CV May 2012
Transcript
CV May 2012
Curriculum Vitae Chryssostomos CHATGILIALOGLU Biographical Sketch Chryssostomos Chatgilialoglu (born 1952) is director of research at the Consiglio Nazionale delle Ricerche (Bologna) since 1991. He was the winner of the Fluka Prize “Reagent of the Year 1990”. His research interests lie in free radical reactions increasingly addressed in the last decade to applications in biomimetic chemistry and biomarkers discovery. Author and editor of several books, including the 4 volumes of Encyclopedia of Radicals in Chemistry, Biology and Materials published by Wiley in 2012. Author and co-author of over 240 papers, and invited speaker over 200 times at congresses and institutions. Supervisor of international PhDs (>15) and post-doctorals (>30), including three Marie Curie IntraEuropean Fellowships and two Marie Curie Research Training Networks. He was the Chairman of COST Action CM0603 on Free Radicals in Chemical Biology (2007-2011) and the Proposer of the new COST Action on Biomimetic Radical Chemistry (20122016). He is President and co-founder of the spin-off company Lipinutragen. Contents Page Short Curriculum Vitae 3 Research Activity 6 Research Quality 11 Reagent of the Year 1990 12 Publications in Journals 13 Publications in Books 46 Publications in Magazines and Online Resources 51 Publications as Meeting Abstract 53 Editorial Activities for Scientific Journals 55 Books 56 Patents 58 Conference and Visiting Activity 59 Invited Lectures at Congresses and Meetings 60 Invited Lectures at Institutions 72 Visiting Scientist at Foreign Istitutions 85 Managerial activity 87 International Appointments 91 Consulting Activity 95 2 Short Curriculum Vitae Surname: Chatgilialoglu First name: Chryssostomos Date and place of birth: Citizenship: Nikea (Greece), 11-11-1952 Greek and Italian Affiliation and official address: ISOF - Consiglio Nazionale delle Ricerche (CNR), Via Piero Gobetti 101, 40129 Bologna, Italy phone: +39-0516398309 fax.: +39-0516398349 e-mail: [email protected] http://www.isof.cnr.it/biofreeradicals/Home.html Education Laurea in Chimica Industriale (1976), University of Bologna Career/Employment (employers, position, and dates) University of York (UK) Postdoctor National Research Council of Canada (Ottawa) Research Associate 1977-1979 1979-1982 Consiglio Nazionale delle Ricerche (Bologna) Professore Visitatore 1983-1985 Consiglio Nazionale delle Ricerche (Bologna) Ricercatore 1985-1991 Consiglio Nazionale delle Ricerche (Bologna) Dirigente di Ricerca 1991- Specialties, Activities Research: - Free radical chemistry - Chemical biology - Radiation studies of biomolecular systems - Omics of cell radical stress and related biomarkers - Molecular design based on radical reactivity and biomimetic models Management: - Leader of BioFreeRadicals Group at ISOF, CNR - Responsible of European and International projects - President and co-founder of the spin-off company Lipinutragen srl 3 Honours, Fellowships, Awards - S.R.C. Postdoctoral Fellowship 1977 – 1979 - Visiting Scientist (National Research Council of Canada, summer 1986) - Director of NATO Advanced Study Institute on Sulfur-Centered Reactive Intermediates in Chemistry and Biology (June 1989) - Visiting Scientist (University of Basel, February – July 1990) - Fluka prize (Reagent of the Year 1990) - NATO senior Fellowship (1991) - Director of NATO Advanced Study Institute on Chemical Synthesis: Gnosis to Prognosis (May 1994) - Wilsmore Fellow (University of Melbourne, Australia, November 1999 – January 2000). - Visiting Professor at Universitè Pierre et Marie Curie, France (April 2000) - Guest Editor of Helvetica Chimica Acta (October 2006) - Chair of COST Action CM0603: Free Radical in Chemical Biology (June 2007 – June 2011) - Visiting Professor at Ludwig-Maximilians-Universität München, Germany (March, May and June 2008) - Guest Editor of CHIMIA (September 2008) - Visiting Professor at Universitè Pierre et Marie Curie, France (June 2009) - The Cheves Walling Lecture 2009 - Chairman of the EUCHEM Conference on “Organic Free Radicals”, Bologna, 28 June - 2 July 2010 - Member of Editorial Board of Journal of Glycomics and Lipidomics since 2011. - Co-Editor of the Encyclopedia of Radicals in Chemistry, Biology and Materials (4 volumes, 73 chapters, 2300 pages), 2012 John Wiley & Sons, Ltd. - Proposer of COST Action CM01203: Biomimetic Radical Chemistry (Sept 2012 – Sept 2016) 4 Publications - Number of papers: 240 (212 in refereed Journals + 32 chapters in Books) - Books: 6 (2 as author and 4 edited) - Patents: 6 - Citations: > 6300 (h-index = 38) Conferences and Seminars - Invited speaker at congresses: 90 - Invited speaker at institutions: 114 5 Research Activity The research activity of Dr. Chatgilialoglu concerns the theme of free radical chemistry, embracing the structure-reactivity relationship of free radicals and their various applications in synthetic methodologies, material science, and life sciences. The thus acquired wide competence on free radical chemistry has been achieved and developed by an interdisciplinary approach, using the fundamental knowledge of organic and physical chemistry as basis for an extension into the fields of synthetic, bioorganic and biological chemistry. The scientific activity is presented here below in a chronological order from 1977 to date, and pertains to the following fields: - Physical Organic Chemistry; - Synthetic Methodologies; - Polymeric Materials; - Biomimetic Chemistry for Technological Applications. Physical Organic Chemistry The studies in physical organic chemistry were predominant in the first ten years. During this period Dr. Chatgilialoglu worked as post-doctoral fellow at the University of York (England) in the group of Prof. R. O. C. Norman. Immediately after he served as Research Associate for three years at the National Research Council of Canada (Ottawa) with Prof. K. U. Ingold. The numerous publications of this period deal with studies of organic and organometallic free radicals using laser flash photolysis and electron paramagnetic resonance techniques, assisted by other analytical techniques, such as mass spectrometry and nuclear magnetic resonance, and combined with theoretical and synthetic models. The knowledge of kinetic methodologies and time-resolved spectroscopies constituted a solid background for the expansion of his scientific activity. In particular, the following subjects have been studied: (i) Structural properties and reactivity of sulfur-centered and nitrogen-centered reactive species. (ii) Group 14 atom-centered radicals (Si, Ge, Sn). Within this topic the most relevant result was the determination of absolute rate constants and Arrhenius 6 parameters for the reaction of alkyl radicals with Group 14 metal hydrides by means of laser flash photolysis. These data allowed, in particular, to examine the reactivity of tributyltin hydride, that is a radical-based reagent largely employed in organic chemistry, and to put the basis for the proposal of silicon hydrides as an important class of reducing agents. (iii) Implementation of techniques for the acquisition of kinetic data (e.g., radical clock methodology). The reactivity of several alkyl and aryl carbon-centered radical species has been studied in the presence of hydrogen atom donors, such as silicon or germanium hydrides and thiols. The radical cyclization reaction has also been studied and applied in radical cascade synthetic strategies starting from alkyl and acyl radicals. (iv) Chemical radiation studies in the last decade of the research activity using gamma-irradiation and pulse radiolysis, for the individuation of fundamental chemical mechanisms, such as the tautomerization of one-electron oxidation of DNA bases, selective generation of radical centers on DNA sugar moieties and free radical reactivity of lipids and proteins. Free radical chemistry has become an important tool for organic synthesis, and its success is mostly due to the basic work concerning free radical reactivity. In this respect, the contribution given by Dr. Chatgilialoglu to fundamental discoveries and knowledge in free radical chemistry is widely recognized in the scientific community at international level. Synthetic Methodologies Starting from the late nineteen-eighties, studies in synthetic methodologies have been carried out, focusing in particular on two subjects: radical-based reducing agents and innovative radical-based synthetic strategies. The studies on Group 14 hydride reactivity carried out in the previous years highlighted a variety of triorganosilanes as interesting reducing agents in a free radical mechanism. In fact, one of them, namely, tris(trimethylsilyl)silane was introduced as a very versatile compound for carrying out several types of radical reactions, from functional group reduction to deoxygenation, carbon-carbon bond formation, cyclization, etc. This was an important discovery in a period when the reagent of choice for radical 7 reduction was tributyltin hydride, which in the environment and particularly in humans exhibits a strong toxicity. The regio-, chemo- and stereoselectivities of this reagent were thoroughly investigated. For his achievements in this field Dr. Chatgilialoglu received the prestigious Fluka prize “Reagent of the Year 1990” (see page 11). More than 1000 publications in chemical research deal with the use of this reagent from groups all over the world. In the following years the class of organosilanes has been investigated systematically, combining kinetic studies with synthetic applications, so that a complete overview of the characteristics and applicability of the different silanes is now available. Today, Dr. Chatgilialoglu is considered one of the most expert scientists in radical reactivity of organosilanes. He is author of reviews on this subject, which appeared in the most prestigious international scientific journals. He is also author of the book “Organosilanes in Radical Chemistry” published by Wiley in 2004. The scientific activity of the last 15-years was focused to synthetic strategies for efficient, selective and environmental-friendly processes. During these studies, radical chemistry has been successfully coupled with ionic processes. Elegant and efficient syntheses have been realized for the preparation of molecular libraries of modified nucleosides, lipids and proteins, which attract strong academic and industrial interests, applicable to diverse fields, from biology and pharmacology to bio- and nanotechnology. In the area of the macromolecule reactivity, the interest has been focused on free radical mechanisms involving DNA and lipids. These macromolecules have received attention from researchers from different fields, due to their peculiar molecular and supramolecular characteristics that allow applications in biology and biotechnology fields to be envisaged. In particular, Dr. Chatgilialoglu was the first to study the mechanism of ribonolactone moiety and the formation of purine cyclonucleosides, which have been further implemented in the area of biomimetic radical chemistry for technological applications. The radical-based approach also involved phospholipids with the discovery of thiyl radical catalyzed isomerization of unsaturated fatty acids. This reaction has been applied to supramolecular organized systems such as liposomes, which have been then implemented for biomimetic chemistry. The cis-trans isomerization has been thoroughly studied in various conditions, establishing the effects of various factors (oxygen, antioxidants, solvents) on the outcome. It is important to note that this conversion changes deeply the properties of the lipid molecules, therefore, it becomes an important tool for bio- and nano-technological applications. For example, in case of triglycerides, 8 the isomerization can be useful to change the physical properties of oils, thus affording new materials for various applications. The experience in nucleoside and lipid chemistry led to the development of synthetic processes in an aqueous environment. This is an ongoing project in Dr. Chatgilialoglu’s group and it includes the “on water” methodology, where the effect of heterogeneous systems coupled with the supramolecular organization of substrates can play an important role for enhancing some selectivity features. The use of tris(trimethylsilyl)silane as reagent in water was developed in this context. Polymeric Materials A further interdisciplinary research deals with polymeric materials, in particular with the modification of commercially available polymers involving radical chemistry. This is a field of enormous industrial interest, and Dr. Chatgilialoglu has been consultant for important companies due to his well-known reputation as free radical expert. In collaboration with the EniChem Company (Milan, Italy) the process of radical carbonylation of 1,4-cis-polybutadiene was studied, and realized under mild conditions of low temperature and moderate pressure. The formation and reactivity of an important radical intermediate and the crucial species for the reaction mechanism, namely, the acyl radical, was studied in detail. Since the polymer characteristics are driven by the cyclization modes occurring in the material, the cyclization was also studied with several appropriately synthesized monomeric models. Dr. Chatgilialoglu was also consultant for six years of Ciba Geigy Ltd (Basel, Switzerland) for organosilane chemistry. The research carried out on the oxidative behavior of poly(hydrosilanes) highlighted the antioxidant activity of these chemicals and the use as process stabilizers in the polyolefin extrusion, that has been world-patented. Biomimetic Chemistry for Technological Applications In the last decade the scientific activity has been increasingly addressed to the field of radical processes under biomimetic conditions, as an extension of the previously described synthetic and mechanistic studies on biomolecules. With a solid background on physical organic chemistry and free radical reactivity, Dr. Chatgilialoglu has effectively 9 contributed to the development of free radicals for nano- and bio-technological applications, evaluating the effects of biomolecules such as DNA, proteins and lipids, having specific supramolecular structures in aqueous systems. In particular, his approach is to design biomimetic models which allow for a systematic study of all possible factors influencing the reactivity of these macro- and supra-molecular systems, including analytical protocols and complete characterization of reaction or transformation products. The reactivity, as well as the library of products derived from the models, are an important basis for starting bio- and nano-technological applications. An immediate application of these achievements can be done in life sciences, due to the biological impact of DNA and lipid molecules being involved in the free radical stress of biosystems. Here we mention two processes which are promising for technological development: the electron excess transfer in double stranded DNA and telomeric Gquadruplex, and the liposome cis-trans isomerization. It is also important to evidence the connection of these studies with the implementation of a strong analytical platform, made by molecular libraries and protocols for the separation and characterization of a large variety of new biomolecular structures including their properties. These libraries can have an enormous impact for a chemical biology approach in the fields of proteomics, genomics and lipidomics, where the knowledge of radical reactions and mechanisms can contribute to the understanding of still unknown molecular bases for bio- and nano-technological applications. 10 Research Quality The quality of the research activity represents a strong commitment in the carrier of Dr. Chatgilialoglu, either in the optimization of the research results to gain a firm leadership in chemical sciences and in the choice of high impact subjects for attracting interest from the scientific community. As a representative example Figure 1 shows that 84 publications out of 212 (40%) have been published in journals of the American Chemical Society, which are well known for the accurate selection of the best subjects and the severe peer review process. In particular, the four review articles published in Accounts of Chemical Research and Chemical Reviews testify the international recognition given to his research; the high number of papers appeared in the Journal of the American Chemical Society represents an indirect measure of the interest of a general chemical audience to the research subjects. The graphic also shows the wide range of chemical publications in specialized areas going from physical chemistry to organic chemistry and chemical biology. Figure 1. 84 Pubblications in ACS journals 30 25 20 15 10 5 0 It is worth underlining the many scientific international collaborations of Dr. Chatgilialoglu. He developed an expertise on free radical chemistry able to communicate with a large variety of scientists. This experience has also allowed him to gather scientists in free radical research, becoming an important reference person for this community, as testified by the chairmanship of two COST Actions and the editing of the Encyclopedia on Free Radicals in Chemistry, Biology and Materials published in 2012 by Wiley. 11 12 Publications in Journals Year 2012 (first five months) 205) Recent applications of the (TMS)3SiH radical-based reagent Chatgilialoglu, C.; Lalevée, J. Molecules 2012, 17, 527–555. 206) Revisiting the reaction of hydroxyl radicals with vicinal diols in water Jiang, D.; Barata-Vallejo, S.; Golding, B. T.; Ferreri, C.; Chatgilialoglu, C. Org. Biomol. Chem. 2012, 10, 1102–1107. 207) Rat liver mitochondrial membrane characteristics and mitochondrial functions are more profoundly altered by dietary lipid quantity than by dietary lipid quality: effect of different nutritional lipid patterns Aoun, M; Feillet-Coudray, C.; Fouret, G.; Chabi, B. Crouzier, D.; Ferreri, C.; Chatgilialoglu, C.; Cabello, C.; Cristol, J. P.; Carbonneau, M.-A.; Coudray, C. Br. J. Nutr. 2012, 107, 647–659. 208) Trans fatty acids: chemical synthesis of eicosapentaenoic acid isomers and detection in rats fed a deodorized fish oil diet Ferreri, C.; Grabovskiy, S.; Aoun, M.; Melchiorre, M.; Kabal’nova, N.; FeilletCoudray, C.; Fouret, G.; Coudray, C.; Chatgilialoglu, C. Chem. Res. Toxicol. 2012, 25, 687–694. 209) Biomimetic Models of Radical Stress and Related Biomarkers Chatgilialoglu, C.; Ferreri, C.; Masi, A.; Melchiorre, M.; Sansone, A.; Terzidis, M. A.; Torreggiani, A. Chimia 2012, 66, 368–371. 210) Investigation of reactions postulated to occur during inhibition of ribonucleotide reductases by 2'-azido-2'-deoxynucleotides Dang, T. P.; Sobczak, A. J.; Mebel A.; Chatgilialoglu, C.; Wnuk, S. F. 13 Tetrahedron 2012, 68, in press (doi:101016/j.tet.2012.04.050) 211) trans Arachidonic acid isomers inhibits NADPH-oxidase activity by direct interaction with enzyme components Souabni, H.; Thoma, V.; Bizouarn, T.; Chatgilialoglu, C.; Siafaka-Kapadai, A.; Baciou, L.; Ferreri, C.; Houée-Lévin, C.; Ostuni, M.A. Biochim. Biophys. Acta - Biomembr. 2012, 1818, in press (doi: 101016/j.bbamem.2012.04.018) 212) The role of functional lipidomics and the development of molecular diagnostic tools Chatgilialoglu, C.; Ferreri, C. Expert Rev. Mol. Diagn. 2012, 12, in press. Year 2011 195) Investigation of excess electron transfer in DNA double-duplex systems allows estimation of absolute excess electron transfer and CPD cleavage rates Fazio, D.; Trindler, C.; Heil, K.; Chatgilialoglu, C.; Carell, T. Chem. Eur. J. 2011, 17, 206–212. 196) Human serum albumin modifications associated with reducing radical stress Salzano, A. M.; Renzone, G.; Scaloni, A.; Torreggiani, A.; Ferreri, C.; Chatgilialoglu, C. Mol. BioSyst. 2011, 7, 889–898. 197) Purine 5’,8-cyclonucleoside lesions: chemistry and biology Chatgilialoglu, C.; Ferreri, C.; Terzidis, M. A. Chem. Soc. Rev. 2011, 40, 1368–1382. 198) Radical-based alkylation of guanine derivatives in aqueous medium Chatgilialoglu, C.; Caminal, C.; Mulazzani, Q. G. Org. Biomol. Chem. 2011, 9, 3494–3498. 14 199) Linoleic acid peroxidation vs cis–trans isomerization: a biomimetic model of free radical reactivity in the presence of thiols Mihaljević, B.; Tartaro, I.; Ferreri, C.; Chatgilialoglu, C. Org. Biomol. Chem. 2011, 9, 3541–3548. 200) Combined Raman and IR spectroscopic studies on the radical-based modifications of methionine Torreggiani, A.; Barata-Vallejo, S.; Chatgilialoglu, C. Anal. Bioanal. Chem. 2011, 401, 1231–1239. 201) Lipid markers of geometrical radical stress: synthesis of mono-trans cholesteryl esters isomers and detection in human plasma Melchiorre, M.; Torreggiani, A.; Chatgilialoglu, C.; Ferreri, C. J. Am. Chem. Soc. 2011, 133, 15184–15190. 202) Radiation-induced reductive modifications of sulfur-containing amino acids within peptides and proteins Chatgilialoglu, C.; Ferreri, C.; Torreggiani, A.; Renzone, G.; Salzano, A. M.; Scaloni, A. J. Proteomics 2011, 74, 2264–2273. 203) Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion Cohen, G.; Riahi, Y.; Shamni, O.; Guichardant, M.; Chatgilialoglu, C.; Ferreri, C.; Kaiser, N.; Sasson, S. Diabetes 2011, 60, 2830–2842. 204) New insights into the reaction paths of hydroxyl radicals with 2’-deoxyguanosine Chatgilialoglu, C.; D’Angelantonio, M.; Kciuk, G.; Bobrowski, K. Chem. Res. Toxicol. 2011, 24, 2200–2206. Year 2010 15 190) One-electron-reduction of 8-bromoisoguanosine and 8-bromoxanthosine in the aqueous phase: sequential versus concerted proton-coupled electron routes Chatgilialoglu, C.; D’Angelantonio, M.; Kaloudis, P.; Mulazzani, Q. G.; Guerra, M. J. Phys. Chem. Lett. 2010, 1, 174–177. 191) Radiation chemical studies of methionine in aqueous solution: understanding the role of molecular oxygen Barata-Vallejo, S.; Ferreri, C.; Postigo, A.; Chatgilialoglu, C. Chem. Res. Toxicol. 2010, 23, 258–263. 192) Separation of cis/trans geometrical fatty acid isomers by silver-exchanged zeolite Y Lykakis, I. N.; Ferreri, C.; Grabovskiy, S. A.; Chatgilialoglu, C. Tetrahedron 2010, 66, 2203–2209. 193) Radiation-induced formation of purine 5',8-cyclonucleosides in isolated and cellular DNA: high stereospecificity and modulating effect of oxygen Belmadoui, N.; Boussicault, F.; Guerra, M.; Ravanat, J. L.; Chatgilialoglu, C.; Cadet, J. Org. Biomol. Chem. 2010, 8, 3211–3219. 194) Base-promoted reaction of 5-hydroxyuracil derivatives with peroxyl radicals Amorati, R.; Valgimigli, L.; Pedulli, G. F.; Grabovskiy, S. A.; Kabal’nova, N. N.; Chatgilialoglu, C. Org. Lett. 2010, 12, 4130–4133. Year 2009 184) Reaction of hydrated electrons with guanine derivatives: tautomerism of intermediate species D’Angelantonio, M.; Russo, M.; Kaloudis, P.; Mulazzani, Q. G.; Wardman, P.; Guerra, M.; Chatgilialoglu, C. J. Phys. Chem. B 2009, 113, 2170–2176. 16 185) A reevaluation of the ambident reactivity of guanine moiety towards hydroxyl radicals Chatgilialoglu, C.; D’Angelantonio, M.; Guerra, M.; Kaloudis, P.; Mulazzani, Q. G. Angew. Chem. Int. Ed. 2009, 48, 2214–2217. 186) Rate constants and transition state geometry of reactions of alkyl, alkoxyl and peroxyl radicals with thiols Denisov, E. T.; Chatgilialoglu, C.; Shestakov, A. F.; Denisova, T. G. Int. J. Chem. Kinet. 2009, 41, 284–293. 187) Hydrosilylation reactions of C-C multiple bonds using (Me3Si)3SiH in water. Comparative study of the radical initiation step Postigo, A.; Kopsov, S.; Zlotsky, S. S.; Ferreri, C.; Chatgilialoglu, C. Organometallics 2009, 28, 3282–3287. 188) Zinc and cadmium complexes of a plant metallothionein under radical stress: desulfurisation reactions associated with the formation of trans lipids in model membranes Torreggiani, A.; Domènech J.; Ferreri, C.; Orihuela, R.; Atrian, S.; Capdevila, M.; Chatgilialoglu, C. Chem. Eur. J. 2009, 15, 6015–6024. 189) Comparison of isoelectronic 8-HO-G and 8-NH2-G derivatives in redox processes Kaloudis, P.; D’Angelantonio, M.; Guerra, M.; Spadafora, M.; Cismas, C.; Gimisis, T.; Mulazzani, Q. G.; Chatgilialoglu, C. J. Am. Chem. Soc. 2009, 131, 15895–15902. Year 2008 171) Fatty acids profile of erythrocyte membranes as possible biomarker of longevity Puca, A. A.; Andrew, P.; Novelli, V.; Viviani, C.; Somalvico, F.; Cirillo, N. A.; Chatgilialoglu, C.; Ferreri, C. Rejuv. Res. 2008, 11, 63–72. 17 172) Solar one-way photoisomerisation of 5’,8-cyclo-2’-deoxyadenosine Jimenez, L. B.; Encinas, S.; Chatgilialoglu, C.; Miranda, M. A. Org. Biomol. Chem. 2008, 6, 1083–1086. 173) (Me3Si)3SiH: Twenty years after its discovery as a radical-based reducing agent Chatgilialoglu, C. Chem. Eur. J. 2008, 14, 2310–2320. 174) Lipid metabolism and diet: Possible mechanisms of slow aging Puca, A.; Chatgilialoglu, C.; Ferreri, C. Int. J. Biochem. Cell B. 2008, 40, 324–333. 175) One-electron reduction of 8-bromo-2-aminoadenosine in the aqueous phase: Radiation chemical and DFT studies of the mechanism Kaloudis, P.; D’Angelantonio, M.; Guerra, M.; Gimisis, T.; Mulazzani, Q. G.; Chatgilialoglu, C. J. Phys. Chem. B 2008, 112, 5209–5217. 176) The reductive desulfurization of Met and Cys residues in bovine RNAse A associated with the trans lipid formation in a mimetic model of biological membranes Ferreri, C.; Chatgilialoglu, C.; Torreggiani, A.; Salzano, A. M.; Renzone, G.; Scaloni, A. J. Proteome Res. 2008, 7, 2007–2015. 177) The Fate of C5’ Radicals of Purine Nucleosides Under Oxidative Conditions Boussicault, F.; Kaloudis, P.; Caminal, C.; Mulazzani, Q. G.; Chatgilialoglu, C. J. Am. Chem. Soc. 2008, 130, 8377–8385. 178) Synthesis of all-trans anandamide: A substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation 18 Ferreri, C.; Anagnostopoulos, D.; Lykakis, I. N.; Chatgilialoglu, C.; SiafakaKapadai, A. Bioorg. Med. Chem. 2008, 16, 8359–8365. 179) Silyl radicals in chemical synthesis Chatgilialoglu, C.; Timokhin, V. I. Adv. Organomet. Chem. 2008, 57, 117–181. 180) Biologically Relevant Small Radicals Bauer, G.; Chatgilialoglu, C.; Gebicki, J. L.; Gebicka, L.; Gescheidt, G.; Golding, B. T.; Goldstein, S.; Kaizer, J.; Merenyi, G.; Speier, G.; Wardman, P. Chimia 2008, 62, 704–712. 181) Lipidomics and Free Radical Modifications of Lipids Chatgilialoglu, C.; Ferreri, C.; Hermetter, A.; Lacote, E.; Mihaljević, B.; Nicolaides, A.; Siafaka –Kapadai, A. Chimia 2008, 62, 713–720. 182) Biomimetic chemistry on tandem protein/lipid damages under reductive radical stress Atrian, S.; Bobrowski, K.; Capdevila, M.; Chatgilialoglu, C.; Ferreri, C.; HouéeLevin, C.; Salzano, A. M.; Scaloni, A.; Torreggiani, A. Chimia 2008, 62, 721–727. 183) DNA damage and radical reactions: mechanistic aspects, formation in cells and repair studies Cadet, J. Carell, T.; Cellai, L.; Chatgilialoglu, C.; Gimisis, T.; Miranda, M.; O'Neill, P.; Ravanat, J.-L.; Robert, M. Chimia 2008, 62, 742–749. Year 2007 162) Reaction of Hydrogen Atom with Met-Enkephalin and Related Peptides 19 Mozziconacci, O.; Bobrowski, K.; Ferreri, C.; Chatgilialoglu, C. Chem. Eur. J. 2007, 13, 2029–2033. 163) Sulfhydryl Radical (HS•/S•–): A Contender for the Isomerization of Double Bonds in Membrane Lipids Lykakis, I. N.; Ferreri, C.; Chatgilialoglu, C. Angew. Chem. Int. Ed. 2007, 46, 1914–1916. 164) Independent Generation of C-5’ Nucleosidyl Radicals in Thymidine and 2’Deoxyguanosine Manetto, A.; Georganakis, D.; Gimisis, T.; Leondiadis, L.; Mayer, P.; Carell, T.; Chatgilialoglu, C. J. Org. Chem. 2007, 72, 3659–3666. 165) One-Electron Reduction of Methanesulfonyl Chloride. The Fate of (MeSO2Cl)•– and MeSO2• Intermediates in Oxygenated Solutions and Their Role in the cis-trans Isomerization of Monounsaturated Fatty Acids Tamba, M.; Dajka, K.; Ferreri, C.; Asmus, K.-D.; Chatgilialoglu, C. J. Am. Chem. Soc. 2007, 129, 8716–8723. 166) Radical Carbonylation with [11C]Carbon Monoxide Promoted by Oxygen-Centered Radicals: Experimental and DFT Studies of the Mechanism Itsenko, O.; Norberg, D.; Rasmussen, T; Långström, B.; Chatgilialoglu, C. J. Am. Chem. Soc. 2007, 129, 9020–9031. 167) Trans Fatty Acids in Membranes: The Free Radical Path Ferreri, C.; Panagiotaki, M.; Chatgilialoglu, C. Mol. Biotechnol. 2007, 37, 19–25. 168) Ring-Opening of the Cyclobutane in Thymine Dimer Radical Anion Chatgilialoglu, C.; Guerra, M.; Kaloudis, P.; Houée-Lévin, C.; Marignier, J.-L.; Swaminathan, V. N.; Carell, T. Chem. Eur. J. 2007, 13, 8979–8984. 20 169) Radical Reactions in Aqueous Medium Using (Me3Si)3SiH Postigo, A.; Kopsov, S.; Ferreri, C.; Chatgilialoglu, C. Org. Lett. 2007, 9, 5159–5162. 170) (5’S)- and (5’R)-5’,8-Cyclo-2’-deoxyguanosine: Mechanistic Insights on the 2'Deoxyguanosin-5'-yl radical Cyclization Chatgilialoglu, C.; Bazzanini, R.; Jimenez, L. B.; Miranda, M. A. Chem. Res. Toxicol. 2007, 20, 1820–1824. Year 2006 148) Investigation of Radical-Based Damage of RNase A in Aqueous Solutions and Lipid Vesicles Torreggiani, A.; Tamba, M.; Manco, I.; Faraone-Mennella, M. R.; Ferreri, C.; Chatgilialoglu, C. Biopolymers 2006, 81, 39–50. 149) Complex Sequence Dependence by Excess Electron Transfer Through DNA with Different Strength Electron Acceptors Manetto, A.; Breeger, S.; Chatgilialoglu, C.; Carell, T. Angew. Chem. Int. Ed. 2006, 44, 318–321. 150) A Facile One-Pot Synthesis of 8-Oxo-7,8-dehydro-(2’-deoxy)adenosine in Water Chatgilialoglu, C.; Navacchia, M. L.; Postigo, A. Tetrahedron Lett. 2006, 47, 711–714. 151) Probing the Influence of cis-trans Isomers on Model Lipid Membrane Fluidity Using cis-Parinaric Acid and a Stop-Flow Technique Ferreri, C.; Pierotti, S.; Chatgilialoglu, C.; Barbieri, A.; Barigelletti, F. Chem. Commun. 2006, 529–531. 21 152) Comparison of Phosphatidylcholine Vesicle Properties Related to Geometrical Isomerism Ferreri, C.; Pierotti, S.; Barbieri, A.; Zambonin, L.; Landi, L.; Rasi, S.; Luisi, P. L.; Barigelletti, F.; Chatgilialoglu, C. Photochem. Photobiol. 2006, 82, 274–280. 153) Reductive Modification of Methionine Residue in Amyloid–β Peptide Kadlcik, V.; Sicard-Roselli, C.; Houée-Levin, C.; Kodicek, M.; Ferreri, C.; Chatgilialoglu, C. Angew. Chem. Int. Ed. 2006, 45, 2595–2598. 154) Occurrence of Trans Fatty Acids in Rats Fed a Trans-Free Diet: A Free RadicalMediated Formation? Zambonin, L.; Ferreri, C.; Cabrini, L.; Prata, C.; Chatgilialoglu, C.; Landi, L. Free Radical Biol. Med. 2006, 40, 1549–1556. 155) C5’-Adenosinyl Radical Cyclization. A Stereochemical Investigation Navacchia M. L.; Chatgilialoglu, C.; Montevecchi, P. C. J. Org. Chem. 2006, 71, 4445–4452. 156) Trans Fatty Acids and Radical Stress: What Are the Real Culprits? Chatgilialoglu, C.; Ferreri, C.; Lykakis, I. N.; Wardman, P. Bioorg. Med. Chem. 2006, 14, 6144–6148. 157) Chemical Radiation Studies of 8-Bromo-2’-deoxyinosine and 8-Bromoinosine in Aqueous Solutions Russo, M.; Jimenez, L. B.; Mulazzani, Q. G.; D’Angelantonio, M.; Guerra, M.; Miranda, M. A.; Chatgilialoglu, C. Chem. Eur. J. 2006, 12, 7684–7693. 158) Tautomerism in the Guanyl Radicals Chatgilialoglu, C.; Caminal C.; Altieri, A.; Vougioukalakis, G. C.; Mulazzani, Q. G.; Gimisis, T.; Guerra, M.; 22 J. Am. Chem. Soc. 2006, 128, 13796–13805. 159) Epoxidation of Polyunsaturated Fatty Acid Double Bonds by Dioxirane Reagent: Regioselectivity and Lipid Supramolecular Organization Grabovskiy, S. A.; Kabal’nova, N. N.; Chatgilialoglu, C.; Ferreri, C. Helv. Chim. Acta 2006, 89, 2243–2253. 160) The tris(trimethylsilyl)silane/thiol reducing system: A tool for measuring rate constants for reactions of carbon-radicals with thiols Chatgilialoglu, C. Helv. Chim. Acta 2006, 89, 2387–2398. 161) The Reaction of Hydrogen Atoms with Methionine Residues: A Model of Reductive Radical Stress Causing Tandem Protein-Lipid Damage Ferreri, C.; Manco, I.; Faraone-Mennella, M. R.; Torreggiani, A.; Tamba, M.; Manara, S.; Chatgilialoglu, C. ChemBioChem 2006, 7, 1738–1744. Year 2005 135) Reactions of Oxide Radical Ion (O•–) with Pyrimidine Nucleosides Chatgilialoglu, C.; Ioele, M.; Mulazzani, Q. G. Radiat. Phys. Chem. 2005, 72, 251–256. 136) The Kinetics of Z/E Isomerization of Methyl Oleate, Catalyzed by Photogenerated Thiyl Radicals Chatgilialoglu, C.; Samadi, A.; Guerra, M.; Fischer, H. ChemPhysChem 2005, 6, 286–291. 137) The Reaction of Benzothiazole Sulfenamide with (TMS)3SiH: An Example of Degenerated-Branched Chain Process Varlamov, V. T.; Ferreri, C.; Chatgilialoglu, C. J. Organomet. Chem. 2005, 690, 1756–1762. 23 138) Trans Lipids Formation Induced by Thiols in Human Monocytic Leukemia Cells Ferreri, C.; Kratzsch, S.; Brede, O.; Marciniak, B.; Chatgilialoglu, C. Free Radic. Biol. Med. 2005, 38, 1180–1187. 139) Radiation Damage of Lysozyme in a Biomimetic Model: Some Insights by Raman Spectroscopy Torreggiani, A.; Tamba, M.; Manco, I.; Faraone-Mennella, M. R.; Ferreri, C.; Chatgilialoglu, C. J. Mol. Struct. 2005, 744, 767–773. 140) Synthesis of All-trans Isomer of Arachidonic Acid and Its Effect on Rabbit Plateled Aggregation Anagnostopoulos, D.; Ferreri, C.; Samadi, A.; Chatgilialoglu, C.; Siafaka-Kapadai, A. Bioorg. Med. Chem. Lett. 2005, 15, 2766–2770. 141) The Influence of Solid–State Molecular Organization on the Reaction Paths of Thiyl Radicals: EPR Experimental Evidence for Radiation Induced Reactions in Clathrates, Polymer Matrices and Lysozyme Faucitano, A.; Buttafava, A.; Mariani, A.; Chatgilialoglu, C. ChemPhysChem 2005, 6, 1100–1107. 142) Trans Lipids: The Free Radical Path Chatgilialoglu, C.; Ferreri, C. Acc. Chem. Res. 2005, 38, 441–448. 143) Trans Fatty Acid and Atopic Eczema/Dermatitis Syndrome: The Relationship with a Free Radical cis—trans Isomerization of Membrane Lipids Ferreri, C.; Angelini, F.; Chatgilialoglu, C.; Dellonte, S.; Moschese, V.; Rossi, P.; Chini, L. Lipids 2005, 40, 661–667. 24 144) Tautomers of One-Electron Oxidized Guanosine Chatgilialoglu, C.; Caminal C.; Guerra, M.; Mulazzani, Q. G. Angew. Chem. Int. Ed. 2005, 44, 6030–6032. 145) Geometrical Trans Lipid Isomers: A New Target for Lipidomics Ferreri, C.; Chatgilialoglu, C. ChemBioChem 2005, 6, 1722–1734. 146) Radical Cyclization Approach to Cyclonucleosides Navacchia, M. L.; Manetto, A.; Montevecchi, P. C.; Chatgilialoglu, C. Eur. J. Org. Chem. 2005, 4640–4648. 147) The Radical-Based Reduction with (TMS)3SiH “on Water” Postigo, A.; Ferreri, C.; Navacchia, M. L.; Chatgilialoglu, C. Synlett 2005, 2854–2856. Year 2004 123) Regioselective Cis-Trans Isomerization of Arachidonic Double Bonds by Thiyl Radicals: The Influence of Phospholipid Supramolecular Organization Ferreri, C.; Samadi, A.; Sassatelli, F.; Landi, L.; Chatgilialoglu, C. J. Am. Chem. Soc. 2004, 126, 1063–1072. 124) Selective Generation and Reactivity of 5'-Adenosinyl and 2'-Adenosinyl Radicals Chatgilialoglu, C.; Duca, M.; Ferreri, C.; Guerra, M.; Ioele, M.; Mulazzani, Q. G.; Strittmatter, H.; Giese, B. Chem. Eur. J. 2004, 10, 1249–1255. 125) Thermal Decomposition of tert-Butyl Perester of Thymidine-5’-carboxylic Acid. Formation and Fate of the Pseudo C4’ Radical Montevecchi, P. C.; Manetto, A.; Navacchia, M. L.; Chatgilialoglu, C. Tetrahedron 2004, 60, 4303–4308. 25 126) Furanyl Nucleosides: Synthesis and Kinetics of Their Formation Chatgilialoglu, C.; Vrantza, D.; Gimisis, T. Tetrahedron Lett. 2004, 45, 4515-4517. 127) Liquid-Phase Oxidation of Pentamethyldisilane with Oxygen Timokhin V. I.; Zaborovskii A. B.; Ferreri C.; Chatgilialoglu C. Russ. J. Gen. Chem. 2004, 74, 469–469. 128) Excess Electron Transfer in G-Quadruplex De Champdoré, M.; De Napoli, L.; Montesarchio, D.; Piccialli, G.; Caminal C.; Mulazzani, Q. G.; Navacchia, M. L.; Chatgilialoglu, C. Chem. Commun. 2004, 1756–1757. 129) A Mechanistic Investigation of (Me3Si)3SiH Oxidation Zaborovskiy A. B.; Lutsyk D. S.; Prystansky R. E.; Kopylets V. I.; Timokhin V. I.; Chatgilialoglu C. J. Organomet. Chem. 2004, 689, 2912–2919. 130) Thiyl Radicals-Catalyzed Isomerization of Oils: An Entry to the Trans Lipid Library Samadi, A.; Andreu, I.; Ferreri, C.; Dellonte, S.; Chatgilialoglu, C. J. Am. Oil Chem. Soc. 2004, 81, 753–758. 131) Synthesis and Biological Evaluation of Novel 1'- Branched and Spironucleoside Analogues Chatgilialoglu, C.; Ferreri, C.; Gimisis, T.; Roberti, M.; Balzarini, J.; De Clercq, E. Nucleosides, Nucleotides & Nucleic Acids 2004, 23, 1565–1581. 132) Liquid–Phase Oxidation of tert-Buthyldimethylsilane Lutsik-Maksim, D. S.; Timokhin V. I.; Zaborovskii, A. B.; Prystanskii, R. E.; Turovskii, A.A.; Chatgilialoglu C. Russ. J. Gen. Chem. 2004, 74, 1508–1512. 26 133) The Photochemistry of 8-Bromo-2’-deoxyadenosine. A Direct Entry to Cyclopurine Lesions Jimenez, L. B.; Encinas, S.; Miranda, M. A.; Navacchia, M. L.; Chatgilialoglu, C. Photochem. Photobiol. Sci. 2004, 3, 1042–1046. 134) A Biomimetic Model of Tandem Radical Damage Involving Sulfur-Containing Protein and Unsaturated Lipids Ferreri, C.; Manco, I.; Faraone-Mennella, M. R.; Torreggiani, A.; Tamba, M.; Chatgilialoglu, C. ChemBioChem 2004, 5, 1710–1712. Year 2003 120) Model Studies of DNA C5' Radicals. Selective Generation and Reactivity of 2'Deoxyadenosin-5'-yl Radical Chatgilialoglu, C.; Guerra, M.; Mulazzani, Q. G. J. Am. Chem. Soc. 2003, 125, 3839–3848. 121) Rate Constants for the β-Elimination of Tosyl Radical from a Variety of Substituted Carbon-Centered Radicals Timokhin, V. I.; Gastaldi, S.; Bertrand, M. P.; Chatgilialoglu, C. J. Org. Chem. 2003, 68, 3532–3537. 122) Kinetics of Liquid–Phase Oxidation of Poly(phenylsilane) Zaborovskiy A. B.; Timokhin V. I.; Chatgilialoglu C. Polym. Sci. Ser. A 2003, 45, 612–616. Year 2002 115) Kinetic and Product Studies of the Reaction of Triorganosilanes with Dimethyldioxirane Grabovskii, S. A.; Kabal’nova, N. N.; Shereshovets, V. V.; Chatgilialoglu, C. Organometallics 2002, 21, 3506–3510. 27 116) 5-Endo-trig Radical Cyclizations: Disfavored or Favored Processes? Chatgilialoglu, C.; Ferreri, C.; Guerra, M.; Timokhin, V.; Froudakis, G.; Gimisis, T. J. Am. Chem. Soc. 2002, 124, 10765–10772. 117) The Kinetics of Thiyl Radical Induced Reactions of Monounsaturated Fatty Acid Esters Chatgilialoglu, C.; Altieri, A.; Fischer, H. J. Am. Chem. Soc. 2002, 124, 12816–12823. 118) Arachidonate Geometrical Isomers Generated by Thiyl Radicals: The Relationship with Trans Lipids detected in Biological Samples Ferreri, C.; Faraone Mennella, M. R.; Formisano, C.; Landi, L.; Chatgilialoglu, C. Free Radic. Biol. Med. 2002, 33, 1516–1526. 119) Geometrical Isomerism of Monounsaturated Fatty Acids: Thiyl Radical Catalysis and Influence of Antioxidant Vitamins Chatgilialoglu, C.; Zambonin, L.; Altieri, A.; Ferreri, C.; Mulazzani, Q. G.; Landi, L.; Free Radic. Biol. Med. 2002, 33, 1681–1692. Year 2001 112) Cis–Trans Isomerization of Polyunsaturated Fatty Acid Residues in Phospholipids Catalyzed by Thiyl Radicals Ferreri, C.; Costantino, C.; Perrotta, L.; Landi, L.; Mulazzani, Q. G.; Chatgilialoglu, C. J. Am. Chem. Soc. 2001, 123, 4459–4468. 113) Free Radicals Associated with DNA Damage Chatgilialoglu, C.; O’Neill, P. Exp. Gerontol. 2001, 36, 1459–1471. 28 114) Reactivity of Tris(trimethylsilyl)silane Towards Diarylaminyl Radicals Varlamov, V. T.; Denisov, E. T.; Chatgilialoglu, C. J. Org. Chem. 2001, 66, 6317–6322. Year 2000 106) Rate Constants for the Reaction of Cumylperoxyl Radicals with Group 14 Hydrides Chatgilialoglu, C.; Timokhin, V. I.; Zaborovskiy, A. B.; Lutsyk, D. S.; Prystansky, R. E. J. Chem. Soc. Perkin Trans 2 2000, 577–581. 107) Radiation Chemical Studies of 8-Bromoguanosine in Aqueous Solution Ioele, M.; Bazzanini, R.; Chatgilialoglu, C.; Mulazzani, Q. G. J. Am. Chem. Soc. 2000, 122, 1900–1907. 108) Fate of the 2’-Deoxyadenosin-5’-yl Radical under Anaerobic Conditions Flyunt, R.; Bazzanini, R.; Chatgilialoglu, C.; Mulazzani, Q. G. J. Am. Chem. Soc. 2000, 122, 4225–4226. 109) cis–trans Isomerization of Monounsaturated Fatty Acid Residues in Phospholipids by Thiyl Radicals Chatgilialoglu, C.; Ferreri, C.; Ballestri, M.; Mulazzani, Q. G.; Landi, L. J. Am. Chem. Soc. 2000, 122, 4593–4601. 110) Model of DNA C1’ Radicals. Structural, Spectral and Chemical Properties of the Thyminylmethyl Radical and the 2’-Deoxyuridin-1’-yl Radical Chatgilialoglu, C.; Ferreri, C.; Bazzanini, R.; Guerra, M.; Choi, S-Y.; Emanuel, C. J.; Horner, J. H.; Newcomb,.M. J. Am. Chem. Soc. 2000, 122, 9525–9533. 111) Radical-Based Reduction of Phosphine Sulfides and Phosphine Selenides by (Me3Si)3SiH Romeo, R.; Wozniak, L. A.; Chatgilialoglu, C. 29 Tetrahedron Lett. 2000, 41, 9899–9902. Year 1999 94) The PdCl2/R3SiH System for the Silylation of Nucleosides Ferreri, C.; Costantino, C.; Romeo, R.; Chatgilialoglu, C. Tetrahedron Lett. 1999, 40, 1197–1200. 95) Rate Constants for the Reaction of Cumylperoxyl Radicals with Bu3SnH and (TMS)3SiH Chatgilialoglu, C.; Timokhin, V. I.; Zaborovskiy, A. B.; Lutsyk, D. S.; Prystansky, R. E. Chem. Commun. 1999, 405–406. 96) The Thiyl Radical-Mediated Isomerization of cis-Monounsaturated Fatty Acid Residues in Phospholipids: A Novel Path of Membrane Damage? Ferreri, C.; Costantino, C.; Landi, L.; Mulazzani, Q. G.; Chatgilialoglu, C. Chem. Commun. 1999, 407–408. 97) Anionically Induced Formation of Anomeric Spironucleosides from 1’-C-Cyano-2’deoxyuridine Chatgilialoglu, C.; Ferreri, C.; Gimisis, T. Tetrahedron Lett. 1999, 40, 2837–2840. 98) Kinetics of 2’-Deoxyuridin-1’-yl Radical Reactions Emanuel, C. J.; Newcomb, M.; Ferreri, C.; Chatgilialoglu, C. J. Am. Chem. Soc. 1999, 121, 2927–2928. 99) Hydrogen Donor Abilities of the Germanium Hydrides Chatgilialoglu, C.; Ballestri, M.; Escudié, J.; Pailhous, I. Organometallics 1999, 18, 2395–2397. 100) Mechanistic and Synthetic Aspects of the C-1’ Radicals in Modified Nucleosides 30 Chatgilialoglu, C. Nucleosides Nucleotides 1999, 18, 547–553. 101) Ex-novo and Revisum Procedures for the Preparation of C-1’ Branched Nucleosides Chatgilialoglu, C.; Costantino, C.; Ferreri, C.; Gimisis, T.; Romagnoli, A.; Romeo, R. Nucleosides Nucleotides 1999, 18, 637–639. 102) C-1’ Radicals in Nucleosides Chatgilialoglu, C. Il Farmaco 1999, 54, 321–325. 103) Chemistry of Acyl Radicals Chatgilialoglu, C.; Crich, D.; Komatsu, M.; Ryu, I. Chem. Rev. 1999, 99, 1991–2069. 104) Hydrogen Donor Abilities of the Group 14 Hydrides Chatgilialoglu, C.; Newcomb, M. Adv. Organomet. Chem. 1999, 44, 67–112. 105) C-1’ Radical-Based Approaches for the Synthesis of Anomeric Spironucleosides Chatgilialoglu, C.; Gimisis, T. Spada, G. P. Chem. Eur. J. 1999, 5, 2866–2876. Year 1998 85) Generation of C-1' Radicals Through a β-(Acyloxy)alkyl Rearrangement in Modified Purines and Pyrimidine Nucleosides Gimisis, T.; Ialongo, G; Chatgilialoglu, C. Tetrahedron 1998, 54, 573–592. 86) One-Carbon Ring Expansion in Cyclopentanones as a Free-Radical Clock Chatgilialoglu, C.; Timokhin, V. I.; Ballestri, M. 31 J. Org. Chem. 1998, 63, 1327–1329. 87) Homolytic reactivity of Group 14 Organometallic Hydrides Towards Nitroxides Lucarini, M.; Marchesi, E.; Pedulli, G.F.; Chatgilialoglu, C. J. Org. Chem. 1998, 63, 1687–1693. 88) The Versatile Behavior of the PdCl2/Et3SiH System. Conversion of Alcohols to the Corresponding Halides and Alkanes Ferreri, C.; Costantino, C.; Chatgilialoglu, C.; Boukherroub, R.; Manuel. G. J. Organomet. Chem. 1998, 554, 135–137. 89) Autoxidation of Poly(hydrosilane)s Chatgilialoglu, C.; Guerrini, A.; Lucarini, M.; Pedulli, G. F.; Carrozza, P.; DaRoit, G.; Borzatta, V.; Lucchini, V. Organometallics 1998, 17, 2169–2176. 90) Spectra and Structure of the 2'-Deoxyuridin-1'-yl Radical Chatgilialoglu, C.; Gimisis, T.; Guerra, M.; Ferreri, C.; Emanuel, C. J.; Horner, J. H.; Newcomb, M.; Lucarini, M.; Pedulli, G.F. Tetrahedron Lett. 1998, 39, 3947–3950. 91) Fate of the C-1’ Peroxyl Radical in the 2’-Deoxyuridine System Chatgilialoglu, C.; Gimisis, T. Chem. Commun. 1998, 1249–1250. 92) Reactions of Oxide Radical Ion (•O–) with Pyrimidine and Purine Derivatives Ioele, M.; Chatgilialoglu, C.; Mulazzani, G. J. Phys. Chem. A 1998, 102, 6259–6265. 93) Catalytic Ferrier Rearrangement of Unsaturated Nucleosides Linker, T.; Sommermann, T.; Gimisis, T.; Chatgilialoglu, C. Tetrahedron Lett. 1998, 39, 9637–9638. 32 Year 1997 81) 5-exo-trig versus 6-endo-trig Cyclization of Alk-5-enoyl Radicals. The Role of OneCarbon Ring Expansion Chatgilialoglu, C.; Ferreri, C.; Lucarini, M.; Venturini, A.; Zavitsas, A. A. Chem. Eur. J. 1997, 3, 376–387. 82) A New Class of Anomeric Spironucleosides Gimisis, T.; Castellari, C.; Chatgilialoglu, C. Chem. Commun. 1997, 2089–2090. 83) Addition of Tris(trimethylsilyl)germyl Radicals to Unsaturated Compounds. An EPR and Product Study Bernardoni, S.; Lucarini, M.; Pedulli, G. F.; Valgimigli, L.; Gevorgyan, V.; Chatgilialoglu, C. J. Org. Chem. 1997, 62, 8009–8014. 84) Free Radical Chemistry Associated with H(RSiH)nH Chatgilialoglu, C.; Ferreri, C.; Vecchi, D.; Lucarini, M.; Pedulli, G. F. J. Organomet. Chem. 1997, 546, 475–481. Year 1996 75) PdCl2-Catalyzed Reduction of Organic Halides by Triethylsilane Boukherroub, R.; Chatgilialoglu, C.; Manuel. G. Organometallics 1996, 15, 1580–1510. 76) 1,5-Radical Translocation Protocol for the Generation of C-1’ Radicals in Nucleosides. Synthesis of Spiro Nucleosides through a Rare 5-endo-trig Cyclization Gimisis, T.; Chatgilialoglu, C. J. Org. Chem. 1996, 61, 1908–1909. 77) Free Radical Carbonylation of 1,4-cis-Polybutadiene 33 Chatgilialoglu, C.; Ferreri, C.; Sommazzi, A. J. Am. Chem. Soc. 1996, 118, 7223–7224. 78) Synthesis of 2-Functionalized Allyl Tris(trimethylsilyl)silanes Chatgilialoglu, C.; Ballestri, M.; Vecchi, D.; Curran, D. P. Tetrahedron Lett. 1996, 35, 6383–6386. 79) 2-Functionalized Allyl Tris(trimethylsilyl)silanes as Radical-Based Allylating Agents Chatgilialoglu, C.; Ferreri, C.; Ballestri, M.; Curran, D. P. Tetrahedron Lett. 1996, 35, 6387–6390. 80) Tris(trimethylsilyl)silane as Mediator in the Radical-Based Allylation Reactions of Allyl and 2-Functionalized Allyl Phenyl Sulfones Chatgilialoglu, C.; Alberti, A.; Ballestri, M.; Macciantelli, D.; Curran, D. P. Tetrahedron Lett. 1996, 35, 6391–6394. Year 1995 66) Rate Constant for the Reaction of Acyl Radicals with Bu3SnH and (TMS)3SiH Chatgilialoglu, C.; Lucarini, M. Tetrahedron Lett. 1995, 36, 1299–1302. 67) 5,10-Dihydro-Silanthrene as a Reagent for the Barton-McCombie Reaction Gimisis, T.; Ballestri, M.; Ferreri, C.; Chatgilialoglu, C.; Boukherroub, R.; Manuel, G. Tetrahedron Lett. 1995, 36, 3897–3900. 68) Rate Constants and Arrhenius Parameters for the Reaction of Acyl Radicals with Bu3SnH and (Me3Si)3SiH Chatgilialoglu, C.; Ferreri, C.; Lucarini, M.; Pedrielli, P.; Pedulli, G. F. Organometallics 1995, 14, 2672–2676. 34 69) (Z)–(E) Interconversion of Olefins by the Addition–Elimination Sequence of the (TMS)3Si• Radical Chatgilialoglu, C.; Ballestri, M.; Ferreri, C.; Vecchi, D. J. Org. Chem. 1995, 60, 3826–3831. 70) Structural and Chemical Properties of Silyl Radicals Chatgilialoglu, C. Chem. Rev. 1995, 95, 1229–1251. 71) Radical Transformations of Nucleosides with (Me3Si)3SiH. Generation of a C-1’ Radical through 1,2-Migration of an Acyloxy Group Gimisis, T.; Ialongo, G.; Zamboni, M.; Chatgilialoglu, C. Tetrahedron Lett. 1995, 36, 6781–6784. 72) A Facile Entry to Secondary Cyclopropylcarbinols: Further Developments in the Stereospecific Synthesis of (E)-Homoallylic Bromides Ferreri, C.; Ambrosone, M.; Chatgilialoglu, C. Synth. Commun. 1995, 25, 3351–3356. 73) Tris(trimethylsilyl)germane as a Radical-Based Reducing Agent Chatgilialoglu, C.; Ballestri, M. Organometallics 1995, 14, 5017–5018. 74) Energies of Activation. The Paradigm of Hydrogen Abstractions by Radicals Zavitsas, A. A.; Chatgilialoglu, C. J. Am. Chem. Soc. 1995, 117, 10645–10654. Year 1994 65) Sulfur-Chlorine Bond Dissociation Enthalpies in Methane- and Benzene-sulfonyl Chlorides Chatgilialoglu, C.; Griller, D.; Kanabus-Kaminska, J. M.; Lossing, F. P. J. Chem. Soc., Perkin Trans. 2 1994, 357–360. 35 Year 1993 61) A Comment on the Use of Triethylsilane as a Radical-Based Reducing Agent Chatgilialoglu, C.; Ferreri, C.; Lucarini, M. J. Org. Chem. 1993, 58, 249–251. 62) Organosilanes as Radical-Based Reducing Agents with Low Hydrogen Donating Abilities Ballestri, M.; Chatgilialoglu, C.; Guerra, M.; Guerrini, A.; Lucarini, M.; Seconi, G. J. Chem. Soc., Perkin Trans. 2 1993, 421–425. 63) An Unexpected Stereochemical Control of Alkene Formation by the Choice of Radical Initiator. The Reversible Addition of (Me3Si)3Si• Radicals to Alkenes Ferreri, C.; Ballestri, M.; Chatgilialoglu, C. Tetrahedron Lett. 1993, 34, 5147–5150. 64) Progress of the Barton-McCombie Methodology: From Tin Hydrides to Silanes Chatgilialoglu, C; Ferreri, C. Res. Chem. Intermed. 1993, 19, 755–775. Year 1992 52) Reactions of Tris(trimethylsilyl)silyl Radicals with Nitroalkanes. EPR, Kinetic, and Product Studies Ballestri, M.; Chatgilialoglu, C.; Lucarini, M.; Pedulli, G. F. J. Org. Chem. 1992, 57, 948–952. 53) The Reaction of Tris(trimethylsilyl)silane with Acid Chlorides Ballestri, M.; Chatgilialoglu, C.; Cardi, N.; Sommazzi, A. Tetrahedron Lett. 1992, 33, 1787–1790. 54) Autoxidation of Tris(trimethylsilyl)silane 36 Chatgilialoglu, C.; Guarini, A.; Guerrini, A.; Seconi, G. J. Org. Chem. 1992, 57, 2207–2208. 55) A Study on the Reducing Abilities of Tris(alkylthio)silanes Chatgilialoglu, C.; Guerra, M.; Guerrini, A.; Seconi, G.; Clark, K. B.; Griller, D.; Kanabus-Kaminska, J. M.; Martinho-Simoes, J. A. J. Org. Chem. 1992, 57, 2427–2433. 56) Organosilanes as Radical-Based Reducing Agents in Synthesis Chatgilialoglu, C. Acc. Chem. Res. 1992, 25, 188–194. 57) Homolytic Substitution Reaction at a Silicon Atom Kulicke, K. J.; Chatgilialoglu, C.; Kopping, B.; Giese, B. Helv. Chim. Acta 1992, 75, 935–939. 58) The Me3Si Substituent Effect on the Reactivity of Silanes. Structural Correlations Between Silyl Radicals and Their Parent Silanes. Chatgilialoglu, C.; Guerrini, A.; Lucarini, M. J. Org. Chem. 1992, 57, 3405–3409. 59) (Me3Si)3SiH: An Efficient Hydrosilylating Agent of Alkenes and Alkynes Kopping, B.; Chatgilialoglu, C.; Zehnder, M.; Giese, B. J. Org. Chem. 1992, 57, 3994–4000. 60) Electron Impact Studies of Alkanesulfonyl Chorides. An Investigation of the Sulfur Dioxide Radical Cation Chatgilialoglu, C.; Guerra, M.; Hamdan, M.; Traldi, P.; Int. J. Mass Spectrom. Ion Processes 1992, 116, 115–125. Year 1991 48) Tris(trimethylsilyl)silane as a Radical-Based Reducing Agent in Synthesis 37 Ballestri, M.; Chatgilialoglu, C.; Clark, K.B.; Griller, D.; Giese, B.; Kopping, B. J. Org. Chem. 1991, 56, 678–683. 49) An Approach to the Electronic Properties of Sulfonyl and Sulfinyl Compounds by Means of Sulfur-33 and Oxygen-17 NMR Barbarella, G.; Bongini, A.; Chatgilialoglu, C.; Zambianchi, M. Phosphorus, Sulfur, and Silicon 1991, 58, 491–494. 50) (Me3Si)3SiSH: A New Radical-Based Reducing Agent Ballestri, M.; Chatgilialoglu, C.; Seconi, G. J. Organomet. Chem. 1991, 408, C1–C4. 51) Rate Constants and Arrherius Parameters for the Reaction of Some Carbon-Centered Radicals with Tris(trimethylsilyl)silane Chatgilialoglu, C.; Dickhaut , J.; Giese, B. J. Org. Chem. 1991, 56, 6399–6403. Year 1990 43) Tris(alkylthio)silanes as New Reducing Agents via Radicals Chatgilialoglu, C.; Guerrini, A.; Seconi, G. Synlett 1990, 219–220. 44) MSXα Study of Absorption Spectra of Free Radicals. Characterization of Rydberg and Valence Transitions in Alkyl Derivatives of Group14 Centered Radicals Chatgilialoglu, C.; Guerra, M. J. Am. Chem. Soc. 1990, 112, 2854–2859. 45) Addition of Tris(trimethylsilyl)silyl Radicals to the Carbonyl Group Alberti, A.; Chatgilialoglu, C. Tetrahedron 1990, 46, 3963–3972. 38 46) 33 S and 17O NMR of Compounds Containing the SO2 Moiety. A Generalization of the "Chlorine Effect" Barbarella, G.; Chatgilialoglu, C.; Tugnoli, V. J. Magn. Reson. 1990, 88, 277–283. 47) Alkyl Isocyanides as Precursors for the Formation of Carbon-Carbon Bonds C. Chatgilialoglu, B. Giese and B. Kopping Tetrahedron Lett. 1990, 31, 6013–6016. Year 1989 38) Tris(trimethylsilyl)silane as Mediator in Organic Synthesis via Radicals Giese, B.; Kopping, B.; Chatgilialoglu, C. Tetrahedron Lett. 1989, 30, 681–684. 39) Rate Constants for the Reaction of Tris(trimethylsilyl)silyl Radicals with Organic Halides Chatgilialoglu, C.; Griller, D.; Lesage, M. J. Org. Chem. 1989, 54, 2492–2494. 40) Amino- and Alkoxysulfonyl Radicals Chatgilialoglu, C.; Griller, D.; Rossini, S. J. Org. Chem. 1989, 54, 2734–2737. 41) Sulfonylium Ions in the Gas Phase Chatgilialoglu, C.; Guerra, M.; Pelli, B.; Traldi, P. Org. Mass Spectrom. 1989, 24, 455–460. 42) Tris(trimethylsilyl)silane: A Catalyst for Radical Mediated Reduction Reactions Lesage, M.; Chatgilialoglu, C.; Griller, D.; Tetrahedron Lett. 1989, 30, 2733–2734. Year 1988 39 36) The Substituent Effect on the Reactivity of Silanes Towards tert-Butoxyl Radicals Chatgilialoglu, C.; Rossini, S. Bull. Chim. Soc. Fr. 1988, 298–300. 37) Tris(trimethylsilyl)silane. A New Reducing Agent Chatgilialoglu, C.; Griller, D.; Lesage, M. J. Org. Chem. 1988, 53, 3641–3642. Year 1987 32) Absolute Rate Constants for the Reaction of Triethylsilyl Radicals with RingSubstituted Benzyl Chlorides Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C. J. Org. Chem. 1987, 52, 938–940. 33) Experimental and Theoretical Approaches to the Optical Absorption Spectra of Sulfonyl Radicals Chatgilialoglu, C.; Griller, D.; Guerra, M. J. Phys. Chem. 1987, 91, 3747–3750. 34) Reduction of Silicon–Hydrogen Bond Strengths Kanabus-Kaminska, J. M.; Hawari, J. A.; Griller, D.; Chatgilialoglu, C. J. Am. Chem. Soc. 1987, 109, 5267–5268. 35) Sulfur-33 NMR of Cyclic Sulfides, Sulfoxides and Sulfones Barbarella, G.; Bongini, A.; Chatgilialoglu, C.; Rossini, S.; Tugnoli, V. J. Org. Chem. 1987, 52, 3857–3860. Year 1986 27) Absolute Rate Constants for the Reactions of α-Toluenesulfonyl Chloride with Carbon-Centered Radicals 40 Chatgilialoglu, C. J. Org. Chem. 1986, 51, 2871–2873. 28) An Investigation of Structure and Conformation of Thiophene-2-sulphonyl Radicals Alberti, A.; Chatgilialoglu, C.; Guerra, M. J. Chem. Soc., Perkin Trans. 2 1986, 1179–1182. 29) On the Addition of Silyl Radicals to Unsaturated Carbonyl Compounds: Regioselectivity of the Attack and 1,3 Carbon to Oxygen Silicon Migration Alberti, A.; Chatgilialoglu, C.; Pedulli, G. F.; Zanirato, P. J. Am. Chem. Soc. 1986, 108, 4993–4998. 30) Arrhenius Parameters for the Reaction of tert-Butoxyl Radicals with Triethylsilane Chatgilialoglu, C. Gazz. Chim. Ital. 1986, 116, 511–513. 31) 33 S and 17O NMR of Compounds Containing the SO2 Moiety. The Chlorine Effect Barbarella, G.; Chatgilialoglu, C.; Rossini, S.; Tugnoli, V. J. Magn. Reson. 1986, 70, 204–212. Year 1985 26) Structural and Optical Absorption Spectra of Some Sulfuranyl Radicals in Solution Chatgilialoglu, C.; Castelhano, A. L.; Griller, D. J. Org. Chem. 1985, 50, 2516–2518. Year 1984 24) Conformational Studies by Dynamic Nuclear Magnetic Resonance. Part 26. Interconversion Barriers between syn- and anti- Conformers of Isomeric Thiophenecarbaldehydes Lunazzi, L.; Placucci, G.; Chatgilialoglu, C.; Macciantelli, D. J. Chem. Soc., Perkin Trans. 2 1984, 819–822. 41 25) Absolute Rate Constants for Hydrogen Abstraction from Aldehydes and Conformational Studies of the Corresponding Aromatic Acyl Radicals Chatgilialoglu, C.; Lunazzi, L.; Macciantelli, D.; Placucci, G. J. Am. Chem. Soc. 1984, 106, 5252–5256. Year 1983 18) Intramolecular and Intermolecular Reactions of Alkenylsilyl Radicals Chatgilialoglu, C.; Woynar, H.; Ingold, K. U.; Davies, A. G. J. Chem. Soc., Perkin Trans. 2 1983, 555–561. 19) Absolute Rate Constants for the Addition of Triethylsilyl Radicals to Various Unsaturated Compounds Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C. J. Am. Chem. Soc. 1983, 105, 3292–3296. 20) A Homoallyl Radical Rearrangement. Kinetics of the Isomerization of the 2,2Dimethyl-3-buten-1-yl Radical to the 1,1-Dimethyl-3-buten-1-yl Radical Chatgilialoglu, C.; Ingold, K. U.; Tse-Sheepy, I.; Warkentin, J. Can. J. Chem. 1983, 61, 1077–1081. 21) Formation, Decay, and Spectral Characterization of Some Alkyl- and ArylSubstituted Carbon-, Silicon-, Germanium-, and Tin-Centered Radicals Chatgilialoglu, C.; Ingold, K. U.; Lusztyk, J.; Nazran, A. S.; Scaiano, J. C. Organometallics 1983, 2, 1332–1335. 22) Kinetic Studies on the Formation and Decay of Some Sulfonyl Radicals Chatgilialoglu, C.; Lunazzi, L.; Ingold, K. U. J. Org. Chem. 1983, 48, 3588–3589. 23) Reaction of Bis(trifluoromethyl)aminoxyl with Cyclopropane Anpo, M.; Chatgilialoglu, C.; Ingold, K. U. 42 J. Org. Chem. 1983, 48, 4104–4106. Year 1982 13) Absolute Rate Constants for the Reactions of tert-Butoxyl Radicals and Some Ketone Triplets with Silanes Chatgilialoglu, C.; Scaiano, J. C.; Ingold, K. U. Organometallics 1982, 1, 466–469. 14) Absolute Rate Constants for the Addition of Triethylsilyl Radicals to the Carbonyl Group Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C. J. Am. Chem. Soc. 1982, 104, 5119–5123. 15) Absolute Rate Constants for the Reaction of Triethylsilyl Radicals with Organic Halides Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C. J. Am. Chem. Soc. 1982, 104, 5123–5127. 16) Attempted Spin Trapping of tert-Butylperoxyl Radicals by Trifluoronitrosomethane Chatgilialoglu, C.; Howard, J. A.; Ingold, K. U. J. Org. Chem. 1982, 47, 4361–4362. 17) Hindered Rotation of the CF3 Group in tert-Butoxy Trifluoromethyl Nitroxide Chatgilialoglu, C.; Ingold, K. U. J. Phys. Chem. 1982, 86, 4372–4375. Year 1981 8) Absolute Rate Constants for Some Reactions Involving Triethylsilyl Radicals in Solution Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C.; Woynar, H. J. Am. Chem. Soc. 1981, 103, 3231–3232. 43 9) Configuration and Conformation of Alkoxyalkyl and Hydroxyalkyl Trifluoromethyl Nitroxides. Anomeric Effects and Nitroxide Conformations Chatgilialoglu, C.; Ingold, K. U. Can. J. Chem. 1981, 59, 1745–1752. 10) "Spontaneous" Formation of Radicals from Nitroso Compounds. Inadvertent Photolysis vs. Molecule Assisted Homolysis Chatgilialoglu, C.; Ingold, K. U. J. Am. Chem. Soc. 1981, 103, 4833–4837. 11) Infrared and Raman Spectra of N,N-Bis(trifluoromethyl)hydroxylamine and Bis(trifluoromethyl) Nitroxide Compton, D. A. C.; Chatgilialoglu, C.; Mantsch, H. H.; Ingold, K. U. J. Phys. Chem. 1981, 85, 3093–3100. 12) Rate Constants and Arrhenius Parameters for the Reactions of Primary, Secondary, and Tertiary Alkyl Radicals with Tri-n-butyltin Hydride Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C. J. Am. Chem. Soc. 1981, 103, 7739–7742. Year 1980 4) Electron Spin Resonance Studies of Radicals formed during the Thermolysis and Photolysis of Sulphoxides and Thiosulphonates Chatgilialoglu, C.; Gilbert, B. C.; Gill, B.; Sexton, M. D. J. Chem. Soc., Perkin Trans. 2 1980, 1141–1150. 5) E.s.r. Studies of the Generation and Structure of Aminosulphonyl (Sulphamoyl) Radicals, R2NSO2• Chatgilialoglu, C.; Gilbert, B. C.; Norman, R. O. C.; Symons, M. C. R. J. Chem. Res. 1980, (S) 185, (M) 2610–2623. 44 6) Investigations of Structure and Conformation. Part 14. INDO and Electron Spin Resonance Studies of Aliphatic Sulphonyl Radicals Chatgilialoglu, C.; Gilbert, B. C.; Norman, R. O. C. J. Chem. Soc., Perkin Trans. 2 1980, 1429–1436. 7) Bis(trifluoromethyl)aminyl and Bis(trifluoromethyl) Nitroxide Chatgilialoglu, C.; Malatesta, V.; Ingold, K. U. J. Phys. Chem. 1980, 84, 3597–3599. Year 1979 2) Investigations of structure and conformation. Part 12. The structure of aromatic sulphonyl radicals: an e.s.r. and INDO molecular orbital study Chatgilialoglu, C.; Gilbert, B. C.; Norman, R. O. C. J. Chem. Soc., Perkin Trans. 2 1979, 770–775. 3) Electron spin resonance studies. Part 57. Alkane- and arene-sulphinate esters: an investigation of their photochemical decomposition and reactions with the t-butoxyl radical Chatgilialoglu, C.; Gilbert, B. C.; Kirk, C. M.; Norman, R. O. C. J. Chem. Soc., Perkin Trans. 2 1979, 1084–1088. Year 1977 1) Addition of some 1,3-diaryltriazenes to tetracyanoethylene Camaggi, C. M.; Leardini, R.; Chatgilialoglu, C. J. Org. Chem. 1977, 42, 2611–2614. 45 Publications in Books 1) Quantum Mechanical Tunneling in Free Radical Reactions. Malatesta, V.; Ingold, K. U.; Chatgilialoglu, C. Fast Reactions in Energetic Systems; Capellos, C.; Walker, R. F., Eds; D. Reidel: Dordrecht, 1981; pp. 541–551. 2) Studies on Some Trifluoromethyl Nitroxide Radicals by EPR Spectroscopy. Chatgilialoglu, C.; Ingold, K. U.; Malatesta, V. Fast Reactions in Energetic Systems; Capellos, C.; Walker, R. F., Eds; D. Reidel: Dordrecht, 1981; pp. 553–559. 3) Radical Reaction: Part 1. Alberti, A.; Chatgilialoglu, C. Organic Reaction Mechanisms; Knipe, A. C.; Watts, W. E., Eds; Wiley: Chichester, 1984; pp. 73–108. 4) Radical Reaction: Part 1. Alberti, A.; Chatgilialoglu, C. Organic Reaction Mechanisms; Knipe, A. C.; Watts, W. E., Eds; Wiley: Chichester, 1985; pp. 83–127. 5) Radical Reaction: Part 1. Alberti, A.; Chatgilialoglu, C. Organic Reaction Mechanisms; Knipe, A. C.; Watts, W. E., Eds; Wiley: Chichester, 1986; pp. 87–137. 6) Formation, Decay, and Spectral Characterization of Some Sulfonyl Radicals. Chatgilialoglu, C. Advances in Chemical Reaction Dynamics; Rentzepis, P. M.; Capellos, C., Eds; D. Reidel: Dordrecht, 1986; pp. 571–579. 7) Radical Reaction: Part 1. 46 Alberti, A.; Chatgilialoglu, C. Organic Reaction Mechanisms; Knipe, A. C.; Watts, W. E., Eds; Wiley: Chichester, 1987; pp. 85–128. 8) Sulfinyl Radicals. Chatgilialoglu, C. The Chemistry of Sulfones and Sulfoxides; Patai, S.; Rappoport, Z.; Stirling, C. J. M., Eds; Wiley: London, 1988; pp. 1081–1087. 9) Sulfonyl Radicals. Chatgilialoglu, C. The Chemistry of Sulfones and Sulfoxides; Patai, S.; Rappoport, Z.; Stirling, C. J. M., Eds; Wiley: London, 1988; pp. 1089–1113. 10) Recent Advances in the Chemistry of Silyl radicals. Chatgilialoglu, C. Paramagnetic Organometallic Species in Activation/Selectivity, Catalysis; Chanon, M.; Julliard, M.; Poite, J. C., Eds; Kluwer: Dordrecht, 1989; pp. 119–129. 11) Silanes as New Reducing Agents in Organic Synthesis. Chatgilialoglu, C. Free Radicals in Synthesis and Biology; Minisci, F., Ed.; Kluwer: Dordrecht, 1989; pp. 115–123. 12) Electronic Absorption Spectra of Free Radicals. Chatgilialoglu, C. Handbook of Organic Photochemistry; Scaiano, J. C., Ed.; CRC Press: Boca Raton, 1989; Vol. II; pp. 3–11. 13) Free Radical Chemistry of Sulfenic Acids and Their Derivatives. Chatgilialoglu, C. The Chemistry of Sulfenic Acids and Their Derivatives; Patai, S., Ed.; Wiley: London, 1990; pp. 549–569. 47 14) Alkanethiylperoxyl Radicals. Chatgilialoglu, C.; Guerra, M. Sulfur–Centered Reactive Intermediates in Chemistry and Biology; Chatgilialoglu, C.; Asmus, K.-D., Eds; Plenum Press: New York, 1990; pp. 31–36. 15) Recent Advances in the Chemistry of Compounds Containing S-Si Moiety. Ballestri, M.; Chatgilialoglu, C.; Dembech, P.; Guerrini, A.; Seconi, G. Sulfur–Centered Reactive Intermediates in Chemistry and Biology; Chatgilialoglu, C.; Asmus, K.-D., Eds; Plenum Press: New York, 1990; pp. 319–325. 16) Proprietà Strutturali e Chimiche di Alcuni Radicali Centrati allo Zolfo. Chatgilialoglu, C. V Convegno Nazionale della Società Italiana per le Ricerche sulle Radiazioni; Serie Simposi (ENEA): Roma, 1991; pp. 247–257. 17) Thiyl Radicals. Chatgilialoglu, C; Guerra, M. Supplement S: The Chemistry of Sulfur-containing Functional Groups; Patai, S.; Rappoport, Z., Ed.; Wiley: London, 1993; pp. 363–394. 18) Free Radical Addition Involving C-C Triple Bonds. Chatgilialoglu, C.; Ferreri, C. Supplement C: The Chemistry of Triple-bonded Functional Groups; Patai, S., Ed.; Wiley: London, 1994; pp. 917–944. 19) The Advancement of Radical-Based Synthetic Strategies: From Reagent Design to Polymer Modification Chatgilialoglu, C. Chemical Synthesis: Gnosis to Prognosis; Chatgilialoglu, C.; Snieckus, V., Eds; Kluwer: Dordrecht, 1996; pp. 263–276. 48 20) Free Radical Chemistry Associated with C-1’ Position of Nucleosides and Nucleic Acids. Chatgilialoglu, C.; Gimisis, T. Free Radicals in Biology and Enviroment; Minisci, F., Ed.; Kluwer: Dordrecht, 1997; pp. 281–292. 21) Tris(trimethylsilyl)silane in Organic Synthesis Chatgilialoglu, C.; Ferreri, C.; Gimisis, T. The Chemistry of Organic Silicon Compounds, Vol 2; Rappoport, S.; Apeloig, Y., Eds.; Wiley: Chichester, 1998; pp. 1539–1579. 22) Sulfur-Centered Radicals in Organic Synthesis Chatgilialoglu, C.; Bertrand, M. P.; Ferreri, C. S-Centered Radicals; Alfassi, Z. B., Ed.; Wiley: Chichester, 1999; pp. 311–354. 23) Organic Synthesis by Radical Reactions Chatgilialoglu, C.; Renaud, P. General Aspects of Free Radical Chemistry; Alfassi, Z. B., Ed.; Wiley: Chichester, 1999; pp. 501–538. 24) Tin Silicon and Related Reducing Agents Chatgilialoglu, C. Radicals in Organic Synthesis, Vol 1; Renaud, P.; Sibi, M. P., Eds; Wiley-VCH: Weinheim, 2001; pp. 28–49. 25) Silyl Radicals Chatgilialoglu, C.; Schiesser, C. H. The Chemistry of Organic Silicon Compounds, Vol 3; Rappoport, S.; Apeloig, Y., Eds.; Wiley: Chichester, 2001; pp. 341–390. 26) Fatty Acids and Phospholipids Chatgilialoglu, C.; Ferreri, C.; 49 Cis-Trans Isomerization: From Biology to Supramolecular Chemistry; Dugave, C., Ed.; Wiley-VCH: Weinheim, 2006; pp. 95–12. 27) Membrane Lipidomics and the Geometry of Unsaturated Fatty Acids: From Biomimetic Models to Biological Consequences Ferreri, C.; Chatgilialoglu, C. Lipidomics. Vol. 1: Methods and Protocols; Armstrong, D., Ed.; Humana Press: New York, 2009; pp. 391–412. 28) Reactivity of nucleic acid sugar radicals Chatgilialoglu, C. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry; Greenberg, M. M., Ed.; Wiley: New Jersey 2009; Chapter 4; pp. 99–133. 29) Biomimetic chemistry: radical reactions in vesicle suspensions Chatgilialoglu, C.; Ferreri, C. Biomimetics, Lerning from Nature; Mukherjee, A., Ed.; IN-TECH: Vienna, 2010; Ch. 6; pp. 117–135. 30) Silanes as Reducing Reagents in Radical Chemistry Chatgilialoglu, C.; Timokhin, V. I. Encyclopedia of Radical in Chemistry, Biology & Materials; Chatgilialoglu, C.; Studer, A., Eds.; Wiley: Chichester, 2012; Vol. 2; Ch. 22; pp. 561–600. 31) Oxidatively Formed Sugar Radicals in Nucleic Acids Gimisis, T.; Chatgilialoglu, C. Encyclopedia of Radical in Chemistry, Biology & Materials; Chatgilialoglu, C.; Studer, A., Eds.; Wiley: Chichester, 2012; Vol. 3; Ch. 46; pp. 1345–1370. 32) Lipid Isomerization Ferreri, C.; Chatgilialoglu, C. Encyclopedia of Radical in Chemistry, Biology & Materials; Chatgilialoglu, C.; Studer, A., Eds.; Wiley: Chichester, 2012; Vol. 3; Ch. 55; pp. 1599–1622. 50 Publications in Magazines and Online Resources 1) (TMS)3SiH in organic synthesis: Part 1 Chatgilialoglu, C. Organic Chemistry Highlights 2004 (article online posting date October 5, 2004). http://www.organic-chemistry.org/Highlights/2004/05October.shtm 2) (TMS)3SiH in organic synthesis: Part 2 Chatgilialoglu, C. Organic Chemistry Highlights 2004 (article online posting date November 5, 2004). http://www.organic-chemistry.org/Highlights/2004/05November.shtm 3) Free radical pathway to geometrical trans lipids Ferreri, C.; Chatgilialoglu, C. Inform 2006, 17, 435–437. 4) 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane Chatgilialoglu, C.; Navacchia M. L.; Perchyonok, T. V. Encyclopedia of Reagents for Organic Synthesis [Online]; John Wiley & Sons Ltd., 2006; DOI: 10.1002/047084289X.rd135.pub2 (article online posting date September 15, 2006). 5) Tris(trimethylsilyl)silane Chatgilialoglu, C. Encyclopedia of Reagents for Organic Synthesis [Online]; John Wiley & Sons Ltd., 2007; DOI: 10.1002/047084289X.rt420.pub2 (article online posting date March 15, 2007) 6) Fats of life… explaining the villainous properties of trans fats Chatgilialoglu, C. Optimum Nutrition 2007 (Issue 2), 40–43. 51 7) The lipidomic approach: Transfer chemical research to a spin-off initiative in health care Ferreri, C.; Chatgilialoglu C.; Ferreri, R. Industry & Higher Education 2008, 22, 403–409. 52 Publications as Meeting Abstracts 1) Trans-Phospholipids in Membranes: Methods of Formation and Properties Chatgilialoglu, C.; Ferreri, C.; Dellonte, S.; Altieri, A.; Sassatelli, F.; Zambonin, L.; Landi, L. Chem. Phys. Lipids 2002, 118, 44–45. 2) Trans-Lipids Formed by a Thiyl Radical Catalyzed Process and Their Relevance in Skin Disorders Ferreri, C.; Chatgilialoglu, C.; Dellonte, S.; Samadi, A.; Manco, I; FaraoneMennella, R.; Neri, I.; Maranini, A. R. Chem. Phys. Lipids 2002, 118, 90–91. 3) All-trans PUFA Synthesis by the Thiyl Radical–Catalysed Methodology and Their Effects on Rabbit Platelet Aggregation Anagnostopoulos, D.; Chatgilialoglu C.; Ferreri C.; Samadi, A.; Siafaka–Kapadai, A. Chem. Phys. Lipids 2004, 130, 67–67. 4) Trans Fatty Acid and Atopic Eczema/Dermatitis Syndrome: The relationship with a free radical cis-trans isomerization of membrane lipids trans LIPIDS in atopic dermatitis. Chini, L.; Angelini, F.; Chatgilialoglu, C.; Dellonte, S.; Moschese, V.; Corrente, S.; Iannini, R.; Chianca, M.; Rossi, P.; Ferreri, C. Clin. Immunol. 2005, 115, S54–S55. 5) Endogenous formation of trans fatty acids in rats fed a trans-free diet Zambonin, L.; Cabrini, L.; Prata, C.; Ferreri, C.; Chatgilialoglu, C.; Landi, L. Chem. Phys. Lipids 2005, 136, 165–166. 6) Trans Lipids and Radical Stress Chatgilialoglu, C.; Ferreri, C. Chem. Phys. Lipids 2006, 143, 80–81. 53 7) Thiyl and sulphonyl radicals as catalytic agents for the cis-trans isomerization of unsaturated fatty acid residues in liposomes Tamba, M.; Mozziconacci, O.; Chatgilialoglu, C.; Ferreri, C Free Radic. Res. 2007, 41, S57–S57. 8) Bleomycin increases trans lipid isomers in human testicular cancer cell membrane Cort, A.; Ozben, T.; Kucuksayan, E.; Melchiorre, M.; Chatgilialoglu, C.; Ferreri, C. FEBS J. 2011, 278, 201–201. 54 Editorial Activities for Scientific Journals Guest Editor 1) Special issue of Helvitica Chimica Acta dedicated to the memory of Professor Hanns Fischer Chatgilialoglu, C.; Gescheidt, G. (Guest Editors) Helvitica Chimica Acta 2006, volume 89, issue 10, pp. 2059 – 2589. 2) Special Issue of CHIMIA dedicated to “Free Radicals in Chemical Biology” Chatgilialoglu, C. (Guest Editor) Chimia 2008, volume 62, issue 9, pp. 703 – 749. Member of Editorial Board 1) For the Journal of Glycomics and Lipidomics since 2011. 55 Books As Author 1) Organosilanes in Radical Chemistry Author: Chryssostomos Chatgilialoglu John Wiley & Sons Ltd, Chichester (UK), 2004. Hardcover, 227 pages; ISBN: 0-471-49870-X http://eu.wiley.com/WileyCDA/WileyTitle/productCd-047149870X.html 2) Membrana Cellulare e Lipidomica: La salute dalla medicina molecolare Authors: Carla Ferreri and Chryssostomos Chatgilialoglu Publisher: CNR Edizioni, Roma, October 2011. http://www.edizioni.cnr.it/ 56 As Editor 1) Sulfur-Centered Reactive Intermediates in Chemistry and Biology Edited by C. Chatgilialoglu and K.-D. Asmus, Plenum Press, New York, 1990. 2) Chemical Synthesis: Gnosis to Prognosis Edited by C. Chatgilialoglu and V. Snieckus, Kluwer Academic Publishers, Dordrecht, 1996. 3314-2 copertina.qxp:A 170 mastro copertine 15/06/10 14:51 Pagina 1 51 C hryssostomos Chatgilialoglu is Research Director at Consiglio Nazionale delle Ricerche, Bologna (Italy). His research interests lie in free radical reactions and in the last decade have been increasingly addressed to applications in life sciences, such as biomimetic chemistry of radical stress and related biomarkers. Edited by Chryssostomos Chatgilialoglu Publisher: Arcane editrice S.r.l., Roma, Italy, June 2010. Proceedings of EUCHEM Conference on Organic Free Radicals edited by C. Chatgilialoglu T his volume covers the proceedings of the 12th EUCHEM Conference on Organic Free Radicals in Bologna, June 28 – July 2, 2010. It covers the main fields of free radical chemistry from organic synthesis to chemical biology and from polymers to materials. Numerous experts from all over the world have contributed with their lectures and papers. The variety of subjects demonstrates the attractiveness of free radical research, foreseeing a period of further growth for this field. COVER: STUDIO BG Organic Free Radicals Organic Free Radicals 3) Proceendings of of EUCHEM Conference on Chryssostomos Chatgilialoglu JUNE 28 – JULY 2, 2010, BOLOGNA, ITALY edited by ISBN 978-88-548-2214-2 9 788854 833142 ARACNE ISBN 978-88-548-3314-2 4) Encyclopedia of Radicals in Chemistry, Biology and Materials (4 volumes, 73 Chapters and over 2300 pages) Edited by Chryssostomos Chatgilialoglu and Armido Studer Publisher: Wiley, Chichester, UK, Ferbuary 2012. ISBN: 978-0-470-97125-3 57 Patents 1) Procedimento per la riduzione di alogenuri organici ai corrispodenti composti dealogenati Chatgilialoglu, C.; Griller, D.; Lesage, M. IT Patent 48150A87 (1987). 2) Polymers containing repeating cycloketonic units, and method for obtaining them Sommazzi, A.; Cardi, N.; Garbassi, F.; Chatgilialoglu, C. US Patent 5,369,187 (1994). 3) Polyhydrosilanes as process stabilizers Carrozza, P.; Borzatta, V.; Chatgilialoglu, C. PCT Int. Appl. WO97/02322 (1997). US Patent 6,005,036 (21.12.1999); TW Patent 122742NI (23.03.2001); JP pending; EP (BE, DE, FR, IT, NL) Patent 836635 (05.12.2001). 4) Polysilane stabilizer containing sterically hindered amine groups Carrozza, P.; Borzatta, V.; Chatgilialoglu, C.; Da Roit, G. PCT Int. Appl. WO00/64965 (2000). US Patent 6,538,055 (25.03.2003); JP pending; KR pending; EP (BE, DE, ES, FR, GB, IT, NL) Patent 1185577 (21.05.2003). 5) Processo per l’isomerizzazione cis/trans di mono-, di-, e tri-gliceridi o loro miscele Ferreri, C.; Chatgilialoglu, C. IT Patent 13227121 (27.04.2005). 6) Metodo analitico per l’identificazione di componenti lipidiche contenenti doppi legami con isomeria trans Ferreri, C.; Chatgilialoglu, C. IT Patent 1327120 (27.04.2005). 58 Conference and Visiting Activity The conference and visiting activity of Dr. Chatgilialoglu is very intense and includes invitations to scientific institutions and to international meetings, as well as several visiting professorships spent in foreign Universities. This activity correlates with the high reputation of the international scientific community that Dr. Chatgilialoglu has achieved, and it can be a clear advantage for establishing firm relationship between Italy and foreing countries. Lists of the commitments are reported in the following pages. In the graph below, the over 114 invited lectures at institutions are distributed geographically. It shows the worldwide recognition of Dr. Chatgilialoglu’s research. Figure 2. Geographical Distribution of Invited Lectures at Institutions Italy (17.5%) Rest of Europe (42.1%) USA (21.1%) Rest of Americas (5.3) Russia, Japan & Australia (14.0%) 59 Invited Lectures at Congresses and Meetings 1) Scuola GDRM. Fenomeni e tecniche emergenti delle risonanze magnetiche: epr e nmr. (Roma, Italy, 19-24 May 1986). Title: Misure di costanti di velocità di process radicali unimolecolari mediante spettroscopia epr 2) Gordon Research Conference on Free Radical Reactions (Newport, USA, 24-28 August 1987). Title: Novel silanes as radical reducing agents 3) NATO Advanced Research Workshop on “Paramagnetic organometallic species in activation, selectivity, catalysis” (Saint-Maximin, France, 4 – 8 October 1987). Title: Recent advances in the chemistry of silyl radicals 4) NATO Advanced Research Workshop on “Free radicals in synthesis and biology” (Bardolino, Italy, 8-13 May 1988). Title: Silanes as new reducing agents in organic synthesis 5) COFEM 88 (Frascati, Italy, 17-20 July 1988). Title: Nuovi agenti riducenti per via radicalica 6) NATO Advanced Study Institute on “Sulfur-centered reactive ointermediates in chemistry and biology (Maratea, Italy, 18-30 June 1989). Title: Novel free radical chain reactions involving organosulfur compounds 7) V Convegno Nazionale della Società Italiana per le Ricerche sulle Radiazioni (Roma, Italy, 12-14 October 1989) Title: Caratterizzazione e reazioni di radicali centrati allo zolfo 8) EUCHEM Conference on Organic Free Radicals (Arles, France, 21-26 August 1990) Title: Organosilanes as radical-based reducing agents in synthesis 60 9) NATO ASI on "Chemical Synthesis: Gnosis to Prognosis" (Ravello, Italy, 8-19 May 1994). Title: The advancement of radical-based synthetic strategies: From reagent design to polymer modification 10) EUCHEM Conference on Organic Free Radicals (Champery, Switzerland, 21-26 August 1994) Title: Acyl radicals as intermediates in the synthesis of new materials 11) NATO Advanced Research Workshop on “Free Radicals in Biology and Environment” (Bardolino, Italy, 25 June 1996) Title: Free radical chemistry associated with the C-1’ position of nucleosides 12) 3rd Winter Research Conferences on “Oxidative Effects of Radiations on Biomolecules and Cells” (Les Arcs, France, 11 May 1997) Title: Reaction of the O•- radical with nucleosides and related compounds 13) 30th Organosilicon Symposium, (London, Canada, 30-31 May 1997) Title: Free radical chemistry associated with organosilanes: from reagent design to polymer application 14) VIII Meeting: Strutture Eterocicliche nella Ricerca Farmaceutica, (Palermo, Italy, 17-20 May 1998). Title: Free radical chemistry associated with the C1' position of nucleosides 15) XIII International Round Table: Nucleosides, Nucleotides, and Their Biological Applications (Montpellier, France 6-10 September 1998). Title: Mechanistic and synthetic aspects of the C-1’ radicals in modified nucleosides 16) Gordon Research Conference on Free Radical Reactions (Plymouth, USA, 11-16 July 1999). Title: What’s new about thiols in free radical chemistry 61 17) 37th IUPAC Congress “Frontiers in Chemistry: Molecular Basis of the Life Sciences” (Berlin, Germany, 14-19 August 1999) Title: Structural Characteristics of C1’ Radical Nucleosides and Their Fate in the Presence of Glutathione Under Anoxic or Aerobic Conditions 18) XXVI Convegno Naz. della Divisione di Chimica Organica (Giardini Naxos, Italy, 1-5 September 1999). Title: Radicali in posizione anomerica di nucleosidi: aspetti sintetici e biologici 19) 2nd COST meeting on Radical Cascade Reactions (Glasgow, UK, 9 September, 1999). Title: 5’,8-cyclopurines: Synthesis and mechanistic aspects 20) The 13th Brisbane Organic Chemistry Symposium (Brisbane, Australia, Nov. 26, 1999) Title: Free radical chemistry associated with the C1' position of nucleosides 21) RACI NSW Organic Group. 20th Annual One Day Symposium (Wollongong, Australia, Nov. 30, 1999) Title: Free radical chemistry associated with the C1' position of nucleosides 22) 24th Annual Synthesis Symposium (Melbourne, Australia, 3 December 1999) Title: Free radical chemistry associated with the C1' position of nucleosides 23) Adelaide Organic Chemistry Symposium (Adelaide, Australia 6 December 1999) Title: Free radical chemistry associated with the C1' position of nucleosides 24) Gomberg 2000, the 8th International Symposium on Organic Free Radicals (Ann Arbor, USA, June 25-29, 2000). Title: Free Radicals in Nucleosides: Serendipity and Planning 62 25) XVIth International Symposium on Medicinal Chemistry (Bologna, Italy, 18-22 September, 2000). Title: Synthesis of conformationally fixed nucleosides via radical cascade reactions 26) 3rd COST meeting on Radical Cascade Reactions (Fribourg, Switzerland, 20-22 October 2000) Title: One-pot Synthesis of 5’,8-cyclopurines 27) Pacifichem 2000. Symposium No. 29: New Developments in Organic Radical Chemistry (Honolulu, USA, 14-19 December 2000). Title: Synthesis of conformationally fixed nucleosides via radical cascade reactions 28) 22nd Miller Conference on Radiation Chemistry (Bowness on Windermere, UK, 712 April 2001). Title: The cis-trans isomerization of unsaturated fatty acid residues in lipids catalyzed by thiyl radicals 29) 4th COST meeting on Radical Cascade Reactions (Madrid, Spain, 4-6 October 2001) Title: Radical cascade reactions in aqueous solutions 30) International Conference on Reactive Intermediates and Reaction Mechanisms (Ascona, Switzerland, 7-12 July 2002) Title: The fate of C5’ radicals in purinef nucleosides 31) 6th Winter Research Conferences on “Oxidative Damage of DNA: Formation and Biological Features” (Les Houches, Francia, 25-26 March 2003) Title: Free radical chemistry in the carbohydrate moiety of nucleosides and nucleostides 32) EYICS 2003 // SULFRAD Conference (Slubice, Poland, 7-11 May 2003) Title: Free radical chemistry in the carbohydrate moiety of nucleosides 63 33) 9th International Symposium on Organic Free Radicals (Porto-Vecchio, France, 611 June 2004) Title: Paradoxical Generation of One-Electron Oxidized 2’-Deoxyguanosine Under Reducing Conditions. Application to Excess Electron Transfer in Oligodeoxyribonucleosides 34) COST P9 on Radiation Damage in Biomelecular Systems (Lyon, France, 24-27 June 2004) Title: Interaction of Electrons with 8-Bromoadenine and 8-Bromoguanine Derivatives 35) 1st Hellenic Symposium on Organic Synthesis (Athens, Greece, 4-6 November 2004) Title: Trans lipids: The Free Radical Path 36) 1st Pacific Symposium on Radical Chemistry (Kanazawa, Japan, 15-16 November 2004) Title: Trans lipids: The Free Radical Path 37) Gordon Research Conference on Free Radical Reactions (Plymouth, USA, 3-8 July 2005) Title: Trans lipids: The Free Radical Path 38) 7th Winter Research Conferences on “Oxidatively Generated Damage to DNA: Formation, Repair and Biological Features” (Les Houches, France, 19-22 March 2006) Title: Radicals for sugar moieties of DNA and RNA models 39) EUCHEM Conference on Organic Free Radicals (Bergen, Norway, 9-13 July 2006) Title: Radical reactions in water, on water and in vescicles 40) 6th CLUSTOXDNA meeting (Valencia, Spain, 29 October - 1 November 2006) Title: Tautomerism in the guanyl radical 64 41) 4th SANIT: Il ruolo della ricerca nella sanità (Rome, Italy, 18-21 April 2007) Title: Spin-off LIPINUTRAGEN 42) 2nd Greek Lipid Forum (Athens, Greece, 7-8 June 2007) Title: Trans Fatty Acids and Radical Stress 43) Melusyn Workshop: Synchrotron Radiation Based Radiobiology (Saint-Aubin, France, 25-26 June 2007) Title: Trans Fatty Acids and Radical Stress 44) 9th Latin American Conference on Physical Organic Chemistry (Córdoba, Argentina, 30 Sept. - 05 Oct. 2007) Title: Biomimetic Chemistry: Radical Reactions in Vesicles Suspensions 45) Oxygen, Stress and Lipids (Dubrovnik, Croatia, 25-27 October 2007) Title: Trans fatty acids and radical stress 46) ESOF 2008. Workshop on “Fats: the bad, the good and the ugly” (Barcelona, Spain, 19 July 2008) Title: Trans fatty acids: From nutrition to radical stress 47) 8th International Conference on Pulse Investigations in Chemistry, Biology and Physics PULS'2008 (Kraków, Poland, 6-12 September, 2008) Title: One-electron reduction of 8-bromopurine nucleosides and excess electron transfer through DNA 48) COST Action CM0603: WG1 Meeting, Consiglio Nazionale delle Ricerche (Bologna, Italy, 11-12 February 2008) Title: Common Antioxidant as Inhibitors of the Radical-Based Lipid Isomerization 49) COST Action CM0603: WG4 Meeting, Hotel Stefanie (Vienna, Austria, 29 Feb. - 1 March 2008) 65 Title: Biomimetic Chemistry: Radical Reactions in Vesicle Suspensions 50) COST Action CM0603: WG2 Meeting, Facultat de Biologia, Universitat de Barcelona (Barcelona, Spain, 6-7 March 2008). Title: Reductive Modification of Methionine and Cysteine Residues in Peptides and Proteins 51) COST Action CM0603: WG3 Meeting. Department of Chemistry and Pharmacy, LMU Munich (Munich, Germany, 14-15 March 2008) Title: 5’,8-Cyclopurine Lesions 52) COST Action CM0603: WG3 Meeting. Centre de l’Ecole de Physique (Les Houches, France, 17-19 January 2009) Title: The Chemistry 5’,8-Cyclopurine Lesions 53) 8th Winter Research Conferences on “Oxidatively DNA Damage (Les Houches, France, 19-23 January 2009) Title: Revising the Reactions of Hydroxyl Radicals and Hydrated Electrons with Guanine Derivatives 54) Conferenza di DPM, Federchimica (Milan, Italy, 25 February 2009) Title: La promozione dell’impresa Spin-off Lipinutragen 55) FEBS Advanced Lecture Course: Mechanisms and Consequences of Free RadicalMediated Oxidative Protein Modification (Antalya, Turkey, 15-20 April 2009). Title: Desulfurization reactions of Met and Cys residues under reductive radical stress 56) FEBS Advanced Lecture Course: Mechanisms and Consequences of Free RadicalMediated Oxidative Protein Modification (Antalya, Turkey, 15-20 April 2009). Title: Free radical-mediated oxidative modifications of Met and Cys residues 66 57) COST Action CM0603: Joint WG1/WG2 meeting, Lordos Beach Hotel (Larnaca, Cyprus, 4 – 6 May 2009) Title: The reaction of thiyl radicals with PUFA: time-resolved experiments and product studies 58) COST Action CM0603: Joint WG4/WG2 meeting, Ramada Hotel, (Balaton Lake, Hungary, 22 – 24 May 2009). Title: The reaction of thiyl radicals with PUFA: completing the picture 59) Organic Free Radicals Ottawa 2009 (OFRO-2009), Ottawa University (Ottawa, Canada, 26 – 30 July 2009) Title: Tautomerism in the Guanyl Radical 60) 26th Miller Conference on Radiation Chemistry (Keszthely, Hungary, 28 Aug. – 2 Sept. 2009) Title: Tautomerism in the Guanyl Radical 61) 1st International Congress of Fatty Liver and Metabolic Syndrome (Budapest, Hungary, 12-14 November 2009). Title: Trans fatty acids in membranes: from nutrition to radical stress 62) NUTRACEUTICA: svipuppo e prospettive (CNR, Roma, Italy, 18 Novemver 2009) Title: Dalla ricerca chimica ad un'impresa spin-off nel campo Lipidomico/Nutraceutico 63) Cellular radical stress and related biomarkers – COST Action CM0603 (University of Athens, Greece, 22 –24 February 2010) Title: Radiation Chemical Studies of Methionine in Aqueous Solution: Understanding the Role of Molecular Oxygen 64) Damages induced in biomolecules by low and high energy radiations – COST Action CM0603 & MELUSYN (FIAP Jean Monnet - Paris, France, 9-12 March 2010) 67 Title: The Reaction of Hydroxyl Radicals with Guanine Derivatives 65) BioInItaly Investiment Forum 2010 (Milano, Italy, 19 – 20 April 2010) Title: Lipinutragen spin-off del CNR 66) Obesità giovanile: alimentazione e sport insieme per la salute (Tenuta di Sarramarina, Matera, Italy, 22 Maggio 2010) Title: Acidi grassi trans: dall’alimentazione allo stress ossidativo 67) 4th Annual Progress Conference, COST–Chemistry and Molecular Sciences and Technologies (Mediterranean Beach Hotel, Limassol, Cyprus, 3 – 5 June 2010). Title: Free Radicals in Chemical Biology – CM0603 68) Lipid Oxidation, Human Diseases and Aging (University of Turin, Italy, 16 – 18 June, 2010) Title: Lipid modification and radical stress in membranes 69) Topical issues of physical-organic, synthetic and medicinal chemistry (Ufa State Petrolium Technological University, Ufa, Russia, 21 – 24 September 2010) Title: Biomimetic models of free radical stress and related biomarkers 70) Workshop: Natural products as drugs and lead for drugs (Orthodox Academy of Crete, Greece, 12 – 15 October 2010) Title: Synthetic and mechanistic pathways of purine 5’,8-cyclonucleoside: The role in DNA 71) XV Congresso Annuale della Società Italiana per le Ricerche sulle Radiazioni (l’Istituto Superiore di Sanità, Roma, Italy, 27 – 29 October 2010) Title: Modelli biomimetici di stress radicalico e biomarcatori correlati 72) Corso ECM: Lipidomica, Nutrizione e Stress (Bologna, Italy, 20 November 2010) Title: Acidi grassi trans nella nutrizione e nello stress cellulare 68 73) Workshop: Epigenetics - Bench to Bedside (Institute of Biophysics, Brno, Czech Republic, 22 – 24 November 2010) Title: Biomarkers of free radical stress 74) Radical stress and defenses – COST Action CM0603 (Boğaziçi University, Istanbul, Turkey, 2 – 3 December 2010) Title: The Reaction of Hydroxyl Radicals with Guanine Derivatives 75) SIRR Workshop on Stress Ossidativo: Danni, Conseguenze e Rimedi (Univerity of Bologna, Italy, 27 May 2011) Title: Modelli biomimetici di stress radicalico e biomarcatori correlati 76) Corso ECM: Lipidomica, Nutrizione e Nutraceutica (Bologna, Italy, 21 May 2011) Title: Oli nella nutrizione e formazione di acidi grassi trans 77) 5th Annual Progress Conference, COST–Chemistry and Molecular Sciences and Technologies (Ma’ale Hachamisha Hotel, Judean Hills, Israel, 2 – 4 June 2011). Title: Free Radicals in Chemical Biology – CM0603 78) Free Radicals in Chemical Biology (Rudjer Boskovic Institute, Zagreb, Croatia, 14 – 17 June 2011) Title: Biomimetic models of radical stress and related biomarkers 79) 17th European Symposium on Organic Chemistry (ESOC) (Creta Maris Hotel, Crete, Greece, 10 – 15 July 2011) Title: Biomimetic models of radical stress and related biomarkers 80) 16th International Symposium On Silicon Chemistry (ISOS) (McMaster University, Hamilton, Canada, 14 – 18 August 2011) Title: The (TMS)3SiH reagent in recent applications 81) 14th International Congress of Radiation Research (ICRR) (The Palace of Culture and Science, Warsaw, Poland, 28 August – 1 September 2011) 69 Title: Chemical radiation studies related to radical-based DNA damage 82) 14th European Conference on the Spectroscopy of Biological Molecules (ECSBM) (University of Coimbra, Portugal, 29 August – 3 September 2011) Title: Chemical radiation studies related to radical-based DNA damage 83) 3rd International MELODI Workshop (Istituto Superiore di Sanità, Rome, Italy, 2 – 4 November 2011) Title: Biomimetic models of radiation-induced radical stress and biomarker discovery 84) International Conference on Metabolomics & System Biology (San Francisco Airport Marriott, USA, 20 – 22 February 2012) Title: Geometrical isomers of unsaturated fatty acids as markers of free radical stress 85) COST-Chemistry and Molecular Science and Technologies, Domain Committee Meeting (Seville, Spain, 15 March 2012) Title of the proposal: Biomimetic Radical Chemistry 86) Emerging Companies: meet the innovation (CNR, Roma, Italy, 23 – 24 May 2012) Title: Lipinutragen spin-off del CNR 87) Corso ECM: Lipidomica e Sovrappeso (Bologna, Italy, 26 May 2012) Title: Acidi grassi trans: biomarcatori di stress e ruolo nell’obesità 88) Congresso Nazionale della Divisione di Chimica Industriale (Firenze, Italy, 11 – 14 June 2012) Title: Lipinutragen spin-off del CNR 89) 11th International Symposium on Organic Free Radicals (Bern, Switzerland, 1 – 5 July 2012) Title: Biomimetic models of radical stress and related biomarkers 70 90) 244th National of the American Chemical Society (Philadelphia, USA, 19 – 23 August 2012) Title: Bio-inspired synthetic strategies of purine 5’,8-cyclonucleoside derivatives 71 Invited Lectures at Institutions (The list of conferences prior to 1991 is not available) 1) 1 March 1991. Facultè des Sciences saint-Jerome, Université D' Aix-Marseille III (France). Title: The design of silanes with different hydrogen donating abilities 2) 4 March 1991. Institut de Chimie Fine, Université Montpellier II (France). Title: Organosilanes as radical-based reducing agents in synthesis 3) 24 April 1991. Dipartimento di Chimica e Chimica Industriale, Università di Pisa (Italy). Title: Organosilani come agenti riducenti per via radicalica 4) 27 May 1991. Institut für Organische Chemie der Universität Basel (Switzerland). Title: Recent advances in the chemistry of tris(trimethylsilyl)silane. 5) 18 June 1991. In occassione delle lezioni tenute dal Prof. D. H. R. Barton per l' Accademia Nazionale dei Lincei, Sala Congressi del CNR (Milan, Italy). Title: Organosilanes as radical-based reducing agents in synthesis 6) 24 November 1991. Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università di Perugia (Italy). Title: Organosilani come agenti riducenti per via radicalica. 7) 26 November 1992. Istituto per la Chimica di Molecole d' interesse Biologico, CNR, Arco Felice (Italy). Title: Organosilani come agenti riducenti per via radicalica 8) 5 February 1993. Additives Division, Ciba-Geigy Limited, Marly (Switzerland). Title: Organosilanes as radical-based reagents in organic synthesis 9) 10 March 1993. Ciba-Geigy S.p.A., Pontecchio Marconi, Bologna (Italy). 72 Title: Organosilanes as radical-based reagents in organic synthesis 10) 22 April 1993. Menarini Industrie Farmaceutiche Riunite S. r. l., Firenze (Italy). Title: Organosilanes as radical-based reagents in organic synthesis 11) 20 October 1993. Dipartimento di Chimica Organica, Università di Ferrara (Italy). Title: Organosilanes as radical-based reagents in organic synthesis 12) 7 December 1993. Centre de Recherches Pierre Fabre, Castres (France) Title: Organosilanes as radical-based reagents in organic synthesis 13) 29 March 1994. Department of Chemistry, University of Pittsburgh (USA) Title: Acyl Radicals: Theory, Kinetics and New Synthetic Strategies 14) 31 March 1994. Department of Chemistry, University of Pittsburgh (USA) Title: Organosilanes as radical-based reagents in organic synthesis 15) 19 January 1995. Chemistry Department, University of Ioannina (Greece). Title: Organosilanes as radical-based reagents in synthesis 16) 4 April 1995. Institut de chimie organique, Université de Fribourg (Switzerland). Title: Organosilicon reagents designed for radical chain reactions 17) 3 January 1996. Department of Chemistry, University of California, Berkeley (USA). Title: Design of organosilanes for radical-based synthetic applications 18) 9 January 1996. Department of Chemistry, University of Stanford (USA). Title: Design of organosilanes for radical-based synthetic applications 19) 23 April 1996. Department of Chemistry, University of Pittsburgh (USA). Title: Poly(hydrosilane)s 73 20) 24 April 1996. Department of Chemistry, University of Pittsburgh (USA). Title: Free radical chemistry associated with the C-1’ position of nucleosides 21) 26 April 1996. Radiation Laboratory, University of Notre Dame (USA). Title: Free radical chemistry associated with the C-1’ position of nucleosides 22) 29 April 1996. Department of Chemistry, Wayne State University, Detroit (USA). Title: Poly(hydrosilane)s 23) 3 May 1996. Additives Division, Ciba-Geigy, Ardslaey (NY) (USA). Title: Poly(hydrosilane)s 24) 20 May 1996. Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia (Italy). Title: Chimica dei radicali liberi correlata alla posizione anomerica di nucleosidi 25) 17 July 1996. Dipartimento di Chimica, Università degli Studi di Pisa (Italy). Title: Poli(sililidruri) compatibili con l’ambiente 26) 4 November 1996. Additives Division, Ciba-Geigy, Marly (Switzerland). Title: Poly(hydrosilane)s 27) 28 May 1997. Department of Chemistry, University of Waterloo (Canada). Titolo: Free radical chemistry associated with the C1' position of nucleosides 28) 3 October 1997. Ciba Specialty Chemicals, Marly (Switzerland). Title: Acyl radicals: from elementary reactions to their role in polymer modification 29) 4 December 1997. Laboratoire de Chimie Moleculaire Organique, Universite d'AixMarseille 3 (France). Title: Free radical chemistry associated with the C1' position of nucleosides 30) 8 June 1998. Ciba Specialty Chemicals, Marly (Switzerland). 74 Title: Chemistry of acyl radicals 31) 8 June 1998. Societè Fribourgeoise de Chimie, Université de Fribourg (Switzerland). Title: Free radical chemistry associated with the C1' position of nucleosides 32) 3 July 1998. Highlights on Radical Reactivity, Area delle Ricerche CNR, Bologna (Italy). Title: How the radical clock methodology can be applied for determining the rate constants of the reactions of alkyl radicals with thiols 33) 8 October 1998. Department of Chemistry, Northwestern University, Evanston (USA). Titolo: Free radical chemistry associated with the C1' position of nucleosides 34) 9 October 1998. Chemistry Department, University of Illinois, Chicago (USA). Title: Free radical chemistry associated with organosilanes: from reagent design to polymer application 35) 13 October 1998. Department of Chemistry, Wayne State University, Detroit (USA). Title: Free radical chemistry associated with organosilanes: from reagent design to polymer application 36) 4 December 1998. Laboratoire de Chimie Organique de Synthèse, Université Pierre et Marie Curie - Paris VI, (France). Title: Free radical chemistry associated with the C1' position of nucleosides 37) 11 March 1999. Chemistry Department, University of Wisconsin (USA). Title: Recent advances in free-radical chemistry of organosilanes 38) 15 March 1999. Chemistry Department, University of Illinois (USA). Title: Free radical chemistry associated with the C1' position of nucleosides 75 39) 17 March 1999. Chemistry Department, Ohio State University (USA). Title: Free radical chemistry associated with organosilanes: From reagent design to polymer application 40) 27 September 1999. Institute of Organic Chemistry, Russian Academy of Science, Ufa (Russia). Title: Free radical chemistry associated with organosilanes: From reagent design to polymer application 41) 4 October 1999. Institute of Chemical Physics, Russian Acad. of Science, Chernogolovka (Russia). Title: Free radical chemistry associated with organosilanes 42) 25 November 1999. Chemistry Griffith University, Brisbane (Australia). Title: Free radical chemistry associated with organosilanes 43) 29 November 1999. Heart Research Institute, Sydney (Australia). Title: The thiyl radical mediated cis/trans isomerization of fatty acid residues in lipids 44) 9 December 1999. Research School of Chemistry, Australian National University, Canberra (Australia). Title: Free radical chemistry associated with organosilanes 45) 16 December 1999. CSIRO Molecular Sciences, Melbourne (Australia). Title: Free radical chemistry associated with organosilanes 46) 13 April 2000. Departement de Synthese Organique, Ecole Polytechnique, (France). Title: The thiyl radical mediated cis/trans isomerization of fatty acid residues in lipids 47) 17 April 2000. Université Pierre et Marie Curie (Paris VI) (France). 76 Title: The thiyl radical mediated cis/trans isomerization of fatty acid residues in lipids 48) 18 April 2000. Institute de Chimie Moléculaire d'Orsay, Université Paris-sud (France). Title: The thiyl radical mediated cis/trans isomerization of fatty acid residues in lipids 49) 13 February 2001. Institut für Polymere, ETH-Zentrum, Zürich (Switzerland). Title: The cis-trans isomerization of unsaturated fatty acid residues in lipids catalyzed by thiyl radicals 50) 15, February 2001. Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II” (Italy). Title: Studi modello del danneggiamento del DNA per via radicalica 51) 10 May 2001. Laboratorio di Immunologia e Biotecnologia Pediatrica, Università di Roma “Tor Vergata” (Italy). Title: Aspetti chimici e biologici di acidi grassi a configurazione trans come costituenti dei lipidi 52) 24 May 2001. Institute of Organic Chemistry, Polish Academy of Sciencies, Warsaw (Poland). Title: Organosilanes as radical based reducing agents 53) 28 May 2001. Department of Organometallic Chemistry, Adam Mickiewicz University, Poznan, (Poland). Title: Organosilanes as radical based reducing agents 54) 29 May 2001. Department of Bioorganic Chemistry, Polish Academy of Sciencies, Lodz (Poland). Title: Synthesis of conformationally fixed nucleosides 77 55) 30 May 2001. Centre of Molecular and Macromolecular Studies, Polish Academy of Sciencies, Lodz (Poland). Title: Organosilanes as radical based reducing agents 56) 11 December 2001. Institute de Tecnologia Quimica UPV-CSIC, Universidad Politécnica de Valencia (Spain). Title: Mechanistic aspects of C1' and C5' radicals in nucleosides 57) 18 December 2001. Centre de Biophysique Moléculaire, CNRS, Orléans (France). Title: Mechanistic aspects of C1' and C5' radicals in nucleosides 58) 20 December 2001. Institut de Chimie des Substances Naturelles, CNRS, Gif-surYvette (France). Title: Synthesis of conformationally fixed nucleosides via radical cascade reactions 59) 13 May 2002. Department of Chemistry, University of Athens (Greece). Title: Mechanistic aspects of C1' and C5' nucleosidyl radicals 60) 20 October 2003. Department of Biochemistry, M. V. Lomonosov Moscow State University (Russia). Title: Cis-trans isomerization of unsaturated fatty acid residues by thiyl radicals: The influence of phospholipid supramolecular organization. 61) 22 October 2003. Moscow Institute of Biochemical Physics, Russian Academy of Science (Russia). Title: Model studies of DNA damage: Selective generation and reactivity of sugar carbon-centered radical. 62) 24 October 2003. Institute of Organic Chemistry, Russian Academy of Science, Ufa (Russia). Title: Cis-trans isomerization of unsaturated fatty acid residues by thiyl radicals: The influence of phospholipid supramolecular organization. 78 63) 14 September 2004. Chemistry of Department, University of Munchen (Germany). Title: Interaction of Hydrated Electrons with 8-Bromoadenine and 8Bromoguanine Derivatives 64) 15 September 2004. Chemistry of Department, University of Uppsala (Sweden). Title: (TMS)3SiH in Consecutive Radical Reactions: Synthesis of Cyclonucleosides 65) 11 November 2004. Division of Molecular Material Science, Osaka City University (Japan). Title: (TMS)3SiH in Consecutive Radical Reactions: Synthesis of Cyclonucleosides 66) 12 November 2004. Institute of Scientific and Industrial Research, Osaka University (Japan). Title: Free Radical Chemistry in the Carbohydrate Moiety of Nucleosides. Model Studies of DNA Damage Title: Interaction of Electrons with 8-Bromoadenine and 8-Bromoguanine Derivatives. Application to the Excess Electron Transfer in Oligonucleostides 67) 13 November 2004. Department of Applied Chemistry, Osaka Prefecture University (Japan). Title: Organosilanes in Radical Chemistry: Principles, Methods and Applications 68) 18 November 2004. Department of Chemistry, Osaka Prefecture University (Japan). Title: (TMS)3SiH in Consecutive Radical Reactions: Synthesis of Cyclonucleosides 69) 19 November 2004. Department of Chemistry, Kyoto University (Japan). Title: Interaction of Electrons with 8-Bromoadenine and 8-Bromoguanine Derivatives. Application to the Excess Electron Transfer in Oligonucleostides 70) 14 January 2005. Institut für Anorganische Chemie, Technische Universität Graz (Austria). Title: (TMS)3SiH in Consecutive Radical Reactions: Synthesis of Cyclonucleosides 79 71) 27 May 2005. Dipartimento di Patologia Generale, Seconda Università degli Studi di Napoli (Italy). Title: Lipidi Trans e Stress Radicalico 72) 2 December 2005. Department of Chemistry, University of Aarhus (Denmark). Title: Lipidi Trans: The Free Radical Path 73) 21 December 2005. Dipartimento di Chimica Generale, Università di Pavia (Italy). Titolo: Lipidi trans: formazione per via radicalica e significato biologico 74) 15 June 2006. Institute of Biochemical Physics, Russian Academy of Science, Moscow (Russia). Title: Trans Lipids: the Free Radical Path 75) 19 June 2006. Institute of Problems in Chemical Physics, Russian Academy of Science, Chernogolovka (Russia). Title: Trans Lipids: the Free Radical Path 76) 9 October 2006. COST office, Brussels (Belgium) Title: Free Radicals in Chemical Biology 77) 9 May 2007. Technische Universität Graz (Austria). Title: Biomimetic Chemistry: Radical Reactions in Vesicles Suspensions 78) 28 September 2007. Universidad Nacional de Córdoba (Argentina) Title: One-electron reduction of 8-bromopurine nucleosides and excess electron transfer through DNA 79) 8 October 2007. Universidad de Belgrano (Buenos Aires, Argentina) Title: Trans fatty acids and radical stress 80) 9 October 2007. Universidad de Belgrano (Buenos Aires, Argentina) Title: Fate of C5’ radicals in DNA and 5’,8-cyclopurine lesions 80 81) 10 October 2007. Universidad de Buenos Aires (Argentina) Title: One-electron reduction of 8-bromopurine nucleosides and excess electron transfer through DNA 82) 25 February 2008. Istituto di Scienze e Tecnologie Molecolari, CNR, Milano (Italy) Title: Acidi Grassi Trans e Stress Radicalico 83) 06 March 2008. Institute for Research in Biomedicine (IRB Barcelona), Parc Científic de Barcelona (Spain). Title: 5’,8-Cyclopurine Lesions: Chemistry and Biology 84) 17 March 2008. Université Pierre et Marie Curie (Paris, France). Title: Free Radical Chemistry for Understanding Biologically Related Mechanisms 85) 17 April 2008. Department of Chemistry and Biochemistry, Florida State University (Tallahassee, USA) Title: One-Electron-Reduction of 8-Bromopurine Derivatives: A Palette of Chemical Behavior Related to DNA 86) 21 April 2008. Chemistry Department, New York University (USA) Title: 5’,8-Cyclopurine Lesions: Chemistry and Biology 87) 24 April 2008. Department of Chemistry, Johns Hopkins University (Barltimore, USA) Title: 5’,8-Cyclopurine Lesions: Chemistry and Biology 88) 19 May 2008. Organische Chemie, Technisch Universität Kaiserslautern (Germany). Title: Free Radical Chemistry for Understanding Biologically Related Mechanisms 89) 20 May 2008. Department of Chemistry and Pharmacy, LMU Munich (Germany) 81 Title: One-Electron-Reduction of 8-Bromopurine Derivatives and Related Systems (Part 1) 90) 29 May 2008. Organisch-Chemisches Institut, Universität Münster (Germany). Title: One-Electron-Reduction of 8-Bromopurine Derivatives: A Palette of Chemical Behavior Related to DNA 91) 02 June 2008. Department of Chemistry and Pharmacy, LMU Munich (Germany) Title: Biomimetic Chemistry: Radical Reactions in Vesicle Suspensions 92) 17 June 2008. Department of Chemistry and Pharmacy, LMU Munich (Germany) Title: One-Electron-Reduction of 8-Bromopurine Derivatives and Related Systems (Part 2) 93) 25 June 2008. Department of Chemistry, Aarhus University (Aarhus, Denmark) Title: 5’,8-Cyclopurine Lesions: Chemistry and Biology 94) 09 June 2009. Université Pierre et Marie Curie - Paris 6, (France) Title: (Part A) Trans fatty acids: From nutrition to radical stress; (Part B) Trans fatty acids: Radical reactions in solution and in vesicle suspensions 95) 16 June 2009. Université Pierre et Marie - Paris 6, (France) Title: (Part A) Free radical-mediated oxidative modifications of Met and Cys residues; (Part B) Desulfurization of Met and Cys Residues under Reductive Radical Stress 96) 23 June 2009. Université Pierre et Marie Curie - Paris 6, (France) Title: Mechanistic studies related to radical-based DNA damage 97) 10 June 2009. University Paris 7 - Diderot (France) Title: Chemical radiation studies related to radical-based DNA damage 98) 19 June 2009. Université Paris-Sud, Orsay (France) 82 Title: Desulfurization of Met and Cys residues under reductive radical stress 99) 23 September 2009. Semenov Institute of Chemical Physics RAS, Moscow (Russia) Title: Tandem protein/lipid damage and Protection for lipid geometric integrity 100) 30 September 2009. Chimica Industriale, University of Bologna (Italy) Title: Ricerca su radicali liberi: un omaggio al professore Gian Franco Pedulli 101) 27 October 2009. Biochemistry Dept., Faculty of Pharmacy, University of Buenos Aires (Argentina) Title: Chemical radiation studies related to radical-based DNA damage 102) 26 November 2010. Dipartimento di Chimica, Università di Salerno, (Italy) Title: Modelli biomimetici di stress radicalico e biomarcatori correlati 103) 5 April 2011. Laboratoire Lésions des Acides Nucléiques, CEA Grenoble (France). Title: Biomimetic models of radical stress and related biomarkers 104) 16 May 2011. Dipartimento di Scienze Farmaceutiche, University of Bologna (Italy) Title: Modelli biomimetici di stress radicalico e biomarcatori correlati 105) 19 May 2011. Dipartimento di Scienze Farmaceutiche, University of Napoli “Federico II” (Italy) Title: Modelli biomimetici di stress radicalico e biomarcatori correlati 106) 26 October 2011. UMR NutrPass, Montpellier (France). Title: Geometrical isomers of unsaturated fatty acids as markers of free radical stress 107) 18 November 2011. Department of Chemistry and Biochemistry, Florida International University, Miami (USA) Title: Biomimetic models of radical stress and related biomarkers 83 108) 21 November 2011. Chemistry Department, New York University, New York, NY (USA) Title: Chemical radiation studies related to radical-based DNA damage 109) 22 November 2011. Chemistry Department, Brookhaven National Laboratory, Upton, NY (USA) Title: Biomimetic models of radical stress and related biomarkers 110) 6 December 2011. School of Chemistry, Newcastle University (UK) Title: Biomimetic models of radical stress and related biomarkers 111) 13 February 2012. Department of Chemistry and Biochemistry, University of California, San Diego, CA (USA) Title: Biomimetic models of radical stress and related biomarkers 112) 15 February 2012. Department of Chemistry, The Scripps Research Institute, La Jolla, CA (USA) Title: Chemical radiation studies related to radical-based DNA damage 113) 17 February 2012. Department of Chemistry and Biochemistry, University of California, Reverside, CA (USA) Title: Biomimetic models of radical stress and related biomarkers 114) 19 April 2012. Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette (France) Title: Biomimetic models of radical stress and related biomarkers 84 Visiting Scientist at Foreign Institutions 1) Division of Chemistry, National Research Council of Canada, Ottawa (Canada). July – August 1986 Invited by Dr. David Griller 2) Department für Chemie der Universität Basel, (Svizzera). February – July 1990 Invited by Prof. Bernd Giese 3) Department für Chemie der Universität Basel, (Svizzera). May – June 1991 (NATO Senior Fellowship) Invited by Prof. Bernd Giese 4) Visit at Russisn Academy of Sciences (RAS) in Ufa e Chernogolovka in the frame of the bilateral agreement CNR / RAS. September 27 - October 6, 1999 Invited by Prof. V. V. Shereshovets e Prof. E. T. Denisov 5) Wilsmore Fellow to the School of Chemistry, University of Melbourne (Australia). November 1999 – January 2000 Invited by Prof. Carl. H. Schiesser 6) Laboratoire de Chimie Organique de Synthèse, Université Pierre et Marie Curie (Francia). April 2000 Invited by Prof. Max Malacria 7) Visit at Polish Academy of Sciences (PAN) in Varsavia, Posnan e Lodz in the frame of the bilateral agreement CNR / PAN. May 24 – June 1, 2001 Invited by Prof. W. J. Stec 85 8) Center for Integrated Protein Science Munich, LMU Munich (Germany). March, May and June 2008 Invited by Prof. Thomas Carell 9) Laboratoire de Chimie Organique de Synthèse, Université Pierre et Marie Curie (France). June 2009 Invited by Prof. Max Malacria 86 Managerial Activity The managerial activity of Dr. Chatgilialoglu concerns various functions, summarized as follows: a) Leader of the BioFreeRadicals group at CNR, ISOF in Bologna, with the task of research planning and supervising, fund raising, strategy and decision making b) Consulting and refereeing activities for companies and institutions c) Responsible functions within European and international projects d) President of the spin-off company Lipinutragen Srl (Bologna) Team leader of the BioFreeRadicals group The BioFreeRadicals group at ISOF (CNR) includes 5 permanent researchers and temporary staff, consisting of pre- and post-doctoral fellows. In 2012 it counts a total of 9 people. The group works on a research project, approved by the CNR, concerning “Biomimetic models of radical stress and related biomarkers”. The financial and human resources for this project are based on the matching fund criteria. Therefore, the managerial activity and group leadership of Dr. Chatgilialoglu are focused on: (i) high level productivity, in terms of research results and publications; (ii) optimal fund raising, in order to create the budget for satisfactory research and human resources. A constant growth of scientific productivity has been maintained during the scientific career of Dr. Chatgilialoglu, as depicted in the diagram of Figure 3. The impressive quantity of the scientific peer-reviewed publications clearly reflects a strong and constant focus on all research subjects of interest. The excellent standard of the research is demonstrated by the fact that the papers appear in high impact journals and receive a remarkable number of citations. The yearly distribution of citations is depicted in Figure 4. The unremitting efforts of cultural renovation and acquisition of multidisciplinary competences have certainly contributed to these achievements. Also, great attention has been devoted to maintaining active international scientific collaborations and participation in exchange visiting programs, for establishing contacts among research groups of different countries. This has been a great strategic help for the set-up of efficient partnerships for increasing productivity and preparing network for research grant applications. 87 Figure 3. Published items in each year up to April 2012 (Web of Science Citation Report) Figure 4. Citations in each year up to April 2012 (Web of Science Citation Report). Sum of the Times Cited: 6325; h-index: 38 The fund raising has also been an important part of the managerial activity, and in the last years this aspect has become more and more crucial. Dr. Chatgilialoglu participated to several research projects within the “V, VI and VII Framework Programs” of the European Commission. He received financial support for the COST Action “Free Radicals in Chemical Biology” for the period June 2007 – June 2011 and he has recently been granted with a four year support for the COST Action “Biomimetic Radical 88 Chemistry” starting September 2012. He managed several European grants over the last three Framework Programs and at the present is the scientist-in-charge of a two years Marie Curie IEF (started April 2012). The role of Dr. Chatgilialoglu has nowadays reached a wide recognition from the free radical chemistry community and from a multidisciplinary context of European research. Consulting and refereeing activity for institutions and companies Dr. Chatgilialoglu also carried out consulting activity, especially with companies involved in applications of free radical reactivity. These contracts were carried our bringing financial resources for the CNR research group. The longest consulting period concerned a six years contact with Ciba Geigy Ltd., with the results from this cooperative endeavor in the field of polysilanes having been world-patented. Dr. Chatgilialoglu plays a significant role in the scientific community as referee for institutions and companies. The most important journals of the chemical field (i.e., J. Am. Chem. Soc. and Angewandte Chemie) are constantly asking him for peer reviewing of manuscripts submitted to them. He acted as Guest Editor for the journals Helvetica Chimica Acta and Chimia. He was also nominated as foreign referee or opponent in public dissertations for PhD degrees at several European universities (e.g., Uppsala, Marseille, Paris, Valencia, Munich, Athens, Montpellier). In 2002 the Greek Ministry of National Education and Religious Affairs appointed him to an international committee for the evaluation of the “Post Graduate Curriculum Programs” offered by the Greek Institution of Higher Education (AEI). Responsible functions within European and international projects Dr. Chatgilialoglu is very active in the relationship with foreign institutions and research groups, in the firm belief that the strong interaction with several countries can reinforce the scientific visibility of the Italian groups and create a critical mass for important advances in science. The managerial activity involved leadership of several projects at international levels concerning collaborative research grants and bilateral scientific cooperation agreements. Among others, he was director of Summer Schools within the frame of NATO Advanced Study Institutes in 1989 and 1994. He was also responsible for three NATO Collaborative Research Grants (3-years-time duration each) 89 with American institutions. In all cases, he acted as both scientific and administrative supervisor. He was the supervisor of two Individual Marie Curie Fellowship in 1996 and 2002, and one ongoing started April 2012. From 2002 to 2007 he participated to two Marie Curie Research Training Networks. For the period 2007-2011 he acted as the chair of the COST Action “Free Radicals in Chemical Biology” and a new COST Action on “Biomimetic Radical Chemistry” is approved starting from September 2012 for four years. President of the spin-off company Lipinutragen Srl The managerial activity in the last five years focused on the creation of a spin-off company based on the research results in lipidomics strongly connected with health, nutrition and quality of life. The research on the lipidomics of radical stress and the formation of trans lipids led to the setting up of an innovative analysis of erythrocyte membranes, which is commercialized as a preventive tool in medicine for ameliorating metabolic status and quality of life. On December 2005, Lipinutragen Srl (http://www.lipinutragen.it) was founded and Dr. Chatgilialoglu was nominated President of this company. The marketing concerns the commercialization of the lipidomic analysis, denominated FAT PROFILE® (European trade mark) to clients in the sector of health care (medical doctors, medical centers, hospitals etc). Recently a new product named FAT PHARMACY® has been launched in the pharmacies. The company also produces a nutraceutical line, named Nutragenika, which represents the first membrane-targeted nutraceuticals available in the market, and it is sold in the Italian pharmacies. This entrepreneurial experience enriches his multidisciplinary skills contributing to improve his formation in the field of science for business. 90 International Appointments 1) NATO Collaborative Research Grant n. 860678. Title: Structural and chemical properties of some sulfur-containing intermediates Common research project between Dr. C. Chatgilialoglu (ICoCEA, CNR) e Dr. D. Griller (Division of Chemistry, National Research Council of Canada). Period: April 1986 - March 1989 2) Progetto Finalizzato Chimica Fine Sottoprogetto Nuove sintesi: Metodologie e campi avanzati di sintesi organica Title: Nuovi processi radicalici a catena selettivi Period: 1989 – 1993 3) Director of NATO Advanced Study Institute Title: Sulfur-Centered Reactive Intermediates in Chemistry and Biology Maratea (Italy), 18 – 30 June 1989 4) NATO Collaborative Research Grant n. 930272. Title: New Reagents for Radical Allylation. Common research project between Dr. C. Chatgilialoglu (ICoCEA, CNR) e Prof. D. P. Curran (Department of Chemistry, University of Pittsburg, USA) Period: April 1993 – March 1996 5) Director of NATO Advanced Study Institute Title: Chemical Synthesis: Gnosis to Prognosis Ravello (Italy), 8 – 19 May 1994 6) Marie Curie Individual Fellowships: Model studies on radical induced DNA cleavage associated with the C-1’ position Scientist in charge: Chatgilialoglu, C. Fellow: Gimisis, T. Contracts No: ERBFMBICT950336 Period: February 1996 – January 1998. 91 7) NATO Collaborative Research Grant n. 970142. Title: Free Radical Chemistry of the C1’ Position of Nucleosides. Common research project between Dr. C. Chatgilialoglu (ICoCEA, CNR) e Prof. M. Newcomb (Chemistry Department, Wayne State University, USA) Period: April 1997 - March 1999 8) COST Programme of European Commission. Title: Radical Cascade Reactions (D12/0005/98) Period: June 1998 – December 2002 9) Scientific cooperation agreement CNR/RAS (Russia). Title: Nuovi sviluppi sulla reattività dei silani in reazioni radicaliche Period: 1999–2001 10) Scientific cooperation agreement CNR/PAN (Poland). Title: Riduzioni di composti organofosforici mediante reattivi organometallici. Nuovi applicazioni. Period: 2000–2002 11) Scientific cooperation agreement CNR/RAS (Russia). Title: Studio del meccanismo e dei prodotti dell’ossidazione di nucleosidi con ozono Period: 2002–2004 12) Marie Curie Individual Fellowships: Trans-unsaturated fatty acid residues in phospholipids: chemical and biological aspects Scientist in charge: Chatgilialoglu, C. Fellow: Samadi, A. Contract No: HPMF-CT-2001-01313 Period: 01.01.2002 – 31.12.2003 13) Research Training Network: Sulfur radical chemistry and biological significance: the protective and damaging roles of thiol and thioether radicals [SULFRAD] Contract No: HPRN-CT-2002-00184 92 Period: 01.09.2002 — 28.02.2006 14) Research Training Network: Selective formation and biochemistry of oxidative clustered DNA damage [CLUSTOXDNA] Contract No: MRTN-CT-2003-505086 Period: 01.02.2004 – 31.07.2007 15) Scientific cooperation agreement CNR/RAS (Russia). Title: Model studies of DNA radicals repair: H-atom abstraction from thiols Period: 2005–2007 16) Chair of COST Action CM0603 Domain: Chemistry and Molecular Sciences and Technologies Action Title: Free Radical in Chemical Biology (CHEMBIORADICAL) Period: June 2007 – June 2011 17) Scientific cooperation agreement CNR/RAS (Russia). Title: Markers of radical stress for membrane lipidomics Period: 2008–2010 18) Scientific cooperation agreement CNR/CONICET (Argentina). Title: Modified unsaturated lipids, radical-based tandem damage and their applications Period: 2009–2010 19) Chair of the 12th EUCHEM Conference on “Organic Free Radicals” Bologna (Italy), June 28 – July 2, 2010 20) Management Committee Member of the Trans-Domain COST Action CMST-TD0905 Action Title: Epigenetics: Bench to Bedside Period: June 2010 – June 2014 93 21) MIUR – PRIN 2009 Title: Oxidative DNA damage: mechanisms and physico-chemical properties of intermediates and products Contract No: 2009K3RH7N Period: 2011 – 2013 22) Marie Curie Actions – Intra European Fellowships (IEF): Formation and roles of the 5',8-cyclo-2'-deoxyguanosine lesion (CYCLOGUO) Scientist in charge: Chatgilialoglu, C. Fellow: Terzidis, M. A. Contract No: PIEF-GA-2011-298555 Period: 01.04.2012 – 31.03.2014 23) Proposer of COST Action CM1203 Domain: Chemistry and Molecular Sciences and Technologies Action Title: Biomimetic Radical Chemistry Period: September 2012 – September 2016 94 Consulting activity 1) Guido Donegani (EniChem), Novara. Italy January 1991 – March 1992 2) Ciba-Geigy Limited, Basel (Switzerland). February 1994 – January 1996 3) CTU consulting for Tribunale di Milano, in the suit ELF Atochem Italia srl vs ICI Imperial Chemical Industries LTD (1994-1996). 4) Ciba-Geigy Limited, Basel (Switzerland). Mau 1996 – April 2000 5) BIOCHIMICI PSN DERMA SpA, Bologna (Italy). June 2000 – December 2001 6) BIORAMA 2000 srl, Bologna (Italy). January 2001 – December 2002 95