Inibitori dell`interazione TCR/MHCII-collagene utili per il

Scheda di dettaglio
Inibitori dell'interazione TCR/MHCII-collagene utili per il trattamento dell'artrite
reumatoide
We recently reported the three-dimensional model structure of the TCR Vβ associated to
Collagen II(261-273)/HLA-DR4 complex (De Rosa et al, PloSOne 2010 Jul 14;5(7):e11550.). This
was used as the starting point for the generation of a pharmacophore model using the software
LigandScout. This program allows the automatic construction and visualization of 3D
pharmacophores from structural data of macromolecule-ligand complexes.
Inventori
Classificazioni
Nicolò Chiara
composti eterociclici
Pirolli Davide
composti eterociclici
Ferraccioli Gianfranco
preparazioni per uso medico, dentale o per l'igiene
personale
composti aciclici o carbociclici
Giardina Bruno
Ria Francesco
DE ROSA MARIA CRISTINA
Sett. tecnologico
Farmaceutica
Titolarità
nuove terapie
Consiglio Nazionale delle Ricerche
Università Cattolica del Sacro Cuore
Keyword
Virtual screening; docking; rheumatoid arthritis; TCR;
immunoscope
Vantaggi
The main advantages of the invention are:
1. The small molecule proposed here selectively blocks only the immune response to the self antigen
involved in rheumatoid arthritis, while leaving the ability of the immune system to deal with infectious
agents intact and efficient.
2. We tested in vitro the toxic effect of the molecules, and could not detect any induction of apoptosis
or necrosis after 3 days of exposure in peripheral blood mononuclear cells for concentrations up to
100 micromolar.
Consiglio Nazionale delle Ricerche - P.le Aldo Moro, 7 - 00185 Roma - E-mail: [email protected]
Applicazioni
Rheumatoid arthritis therapy.
Consiglio Nazionale delle Ricerche - P.le Aldo Moro, 7 - 00185 Roma - E-mail: [email protected]