Europass CV - Corso di Dottorato in Biotecnologie applicate e

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Curriculum Vitae
Europass
Informazioni personali
Cognome(i) / Nome(i)
Spagnoli Luigi Giusto
Indirizzo(i)
Via Aldo Bigelli 47, 00017 Nerola RM (Italia)
Telefono(i)
39 062023751
E-mail
Cittadinanza
Cellulare
393396107658
[email protected]
Italiana
Data di nascita
4/6/1942
Sesso
Maschile
Esperienza professionale
Date
Lavoro o posizione ricoperti
Principali attività e responsabilità
Nome e indirizzo del datore di lavoro
Tipo di attività o settore
Date
Nome e indirizzo del datore di lavoro
Date
Lavoro o posizione ricoperti
Date
Date
Date
University Teacher/Scientist
1985-date: Full Professsor of Anatomic Pathology, University of Rome “Tor Vergata”
University of Rome Tor Vergata
V.le Montpellier, 00133 Rome RM (Italia)
University/Academic research
28/12/1985 - 1992
Director of the Department of Surgery, University of Rome “Tor Vergata”
University of Rome Tor Vergata
00133 Roma (Italia)
1987 - 2001
Surgical Pathology
Chief of Surgical Pathology Service, S.Eugenio Hospital, Rome
1997 - 2008
Director of the Department of Biopathology and Image Diagnostics, University of Rome “Tor Vergata”
1999 - 2012
Coordinator of the Research-Doctorate “Advanced Technologies in Biomedicine” University of Rome
“Tor Vergata”
2002 - 2012
Chief of Surgical Pathology, Policlinico Università Tor Vergata, Rome
Date 1984 - 1987
Principali tematiche/competenza
professionali acquisite
Date
Pagina 1 / 11 - Curriculum vitae di
Member of the Committee for scientific research, of Public Education Ministry
1988 - 1991
Member of the Committee for Biotechnology and Bioinstrumentations of National Council of Research
Per maggiori informazioni su Europass: http://europass.cedefop.europa.eu
© Unione europea, 2002-2010 24082010
Date
Date
Date
Date
Date
1999 - 2000
Member of Guarantee Committee of COFIN, MURST
2001 - 2005
Director-general of IFO (Istituti Fisioterapici Ospitalieri)
2004 - 2005
Member of the Working Group for Biobanks Certification, National Committee for Biosafety and
Biotechnologies, Presidency of Italian Council of Ministers
2004 - 2008
Member of Scientific Committee of ENEA
2005 - 2012
Director-general of “Alleanza contro il Cancro”
Istruzione e formazione
1966:
1968:
1969:
1974:
Doctor of Medicine, University of Rome “La Sapienza”
Specialist in Oncology, University of Rome “La Sapienza”
Specialist in General Pathology, University of Rome “La Sapienza”
Specialist in Anatomic Pathology, University of Rome “La Sapienza”
Fellowship and Visiting appointments :
1968
Assistent Professeur de l'Institute de Histologie ed
Embriologie Université de Genève
1969
Award for scientific activity -- Università di Roma
1973-1975 Research fellow-Department of Pathology - Pennsylvania
University Philadelphia-USA
1977
Visiting Professor---Pennsylvania University - Philadelphia
1989
Visiting Professor Pennsylvania University -- Philadelphia
1991
Visiting Professor University of Western Ontario--Canada
1991
Visiting Professor The Medical College of Pennsylvania
1996:
Visiting Professor, Mayo Clinic, Rochester, Minnesota
USA
1998:
Visiting Professor, AFIP of Washington, USA
2000:
Visiting Professor, Mayo Clinic, Rochester, Minnesota ,USA
2002:
Visiting Professor, Mayo Clinic, Rochester, Minnesota, USA
© Unione europea, 2002-2010 24082010
Research Interests:
Atherosclerosis and vascular pathology:
a) role of carotid thrombosis in the pathogenesis of cerebrovascular syndromes; b) correlation between
the morphological aspects of human fibroatheromasic plaque and the various risk factors; c) role of
inflammatory cells in the development of human and experimental atherosclerotic plaque; d) study of
inflammatory, metabolic and genetic markers of atherosclerotic plaque vulnerability; e) role of chlamydia
pneumoniae in the pathogenesis of acute coronary syndromes; f) role of oxidative stress and oxidated
lipoproteins in the progression of human atherosclerotic plaque; g) age-related morphological and
morphometrical changes of cellular and interstitial tissue of arterial wall; h) role of metalloproteinases in
the pathogenesis of aneurysms of abdominal aorta, of atherosclerosis and restenosis; i) role of
myocardial inflammation as pathogenetic factor of coronary syndromes; l) the effect of treatment with
calcium antagonist drugs on some cellular markers of hypertension in the aorta of spontaneously
hypertensive rats.
Clinical and experimental oncology:
Breast cancer : prognostic factors; Thyroid tumour: latency, cell-C hyperplasy; Non-Hodgkin lymphoma:
prognosis factors; Bladder cancer: prognosis factors.
Studies on new prognostic and diagnostic markers of tumour progression and therapeutic success:
Expression and activity of new caretaker genes involved in the maintenance of genomic stability and
DNA repair.
In vitro and in vivo studies in primary and metastatic colorectal cancer:
-New prognostic and predictive factors for colon carcinoma, clinical and molecular studies: new markers
of aggressiveness of the tumors in situ and in serum.
Role of Clusterin and its nuclear isoform as mediator of anti-tumoral effects of chemotherapics.
- Role of miRNA in the colon carcinoma progression
-New metabolic target validation involved in tumor progression
Capacità e competenze
personali
Madrelingua(e)
Italiano
Altra(e) lingua(e)
Comprensione
Autovalutazione
Livello europeo (*)
Inglese
Ascolto
Lettura
Parlato
Interazione orale
Produzione orale
B1 Utente autonomo C1 Utente avanzato B1 Utente autonomo B1 Utente autonomo C1 Utente avanzato
(*) Quadro comune europeo di riferimento per le lingue
Ulteriori informazioni Total IF = 530
HF = 27
Scritto
© Unione europea, 2002-2010 24082010
IMPEGNO DIDATTICO-FORMATIVO
NELL’AMBITO DEL DOTTORATO
Il Prof. Spagnoli dal 1999 al 2011 è stato Coordinatore del Dottorato di Ricerca in Tecnologie
avanzate in biomedicina” e dal 2011 ad oggi del Dottorato in Biotecnologie Applicate e
Medicina traslazionale
In tale ambito ha svolto attività di tutor durante l’attività sperimentale e la preparazione della tesi di
tutti i dottorandi,
Ha svolto inoltre le seguenti attività seminariali, nell’ultimo anno accademico e/o precedenti:
1) V Corso Teorico-Pratico in Anatomia Patologica, aa 2003-04
2) VI Corso Teorico-Pratico in Anatomia Patologica aa 2004-05
3) VII Corso Teorico-Pratico in Anatomia Patologica, aa 2005-06
4) VIII Corso Teorico-Pratico in Anatomia Patologica, aa 2006-07
5) IX Corso Teorico-Pratico in Anatomia Patologica, aa 2007-08
6) X Corso Teorico-Pratico in Anatomia Patologica, aa 2008-09
7) XI Corso Teorico-Pratico in Anatomia Patologica, aa 2009-10
8) XXI Riunione Scientifica biennale della Associazione per la Patologia Cardiovascolare Italiana,
aa 2010-11
9) Vari seminari sulla patologia cardiovascolare
10) Vari seminari sulla organizzazione e gestione delle biobanche
© Unione europea, 2002-2010 24082010
RECENTI PUBBLICAZIONI
1
Formosa, A., Lena, A. M., Markert, E. K., Cortelli, S., Miano, R., Mauriello, A., Croce, N.,
Vandesompele, J., Mestdagh, P., Finazzi-Agro, E., Levine, A. J., Melino, G., Bernardini, S. and
Candi, E., DNA methylation silences miR-132 in prostate cancer, Oncogene, 2012.
2
Tarantino, U., Ferlosio, A., Arcuri, G., Spagnoli, L. G. and Orlandi, A., Transglutaminase 2 as
a biomarker of osteoarthritis: an update, Amino Acids, 2011.
3
Mauriello, A., Servadei, F., Sangiorgi, G., Anemona, L., Giacobbi, E., Liotti, D. and Spagnoli,
L. G., Asymptomatic carotid plaque rupture with unexpected thrombosis over a non-canonical
vulnerable lesion, Atherosclerosis, 2011, 218: 356-362.
4
Di Stefani, A., Gabellini, M., Ferlosio, A., Spagnoli, L. G., Chimenti, S. and Orlandi, A.,
Cerebriform plantar hyperplasia: the clinico-pathological hallmark of Proteus syndrome, Acta Derm
Venereol, 2011, 91: 580-581.
5
Lombardo, C., Bottero, S., d'Alessandro, F., Giacomini, M., Guderzo, A., Moretti, F.,
Marincola, M., Pesce, G., Pierotti, M. A., Spagnoli, L. G. and Belardelli, F., TRAIN: Training through
Research Application Italian iNitiative, Int J Biol Markers, 2011, 26: 136-138.
6
Sancesario, G., Palmieri, G., Viola, G., Fontana, C., Perfetti, A., Anemona, L., Floris, R.,
Marziali, S., Bernardi, G. and Spagnoli, L. G., Difficulty diagnosing chronic cryptococcal meningitis
in idiopathic CD4+ lymphocytopenia, Neurol Sci, 2011, 32: 519-524.
7
Viticchie, G., Lena, A. M., Latina, A., Formosa, A., Gregersen, L. H., Lund, A. H., Bernardini,
S., Mauriello, A., Miano, R., Spagnoli, L. G., Knight, R. A., Candi, E. and Melino, G., MiR-203
controls proliferation, migration and invasive potential of prostate cancer cell lines, Cell Cycle,
2011, 10: 1121-1131.
8
Orlandi, A., Ferlosio, A., Roselli, M., Chiariello, L. and Spagnoli, L. G., Cardiac sarcomas: an
update, J Thorac Oncol, 2010, 5: 1483-1489.
9
Stasi, M. A., Scioli, M. G., Arcuri, G., Mattera, G. G., Lombardo, K., Marcellini, M., Riccioni,
T., De Falco, S., Pisano, C., Spagnoli, L. G., Borsini, F. and Orlandi, A., Propionyl-L-carnitine
improves postischemic blood flow recovery and arteriogenetic revascularization and reduces
endothelial NADPH-oxidase 4-mediated superoxide production, Arterioscler Thromb Vasc Biol,
2010, 30: 426-435.
10 Pucci, S., Mazzarelli, P., Nucci, C., Ricci, F. and Spagnoli, L. G., CLU "in and out": looking for
a link, Adv Cancer Res, 2009, 105: 93-113.
11 Mazzarelli, P., Pucci, S. and Spagnoli, L. G., CLU and colon cancer. The dual face of CLU:
from normal to malignant phenotype, Adv Cancer Res, 2009, 105: 45-61.
12 Orlandi, A., Ferlosio, A., Arcuri, G., Scioli, M. G., De Falco, S. and Spagnoli, L. G., Flt-1
expression influences apoptotic susceptibility of vascular smooth muscle cells through the NFkappaB/IAP-1 pathway, Cardiovasc Res, 2010, 85: 214-223.
13 Mauriello, A., Sangiorgi, G. M., Virmani, R., Trimarchi, S., Holmes, D. R., Jr., Kolodgie, F. D.,
Piepgras, D. G., Piperno, G., Liotti, D., Narula, J., Righini, P., Ippoliti, A. and Spagnoli, L. G., A
pathobiologic link between risk factors profile and morphological markers of carotid instability,
Atherosclerosis, 2010, 208: 572-580.
14 Pucci, S., Bonanno, E., Sesti, F., Mazzarelli, P., Mauriello, A., Ricci, F., Zoccai, G. B., Rulli,
F., Galata, G. and Spagnoli, L. G., Clusterin in stool: a new biomarker for colon cancer screening?,
Am J Gastroenterol, 2009, 104: 2807-2815.
© Unione europea, 2002-2010 24082010
15 D'Angelo, E., Spagnoli, L. G. and Prat, J., Comparative clinicopathologic and
immunohistochemical analysis of uterine sarcomas diagnosed using the World Health Organization
classification system, Hum Pathol, 2009, 40: 1571-1585.
16 Giannoni, M. F., Vicenzini, E., Citone, M., Ricciardi, M. C., Irace, L., Laurito, A., Scucchi, L.
F., Di Piero, V., Gossetti, B., Mauriello, A., Spagnoli, L. G., Lenzi, G. L. and Valentini, F. B.,
Contrast carotid ultrasound for the detection of unstable plaques with neoangiogenesis: a pilot
study, Eur J Vasc Endovasc Surg, 2009, 37: 722-727.
17 Orlandi, A., Hao, H., Ferlosio, A., Clement, S., Hirota, S., Spagnoli, L. G., Gabbiani, G. and
Chaponnier, C., Alpha actin isoforms expression in human and rat adult cardiac conduction
system, Differentiation, 2009, 77: 360-368.
18 Cervelli, V., Gentile, P., Scioli, M. G., Grimaldi, M., Casciani, C. U., Spagnoli, L. G. and
Orlandi, A., Application of platelet-rich plasma in plastic surgery: clinical and in vitro evaluation,
Tissue Eng Part C Methods, 2009, 15: 625-634.
19 Pucci, S., Mazzarelli, P., Sesti, F., Boothman, D. A. and Spagnoli, L. G., Interleukin-6 affects
cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer
progression, Cell Cycle, 2009, 8: 473-481.
20 Orlandi, A., Costantini, S., Campione, E., Ferlosio, A., Amantea, A., Bianchi, L., Chimenti, S.
and Spagnoli, L. G., Relation between animal-type melanoma and reduced nuclear expression of
glutathione S-transferase pi, Arch Dermatol, 2009, 145: 55-62.
21 Mercatelli, N., Coppola, V., Bonci, D., Miele, F., Costantini, A., Guadagnoli, M., Bonanno, E.,
Muto, G., Frajese, G. V., De Maria, R., Spagnoli, L. G., Farace, M. G. and Ciafre, S. A., The
inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma
xenografts in mice, PLoS One, 2008, 3: e4029.
22 Orlandi, A., Di Lascio, A., Francesconi, A., Scioli, M. G., Arcuri, G., Ferlosio, A. and Spagnoli,
L. G., Stem cell marker expression and proliferation and apoptosis of vascular smooth muscle
cells, Cell Cycle, 2008, 7: 3889-3897.
23 Fabiano, S., Mancino, S., Stefanini, M., Chiocchi, M., Mauriello, A., Spagnoli, L. G. and
Simonetti, G., High-resolution multicontrast-weighted MR imaging from human carotid
endarterectomy specimens to assess carotid plaque components, Eur Radiol, 2008, 18: 29122921.
24 Ronci, M., Bonanno, E., Colantoni, A., Pieroni, L., Di Ilio, C., Spagnoli, L. G., Federici, G. and
Urbani, A., Protein unlocking procedures of formalin-fixed paraffin-embedded tissues: application to
MALDI-TOF imaging MS investigations, Proteomics, 2008, 8: 3702-3714.
25 Coli, S., Magnoni, M., Sangiorgi, G., Marrocco-Trischitta, M. M., Melisurgo, G., Mauriello, A.,
Spagnoli, L., Chiesa, R., Cianflone, D. and Maseri, A., Contrast-enhanced ultrasound imaging of
intraplaque neovascularization in carotid arteries: correlation with histology and plaque
echogenicity, J Am Coll Cardiol, 2008, 52: 223-230.
26 Orlandi, A., Oliva, F., Taurisano, G., Candi, E., Di Lascio, A., Melino, G., Spagnoli, L. G. and
Tarantino, U., Transglutaminase-2 differently regulates cartilage destruction and osteophyte
formation in a surgical model of osteoarthritis, Amino Acids, 2009, 36: 755-763.
27 Lombardo, C., Albanese, D., Belardelli, F., d'Alessandro, F., Giacomini, M., Rondanina, T.
and Spagnoli, L. G., Training and mobility: a priority for the Organisation of the European Cancer
Institutes. How a national mobility initiative could enhance EU cooperation in cancer research
contributing to the development of an European Research Area: the example of The Italian
Comprehensive Cancer Centers' Network "Alleanza Contro il Cancro", Tumori, 2008, 94: 147-153.
© Unione europea, 2002-2010 24082010
28 Zuena, A. R., Mairesse, J., Casolini, P., Cinque, C., Alema, G. S., Morley-Fletcher, S., Chiodi,
V., Spagnoli, L. G., Gradini, R., Catalani, A., Nicoletti, F. and Maccari, S., Prenatal restraint stress
generates two distinct behavioral and neurochemical profiles in male and female rats, PLoS One,
2008, 3: e2170.
29 Castellano, I., Sapino, A., Arisio, R., Viale, G., Bussolati, G., Bandelloni, R., Barresi, G.,
Bersiga, A., Bordi, C., Botti, G., Cosimi, F., D'Amore, E., Doglioni, C., Marchetti, A., Nappi, O.,
Romeo, F., Roncalli, M., Russo, R., Santinelli, A., Spagnoli, L. G., Tanda, F., Tricomi, P., Trentini,
G., Zanconati, F. and Iurlaro, M., Fluorescent in situ hybridization as a screening test for HER2
amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases, Oncol
Rep, 2008, 19: 1271-1275.
30 Trapasso, F., Pichiorri, F., Gaspari, M., Palumbo, T., Aqeilan, R. I., Gaudio, E., Okumura, H.,
Iuliano, R., Di Leva, G., Fabbri, M., Birk, D. E., Raso, C., Green-Church, K., Spagnoli, L. G.,
Venuta, S., Huebner, K. and Croce, C. M., Fhit interaction with ferredoxin reductase triggers
generation of reactive oxygen species and apoptosis of cancer cells, J Biol Chem, 2008, 283:
13736-13744.
31 Mazzarelli, P., Pucci, S., Bonanno, E., Sesti, F., Calvani, M. and Spagnoli, L. G., Carnitine
palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation?, Cancer Biol
Ther, 2007, 6: 1606-1613.
32 Bonanno, E., Rulli, F., Galata, G., Pucci, S., Sesti, F., Farinon, A. M. and Spagnoli, L. G.,
Stool test for colorectal cancer screening: what is going on?, Surg Oncol, 2007, 16 Suppl 1: S4345.
33 Spagnoli, L. G., Bonanno, E., Sangiorgi, G. and Mauriello, A., Role of inflammation in
atherosclerosis, J Nucl Med, 2007, 48: 1800-1815.
34 Orlandi, A., Francesconi, A., Ferlosio, A., Di Lascio, A., Marcellini, M., Pisano, C. and
Spagnoli, L. G., Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit, J
Cardiovasc Pharmacol, 2007, 50: 168-175.
35 Orlandi, A., Ferlosio, A., Pellegrino, A. and Spagnoli, L. G., Right atrial hemangioma:
clinicopathological considerations of a case, Interact Cardiovasc Thorac Surg, 2003, 2: 38-39.
36 Orlandi, A., Francesconi, A., Angeloni, C., Palmieri, G., Fulvia, G., Ciotti, M., Criscuolo, A.,
Sesti, F. and Spagnoli, L. G., Prevalence and genotyping of human papillomavirus infection in
women with vulvodynia, Acta Obstet Gynecol Scand, 2007, 86: 1003-1010.
37 Ricci, F., Pucci, S., Sesti, F., Missiroli, F., Cerulli, L. and Spagnoli, L. G., Modulation of
Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photooxidative cell damage, Ophthalmic Res, 2007, 39: 164-173.
38 Spagnoli, L. G., Pucci, S., Bonanno, E., Cassone, A., Sesti, F., Ciervo, A. and Mauriello, A.,
Persistent Chlamydia pneumoniae infection of cardiomyocytes is correlated with fatal myocardial
infarction, Am J Pathol, 2007, 170: 33-42.
39 Orlandi, A., Francesconi, A., Marcellini, M., Di Lascio, A. and Spagnoli, L. G., Propionyl-Lcarnitine reduces proliferation and potentiates Bax-related apoptosis of aortic intimal smooth
muscle cells by modulating nuclear factor-kappaB activity, J Biol Chem, 2007, 282: 4932-4942.
40 Caruso, R., Pallone, F., Fina, D., Gioia, V., Peluso, I., Caprioli, F., Stolfi, C., Perfetti, A.,
Spagnoli, L. G., Palmieri, G., Macdonald, T. T. and Monteleone, G., Protease-activated receptor-2
activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and
proliferation, Am J Pathol, 2006, 169: 268-278.
41 Sangiorgi, G., Mauriello, A., Bonanno, E., Oxvig, C., Conover, C. A., Christiansen, M.,
Trimarchi, S., Rampoldi, V., Holmes, D. R., Jr., Schwartz, R. S. and Spagnoli, L. G., PregnancyPagina 7 / 11 - Curriculum vitae di
© Unione europea, 2002-2010 24082010
associated plasma protein-a is markedly expressed by monocyte-macrophage cells in vulnerable
and ruptured carotid atherosclerotic plaques: a link between inflammation and cerebrovascular
events, J Am Coll Cardiol, 2006, 47: 2201-2211.
42 Candi, E., Rufini, A., Terrinoni, A., Dinsdale, D., Ranalli, M., Paradisi, A., De Laurenzi, V.,
Spagnoli, L. G., Catani, M. V., Ramadan, S., Knight, R. A. and Melino, G., Differential roles of p63
isoforms in epidermal development: selective genetic complementation in p63 null mice, Cell Death
Differ, 2006, 13: 1037-1047.
43 Orlandi, A., Ferlosio, A., Ciucci, A., Francesconi, A., Lifschitz-Mercer, B., Gabbiani, G.,
Spagnoli, L. G. and Czernobilsky, B., Cellular retinol binding protein-1 expression in endometrial
hyperplasia and carcinoma: diagnostic and possible therapeutic implications, Mod Pathol, 2006,
19: 797-803.
44 Orlandi, A., Ciucci, A., Ferlosio, A., Genta, R., Spagnoli, L. G. and Gabbiani, G., Cardiac
myxoma cells exhibit embryonic endocardial stem cell features, J Pathol, 2006, 209: 231-239.
45 Orlandi, A., Bochaton-Piallat, M. L., Gabbiani, G. and Spagnoli, L. G., Aging, smooth muscle
cells and vascular pathobiology: implications for atherosclerosis, Atherosclerosis, 2006, 188: 221230.
46 Spagnoli, L. G. and Venturini, C., [Human tissue banks: objectives and regulatory aspects in
Italy and Europe], Pathologica, 2005, 97: 192-193.
47 Orlandi, A., Ferlosio, A., Gabbiani, G., Spagnoli, L. G. and Ehrlich, P. H., Phenotypic
heterogeneity influences the behavior of rat aortic smooth muscle cells in collagen lattice, Exp Cell
Res, 2005, 311: 317-327.
48 Annovazzi, A., Bonanno, E., Arca, M., D'Alessandria, C., Marcoccia, A., Spagnoli, L. G., Violi,
F., Scopinaro, F., De Toma, G. and Signore, A., 99mTc-interleukin-2 scintigraphy for the in vivo
imaging of vulnerable atherosclerotic plaques, Eur J Nucl Med Mol Imaging, 2006, 33: 117-126.
49 Orlandi, A., Ciucci, A., Ferlosio, A., Pellegrino, A., Chiariello, L. and Spagnoli, L. G.,
Increased expression and activity of matrix metalloproteinases characterize embolic cardiac
myxomas, Am J Pathol, 2005, 166: 1619-1628.
50 Mauriello, A., Sangiorgi, G., Fratoni, S., Palmieri, G., Bonanno, E., Anemona, L., Schwartz, R.
S. and Spagnoli, L. G., Diffuse and active inflammation occurs in both vulnerable and stable
plaques of the entire coronary tree: a histopathologic study of patients dying of acute myocardial
infarction, J Am Coll Cardiol, 2005, 45: 1585-1593.
51 Garcia-Touchard, A., Henry, T. D., Sangiorgi, G., Spagnoli, L. G., Mauriello, A., Conover, C.
and Schwartz, R. S., Extracellular proteases in atherosclerosis and restenosis, Arterioscler Thromb
Vasc Biol, 2005, 25: 1119-1127.
52 Orlandi, A., Pucci, S., Ciucci, A., Pichiorri, F., Ferlosio, A. and Spagnoli, L. G., Modulation of
clusterin isoforms is associated with all-trans retinoic acid-induced proliferative arrest and
apoptosis of intimal smooth muscle cells, Arterioscler Thromb Vasc Biol, 2005, 25: 348-353.
53 Orlandi, A., Ferlosio, A., Ciucci, A., Pellegrino, A. and Spagnoli, L. G., Unusual cardiac
tumour with perivascular myoid differentiation: a case report, J Clin Pathol, 2004, 57: 1338-1340.
54 Orlandi, A., Francesconi, A., Marcellini, M., Ferlosio, A. and Spagnoli, L. G., Role of ageing
and coronary atherosclerosis in the development of cardiac fibrosis in the rabbit, Cardiovasc Res,
2004, 64: 544-552.
55 Orlandi, A., Ferlosio, A., Ciucci, A., Sesti, F., Lifschitz-Mercer, B., Gabbiani, G., Spagnoli, L.
G. and Czernobilsky, B., Cellular retinol-binding protein-1 expression in endometrial stromal cells:
physiopathological and diagnostic implications, Histopathology, 2004, 45: 511-517.
© Unione europea, 2002-2010 24082010
56 Spagnoli, L. G., Mauriello, A., Sangiorgi, G., Fratoni, S., Bonanno, E., Schwartz, R. S.,
Piepgras, D. G., Pistolese, R., Ippoliti, A. and Holmes, D. R., Jr., Extracranial thrombotically active
carotid plaque as a risk factor for ischemic stroke, JAMA, 2004, 292: 1845-1852.
57 Bianchi, L., Orlandi, A., Campione, E., Angeloni, C., Costanzo, A., Spagnoli, L. G. and
Chimenti, S., Topical treatment of basal cell carcinoma with tazarotene: a clinicopathological study
on a large series of cases, Br J Dermatol, 2004, 151: 148-156.
58 Abbate, A., Bonanno, E., Mauriello, A., Bussani, R., Biondi-Zoccai, G. G., Liuzzo, G., Leone,
A. M., Silvestri, F., Dobrina, A., Baldi, F., Pandolfi, F., Biasucci, L. M., Baldi, A., Spagnoli, L. G. and
Crea, F., Widespread myocardial inflammation and infarct-related artery patency, Circulation, 2004,
110: 46-50.
59 Pucci, S., Bonanno, E., Pichiorri, F., Mazzarelli, P. and Spagnoli, L. G., The expression and
the nuclear activity of the caretaker gene ku86 are modulated by somatostatin, Eur J Histochem,
2004, 48: 103-110.
60 Garg, S. K., Volpe, E., Palmieri, G., Mattei, M., Galati, D., Martino, A., Piccioni, M. S.,
Valente, E., Bonanno, E., De Vito, P., Baldini, P. M., Spagnoli, L. G., Colizzi, V. and Fraziano, M.,
Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo, J Infect Dis, 2004,
189: 2129-2138.
61 Sileri, P., Sica, G., Gentileschi, P., Venza, M., Manzelli, A., Palmieri, G., Spagnoli, L. G.,
Testa, G., Benedetti, E. and Gaspari, A. L., Ischemic preconditioning protects intestine from
prolonged ischemia, Transplant Proc, 2004, 36: 283-285.
62 Contino, G., Amati, F., Pucci, S., Pontieri, E., Pichiorri, F., Novelli, A., Botta, A., Mango, R.,
Nardone, A. M., Sangiuolo, F. C., Citro, G., Spagnoli, L. G. and Novelli, G., Expression analysis of
the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues, Gene, 2004, 328:
69-74.
63 Monteleone, G., Del Vecchio Blanco, G., Palmieri, G., Vavassori, P., Monteleone, I.,
Colantoni, A., Battista, S., Spagnoli, L. G., Romano, M., Borrelli, M., MacDonald, T. T. and Pallone,
F., Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori
infection, Gastroenterology, 2004, 126: 674-682.
64 Pucci, S., Bonanno, E., Pichiorri, F., Angeloni, C. and Spagnoli, L. G., Modulation of different
clusterin isoforms in human colon tumorigenesis, Oncogene, 2004, 23: 2298-2304.
65 Orlandi, A., Fratoni, S., Hermann, I. and Spagnoli, L. G., Symptomatic laryngeal nodular
chondrometaplasia: a clinicopathological study, J Clin Pathol, 2003, 56: 976-977.
66 Carbone, G. L., Mauriello, A., Christiansen, M., Oxvig, C., Spagnoli, L. G., Schwartz, R. S.
and Sangiorgi, G., [Unstable carotid plaque: biochemical and cellular marker of vulnerability], Ital
Heart J Suppl, 2003, 4: 398-406.
67 Orlandi, A., Bianchi, L., Ferlosio, A., Innocenzi, I. and Spagnoli, L. G., The origin of
osteoclast-like giant cells in atypical fibroxanthoma, Histopathology, 2003, 42: 407-410.
68 Suurmeijer, A. J., Clement, S., Francesconi, A., Bocchi, L., Angelini, A., Van Veldhuisen, D.
J., Spagnoli, L. G., Gabbiani, G. and Orlandi, A., Alpha-actin isoform distribution in normal and
failing human heart: a morphological, morphometric, and biochemical study, J Pathol, 2003, 199:
387-397.
69 Spagnoli, L. G., Bonanno, E., Mauriello, A., Palmieri, G., Partenzi, A., Sangiorgi, G. and Crea,
F., Multicentric inflammation in epicardial coronary arteries of patients dying of acute myocardial
infarction, J Am Coll Cardiol, 2002, 40: 1579-1588.
© Unione europea, 2002-2010 24082010
70 Biancone, L., Palmieri, G., Lombardi, A., Vavassori, P., Monteleone, I., Del Vecchio Blanco,
G., Colantoni, A., Spagnoli, L., Tonelli, F. and Pallone, F., Cytoskeletal proteins and resident flora,
Dig Liver Dis, 2002, 34 Suppl 2: S34-36.
71 Federici, M., Menghini, R., Mauriello, A., Hribal, M. L., Ferrelli, F., Lauro, D., Sbraccia, P.,
Spagnoli, L. G., Sesti, G. and Lauro, R., Insulin-dependent activation of endothelial nitric oxide
synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary
endothelial cells, Circulation, 2002, 106: 466-472.
72 Orlandi, A., Francesconi, A., Clement, S., Ropraz, P., Spagnoli, L. G. and Gabbiani, G., High
levels of cellular retinol binding protein-1 expression in leiomyosarcoma: possible implications for
diagnostic evaluation, Virchows Arch, 2002, 441: 31-40.
73 Orlandi, A., Ferlosio, A., Dell'Anna, V., Quitadamo, R., Pellegrino, A. and Spagnoli, L. G.,
Undifferentiated sarcoma of the heart: a rare clinicopathologic presentation, J Thorac Cardiovasc
Surg, 2002, 124: 192-193.
74 Spagnoli, L. G., Mauriello, A., Fratoni, S., Anemona, L. and Bonanno, E., [Risk factors of
transient cerebral ischemic episodes: hyperfibrinogenemia and carotid histopathology], Recenti
Prog Med, 2002, 93: 318-321.
75 Bonanno, E., Tagliafierro, G., Carla, E. C., Montinari, M. R., Pagliara, P., Mascetti, G.,
Spagnoli, L. G. and Dini, L., Synchronized onset of nuclear and cell surface modifications in U937
cells during apoptosis, Eur J Histochem, 2002, 46: 61-74.
76 Biancone, L., Geboes, K., Spagnoli, L. G., Del Vecchio Blanco, G., Monteleone, I., Vavassori,
P., Palmieri, G., Chimenti, S. and Pallone, F., Metastatic Crohn's disease of the forehead, Inflamm
Bowel Dis, 2002, 8: 101-105.
77 Iuliano, L., Micheletta, F., Violi, F. and Spagnoli, L. G., Effect of ramipril and vitamin E on
atherosclerosis, Circulation, 2002, 105: E5-6.
78 Orlandi, A., Marcellini, M., Pesce, D., Calvani, M. and Spagnoli, L. G., Propionyl-L-carnitine
reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating
proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells, Atherosclerosis,
2002, 160: 81-89.
79 Kotlyar, A. A., Vered, Z., Goldberg, I., Chouraqui, P., Nas, D., Fridman, E., Chen-Levy, Z.,
Fytlovich, S., Sangiorgi, G., Spagnoli, L. G., Orlandi, A., Savion, N., Eldar, M. and Scheinowitz, M.,
Insulin-like growth factor I and II preserve myocardial structure in postinfarct swine, Heart, 2001,
86: 693-700.
80 Sangiorgi, G., D'Averio, R., Mauriello, A., Bondio, M., Pontillo, M., Castelvecchio, S.,
Trimarchi, S., Tolva, V., Nano, G., Rampoldi, V., Spagnoli, L. G. and Inglese, L., Plasma levels of
metalloproteinases-3 and -9 as markers of successful abdominal aortic aneurysm exclusion after
endovascular graft treatment, Circulation, 2001, 104: I288-295.
81 Orlandi, A., Francesconi, A., Cocchia, D., Corsini, A. and Spagnoli, L. G., Phenotypic
heterogeneity influences apoptotic susceptibility to retinoic acid and cis-platinum of rat arterial
smooth muscle cells in vitro: Implications for the evolution of experimental intimal thickening,
Arterioscler Thromb Vasc Biol, 2001, 21: 1118-1123.
82 Orlandi, A., Piccione, E., Francesconi, A. and Spagnoli, L. G., Simultaneous vulvar
intraepithelial neoplasia and Paget's disease: report of two cases, Int J Gynecol Cancer, 2001, 11:
224-228.
83 Rajamannan, N. M., Sangiorgi, G., Springett, M., Arnold, K., Mohacsi, T., Spagnoli, L. G.,
Edwards, W. D., Tajik, A. J. and Schwartz, R. S., Experimental hypercholesterolemia induces
apoptosis in the aortic valve, J Heart Valve Dis, 2001, 10: 371-374.
© Unione europea, 2002-2010 24082010
84 Santeusanio, G., Ventura, L., Mauriello, A., Carosi, M., Spagnoli, L. G., Maturo, P.,
Terranova, L. and Romanini, C., Isolated ovarian metastasis from a spindle cell malignant
melanoma of the choroid 14 years after enucleation: prognostic implication of the keratin
immunophenotype, Appl Immunohistochem Mol Morphol, 2000, 8: 329-333.
85 Santeusanio, G., Mauriello, A., Ventura, L., Liberati, F., Colantoni, A., Lasorella, R. and
Spagnoli, L. G., Immunohistochemical analysis of estrogen receptors in breast carcinomas using
monoclonal antibodies that recognize different domains of the receptor molecule, Appl
Immunohistochem Mol Morphol, 2000, 8: 275-284.
86 Orlandi, A., Marcellini, M. and Spagnoli, L. G., Aging influences development and progression
of early aortic atherosclerotic lesions in cholesterol-fed rabbits, Arterioscler Thromb Vasc Biol,
2000, 20: 1123-1136.
87 Iuliano, L., Mauriello, A., Sbarigia, E., Spagnoli, L. G. and Violi, F., Radiolabeled native lowdensity lipoprotein injected into patients with carotid stenosis accumulates in macrophages of
atherosclerotic plaque : effect of vitamin E supplementation, Circulation, 2000, 101: 1249-1254.
88 Signore, A., Chianelli, M., Annovazzi, A., Bonanno, E., Spagnoli, L. G., Pozzilli, P., Pallone,
F. and Biancone, L., 123I-interleukin-2 scintigraphy for in vivo assessment of intestinal
mononuclear cell infiltration in Crohn's disease, J Nucl Med, 2000, 41: 242-249.
89 Mauriello, A., Sangiorgi, G., Palmieri, G., Virmani, R., Holmes, D. R., Jr., Schwartz, R. S.,
Pistolese, R., Ippoliti, A. and Spagnoli, L. G., Hyperfibrinogenemia is associated with specific
histocytological composition and complications of atherosclerotic carotid plaques in patients
affected by transient ischemic attacks, Circulation, 2000, 101: 744-750.
90 Bonanno, E., Mauriello, A., Partenzi, A., Anemona, L. and Spagnoli, L. G., Flow cytometry
analysis of atherosclerotic plaque cells from human carotids: a validation study, Cytometry, 2000,
39: 158-165.
© Unione europea, 2002-2010 24082010

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