206. doi: 10.1371/journal.pone.0082206.
33. Paldino E, Cenciarelli C, Giampaolo A, Milazzo L, Pescatori M, Hassan HJ, Casalbore P.
Induction of dopaminergic neurons from human Wharton's jelly mesenchymal stem cell by forskolin.
J Cell Physiol. 2014 Feb;229(2):232-44. doi: 10.1002/jcp.24442.
32. Pescatori M, Bedognetti D, Venturelli E, Ménard-Moyon C, Bernardini C, Muresu E, Piana A,
Maida G, Manetti R, Sgarrella F, Bianco A, Delogu LG. Functionalized carbon nanotubes as
immunomodulator systems. Biomaterials. 2013 Jun;34(18):4395-403. doi:
10.1016/j.biomaterials.2013.02.052. Epub 2013 Mar 16.
31.Weigelt K, Bergink V, Burgerhout KM, Pescatori M, Wijkhuijs A, Drexhage HA. Down-regulation
of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum
psychosis. Brain Behav Immun. 2013 Jan 4. doi:pii: S0889-1591(12)00548-X.
10.1016/j.bbi.2012.12.018. [Epub ahead of print] PMID:23295264 I.F.4.720
30. Tasca G*, Pescatori M*, Monforte M, Mirabella M, Iannaccone E, Frusciante R, Cubeddu T,
Laschena F, Ottaviani P, Ricci E. Different molecular signatures in magnetic resonance imaging-staged
facioscapulohumeral muscular dystrophy muscles. PLoS One. 2012;7(6):e38779. Epub 2012 Jun 13.
*Equal contribution
29. Palermo AT, Palmer RE, So KS, Oba-Shinjo SM, Zhang M, Richards B, Madhiwalla ST, Finn PF,
Hasegawa A, Ciociola KM, Pescatori M, McVie-Wylie AJ, Mattaliano RJ, Madden SL, Marie SK,
Klinger KW, Pomponio RJ. Transcriptional response to GAA deficiency (Pompe disease) in infantileonset patients. Mol Genet Metab. 2012 Jul;106(3):287-300. Epub 2012 May 14.
28. Gene Expression Profile of Adult Human Olfactory Bulb and Embryonic Neural Stem Cell
Suggests Distinct Signaling Pathways and Epigenetic Control. PLoS One. 2012, accettato 2012 Feb,
11: in stampa
27. Ledda S, Bebbere D, Ariu F, Pescatori M, Pau S, Zedda MT, Bogliolo L. Unveiling mRNA
changes during meiotic progression and pre-implantation development: help from large animal models.
Curr Pharm Des. 2012 Jan 1;18(3):256-63.
26. Marei HE, Ahmed AE, Michetti F, Pescatori M, Pallini R, Casalbore P, Cenciarelli C, Elhadidy M.
Gene expression profile of adult human olfactory bulb and embryonic neural stem cell suggests distinct
signaling pathways and epigenetic control. PLoS One. 2012;7(4):e33542. doi:
10.1371/journal.pone.0033542. Epub 2012 Apr 2.
25. Qiuwei Pan, Suomi M.G. Fouraschen, Fatima S.F. Aerts Kaya, Monique M. Verstegen,
Mario Pescatori, Andrew P. Stubbs, Wilfred van IJcken, Antoine van der Sloot, Ron
Smits, Jaap Kwekkeboom, Herold J. Metselaar, Geert Kazemier, Jeroen de Jonge, Hugo
W. Tilanus, Gerard Wagemaker, Harry L.A. Janssen and Luc J.W. van der Laan. Mobilization of
hepatic mesenchymal stem cells from adult human liver grafts. Liver Transpl. 2011 May;17(5):596609. doi: 10.1002/lt.22260.
24. Crop MJ, Baan CC, Korevaar SS, Ijzermans JN, Pescatori M, Stubbs AP, Van Ijcken WF, Dahlke
MH, Eggenhofer E, Weimar W, Hoogduijn MJ. Inflammatory conditions affect gene expression and
function of human adipose tissue-derived mesenchymal stem cells. Clin Exp Immunol. 2010 Sep 5.
23. Bugli F, Graffeo R, Pescatori M, Sterbini FP, Torelli R, Masucci L, Manzara S, Fadda G. Human
antibodies from phage display libraries: expression of recombinant full length immunoglobulin G
specific to the hepatitis C virus E2 glycoprotein. New Microbiol. 2009 Oct;32(4):341-9.
22. Fasanaro P, Greco S, Lorenzi M, Pescatori M, Brioschi M, Kulshreshtha R, Banfi C, Stubbs A,
Calin GA, Ivan M, Capogrossi MC, Martelli F. An integrated approach for experimental target
identification of hypoxia-induced miR-210. J Biol Chem. 2009 Dec 11;284(50):35134-43. Epub 2009
Oct 13.
21. van Oostrom O, de Kleijn DP, Fledderus JO, Pescatori M, Stubbs A, Tuinenburg A, Lim SK,
Verhaar MC. Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of
patients with type 1 diabetes: a case-control pilot study. Cardiovasc Diabetol. 2009 Aug 25;8:47.
20. Greco S, De Simone M, Colussi C, Zaccagnini G, Fasanaro P, Pescatori M, Cardani R, Perbellini
R, Isaia E, Sale P, Meola G, Capogrossi MC, Gaetano C, Martelli F. Common micro-RNA signature in
skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute
ischemia. FASEB J. 2009 Oct;23(10):3335-46. Epub 2009 Jun 15.
19. Colussi C, Mozzetta C, Gurtner A, Illi B, Rosati J, Straino S, Ragone G, Pescatori M, Zaccagnini
G, Antonini A, Minetti G, Martelli F, Piaggio G, Gallinari P, Steinkuhler C, Clementi E, Dell'Aversana
C, Altucci L, Mai A, Capogrossi MC, Puri PL, Gaetano C. HDAC2 blockade by nitric oxide and
histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment.
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19183-7.
18. Bugli F, Graffeo R, Sterbini FP, Torelli R, Masucci L, Sali M, Grasso A, Rufini S, Ricci E, Fadda
G, Pescatori M. Monoclonal antibody fragment from combinatorial phage display library neutralizes
alpha-latrotoxin activity and abolishes black widow spider venom lethality, in mice. Toxicon. 2007 Nov
23.
17. Morosetti R, Mirabella M, Gliubizzi C, Broccolini A, Sancricca C, Pescatori M, Gidaro T, Tasca
G, Frusciante R, Tonali PA, Cossu G, Ricci E. Isolation and characterization of mesoangioblasts from
facioscapulohumeral muscular dystrophy muscle biopsies. Stem Cells. 2007 Dec;25(12):3173-82.
16. Pescatori M, Broccolini A, Minetti C, Bertini E, Bruno C, D'amico A, Bernardini C, Mirabella M,
Silvestri G, Giglio V, Modoni A, Pedemonte M, Tasca G, Galluzzi G, Mercuri E, Tonali PA, Ricci E.
Gene expression profiling in the early phases of DMD: a constant molecular signature characterizes
DMD muscle from early postnatal life throughout disease progression. FASEB J. 21(4):1210-26. Epub
2007 Jan 30.
15. Celegato B, Capitanio D, Pescatori M, Romualdi C, Pacchioni B, Cagnin S, Viganò A, Colantoni
L, Begum S, Ricci E, Wait R, Lanfranchi G, Gelfi C. Parallel protein and transcript profiles of FSHD
patient muscles correlate to the D4Z4 arrangement and reveal a common impairment of slow to fast
fibre differentiation and a general deregulation of MyoD-dependent genes. Proteomics. 2006
Oct;6(19):5303-21.
14. Zocco MA, Carloni E, Pescatori M, Saulnier N, Lupascu A, Nista EC, Novi M, Candelli M,
Cimica V, Mihm S, Gasbarrini G, Ramadori G, Gasbarrini A. Characterization of gene expression
profile in rat Kupffer cells stimulated with IFN-alpha or IFN-gamma. Dig Liver Dis. 38(8):563-77.
Epub 2006 Jun 27.
13. Giglio V., Pasceri V., Messano L., Parisi Q., Rinelli G., Pasquini L., Dello Russo A., Broccolini A.,
Galluzzi G., Pescatori M., Mirabella M., Gidaro T., Mangiola F., Ricci E. Integrated backscatter in
Becker muscular dystrophy patients with functionally normal heart: myocardial ultrasound tissue
characterization study.. J Am Coll Cardiol. 47(3):686-8. Epub 2006 Jan 18.
12. Broccolini A., Gidaro T., Morosetti R., Gliubizzi C., Servidei T., Pescatori M., Tonali P.A., Ricci
E., Mirabella M. Neprilysin participates in skeletal muscle regeneration and is accumulated in
abnormal muscle fibres of inclusion body myositis. J Neurochem. 96(3):777-89. Epub 2006 Jan 9.
11. Petrini S, Tessa A, Stallcup WB, Sabatelli P, Pescatori M, Giusti B, Carrozzo R, Verardo M,
Bergamin N, Columbaro M, Bernardini C, Merlini L, Pepe G, Bonaldo P, Bertini E. Altered expression
of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency. Mol Cell Neurosci. 2005
Nov;30(3):408-17.
10. Broccolini A, Ricci E, Cassandrini D, Gliubizzi C, Bruno C, Tonoli E, Silvestri G, Pescatori M,
Rodolico C, Sinicropi S, Servidei S, Zara F, Minetti C, Tonali PA, Mirabella M. Novel GNE mutations
in Italian families with autosomal recessive hereditary inclusion-body myopathy. Hum Mutat. 2004
Jun;23(6):632.
9. Broccolini A, Ricci E, Pescatori M, Papacci M, Gliubizzi C, D'Amico A, Servidei S, Tonali P,
Mirabella M. Insulin-like growth factor I in inclusion-body myositis and human muscle cultures. J
Neuropathol Exp Neurol. 2004 Jun;63(6):650-9.
8. Di Lazzaro V, Oliviero A, Tonali PA, Felicetti L, De Marco MB, Saturno E, Pilato F, Pescatori M,
Dileone M, Pasqualetti P, Ricci E. Changes in motor cortex excitability in facioscapulohumeral
muscular dystrophy. Neuromuscul Disord. 2004 Jan;14(1):39-45.
7. Broccolini A, Pescatori M, D'Amico A, Sabino A, Silvestri G, Ricci E, Servidei S, Tonali PA,
Mirabella M. An Italian family with autosomal recessive inclusion-body myopathy and mutations in
the GNE gene. Neurology. 2002 Dec 10;59(11):1808-9.
6. Pescatori M, Grasso A. Characterization of the epitope for 4C4.1 mAb on alpha-latrotoxin using
phage display-peptide libraries: prevention of toxin-dependent 45Ca(2+) uptake in non-neuronal
human embryonic cells transiently expressing latrophilin. Biochimie. 2000 Sep-Oct;82(9-10):909-14.
IF 3.787
5. Rufini S, de Vito P, Balestro N, Pescatori M, Luly P, Incerpi S. PLA(2) stimulation of Na(+)/H(+)
antiport and proliferation in rat aortic smooth muscle cells. Am J Physiol. 1999 Oct;277(4 Pt 1):C81422.
4. Grasso A, Pescatori M. Structural and functional studies of latrodectin from the venom of black
widow spider (Latrodectus tredecimguttatus). Adv Exp Med Biol. 1996;391:237-43.
3. Kohan SA, Pescatori M, Brecha NC, Mastrogiacomo A, Umbach JA, Gundersen CB. Cysteine
string protein immunoreactivity in the nervous system and adrenal gland of rat. J Neurosci. 1995
Sep;15(9):6230-8.
2. Pescatori M, Bradbury A, Bouet F, Gargano N, Mastrogiacomo A, Grasso A. The cloning of a
cDNA encoding a protein (latrodectin) which co-purifies with the alpha-latrotoxin from the black
widow spider Latrodectus tredecimguttatus (Theridiidae). Eur J Biochem. 1995 May 15;230(1):322-8.
1. Pescatori M, Grasso A. A tissue-specific protein of the venom gland of black widow spider affects
alpha-latrotoxin action. Ann N Y Acad Sci. 1994 Mar 9;710:38-47. Review.
Scientific Books:
A. Grasso and M. Pescatori (1994). Biological properties of a protein of the venom gland of Black
Widow spider (Latrodectus tredecimguttatus) probed by specific antibodies. In N.H. Tan, S. L. Do, V.
Thambyrajah and N Azila Eds.,
Advances in Venom and Toxins Research, Malaysian Society on Toxinology, Kuala Lumpur, Malaysia,
pp. 59-74.
A. Grasso, S. Kawai, M. Kobayashi and M. Pescatori (1998). Purification, function
and selectivity Latrotoxin. In P. Lazarovici, A. Grasso and M. Lineal Eds., Secretory Systems and
Toxins, Harwood Academic Publishers gmbh, Amsterdam.
Tesi:
M. Pescatori (1993). “Struttura e clonaggio di una componente del veleno del ragno Latrodectus
tredecimguttatus che copurifica con l'-latrotossina”.
Tesi di Laurea in Scienze Biologiche.
Università "La Sapienza", Roma, IT.
M. Pescatori (1999). Anticorpi chimerici umanizzati con proprietà neutralizzanti nei confronti della
alpha-latrotossina. “
Tesi di Dottorato in Biologia Cellulare e Molecolare
Università di "Tor vergata", Roma, IT.
.