Pubblicazioni (scarica PDF) - Istituto Nazionale dei Tumori
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Pubblicazioni (scarica PDF) - Istituto Nazionale dei Tumori
Annexes 1. Di Cosimo S, Bregni G, Daidone MG, Cinquini M, de Braud F, Torri V. Waiting for Godot: Predictive factors for adjuvant treatment of patients with luminal breast cancer. Breast. 2016 Apr 22. pii: S0960-9776(16)00017-5. doi: 10.1016/j.breast.2016.02.002. 2. Falanga A, Santoro A, Labianca R, De Braud F, Gasparini G, D'Alessio A, Barni S, Iacoviello L; HYPERCAN Study Group. Hypercoagulation screening as an innovative tool for risk assessment, early diagnosis and prognosis in cancer: the HYPERCAN study. Thromb Res. 2016 Apr;140 Suppl 1:S55-9. doi: 10.1016/S0049-3848(16)300998. 3. Grassi P, Doucet L, Giglione P, Grünwald V, Melichar B, Galli L, De Giorgi U, Sabbatini R, Ortega C, Santoni M, Bamias A, Verzoni E, Derosa L, Studentova H, Pacifici M, Coppa J, Mazzaferro V, de Braud F, Porta C, Escudier B, Procopio G. Clinical Impact of Pancreatic Metastases from Renal Cell Carcinoma: A Multicenter Retrospective Analysis. PLoS One. 2016 Apr 11;11(4):e0151662. doi: 10.1371/journal.pone.0151662. eCollection 2016 4. Pusceddu S, De Braud F, Lo Russo G, Concas L, Femia D, Vernieri C, Indini A, Formisano B, Buzzoni R. How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies. Oncotarget. 2016 Apr 5. doi: 10.18632/oncotarget.8601. Review 5. Pelosi G, Pellegrinelli A, Fabbri A, Tamborini E, Perrone F, Settanni G, Busico A, Picciani B, Testi MA, Militti L, Maisonneuve P, Valeri B, Sonzogni A, Proto C, Garassino M, De Braud F, Pastorino U. Deciphering intra-tumor heterogeneity of lung adenocarcinoma confirms that dominant, branching, and private gene mutations occur within individual tumor nodules. Virchows Arch. 2016 Apr 7. 6. Falvella FS, Cremolini C, Miceli R, Nichetti F, Cheli S, Antoniotti C, Infante G, Martinetti A, Marmorino F, Sottotetti E, Berenato R, Caporale M, Colombo A, de Braud F, Di Bartolomeo M, Clementi E, Loupakis F, Pietrantonio F. Variant alleles in factor V, prothrombin, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase and risk of thromboembolism in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab. Pharmacogenomics J. 2016 Mar 22. doi: 10.1038/tpj.2016.22. 7. Stathis A, Zucca E, Bekradda M, Gomez-Roca C, Delord JP, de La Motte Rouge T, UroCoste E, de Braud F, Pelosi G, French CA. Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK8628. Cancer Discov. 2016 May;6(5):492-500. 8. Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC. Treatment of lung large cell neuroendocrine carcinoma.Tumour Biol. 2016 Mar 4. 9. Pusceddu S, Lo Russo G, Macerelli M, Proto C, Vitali M, Signorelli D, Ganzinelli M, Scanagatta P, Duranti L, Trama A, Buzzoni R, Pelosi G, Pastorino U, de Braud F, Garassino MC. Diagnosis and management of typical and atypical lung carcinoids.Crit Rev Oncol Hematol. 2016 Apr;100:167-76. doi: 10.1016/j.critrevonc.2016.02.009. Review. 10. Giampieri R, Caporale M, Pietrantonio F, De Braud F, Negri FV, Giuliani F, Pusceddu V, Demurtas L, Restivo A, Fontanella C, Aprile G, Cascinu S, Scartozzi M. Second-line angiogenesis inhibition in metastatic colorectal cancer patients: Straightforward or overcrowded? Crit Rev Oncol Hematol. 2016 Apr;100:99-106. doi: 10.1016/j.critrevonc.2016.02.005. Review. 11. Pusceddu S, Buzzoni R, Vernieri C, Concas L, Marceglia S, Giacomelli L, Milione M, Leuzzi L, Femia D, Formisano B, Mazzaferro V, de Braud F. Metformin with everolimus and octreotide in pancreatic neuroendocrine tumor patients with diabetes. Future Oncol. 2016 May;12(10):1251-60. doi: 10.2217/fon-2015-0077. 12. Necchi A, Lo Vullo S, Mariani L, Raggi D, Giannatempo P, Calareso G, Togliardi E, Crippa F, Di Genova N, Perrone F, Colecchia M, Paolini B, Pelosi G, Nicolai N, Procopio G, Salvioni R, De Braud FG. An open-label, single-arm, phase 2 study of the Aurora kinase A inhibitor alisertib in patients with advanced urothelial cancer. Invest New Drugs. 2016 Apr;34(2):236-42. doi: 10.1007/s10637-016-0328-9. 13. Pelosi G, Perrone F, Tamborini E, Fabbri A, Testi MA, Busico A, Settanni G, Picciani B, Bovio E, Sonzogni A, Valeri B, Garassino M, De Braud F, Pastorino U. Doing more with less: fluorescence in situ hybridization and gene sequencing assays can be reliably performed on archival stained tumor tissue sections. Virchows Arch. 2016 Apr;468(4):45161. doi: 10.1007/s00428-016-1906-0. 14. Indini A, Di Nicola M, Del Vecchio M, De Braud F. Immune Suppression and Response to Ipilimumab: Assessing Risk-to-Benefit Ratio. J Clin Oncol. 2016 Jan 19. pii: JCO650028. [Epub ahead of print] No abstract available. PMID:26786928 15. Fazio N, Biffi R, Maibach R, Hayoz S, Thierstein S, Brauchli P, Bernhard J, Stupp R, Andreoni B, Renne G, Crosta C, Morant R, Chiappa A, Luca F, Zampino MG, Huber O, Goldhirsch A, de Braud F, Roth AD; Swiss Group for Clinical Cancer Research (SAKK) and the European Institute of Oncology (IEO), Milan, Italy. Pre-operative versus postoperative docetaxel-cisplatin-fluorouracil (TCF) chemotherapy in locally advanced resectable gastric carcinoma: 10-year follow-up of the SAKK 43/99 phase III trial. Ann Oncol. 2015 Dec 27. pii: mdv620. 16. Vergani E, Di Guardo L, Dugo M, Rigoletto S, Tragni G, Ruggeri R, Perrone F, Tamborini E, Gloghini A, Arienti F, Vergani B, Deho P, De Cecco L, Vallacchi V, Frati P, Shahaj E, Villa A, Santinami M, De Braud F, Rivoltini L, Rodolfo M. Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b. Oncotarget. 2015 Dec 14. doi: 10.18632/oncotarget.6599. 17. Penna I, Molla A, Grazia G, Cleris L, Nicolini G, Perrone F, Picciani B, Del Vecchio M, de Braud F, Mortarini R, Anichini A. Primary cross-resistance to BRAFV600E-, MEK1/2and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade. Oncotarget. 2015 Dec 14. doi: 10.18632/oncotarget.6600. 18. Goff LW, Cohen RB, Berlin J, De Braud FG, Lyshchik A, Noberasco C, Bertolini F, Carpentieri M, Gallo Stampino C, Abbattista A, Wang E, Borghaei H. A Phase I Study of the Anti-Activin Receptor-Like Kinase 1 (ALK-1) Monoclonal Antibody PF-03446962 in Patients with Advanced Solid Tumors. Clin Cancer Res. 2015 Dec 11. pii: clincanres.1622.2015. 19. Zanardi E, Bregni G, de Braud F, Di Cosimo S. Better Together: Targeted Combination Therapies in Breast Cancer. Semin Oncol. 2015 Dec;42(6):887-95. doi: 10.1053/j.seminoncol.2015.09.029. Epub 2015 Sep 24. Review 20. Catania C, Feroce I, Barile M, Goldhirsch A, De Pas T, de Braud F, Boselli S, Adamoli L, Radice D, Rossi A, Spitaleri G, Noberasco C, Bonanni B. Improved health perception after genetic counselling for women at high risk of breast and/or ovarian cancer: construction of new questionnaires-an Italian exploratory study. J Cancer Res Clin Oncol. 2015 Nov 17 21. Pietrantonio F, de Braud F, Milione M, Maggi C, Iacovelli R, Dotti KF, Perrone F, Tamborini E, Caporale M, Berenato R, Leone G, Pellegrinelli A, Bossi I, Festinese F, Federici S, Di Bartolomeo M. Dose-Dense Temozolomide in Patients with MGMTSilenced Chemorefractory Colorectal Cancer. Target Oncol. 2015 Nov 4 22. Iacovelli R, Pietrantonio F, Maggi C, de Braud F, Di Bartolomeo M. Combination or single-agent chemotherapy as adjuvant treatment of gastric cancer: A systematic review and meta-analysis of published trials. Crit Rev Oncol Hematol. 2015 Oct 9. pii: S10408428(15)30043-3. doi: 10.1016/j.critrevonc.2015.09.002. 23. Signorelli D, Macerelli M, Proto C, Vitali M, Cona MS, Agustoni F, Zilembo N, Platania M, Trama A, Gallucci R, Ganzinelli M, Pelosi G, Pastorino U, de Braud F, Garassino MC, Lo Russo G. Systemic approach to malignant pleural mesothelioma: what news of chemotherapy, targeted agents and immunotherapy? Tumori. 2015 Oct 15;0(0):0. doi: 10.5301/tj.5000436. 24. Pietrantonio F, Cremolini C, Aprile G, Lonardi S, Orlandi A, Mennitto A, Berenato R, Antoniotti C, Casagrande M, Marsico V, Marmorino F, Cardellino GG, Bergamo F, Tomasello G, Formica V, Longarini R, Giommoni E, Caporale M, Di Bartolomeo M, Loupakis F, de Braud F. Single-Agent Panitumumab in Frail Elderly Patients With Advanced RAS and BRAF Wild-Type Colorectal Cancer: Challenging Drug Label to Light Up New Hope. Oncologist. 2015 Nov;20(11):1261-5. doi: 10.1634/theoncologist.20150171 25. Pelosi G, Fabbri A, Tamborini E, Perrone F, Testi AM, Settanni G, Busico A, Centonze G, Braidotti P, Bulfamante G, De Braud F, Garassino M, Pastorino U. Challenging Lung Carcinoma with Coexistent ΔNp63/p40 and Thyroid Transcription Factor-1 Labeling Within the Same Individual Tumor Cells. J Thorac Oncol. 2015 Oct;10(10):1500-2. doi: 10.1097/JTO.0000000000000553. 26. de Braud F, Cascinu S, Spitaleri G, Pilz K, Clementi L, Liu D, Sikken P, De Pas T. A phase I, dose-escalation study of volasertib combined with nintedanib in advanced solid tumors. Ann Oncol. 2015 Nov;26(11):2341-6. doi: 10.1093/annonc/mdv354. 27. Zappasodi R, de Braud F, Di Nicola M. Lymphoma Immunotherapy: Current Status. Front Immunol. 2015 Sep 1;6:448. doi: 10.3389/fimmu.2015.00448. eCollection 2015. Review. PMID: 26388871 28. Pinciroli P, Won H, Iyer G, Canevari S, Colecchia M, Giannatempo P, Raggi D, Pierotti MA, De Braud FG, Solit DB, Rosenberg JE, Berger MF, Necchi A. Molecular Signature of Response to Pazopanib Salvage Therapy for Urothelial Carcinoma. Clin Genitourin Cancer. 2015 Aug 7. pii: S1558-7673(15)00190-1. doi: 10.1016/j.clgc.2015.07.017 29. Bregni G, Galli G, Gevorgyan A, de Braud F, Di Cosimo S. Trastuzumab cardiac toxicity: a problem we put our heart into. Tumori. 2015 Aug 3;0(0):0. doi: 10.5301/tj.5000393. 30. Pietrantonio F, Aprile G, Rimassa L, Franco P, Lonardi S, Cremolini C, Biondani P, Sbicego EL, Pasqualetti F, Tomasello G, Niger M, Casagrande M, Ghidini M, Muni R, Montrone S, Bergamo F, Berenato R, Fontanella C, Bozzarelli S, Moretto R, Battaglin F, Di Bartolomeo M, de Braud F, Miceli R. A new nomogram for estimating survival in patients with brain metastases secondary to colorectal cancer. Radiother Oncol. 2015 Sep 4. pii: S0167-8140(15)00448-X. doi: 10.1016/j.radonc.2015.08.023 31. Schmoll HJ, Tabernero J, Maroun J, de Braud F, Price T, Van Cutsem E, Hill M, Hoersch S, Rittweger K, Haller DG. Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid As Adjuvant Therapy for Stage III Colon Cancer: Final Results of the NO16968 Randomized Controlled Phase III Trial. J Clin Oncol. 2015 Nov 10;33(32):3733-40. doi: 10.1200/JCO.2015.60.9107. 32. Pelosi G, Fabbri A, Papotti M, Rossi G, Cavazza A, Righi L, Tamborini E, Perrone F, Settanni G, Busico A, Testi MA, Maisonneuve P, De Braud F, Garassino M, Valeri B, Sonzogni A, Pastorino U. Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge. J Thorac Oncol. 2015 Nov;10(11):1560-9. doi: 10.1097/JTO.0000000000000658. 33. Celio L, Bonizzoni E, De Braud F, Agustoni F, Aapro M. Should clinicians always administer dexamethasone beyond 24 h after chemotherapy to control delayed nausea and vomiting caused by moderately emetogenic regimens? Insight from the re-evaluation of two randomized studies. Support Care Cancer. 2015 Aug 6. 34. Pusceddu S, De Braud F, Festinese F, Bregant C, Lorenzoni A, Maccauro M, Milione M, Concas L, Formisano B, Leuzzi L, Mazzaferro V, Buzzoni R. Evolution in the treatment of gastroenteropancreatic-neuroendocrine neoplasms, focus on systemic therapeutic options: a systematic review. Future Oncol. 2015;11(13):1947-59. doi: 10.2217/fon.15.86. 35. Zanardi E, Verzoni E, Grassi P, Necchi A, Giannatempo P, Raggi D, De Braud F, Procopio G. Clinical experience with temsirolimus in the treatment of advanced renal cell carcinoma. Ther Adv Urol. 2015 Jun;7(3):152-61. doi: 10.1177/1756287215574457. Review. PMID:26161146 36. Cremolini C, Di Bartolomeo M, Amatu A, Antoniotti C, Moretto R, Berenato R, Perrone F, Tamborini E, Aprile G, Lonardi S, Sartore-Bianchi A, Fontanini G, Milione M, Lauricella C, Siena S, Falcone A, de Braud F, Loupakis F, Pietrantonio F. BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis. Ann Oncol. 2015 Oct;26(10):2092-7. doi: 10.1093/annonc/mdv290. 37. Barault L, Amatu A, Bleeker FE, Moutinho C, Falcomatà C, Fiano V, Cassingena A, Siravegna G, Milione M, Cassoni P, De Braud F, Rudà R, Soffietti R, Venesio T, Bardelli A, Wesseling P, de Witt Hamer P, Pietrantonio F, Siena S, Esteller M, Sartore-Bianchi A, Di Nicolantonio F. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer. Ann Oncol. 2015 Sep;26(9):1994-9. doi: 10.1093/annonc/mdv272 38. Pietrantonio F, Cremolini C, Petrelli F, Di Bartolomeo M, Loupakis F, Maggi C, Antoniotti C, de Braud F, Falcone A, Iacovelli R. First-line anti-EGFR monoclonal antibodies in panRAS wild-type metastatic colorectal cancer: A systematic review and meta-analysis. Crit Rev Oncol Hematol. 2015 Oct;96(1):156-66. doi: 10.1016/j.critrevonc.2015.05.016. 39. Long GV, Stroyakovskiy D, Gogas H, Levchenko E, de Braud F, Larkin J, Garbe C, Jouary T, Hauschild A, Grob JJ, Chiarion-Sileni V, Lebbe C, Mandalà M, Millward M, Arance A, Bondarenko I, Haanen JB, Hansson J, Utikal J, Ferraresi V, Kovalenko N, Mohr P, Probachai V, Schadendorf D, Nathan P, Robert C, Ribas A, DeMarini DJ, Irani JG, Swann S, Legos JJ, Jin F, Mookerjee B, Flaherty K. Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial. Lancet. 2015 Aug 1;386(9992):444-51. doi: 10.1016/S0140-6736(15)60898-4. 40. Pietrantonio F, Mazzaferro V, Miceli R, Cotsoglou C, Melotti F, Fanetti G, Perrone F, Biondani P, Muscarà C, Di Bartolomeo M, Coppa J, Maggi C, Milione M, Tamborini E, de Braud F. Pathological response after neoadjuvant bevacizumab- or cetuximab-based chemotherapy in resected colorectal cancer liver metastases. Med Oncol. 2015 Jul;32(7):182. doi: 10.1007/s12032-015-0638-3. 41. Raggi D, Mariani L, Giannatempo P, Lo Vullo S, Giardiello D, Nicolai N, Piva L, Biasoni D, Catanzaro M, Torelli T, Stagni S, Maffezzini M, Calareso G, Magni M, Di Nicola M, Verzoni E, Grassi P, Procopio G, De Braud F, Pizzocaro G, Salvioni R, Necchi A. Prognostic reclassification of patients with intermediate-risk metastatic germ cell tumors: Implications for clinical practice, trial design, and molecular interrogation. Urol Oncol. 2015 Jul;33(7):332.e19-24. doi: 10.1016/j.urolonc.2015.04.008. 42. Pietrantonio F, Orlandi A, Inno A, Da Prat V, Spada D, Iaculli A, Di Bartolomeo M, Morosi C, de Braud F. Bevacizumab-based neoadjuvant chemotherapy for colorectal cancer liver metastases: Pitfalls and helpful tricks in a review for clinicians. Crit Rev Oncol Hematol. 2015 Sep;95(3):272-81. doi: 10.1016/j.critrevonc.2015.04.008. Epub 2015 Apr 25. Review. 43. Panzuto F, Rinzivillo M, Fazio N, de Braud F, Luppi G, Zatelli MC, Lugli F, Tomassetti P, Riccardi F, Nuzzo C, Brizzi MP, Faggiano A, Zaniboni A, Nobili E, Pastorelli D, Cascinu S, Merlano M, Chiara S, Antonuzzo L, Funaioli C, Spada F, Pusceddu S, Fontana A, Ambrosio MR, Cassano A, Campana D, Cartenì G, Appetecchia M, Berruti A, Colao A, Falconi M, Delle Fave G. Real-world study of everolimus in advanced progressive neuroendocrine tumors. Oncologist. 2015 May;20(5):570. doi: 10.1634/theoncologist.2014-0037erratum. 44. Falvella FS, Caporale M, Cheli S, Martinetti A, Berenato R, Maggi C, Niger M, Ricchini F, Bossi I, Di Bartolomeo M, Sottotetti E, Bernardi FF, de Braud F, Clementi E, Pietrantonio F. Undetected toxicity risk in pharmacogenetic testing for dihydropyrimidine dehydrogenase. Int J Mol Sci. 2015 Apr 21;16(4):8884-95. doi: 10.3390/ijms16048884. Review. 45. Di Bartolomeo M, Pietrantonio F, Pellegrinelli A, Martinetti A, Mariani L, Daidone MG, Bajetta E, Pelosi G, de Braud F, Floriani I, Miceli R. Osteopontin, E-cadherin, and βcatenin expression as prognostic biomarkers in patients with radically resected gastric cancer. Gastric Cancer. 2015 Apr 11. PMID: 25862567 46. Grassi P, Verzoni E, Porcu L, Iacovelli R, de Braud F, Procopio G. Sites of disease as predictors of outcome in metastatic renal cell carcinoma patients treated with first-line sunitinib or sorafenib. Ther Adv Urol. 2015 Apr;7(2):59-68. doi10.1177/1756287215571809. 47. Petrelli F, Pietrantonio F, Cremolini C, Di Bartolomeo M, Coinu A, Lonati V, de Braud F, Barni S. Early tumour shrinkage as a prognostic factor and surrogate end-point in colorectal cancer: A systematic review and pooled-analysis. Eur J Cancer. 2015 Mar 17. pii: S09598049(15)00211-7. doi: 10.1016/j.ejca.2015.02.011. 48. Schadendorf D, Amonkar MM, Stroyakovskiy D, Levchenko E, Gogas H, de Braud F, Grob JJ, Bondarenko I, Garbe C, Lebbe C, Larkin J, Chiarion-Sileni V, Millward M, Arance A, Mandalà M, Flaherty KT, Nathan P, Ribas A, Robert C, Casey M, DeMarini DJ, Irani JG, Aktan G, Long GV. Health-related quality of life impact in a randomised phase III study of the combination of dabrafenib and trametinib versus dabrafenib monotherapy in patients with BRAF V600 metastatic melanoma. Eur J Cancer. 2015 Mar 17. pii: S09598049(15)00220-8. doi: 10.1016/j.ejca.2015.03.004. 49. Falvella FS, Cheli S, Martinetti A, Mazzali C, Iacovelli R, Maggi C, Gariboldi M, Pierotti MA, Di Bartolomeo M, Sottotetti E, Mennitto R, Bossi I, de Braud F, Clementi E, Pietrantonio F. DPD and UGT1A1 deficiency in colorectal cancer patients receiving triplet chemotherapy with fluoropyrimidines, oxaliplatin and irinotecan. Br J Clin Pharmacol. 2015 Mar 17. doi: 10.1111/bcp.12631. 50. Lucibello M, Adanti S, Antelmi E, Dezi D, Ciafrè S, Carcangiu ML, Zonfrillo M, Nicotera G, Sica L, De Braud F, Pierimarchi P. Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells. Oncotarget. 2015 Mar 10;6(7):52755291. 51. Di Cosimo S, Bianchi GV, Bregni G, de Braud F. Prognosis of women with early breast cancer and PIK3CA mutations.Breast. 2015 Mar 12. pii: S0960-9776(15)00043-0. doi: 10.1016/j.breast.2015.02.028. [ 52. Baratti D, Kusamura S, Maggi C, de Braud F, Deraco M, Di Bartolomeo M, Pietrantonio F. In reply. Oncologist. 2015 Mar;20(3):e5. doi: 10.1634/theoncologist.2014-423. 53. Dugo M, Nicolini G, Tragni G, Bersani I, Tomassetti A, Colonna V, Del Vecchio M, De Braud F, Canevari S, Anichini A, Sensi M. A melanoma subtype with intrinsic resistance to BRAF inhibition identified by receptor tyrosine kinases gene-driven classification. Oncotarget. 2015 Mar 10;6(7):5118-5133 54. Musella V, Pietrantonio F, Di Buduo E, Iacovelli R, Martinetti A, Sottotetti E, Bossi I, Maggi C, Di Bartolomeo M, de Braud F, Daidone MG, Cappelletti V. Circulating tumor cells as a longitudinal biomarker in patients with advanced chemorefractory, RAS-BRAF wild-type colorectal cancer receiving cetuximab or panitumumab. Int J Cancer. 2015 Feb 20. doi: 10.1002/ijc.29493. 55. Pietrantonio F, Petrelli F, Coinu A, Di Bartolomeo M, Borgonovo K, Maggi C, Cabiddu M, Iacovelli R, Bossi I, Lonati V, Ghilardi M, de Braud F, Barni S. Predictive role of BRAF mutations in patients with advanced colorectal cancer receiving cetuximab and panitumumab: A meta-analysis. Eur J Cancer. 2015 Mar;51(5):587-594. doi: 10.1016/j.ejca.2015.01.054. 56. Crippa F, Agresti R, Sandri M, Mariani G, Padovano B, Alessi A, Bianchi G, Bombardieri E, Maugeri I, Rampa M, Carcangiu ML, Trecate G, Pascali C, Bogni A, Martelli G, de Braud F. 18F-FLT PET/CT as an imaging tool for early prediction of pathological response in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy: a pilot study. Eur J Nucl Med Mol Imaging. 2015 Feb 12. 10.1007/s00259015-2995-8 57. Serpico D, Porcu L, Tessari A, Gevorgyan A, Bregni G, Galli G, de Braud F, Torri V, Di Cosimo S. Disease progression pattern in metastatic breast cancer patients treated with antiHER2 therapies.Clin Transl Oncol. 2015 Jan 21. DOI 10.1007/s12094-015-1274-2 58. Di Bartolomeo M, Maggi C, Ricchini F, Pietrantonio F, Iacovelli R, de Braud F, Inno A. Bevacizumab treatment in the elderly patient with metastatic colorectal cancer. Clin Interv Aging. 2015 Jan 5;10:127-33. doi: 10.2147/CIA.S54675. eCollection 2015. PMID:25584021 59. Zappasodi R, Ruggiero G, Guarnotta C, Tortoreto M, Tringali C, Cavanè A, Cabras AD, Castagnoli L, Venerando B, Zaffaroni N, Gianni AM, De Braud F, Tripodo C, Pupa SM, Di Nicola M. HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma. Blood 2015 Mar 12;125(11):1768-71. doi: 10.1182/blood-2014-07-590034. Epub 2015 Jan 8. 60. Catania C, Maur M, Berardi R, Rocca A, Di Giacomo AM, Spitaleri G, Masini C, Pierantoni C, González-Iglesias R, Zigon G, Tasciotti A, Giovannoni L, Lovato V, Elia G, Menssen HD, Neri D, Cascinu S, Conte PF, de Braud F. The tumour-targeting immunocytokine F16-IL2 in combination with doxorubicin: dose escalation in patients with advanced solid tumours and expansion into patients with metastatic breast cancer. Cell Adh Migr. 2015 Jan 2;9(1-2):14-21. doi: 10.4161/19336918.2014.983785. 61. Solomon BJ, Mok T, Kim DW, Wu YL, Nakagawa K, Mekhail T, Felip E, Cappuzzo F, Paolini J, Usari T, Iyer S, Reisman A, Wilner KD, Tursi J, Blackhall F; PROFILE 1014 Investigators. Collaborators First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014 Dec 4;371(23):2167-77. doi: 10.1056/NEJMoa1408440. 62. Iacovelli R, Pietrantonio F, Palazzo A, Maggi C, Ricchini F, de Braud F, Di Bartolomeo M. Incidence and relative risk of grade 3 and 4 diarrhoea in patients treated with capecitabine or 5-fluorouracil: a meta-analysis of published trials. Br J Clin Pharmacol. 2014 Dec;78(6):1228-37. doi: 10.1111/bcp.12449 63. Inno A, Fanetti G, Di Bartolomeo M, Gori S, Maggi C, Cirillo M, Iacovelli R, Nichetti F, Martinetti A, de Braud F, Bossi I, Pietrantonio F. Role of MGMT as biomarker in colorectal cancer.World J Clin Cases. 2014 Dec 16;2(12):835-9. doi: 10.12998/wjcc.v2.i12.835. Review 64. Pietrantonio F, Iacovelli R, Di Bartolomeo M, de Braud F. FOLFIRI with cetuximab or bevacizumab: FIRE-3. Lancet Oncol. 2014 Dec;15(13):e581. doi: 10.1016/S14702045(14)70397-3. 65. Iacovelli R, Verzoni E, Grassi P, Farcomeni A, de Braud F, Procopio G. Rationale and protocol of SOAP: a phase II study to evaluate the efficacy of sorafenib as second-line treatment after pazopanib in patients with advanced renal cell carcinoma. Tumori. 2014 Nov-Dec;100(6):282e-5e. doi: 10.1700/1778.19296.PMID: 25688511 66. Pusceddu S, de Braud F, Concas L, Bregant C, Leuzzi L, Formisano B, Buzzoni R. Rationale and protocol of the MetNET-1 trial, a prospective, single center, phase II study to evaluate the activity and safety of everolimus in combination with octreotide LAR and metformin in patients with advanced pancreatic neuroendocrine tumors. Tumori. 2014 Nov-Dec;100(6):286e-9e. doi: 10.1700/1778.19298.PMID:25688512 67. Serpico D, Trama A, Haspinger ER, Agustoni F, Botta L, Berardi R, Palmieri G, Zucali P, Gallucci R, Broggini M, Gatta G, Pastorino U, Pelosi G, de Braud F, Garassino MC; on behalf of TYME (TYmic MalignanciEs) Collaborative Group. Available evidence and new biological perspectives on medical treatment of advanced thymic epithelial tumors.Ann Oncol. 2014 Nov 19. pii: mdu527. [Epub ahead of print] Review 68. Procopio G, Testa I, Verzoni E, Iacovelli R, Grassi P, Galli G, De Braud F, Saravia D, Salvioni R. Time from Nephrectomy as a Prognostic Factor in Metastatic Renal Cell Carcinoma Patients Receiving Targeted Therapies: Overall Results from a Large Cohort of Patients. Oncology. 2014 Nov 4;88(3):133-138. 69. Iacovelli R, Pietrantonio F, Farcomeni A, Maggi C, Palazzo A, Ricchini F, de Braud F, Di Bartolomeo M. Chemotherapy or targeted therapy as second-line treatment of advanced gastric cancer. A systematic review and meta-analysis of published studies. PLoS One. 2014 Sep 30;9(9):e108940. doi: 10.1371/journal.pone.0108940. eCollection 2014 70. Long GV, Stroyakovskiy D, Gogas H, Levchenko E, de Braud F, Larkin J, Garbe C, Jouary T, Hauschild A, Grob JJ, Chiarion Sileni V, Lebbe C, Mandalà M, Millward M, Arance A, Bondarenko I, Haanen JB, Hansson J, Utikal J, Ferraresi V, Kovalenko N, Mohr P, Probachai V, Schadendorf D, Nathan P, Robert C, Ribas A, DeMarini DJ, Irani JG, Casey M, Ouellet D, Martin AM, Le N, Patel K, Flaherty K. Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N Engl J Med. 2014 Nov 13;371(20):1877-88. doi: 10.1056/NEJMoa1406037. 71. Iacovelli R, Santoni M, de Braud F, Cascinu S, Procopio G. Highlights from the ASCO Genitourinary Symposium 2014: focus on renal and prostate cancer. Expert Rev Anticancer Ther. 2014 Aug 27:1-3 72. Martinetti A, Miceli R, Sottotetti E, Di Bartolomeo M, de Braud F, Gevorgyan A, Dotti KF, Bajetta E, Campiglio M, Bianchi F, Bregni G, Pietrantonio F. Circulating biomarkers in advanced colorectal cancer patients randomly assigned to three bevacizumab-based regimens. Cancers (Basel). 2014 Aug 29;6(3):1753-68. doi: 10.3390/cancers6031753 73. Giannatempo P, Greco T, Mariani L, Nicolai N, Tana S, Farè E, Raggi D, Piva L, Catanzaro M, Biasoni D, Torelli T, Stagni S, Avuzzi B, Maffezzini M, Landoni G, De Braud F, Gianni AM, Sonpavde G, Salvioni R, Necchi A. Radiotherapy or chemotherapy for clinical stage IIA and IIB seminoma: a systematic review and meta-analysis of patient outcomes† Ann Oncol. 2014 Sep 11. pii: mdu447. [Epub ahead of print] Review. 74. Verzoni E, Pusceddu S, Buzzoni R, Garanzini E, Damato A, Biondani P, Testa I, Grassi P, Bajetta E, de Braud F, Procopio G. Safety profile and treatment response of everolimus in different solid tumors: an observational study. Future Oncol. 2014;10(9):1611-7. doi: 10.2217/fon.14.31 75. Iacovelli R, Santoni M, Verzoni E, Grassi P, Testa I, de Braud F, Cascinu S, Procopio G. Everolimus and Temsirolimus Are Not the Same Second-Line in Metastatic Renal Cell Carcinoma. A Systematic Review and Meta-Analysis of Literature Data. Clin Genitourin Cancer. 2014 Aug 2. pii: S1558-7673(14)00153-0. doi: 10.1016/j.clgc.2014.07.006 76. Necchi A, Giannatempo P, Paolini B, Lo Vullo S, Marongiu M, Farè E, Raggi D, Nicolai N, Piva L, Catanzaro M, Biasoni D, Torelli T, Stagni S, Maffezzini M, Gianni AM, De Braud F, Mariani L, Sonpavde G, Colecchia M, Salvioni R. Immunohistochemistry to Enhance Prognostic Allocation and Guide Decision-Making of Patients With Advanced Urothelial Cancer Receiving First-Line Chemotherapy. Clin Genitourin Cancer. 2014 Aug 8. pii: S1558-7673(14)00174-8. doi: 10.1016/j.clgc.2014.08.002 77. Pietrantonio F, Maggi C, Di Bartolomeo M, Facciorusso MG, Perrone F, Testi A, Iacovelli R, Miceli R, Bossi I, Leone G, Milione M, Pelosi G, de Braud F. Gain of ALK Gene Copy Number May Predict Lack of Benefit from Anti-EGFR Treatment in Patients with Advanced Colorectal Cancer and RAS-RAF-PI3KCA Wild-Type Status. PLoS One. 2014 Apr 1;9(4):e92147. doi: 10.1371/journal.pone.0092147. eCollection 2014. 78. Catania C, Radice D, Spitaleri G, Adamoli L, Noberasco C, Delmonte A, Vecchio F, de Braud F, Toffalorio F, Goldhirsch A, De Pas T. The choice of whether to participate in a phase I clinical trial: increasing the awareness of patients with cancer. An exploratory study. Psychooncology. 2014 Mar;23(3):322-9. doi: 10.1002/pon.3424. Epub 2013 Oct 10.PMID: 24123459 79. Verzoni E, Grassi P, Testa I, Iacovelli R, Biondani P, Garanzini E, De Braud F, Procopio G.Targeted treatments in advanced renal cell carcinoma: focus on axitinib. Pharmgenomics Pers Med. 2014 Mar 27;7:107-116. eCollection 2014. Review. 249. 80. Procopio G, Verzoni E, Biondani P, Grassi P, Testa I, Garanzini E, De Braud F. Rationale and protocol of RESORT, a randomized, open-label, multicenter phase II study to evaluate the efficacy of sorafenib in patients with advanced renal cell carcinoma after radical resection of the metastases. Tumori. 2014 Jan-Feb;100(1):28e-30e. doi:10.1700/1430.15834. 81. Necchi A, Giannatempo P, Mariani L, Farè E, Raggi D, Pennati M, Zaffaroni N, Crippa F, Marchianò A, Nicolai N, Maffezzini M, Togliardi E, Daidone MG, Gianni AM, Salvioni R, De Braud F. PF-03446962, a fully-human monoclonal antibody against transforming growth-factor β (TGFβ) receptor ALK1, in pre-treated patients with urothelial cancer: an open label, single-group, phase 2 trial. Invest New Drugs. 2014 Feb 26. Invest New Drugs (2014) 32:555–560 DOI 10.1007/s10637-014-0074-9 82. Platania M, Valeri B, Marchianò A, Calareso G, Agustoni F, Haspinger E, Pusceddu S, Garassino MC, Gelsomino F, de Braud F. Fatal case of hepatic portal venous gas following palliative stenting and chemotherapy for occlusive advanced colorectal cancer. Int J Colorectal Dis. Int J Colorectal Dis. 2015 Mar;30(3):429-30. doi: 10.1007/s00384-0141993-9. Epub 2014 Aug 21 83. Panzuto F, Rinzivillo M, Fazio N, de Braud F, Luppi G, Zatelli MC, Lugli F, Tomassetti P, Riccardi F, Nuzzo C, Brizzi MP, Faggiano A, Zaniboni A, Nobili E, Pastorelli D, Cascinu S, Merlano M, Chiara S, Antonuzzo L, Funaioli C, Spada F, Pusceddu S, Fontana A, Ambrosio MR, Cassano A, Campana D, Cartenì G, Appetecchia M, Berruti A, Colao A, Falconi M, Delle Fave G. Real-World Study of Everolimus in Advanced Progressive Neuroendocrine Tumors. Oncologist. 2014 Aug 12. pii: theoncologist.2014-0037. 84. Procopio G, Verzoni E, De Braud F. Butterfly and Renal Cell Cancer: Out of Chaos Comes Order. J Clin Oncol. 2014 Jul 28. pii: JCO.2014.56.4757. 85. Pietrantonio F, Maggi C, Fanetti G, Iacovelli R, Di Bartolomeo M, Ricchini F, Deraco M, Perrone F, Baratti D, Kusamura S, Tamborini E, Castano A, Consonni PV, Bossi I, Gavazzi C, Milione M, Pelosi G, de Braud F. FOLFOX-4 Chemotherapy for Patients With Unresectable or Relapsed Peritoneal Pseudomyxoma. Oncologist. 2014 Aug;19(8):845-50. doi: 10.1634/theoncologist.2014-0106. 86. Pietrantonio F, Biondani P, Perrone F, Di Bartolomeo M, Pacifici M, Milione M, Melotti F, Maggi C, Montemurro G, Bossi I, Mariani L, de Braud F. TP53 mutations in advanced colorectal cancer: the dark side of the moon. Oncology. 2014;86(5-6):289-94. doi: 10.1159/000360088. 87. Pelosi G, Haspinger ER, Bimbatti M, Leone G, Paolini B, Fabbri A, Tamborini E, Perrone F, Testi A, Garassino M, Maisonneuve P, de Braud F, Pilotti S, Pastorino U. Does Immunohistochemistry Affect Response to Therapy and Survival of Inoperable Non-Small Cell Lung Carcinoma Patients? A Survey of 145 Stage III-IV Consecutive Cases. Int J Surg Pathol. 2014 Apr;22(2):136-48. doi: 10.1177/1066896913511527. 88. Celio L, de Braud F, Aapro M. Aprepitant versus dexamethasone for delayed emesis: what is the role of the 5-hydroxytryptamine type 3 receptor antagonist palonosetron? J Clin Oncol. 2014 Jul 10;32(20):2185-6. doi: 10.1200/JCO.2014.55.4352. 89. Simbolo M1, Fassan M, Ruzzenente A, Mafficini A, Wood LD, Corbo V, Melisi D, Malleo G, Vicentini C, Malpeli G, Antonello D, Sperandio N, Capelli P, Tomezzoli A, Iacono C, Lawlor RT, Bassi C, Hruban RH, Guglielmi A, Tortora G, de Braud F, Scarpa A. Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups. Oncotarget. 2014 May 15;5(9):2839-52. 90. Buzzoni R, Pusceddu S, Bajetta E, De Braud F, Platania M, Iannacone C, Cantore M, Mambrini A, Bertolini A, Alabiso O, Ciarlo A, Turco C1, Mazzaferro V. Activity and safety of RAD001 (everolimus) in patients affected by biliary tract cancer progressing after prior chemotherapy: a phase II ITMO study. Ann Oncol. 2014 Aug;25(8):1597-603. doi: 10.1093/annonc/mdu175. 91. Iacovelli R, Verzoni E, De Braud FM, Procopio G. Study design and clinical evidence in mRCC: can we save axitinib as a first-line therapy? Cancer Biol Ther. 2014 May;15(5):486-8. doi: 10.4161/cbt.28161. 92. Biondani P, Verzoni E, Torri V, Porcu L, Grassi P, Testa I, DE Braud F, Procopio G. Sequential Tyrosine Kinase Inhibitors (TKIs) in metastatic renal cell carcinoma: results from a large cohort of patients. Anticancer Res. 2014 May;34(5):2395-8. 93. Toffalorio F, Spitaleri G, Catania C, Dal Zotto L, Noberasco C, Delmonte A, Santarpia M, Vecchio F, Brunelli V, Rampinelli C, Barberis M, Fumagalli C, Zucchetti M, Zangarini M, Diena T, Danesi R, de Braud F, De Pas T. Phase ib of sorafenib in combination with everolimus in patients with advanced solid tumors, selected on the basis of molecular targets.Oncologist. 2014 Apr;19(4):344-5. doi: 10.1634/theoncologist.2013-0335. 94. Seregni E, Maccauro M, Chiesa C, Mariani L, Pascali C, Mazzaferro V, De Braud F, Buzzoni R, Milione M, Lorenzoni A, Bogni A, Coliva A, Vullo SL, Bombardieri E. Treatment with tandem [90Y]DOTA-TATE and [ 177Lu]DOTA-TATE of neuroendocrine tumours refractory to conventional therapy. Eur J Nucl Med Mol Imaging. 2014 Feb;41(2):223-30. 95. Procopio G, Testa I, Iacovelli R, Grassi P, Verzoni E, Garanzini E, Colecchia M, Torelli T, DE Braud F. Treatment of collecting duct carcinoma: current status and future perspectives. Anticancer Res. 2014 Feb;34(2):1027-30. 96. Haspinger ER, Garassino MC, Torri V, Cinquini M, De Braud F, Gelsomino F. Do We Really Need Another Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in First-Line Treatment for Patients With Non-Small-Cell Lung Cancer and EGFR Mutations? J Clin Oncol. 2014 Feb 3. 97. Lawler M, Le Chevalier T, Murphy MJ Jr, Banks I, Conte P, De Lorenzo F, Meunier F, Pinedo HM, Selby P, Armand JP, Barbacid M, Barzach M, Bergh J, Bode G, Cameron DA, de Braud F, de Gramont A, Diehl V, Diler S, Erdem S, Fitzpatrick JM, Geissler J, Hollywood D, Højgaard L, Horgan D, Jassem J, Johnson PW, Kapitein P, Kelly J, Kloezen S, La Vecchia C, Löwenberg B, Oliver K, Sullivan R, Tabernero J, Van de Velde CJ, Wilking N, Wilson R, Zielinski C, Zur Hausen H, Johnston PG. A Catalyst for Change: The European Cancer Patient's Bill of Rights. Oncologist. 2014 Feb 3. 98. Pietrantonio F, Perrone F, de Braud F, Castano A, Maggi C, Bossi I, Gevorgyan A, Biondani P, Pacifici M, Busico A, Gariboldi M, Festinese F, Tamborini E, Di Bartolomeo M. Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation. Ann Oncol. 2014 Feb;25(2):404-8. doi: 10.1093/annonc/mdt547. 99. Di Cosimo S, Serpico D, Porcu L, Molino L, Fanetti G, Torri V, de Braud F. Clinical Outcome of HER2-positive Breast Cancer Patients after Failure on Adjuvant Trastuzumab: The Potential of the Time to Relapse. Clin Oncol (R Coll Radiol). 2014 Mar;26(3):174. doi: 10.1016/j.clon.2013.11.028. 100. Gelsomino F, Facchinetti F, Haspinger ER, Garassino MC, Trusolino L, De Braud F, Tiseo M. Targeting the MET gene for the treatment of non-small-cell lung cancer. Crit Rev Oncol Hematol. 2014 Feb;89(2):284-99. doi: 10.1016/j.critrevonc.2013.11.006. 101. Necchi A, Pennati M, Zaffaroni N, Landoni E, Giannatempo P, Raggi D, Schwartz LH, Morosi C, Crippa F, Farè E, Nicolai N, Lanocita R, Sava T, Sacco C, Messina C, Ortega C, De Braud FG, Salvioni R, Daidone MG, Gianni AM, Mariani L. Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy. Br J Cancer. 2014 Jan 7;110(1):26-33. doi: 10.1038/bjc.2013.719. 102. Agustoni F, Platania M, Vitali M, Zilembo N, Haspinger E, Sinno V, Gallucci R, de Braud F, Garassino MC. Emerging toxicities in the treatment of non-small cell lung cancer: Ocular disorders. Cancer Treat Rev.doi:pii: S0305-7372(13)00097-2. 10.1016/j.ctrv.2013.05.005. Cancer Treat Rev. 2014 Feb;40(1):197-203. doi: 10.1016/j.ctrv.2013.05.005. Epub 2013 Jul 10. 103. Necchi A, Mariani L, Giannatempo P, Raggi D, Farè E, Nicolai N, Piva L, Biasoni D, Catanzaro M, Torelli T, Stagni S, Maffezzini M, Pizzocaro G, De Braud FG, Gianni AM, Salvioni R.Long-Term Efficacy and Safety Outcomes of Modified (Simplified) MVAC Methotrexate /Vinblastine /Doxorubicin/Cisplatin) as Frontline Therapy for Unresectable or Metastatic Urothelial Cancer. Clin Genitourin Cancer. 2013 Nov 21. pii: S15587673(13)00293-0. doi: 10.1016/j.clgc.2013.11.022. 104. Iacovelli R, Verzoni E, De Braud F, Procopio G. First line treatment of metastatic renal cell carcinoma: Two standards with different toxicity profile. Cancer Biol Ther. 2014 Jan 1;15(1):19-21. doi: 10.4161/cbt.27150. 105. Improta G, Pelosi G, Tamborini E, Donia M, Santinami M, de Braud F, Fraggetta F.Biological insights into BRAFV600 mutations in melanoma patient: Not mere therapeutic targets. Oncoimmunology. 2013 Aug 1;2(8):e25594. Epub 2013 Jul 3.PMID:24179707 106. Jiao Y, Pawlik TM, Anders RA, Selaru FM, Streppel MM, Lucas DJ, Niknafs N, Guthrie VB, Maitra A, Argani P, Offerhaus GJ, Roa JC, Roberts LR, Gores GJ, Popescu I, Alexandrescu ST, Dima S, Fassan M, Simbolo M, Mafficini A, Capelli P, Lawlor RT, Ruzzenente A, Guglielmi A, Tortora G, de Braud F, Scarpa A, Jarnagin W, Klimstra D, Karchin R, Velculescu VE, Hruban RH, Vogelstein B, Kinzler KW, Papadopoulos N, Wood LD.Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat Genet. 2013 Dec;45(12):1470-3. doi: 10.1038/ng.2813. 107. Verzoni E, de Braud F, Fabiani F, Grassi P, Testa I, Procopio G. Patient approach in advanced/metastatic renal cell carcinoma: focus on the elderly population and treatmentrelated toxicity. Future Oncol. 2013 Nov;9(11):1599-607. doi: 10.2217/fon.13.150.PMID: 24156321 108. Catania C, Radice D, Spitaleri G, Adamoli L, Noberasco C, Delmonte A, Vecchio F, de Braud F, Toffalorio F, Goldhirsch A, De Pas T. The choice of whether to participate in a phase I clinical trial: increasing the awareness of patients with cancer. An exploratory study. Psychooncology. 2013 Oct 10. doi: 10.1002/pon.3424. [ 109. Procopio G, Grassi P, Testa I, Verzoni E, Torri V, Salvioni R, Valdagni R, de Braud F. Safety of Abiraterone Acetate in Castration-resistant Prostate Cancer Patients With Concomitant Cardiovascular Risk Factors. Am J Clin Oncol. 2013 Sep 21.[Epub ahead of print]PMID:24064757 110. Pietrantonio F, Perrone F, Biondani P, Maggi C, Lampis A, Bertan C, Venturini F, Tondulli L, Ferrari D, Ricci V, Villa F, Barone G, Bianco N, Ghidini A, Bossi I, Fanetti G, Di Bartolomeo M, de Braud F. Single agent panitumumab in KRAS wild-type metastatic colorectal cancer patients following cetuximab-based regimens: Clinical outcome and biomarkers of efficacy. Cancer Biol Ther. 2013 Sep 4;14(12). 111. Pérez-Vargas JC, Biondani P, Maggi C, Gariboldi M, Gloghini A, Inno A, Volpi CC, Gualeni AV, di Bartolomeo M, de Braud F, Castano A, Bossi I, Pietrantonio F. Role of cMET in the Development and Progression of Colorectal Cancer. Int J Mol Sci. 2013 Sep 3;14(9):18056-77. doi: 10.3390/ijms140918056. 112. Grassi P, Verzoni E, Mariani L, De Braud F, Coppa J, Mazzaferro V, Procopio G. Prognostic Role of Pancreatic Metastases From Renal Cell Carcinoma: Results From an Italian Center. Clin Genitourin Cancer. 2013 Jun 19. doi:pii: S1558-7673(13)00083-9. 10.1016/j.clgc.2013.04.022. 113. Damian S, Celio L, De Benedictis E, Mariani P, Agustoni F, Ricchini F, De Braud F. Is a Dexamethasone-Sparing Strategy Capable of Preventing Acute and Delayed Emesis Caused by Combined Doxorubicin and Paclitaxel for Breast Cancer? Analysis of a Phase II Trial. Oncology. 2013 May 22;84(6):371-377. 114. Pietrantonio F, Biondani P, Ciurlia E, Fanetti G, Tessari A, Bertarelli G, Bossi I, Musella V, Melotti F, Di Bartolomeo M, Valvo F, Pellegrinelli A, Milione M, Perrone F, de Braud F. Role of BAX for outcome prediction in gastrointestinal malignancies. Med Oncol. 2013 Sep;30(3):610. doi: 10.1007/s12032-013-0610-z. 115. Damato A, Pusceddu S, Milione M, Mazzaferro V, Magli M, Seregni E, De Braud F, Buzzoni R. Well-differentiated neuroendocrine tumor of tailgut cyst. A rare entity with controversial medical opportunities. Tumori. 2013 Jul-Aug; 99(4):e148-51. doi: 10.1700/1361.15113. 116. Celio L, Ricchini F, De Braud F. Safety, efficacy, and patient acceptability of singledose fosaprepitant regimen for the prevention of chemotherapy-induced nausea and vomiting. Patient Prefer Adherence. 2013 May 7;7:391-400. doi: 10.2147/PPA.S31288. 117. Buzzoni R, Pusceddu S, Damato A, Meroni E, Cumali A, Milione M, Mazzaferro V, De Braud F, Spreafico C, Maccauro M, Zaffaroni N, Castellani MR. Malignant pheochromocytoma and paraganglioma: future considerations for therapy. Q J Nucl Med Mol Imaging. 2013 Apr 18. 118. Pietrantonio F, De Braud F, Da Prat V, Perrone F, Pierotti MA, Gariboldi M, Fanetti G, Biondani P, Pellegrinelli A, Bossi I, Di Bartolomeo M. A review on biomarkers for prediction of treatment outcome in gastric cancer. Anticancer Res. 2013 Apr;33(4):1257-66 119. Pusceddu S, Buzzoni R, De Braud F. Pancreatic well-differentiated neuroendocrine neoplasms (pWDNENs): what place for everolimus and sunitinib derived from ESMO clinical practice guidelines in the therapeutic algorithm? Ann Oncol. 2013 May;24(5):1415-6. doi: 10.1093/annonc/mdt102. 120. Pelosi G, Rossi G, Cavazza A, Righi L, Maisonneuve P, Barbareschi M, Graziano P, Pastorino U, Garassino M, de Braud F, Papotti M. ΔNp63 (p40) Distribution Inside Lung Cancer: A Driver Biomarker Approach to Tumor Characterization. Int J Surg Pathol. 2013 Jun;21(3):229-39. doi: 10.1177/1066896913476750. 121. Garassino MC, Platania M, Broggini M, Torri V, De Braud F. To Target or Not to Target, That Is the Question. J Clin Oncol. 2013 Mar 20;31(9):1254. doi: 10.1200/JCO.2012.45.9818 122. Bampo C, Alessi A, Fantini S, Bertarelli G, de Braud F, Bombardieri E, Valvo F, Crippa F, Di Bartolomeo M, Mariani L, Milione M, Biondani P, Avuzzi B, Chiruzzi C, Pietrantonio F. Is the Standardized Uptake Value of FDG-PET/CT Predictive of Pathological Complete Response in Locally Advanced Rectal Cancer Treated with Capecitabine-Based Neoadjuvant Chemoradiation?.Oncology. 2013 Jan 15;84(4):191-199. 123. Pietrantonio F, Biondani P, Milione M, Melotti F, Bertarelli G, Perrone F, de Braud F, Mariani L, Fanetti G, Cortinovis D, Di Bartolomeo M. Lack of Bax expression is associated with irinotecan-based treatment activity in advanced colorectal cancer patients. Clin Transl Oncol. 2012 Nov 21. [Epub ahead of print] 124. Spitaleri G, Berardi R, Pierantoni C, De Pas T, Noberasco C, Libbra C, GonzálezIglesias R, Giovannoni L, Tasciotti A, Neri D, Menssen HD, de Braud F. Phase I/II study of the tumour-targeting human monoclonal antibody-cytokine fusion protein L19-TNF in patients with advanced solid tumours. J Cancer Res Clin Oncol. 2012 Nov 17. 125. Procopio G, Verzoni E, de Braud F. Targeted Therapies and Survival: What We Can Learn from Studies in Advanced Renal Cell Carcinoma. Oncology. 2013;84(1):39-42. Epub 2012 Oct 17. 126. Díaz-Rubio E, Pietrantonio F, de Braud F. Continuing Single-Agent Bevacizumab as Maintenance Therapy After Induction XELOX (or FOLFOX) Plus Bevacizumab in FirstLine Treatment of Metastatic Colorectal Cancer. Oncologist. 2012;17(11):1426-8. doi: 10.1634/theoncologist.2012-0075. 127. Gallerani E, Zucchetti M, Brunelli D, Marangon E, Noberasco C, Hess D, Delmonte A, Martinelli G, Böhm S, Driessen C, De Braud F, Marsoni S, Cereda R, Sala F, D'Incalci M, Sessa C. A first in human phase I study of the proteasome inhibitor CEP-18770 in patients with advanced solid tumours and multiple myeloma.Eur J Cancer. 2012 Oct 8. doi:pii: S0959-8049(12)00723-X. 10.1016/j.ejca.2012.09.009 128. Procopio G, Verzoni E, Iacovelli R, Biasoni D, Testa I, Porcu L, De Braud F. Prognostic factors for survival in patients with metastatic renal cell carcinoma treated with targeted therapies. r J Cancer. 2012 Sep 11. doi: 10.1038/bjc.2012.327. 129. Pietrantonio F, Garassino MC, Torri V, de Braud F. Reply to FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer-subgroup analysis of patients with KRAS-mutated tumours in the randomised German AIO study KRK-0306. Ann Oncol. 2012 Aug 8 130. Celio L, Agustoni F, Testa I, Dotti K, De Braud F. Palonosetron: an evidence-based choice in prevention of nausea and vomiting induced by moderately emetogenic chemotherapy. Tumori. 2012 May;98(3):279-86. 131. Necchi A, Mariani L, Zaffaroni N, Schwartz LH, Giannatempo P, Crippa F, Morosi C, Lanocita R, Sava T, Ortega C, Messina C, Sacco C, Pennati M, Daidone MG, Nicolai N, De Braud F, Gianni AM, Salvioni R. Pazopanib in advanced and platinum-resistant urothelial cancer: an open-label, single group, phase 2 trial. Lancet Oncol. 2012 Aug;13(8):810-6. 132. Panzuto F, Campana D, Fazio N, Brizzi MP, Boninsegna L, Nori F, Di Meglio G, Capurso G, Scarpa A, Dogliotti L, De Braud F, Tomassetti P, Delle Fave G, Falconi M. Risk Factors for Disease Progression in Advanced Jejunoileal Neuroendocrine Tumors. Neuroendocrinology 2012;96:32-40. 133. Perrone F, de Braud F, Labianca R, Tomino C, Roila F. Tackling off-label use of anticancer drugs. Clin Oncol. 2012 Aug 1;30(22):2800. 134. Pietrantonio F, Biondani P, de Braud F, Pellegrinelli A, Bianchini G, Perrone F, Formisano B, Di Bartolomeo M. Bax expression is predictive of favorable clinical outcome in chemonaive advanced gastric cancer patients treated with capecitabine, oxaliplatin, and irinotecan regimen. Transl Oncol. 2012 Jun;5(3):155-9. 135. Pelosi G, Gasparini P, Cavazza A, Rossi G, Graziano P, Barbareschi M, Perrone F, Barberis M, Takagi M, Kunimura T, Yamada T, Nakatani Y, Pastorino U, Scanagatta P, Sozzi G, Garassino M, De Braud F, Papotti M. Multiparametric molecular characterization of pulmonary sarcomatoid carcinoma reveals a nonrandom amplification of anaplastic lymphoma kinase (ALK) gene. Lung Cancer. 2012 Sep;77(3):507-14. 136. Biondani P, Procopio G, Pietrantonio F, de Braud F, Verzoni E. New perspectives in advanced genitourinary malignancies. Tumori. 2012 Mar-Apr; 98(2):267-9. 137. Toffalorio F, Radice D, Spaggiari L, Sinno V, Barberis M, Spitaleri G, Giovannini M, Delmonte A, Catania C, Noberasco C, Brambilla D, de Braud F, Veronesi G, Solli P, De Pas T. Features and prognostic factors of large node-negative non-small-cell lung cancers shifted to stage II. J Thorac Oncol. 2012 Jul;7(7):1124-30. 138. M. Milione , S. Pusceddu, P. Gasparini, F. Melotti, P. Maisonneuve, V. Mazzaferro, FG. de Braud and G.Pelosi Succinate Dehydrogenase B Subunit Immunohistochemical Expression Predicts Aggressiveness in Wel Differentiated Neuroendocrine Tumors of the Ileum. Cancers 2012, 4(3), 808-820; doi:10.3390/cancers4030808 139. Ribi K, Aldridge J, Phillips KA, Thompson A, Harvey V, Thürlimann B, Cardoso F, Pagani O, Coates AS, Goldhirsch A, Price KN, Gelber RD, Bernhard J; BIG 1-98 Collaborative Group; International Breast Cancer Study Group. Subjective cognitive complaints one year after ceasing adjuvant endocrine treatment for early-stage breast cancer. Br J Cancer. 2012 May 8;106(10):1618-25. 140. Procopio G, Verzoni E, De Braud F. Re: Camillo Porta, Emiliano Calvo, Miguel A. Climent, et al. Efficacy and safety of everolimus in elderly patients with metastatic renal cell carcinoma: an exploratory analysis of the outcomes of elderly patients in the RECORD-1 Trial. Eur Urol 2012; 61:826-33. 141. De Pas T, Giovannini M, Rescigno M, Catania C, Toffalorio F, Spitaleri G, Delmonte A, Barberis M, Spaggiari L, Solli P, Veronesi G, De Braud F. Vaccines in non-small cell lung cancer: Rationale, combination strategies and update on clinical trials. Crit Rev Oncol Hematol. 2012 Sep;83(3):432-43. 142. Spada F, Pelosi G, Squadroni M, Lorizzo K, Farris A, de Braud F., Fazio N. Neuroendocrine tumour arising inside a retro-rectal tailgut cyst: report of two cases and a review of the literature. Ecancermedicalscience. 2011;5:201. 143. Eigentler TK, Weide B, de Braud F, Spitaleri G, Romanini A, Pflugfelder A,GonzálezIglesias R, Tasciotti A, Giovannoni L, Schwager K, Lovato V, Kaspar M, Trachsel E, Menssen HD, Neri D, Garbe C. A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma. Clin Cancer Res. 2011 Dec 15;17(24):7732-42. Epub 2011 Oct 25. PubMed PMID: 22028492. 144. Regan MM, Neven P, Giobbie-Hurder A, Goldhirsch A, Ejlertsen B, Mauriac L,Forbes JF, Smith I, Láng I, Wardley A, Rabaglio M, Price KN, Gelber RD, Coates AS, Thürlimann B, de Braud F; BIG 1-98 Collaborative Group; International Breast Cancer Study Group (IBCSG). Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 198 randomised clinical trial at 8·1 years median follow-up. Lancet Oncol. 2011 Nov;12(12):1101-8. Epub 2011 Oct 20. PubMed PMID: 22018631; PubMed Central PMCID: PMC3235950. 145. Chirgwin J, Sun Z, Smith I, Price KN, Thürlimann B, Ejlertsen B, Bonnefoi H, Regan MM, Goldhirsch A, Coates AS, de Braud F; BIG 1-98 Collaborative and International Breast Cancer Study Groups. The advantage of letrozole over tamoxifen in the BIG 1-98 trial is consistent in younger postmenopausal women and in those with chemotherapyinduced menopause.Breast Cancer Res Treat. 2012 Jan;131(1):295-306.Epub 2011 Sep 4. PubMed PMID: 21892704. 146. De Pas T, Toffalorio F, Manzotti M, Fumagalli C, Spitaleri G, Catania C,Delmonte A, Giovannini M, Spaggiari L, de Braud F, Barberis M. Activity of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring rare epidermal growth factor receptor mutations.J Thorac Oncol. 2011 Nov;6(11):1895-901. 147. Regan MM, Price KN, Giobbie-Hurder A, Thürlimann B, Gelber RD, de Braud F; InternationalBreast Cancer Study Group and BIG 1-98 Collaborative Group. Interpreting Breast International Group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer. Breast Cancer Res. 2011 May 26;13(3):209. 148. De Pas T, Rosati G, Spitaleri G, Boni C, Tucci A, Frustaci S, Scalamogna R, Radice D, Boselli S, Toffalorio F, Catania C, Noberasco C, Delmonte A, Vecchio F, de Braud F. Optimizing clinical care in patients with advanced soft tissue sarcoma: a phase II study of a new schedule of high-dose continuous infusion ifosfamide and doxorubicin combination. Chemotherapy. 2011;57(3):217-24. 149. Panzuto F, Boninsegna L, Fazio N, Campana D, Pia Brizzi M, Capurso G, Scarpa A, De Braud F, Dogliotti L, Tomassetti P, Delle Fave G, Falconi M. Metastatic and locally advanced pancreatic endocrine carcinomas: analysis of factors associated with disease progression. J Clin Oncol. 2011 Jun 10;29(17):2372-7. 150. Joensuu H, De Braud F, Grignagni G, De Pas T, Spitalieri G, Coco P, Spreafico C, Boselli S, Toffalorio F, Bono P, Jalava T, Kappeler C, Aglietta M, Laurent D, Casali PG. Vatalanib for metastatic gastrointestinal stromal tumour (GIST) resistant to imatinib: final results of a phase II study. Br J Cancer. 2011 May 24;104(11):1686-90. 151. Haller DG, Tabernero J, Maroun J, de Braud F, Price T, Van Cutsem E, Hill M, Gilberg F, Rittweger K, Schmoll HJ. Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer. J Clin Oncol. 2011 Apr 10;29(11):1465-71. 152. De Pas TM, Toffalorio F, Giovannetti E, Radice D, Russo F, Angeli I, Calamai G, SpitaleriG, Catania C, Noberasco C, Milani A, Pelosi G, Danesi R, De Braud F. Optimizing pemetrexed-gemcitabine combination in patients with advanced non-smallcell lung cancer: a pharmacogenetic approach. J Thorac Oncol. 2011 Apr;6(4):768-73. 153. Gregorc V, De Braud FG, De Pas TM, Scalamogna R, Citterio G, Milani A,Boselli S, Catania C, Donadoni G, Rossoni G, Ghio D, Spitaleri G, Ammannati C,Colombi S, Caligaris-Cappio F, Lambiase A, Bordignon C. Phase I study of NGR-hTNF, a selective vascular targeting agent, in combination with cisplatin in refractory solid tumors. Clin Cancer Res. 2011 Apr 1;17(7):1964-72. 154. Bokemeyer C, Bondarenko I, Hartmann JT, de Braud F, Schuch G, Zubel A, Celik I, Schlichting M, Koralewski P. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol. 2011 Jan 12. 155. Jonker DJ, Rosen LS, Sawyer MB, de Braud F, Wilding G, Sweeney CJ, Jayson GC, McArthur GA, Rustin G, Goss G, Kantor J, Velasquez L, Syed S, Mokliatchouk O,Feltquate DM, Kollia G, Nuyten DS, Galbraith S. A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor,brivanib, in patients with advanced or metastatic solid tumors. Ann Oncol. 2011Jun:22(6):1413-9. 156. Fazio N, Cinieri S, Lorizzo K, Squadroni M, Orlando L, Spada F, Maiello E, Bodei L, Paganelli G, Delle Fave G, de Braud F. Biological targeted therapies in patients with advanced enteropancreatic neuroendocrine carcinomas. Cancer Treat Rev. 2010 Nov;36 Suppl 3:S87-94. Review. 157. Johannsen M, Spitaleri G, Curigliano G, Roigas J, Weikert S, Kempkensteffen C, Roemer A, Kloeters C, Rogalla P, Pecher G, Miller K, Berndt A, Kosmehl H, Trachsel E, Kaspar M, Lovato V, González-Iglesias R, Giovannoni L, Menssen HD, Neri D, de Braud F. The tumour-targeting human L19-IL2 immunocytokine: preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma. Eur J Cancer.2010 Nov;46(16):2926-35. 158. Santoro A, Pressiani T, Citterio G, Rossoni G, Donadoni G, Pozzi F, Rimassa L, Personeni N, Bozzarelli S, Rossoni G, Colombi S, De Braud FG, Caligaris-Cappio F, Lambiase A, Bordignon C. Activity and safety of NGR-hTNF, a selective vascular-targeting agent, in previously treated patients with advanced hepatocellular carcinoma. Br J Cancer. 2010 Sep 7; 159. De Pas T, de Braud F, Veronesi G. Adjuvant chemotherapy in new stage II pN0 non-small cell lung cancer: a new issue for a case-by-case decision making process. J Thorac Oncol. 2010 May;5(5):754. 160. Gregorc V, Zucali PA, Santoro A, Ceresoli GL, Citterio G, De Pas TM, Zilembo N, De Vincenzo F, Simonelli M, Rossoni G, Spreafico A, Grazia Viganò M, Fontana F, De Braud FG, Bajetta E, Caligaris-Cappio F, Bruzzi P, Lambiase A, Bordignon C. Phase II study of asparagine-glycine-arginine-human tumor necrosis factor alpha, a selective vascular targeting agent, in previously treated patients with malignant pleural mesothelioma. J Clin Oncol. 2010 May 20;28(15). 161. Roila F, Ballatori E, Labianca R, De Braud F, Borgonovo K, Martelli O, Gallo C, Tinazzi A, Perrone F; Italian Medical Oncology Association (AIOM). Off-label prescription of antineoplastic drugs: an Italian prospective, observational, survey. Tumori. 2009 Nov-Dec;95(6): multicenter 162. Catania C, De Pas T, Minchella I, De Braud F, Micheli D, Adamoli L, Spitaleri G, Noberasco C, Milani A, Zampino MG, Toffalorio F, Radice D, Goldhirsch A, Nolè F. "Waiting and the Waiting Room: How Do You Experience Them?" Emotional Implications and Suggestions from Patients with Cancer. J Cancer Educ. 2010 Mar 4. 163. Labianca R, Beretta GD, Kildani B, Milesi L, Merlin F, Mosconi S, Pessi MA, Prochilo T, Quadri A, Gatta G, de Braud F, Wils J. Colon cancer. Crit Rev Oncol Hematol. 2010 May;74(2):106-33. 164. De Pas T, Raimondi S, Pelosi G, Spaggiari L, De Braud F, Veronesi G, Maisonneuve P. A critical appraisal of the adjuvant chemotherapy guidelines for patients with completely resected T3N0 non-small-cell lung cancer. Acta Oncol. 2010 May;49(4). 165. Catania C, Pelosi G, Fazio N, Biffi R, Spitaleri G, Noberasco C, Zampino MG, Maggioni A, Trifirò G, Toffalorio F, Vigna PD, De Braud F, De Pas T. A FOLFIRIinduced complete tumor response in a patient with FOLFOX-refractory metastatic duodenal adenocarcinoma. Acta Oncol. 2010;49(1):120-1. 166. Noberasco C, Spitaleri G, Mancuso P, Zorzino L, Radice D, Milani A, Rocca A, Bertolini F, Sandri MT, Curigliano G, de Pas T, Jemos C, Omodeo Salè E, Boselli S, de Braud F. Safety, tolerability and biological effects of long-term metronomic administration of non-cytotoxic anti-angiogenic agents. Oncology. 2009;77(6):358-65 167. Toffalorio F, Giovannetti E, De Pas T, Radice D, Pelosi G, Manzotti M, Minocci D, Spaggiari L, Spitaleri G, Noberasco C, Catania C, Boselli S, Danesi R, de Braud F. Expression of gemcitabine- and cisplatin-related genes in non-small-cell lung cancer. Pharmacogenomics J. 2010 Jun;10(3):180-90. 168. De Pas TM, Toffalorio F, Catania C, Noberasco C, Spitaleri G, Spaggiari L, De Braud F. Gemcitabine and pemetrexed combination: the key role of the sequence of drugs administration. Ann Oncol. 2009 Oct;20(10):1747-8. Epub 2009 Aug 18. 169. Fazio N, Luca F, Monfardini L, Pelosi G, Bodei L, Lorizzo K, Di Meglio G, Gibelli B, Ravizza D, Bonomo G, Grana CM, Baio S, Squadroni M, Paganelli G, de Braud F. Right pelvic mass in a patient with a radically resected carcinoid of he appendix. Gut. 2009 Sep;58(9) 170. Sessa C, Cresta S, Noberasco C, Capri G, Gallerani E, De Braud F, Zucchetti M, D'Incalci M, Locatelli A, Marsoni S, Corradino I, Minoia C, Zintl P, Gianni L. Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours. Eur J Cancer. 2009 Aug;45(12):2116-22 171. Curigliano G, Spitaleri G, De Cobelli O, Scardino E, Sbanotto A, de Braud F. Health-related quality of life in patients with hormone refractory prostate cancer receiving gefitinib. Urol Int. 2009; 82(2):196-202 172. Capurso G, Fazio N, Festa S, Panzuto F, de Braud F, Delle Fave G. Molecular target therapy for gastroenteropancreatic endocrine tumours: Biological rationale and clinical perspectives. Crit Rev Oncol Hematol. 2009 Feb 25. 173. Zampino MG, Magni E, Leonardi MC, Petazzi E, Santoro L, Luca F, Chiappa A, Petralia G, Trovato C, Fazio N, Orecchia R, Nolè F, de Braud F. Capecitabine Initially Concomitant to Radiotherapy Then Perioperatively Administered in Locally Advanced Rectal Cancer. Int J Radiat Oncol Biol Phys. 2009 Feb 9. 174. Catalano G, De Pas T, Spaggiari L, Gandini S, Jereczek-Fossa BA, de Braud F, Leo F, Veronesi G, Orecchia R. Three-times daily radiotherapy after chemotherapy in stage III non-small cell lung cancer. Single-institution prospective study. Anticancer Res. 2008 NovDec; 28(6B):4121-7. 175. Biffi R, Orsi F, Pozzi S, Pace U, Bonomo G, Monfardini L, Della Vigna P, Rotmensz N, Radice D, Zampino MG, Fazio N, de Braud F, Andreoni B, Goldhirsch A. Best choice of central venous insertion site for the prevention of catheter-related complications in adult patients who need cancer therapy: a randomized trial. Ann Oncol. 2009 Jan 29 176. Spitaleri G, Matei DV, Curigliano G, Detti S, Verweij F, Zambito S, Scardino E, Rocco B, Nolè F, Ariu L, De Pas T, de Braud F, De Cobelli O. Phase II trial of estramustine phosphate and oral etoposide in patients with hormone-refractory prostate cancer. Ann Oncol. 2009 Mar; 20(3):498-502. Epub 2009 Jan 12. PubMed PMID: 19139180; PubMed Central PMCID: PMC2648011. 177. Sessa C, Perotti A, Noberasco C, De Braud F, Gallerani E, Cresta S, Zucchetti M, Viganò L, Locatelli A, Jimeno J, Feilchenfeldt JW, D'Incalci M, Capri G, Ielmini N, Gianni L. Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer. Eur J Cancer. 2009 May; 45(7):1153-61. Epub 2008 Dec 27. PubMed PMID: 19114300. 178. De Pas T, Spitaleri G, Pelosi G, De Carlis L, Lorizzo K, Locatelli M, Curigliano G, Toffalorio F, Catania C, de Braud F. Erlotinib combined with cyclosporine in a livertransplant recipient with epidermal growth factor receptor-mutated non-small cell lung cancer. J Thorac Oncol. 2009 Jan; 4 (1):138-9.. 179. Zampino MG, Labianca R, Beretta GD, Magni E, Gatta G, Leonardi MC, Chiappa A, Biffi R, de Braud F, Wils J. Rectal cancer. Crit Rev Oncol Hematol. 2009 May; 70(2):16082. Epub 2008 Dec 6. 180. Lorizzo K, Fazio N, Radice D, Boselli S, Ariu L, Zampino MG, Nolè F, Magni E, Ardito R, Minchella I, Rocca A, Di Meglio G, Squadroni M, de Braud F. Simplified FOLFIRI in pre-treated patients with metastatic gastric cancer. Cancer Chemother Pharmacol. 2008 Nov 26. [ 181. Catania C, De Pas T, Goldhirsch A, Radice D, Adamoli L, Medici M, Verri E, Marenghi C, de Braud F, Nolè F. Participation in clinical trials as viewed by the patient: understanding cultural and emotional aspects which influence choice. Oncology. 2008; 74 (3-4):177-87. 182. De Pas T, Toffalorio F, Colombo P, Trifirò G, Pelosi G, Vigna PD, Manzotti M, Agostini M, de Braud F. Brief report: activity of imatinib in a patient with platelet-derivedgrowth-factor receptor positive malignant solitary fibrous tumor of the pleura. J Thorac Oncol. 2008 Aug; 3 (8):938-41. 183. Floriani I, Rotmensz N, Albertazzi E, Torri V, De Rosa M, Tomino C, de Braud F. Approaches to interim analysis of cancer randomised clinical trials with time to event endpoints: A survey from the Italian National Monitoring Centre for Clinical Trials. Trials. 2008 Jul 25; 9:46. 184. Zampino MG, Magni E, Santoro L, Zorzino L, Dell'orto P, Sonzogni A, Fazio N, Monfardini L, Chiappa A, Biffi R, de Braud F. Epidermal growth factor receptor serum (sEGFR) level may predict response in patients with EGFR positive advanced colorectal cancer treated with gefitinib? Cancer Chemother Pharmacol. 2008 Dec; 63 (1):139-48. 185. Curigliano G, Spitaleri G, Fingert HJ, de Braud F, Sessa C, Loh E, Cipolla C, De Pas T, Goldhirsch A, Shah R. Drug-induced QTc interval prolongation: a proposal towards an efficient and safe anticancer drug development. Eur J Cancer. 2008 Mar; 44 (4):494-500. 186. Joensuu H, De Braud F, Coco P, De Pas T, Putzu C, Spreafico C, Bono P, Bosselli S, Jalava T, Laurent D, Casali PG. Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate. Ann Oncol. 2008 Jan; 19 (1):173-7. 187. De Pas T, Spitaleri G, Pruneri G, Curigliano G, Noberasco C, Luini A, Andreoni B, Testori A, de Braud F. Dendritic cell sarcoma: an analytic overview of the literature and presentation of original five cases. Crit Rev Oncol Hematol. 2008 Jan; 65 (1):1-7. 188. Fazio N, Di Meglio G, Lorizzo K, de Brand F. Miliary Hepatic Metastases from Neuroendocrine Carcinoma. Dig Surg. 2008 Oct 1; 25 (5):330. [Epub ahead of print] No abstract available. 189. Zampino MG, Magni E, Massacesi C, Zaniboni A, Martignetti A, Zorzino L, Lorizzo K, Santoro L, Boselli S, de Braud F. First clinical experience of orally active epidermal growth factor receptor inhibitor combined with simplified FOLFOX6 as first-line treatment for metastatic colorectal cancer. Cancer. 2007 Aug 15; 110 (4):752-8. 190. Zatelli MC, Torta M, Leon A, Ambrosio MR, Gion M, Tomassetti P, De Braud F, Delle Fave G, Dogliotti L, Uberti EC; On behalf of the Italian CromaNet Working Group. Chromogranin A as a marker of neuroendocrine neoplasia: an Italian Multicenter Study. Endocr Relat Cancer. 2007 Jun; 14 (2):473-82. 191. De Pas T, Spitaleri G, Pruneri G, Curigliano G, Noberasco C, Luini A, Andreoni B, Testori A, de Braud F. Dendritic cell sarcoma: An analytic overview of the literature and presentation of original five cases. Crit Rev Oncol Hematol. 2007 Jul 18; 192. Roth AD, Fazio N, Stupp R, Falk S, Bernhard J, Saletti P, Koberle D, Borner MM, Rufibach K, Maibach R, Wernli M, Leslie M, Glynne-Jones R, Widmer L, Seymour M, de Braud F; Swiss Group for Clinical Cancer Research. Docetaxel, cisplatin, and fluorouracil; docetaxel and cisplatin; and epirubicin, cisplatin, and fluorouracil as systemic treatment for advanced gastric carcinoma: a randomized phase II trial of the Swiss Group for Clinical Cancer Research. J Clin Oncol. 2007 Aug 1;25 (22):3217-23. 193. Curigliano G, De Braud F, Teresa Sandri M, Renne G, Zorzino L, Scardino E, Rocco B, Spitaleri G, De Pas T, Noberasco C, Nole F, Verweij F, Matei V, De Cobelli O. Gefitinib combined with endocrine manipulation in patients with hormone-refractory prostate cancer: quality of life and surrogate markers of activity. Anticancer Drugs. 2007 Sep;18 (8):949-54. 194. Joensuu H, De Braud F, Coco P, De Pas T, Putzu C, Spreafico C, Bono P, Bosselli S, Jalava T, Laurent D, Casali P. Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate. Ann Oncol. 2007 Aug 14; 195. Fazio N, Biffi R, Curigliano G, Lorizzo K, Zampino MG, de Braud F, Chiappa A, Roth A, Goldhirsch A. Re: Adjuvant treatment of high-risk, radically resected gastric cancer patients with 5-fluorouracil, leucovorin, cisplatin, and epidoxorubicin in a randomized controlled trial. J Natl Cancer Inst. 2007 Sep 5;99 (17):1345-6; author reply 1346-7. 196. Milani A, De Pas T, Noberasco C, McDonnell C, Libutti L, Limardi I, Zencovich C, Boselli S, Bianchi M, de Braud F. A 15-min premedication for 1-h paclitaxel infusion: optimizing patients' care. Lung Cancer. 2007 Nov;58 (2):300-1. 197. Curigliano G, Spitaleri G, Fingert HJ, de Braud F, Sessa C, Loh E, Cipolla C, De Pas T, Goldhirsch A, Shah R. Drug-induced QTc interval prolongation: A proposal towards an efficient and safe anticancer drug development. Eur J Cancer. 2007 Nov 15; 198. Zampino MG, Magni E, Massacesi C, Zaniboni A, Martignetti A, Zorzino L, Lorizzo K, Santoro L, Boselli S, de Braud F. First clinical experience of orally active epidermal growth factor receptor inhibitor combined with simplified FOLFOX6 as first-line treatment for metastatic colorectal cancer. Cancer. 2007 Aug 15;110 (4):752-8. 199. Veronesi G, Scanagatta P, Leo F, De Pas T, Pelosi G, Catalano G, Gandini S, deBraud F, Spaggiari L. Adjuvant surgery after carboplatin and VP16 in resectable small cell lung cancer. J Thorac Oncol. 2007 Feb; 2 (2):131-4. 200. Curigliano G, Pelosi G, De Pas T, Renne G, De Cobelli O, Manzotti M, Spitaleri G, de Braud F. Absence of epidermal growth factor receptor gene mutations in patients with hormone refractory prostate cancer not responding to gefitinib. Prostate. 2007 Feb 8; 201. Schmoll HJ, Cartwright T, Tabernero J, Nowacki MP, Figer A, Maroun J, Price T, Lim R, Van Cutsem E, Park YS, McKendrick J, Topham C, Soler-Gonzalez G, de Braud F, Hill M, Sirzen F, Haller DG. Phase III trial of capecitabine plus oxaliplatin as adjuvant therapy for stage III colon cancer: a planned safety analysis in 1,864 patients. J Clin Oncol. 2007 Jan 1;25 (1):102-9. 202. De Pas TM, de Braud F, Catalano G, Putzu C, Veronesi G, Leo F, Solli PG, Brambilla D, Paganelli G, Spaggiari L. Oligometastatic non-small cell lung cancer: a multidisciplinary approach in the positron emission tomographic scan era. Ann Thorac Surg. 2007 Jan;83 (1):231-4. 203. Bajetta E, Procopio G, Catena L, Martinetti A, De Dosso S, Ricci S, Lecchi AS, Boscani PF, Iacobelli S, Carteni G, De Braud F, Loli P, Tartaglia A, Bajetta R, Ferrari L. Lanreotide autogel every 6 weeks compared with Lanreotide microparticles every 3 weeks in patients with well differentiated neuroendocrine tumors: a Phase III Study. Cancer. 2006 Nov 15;107 (10):2474-81. 204. De Pas T, Putzu C, Curigliano G, Noberasco C, Sabrina B, Catania C, Orlando L, Milani A, Spaggiari L, de Braud F. A proper schedule of weekly paclitaxel and gemcitabine combination is highly Active and very well tolerated in NSCLC patients. Lung Cancer. 2006 Dec;54 (3):359-64. 205. Curigliano G, Spitaleri G, de Braud F, Goldhirsch A. Reply to Letter to the Editor: 'Toxic epidermal necrolysis in patients with malignancies', by G. Gravante, G. Esposito, M. Marianetti, D. Delogu, G. Sconocchia & A. Montone (doi:10.1093/annonc/mdl089). Ann Oncol. 2006 Oct;17 (10):1601-2. 206. Mey V, Giovanetti E, de Braud F, Nannizzi S, Curigliano G, Verweij F, de Corbelli O, Pece S, Tacca MD, Danesi R. In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients. Br J Cancer. 2006 Jul 25 207. Fazio N, Grana C, Pelosi G, Torrisi R, Di Meglio G, Tradati N, Lorizzo K, de Braud F. Successful chemotherapy and 90Y-DOTATOC in a patient with mediastinal aggressive neuroendocrine carcinoma. Acta Oncol. 2006;45 (5):627-9 208. Zampino MG, Lorizzo K, Rocca A, Locatelli M, Zorzino L, Manzoni S, Mazzetta C, Fazio N, Biffi R, de Braud F. Oxaliplatin combined with 5-fluorouracil and methotrexate in advanced colorectal cancer. Anticancer Res. 2006 May-Jun; 26 (3B).2425-8 209. Fazio N, de Braud F, Fave GD, Oberg K. Interferon-{alpha} and somatostatin analog in patients with gastroenteropancreatic neuroendocrine carcinoma : single agent or combination ? Ann Oncol.2006 Jun 23 210. Humbert M, Doumerc N, de Braud F, Fofana M, Blanchet P. Self-retaining ureteric removal of an encrusted ureteric stent after 10 years Prog Urol. 2006 Apr;16 (2):204-7. 211. Curigliano G, Magni E, Renne G, de Corbelli O, Rescigno M, Torrisi R, Spitaleri G, Pietri E, de Braud F, Goldhirsch A. “Burned out” phenomenon of the testis in retroperitoneal seminoma. Acta Oncol. 2006;45 (3):335-6 212. Curigliano G, Formica V, De Pas T, Spitaleri G, Pietri E, Fazio N, de Braud F, Goldhirsch A. Life-threatening toxic epidermal necrolysis durino voriconazole therapy for invasive aspergillosis after chemotherapy. Ann Oncol. 2006 Jul; 17(7):1174-5. 213. Bracarda S, de Corbelli O, Greco C, Prayer-Galetti T, Valdagni R, Gatta G, de Braud F, Bartsch G. Cancer of the prostate. Crit Rev Oncol Hematol. 2005 Dec; 56 (3):379-96 214. Curigliano G, Spitaleri G, Pietri E, Rescigno M, de Braud F, Cardillo A, Munzone E, Rocca A, Bonizzi G, Brichard V, Orlando L, Goldhirsch A. Breast cancer vaccines: a clinical reality or fairy tale? Ann Oncol. 2006 May; 17(5):750-62. 215. Leon A, Torta M, Dittadi R, degli Uberti E, Ambrosio MR, Delle Fave G, de Braud F, Tomassetti P, Gion M, Dogliotti L. Comparison between two methods in the determination of circulating chromogranin A in neuroendocrine tumors (NETs): results of a prospective multicenter observational study. Int J Biol Markers. 2005 Jul-Sep; 20(3):15668 216. Curigliano G, Colleoni M, Mandala M, De Pas T, Spitaleri G, de Braud F, Goldhirsch A. Prophylaxis for venous thromboembolism in cancer patients with a central vein catheter: new tones for an old song. J Clin Oncol. 2005 Oct 1; 23(28):7243-4; author reply 7244. 217. Curigliano G, Petit JY, Bertolini F, Colleoni M, Peruzzotti G, de Braud F, Gandini S, Giraldo A, Martella S, Orlando L, Munzone E, Pietri E, Luini A, Goldhirsch A. Systemic Effects of Surgery : Quantitative Analysis of Circulating Basic Fibroblast Growth Factor (bFGF), Vascular Endothelial Growth Factor (VEGF) and Transforming Growth Factor Beta (TGF-beta) in Patients with Breast Cancer Who Underwent Limited or Extended Surgery. Breast Cancer Res Treat. 2005 Sep.; 93(1):35-40 218. De Pas T, Putzu C, Pelosi G, Curigliano G, Noberasco C, Zampino G, Fazio N, Formica V, Spaggiari L, de Braud F Target-treatment and patients’ selection: can we still neglect the timing of tissue collection? J Clin Oncol. 2005 Sep 1; 23(25):6275-5;author reply 6275-6. 219. Twelves CJ, Butts CA, Cassidy J, Conroy T, de Braud F, Diaz-Rubio E, Tabernero JM, Schoffski P, Figer A, Brunet R, Grossmann J, Sobrero AF, Van Cutsem EJ. Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: post hoc analysis of a large phase II study. Cli Colorectal Cancer. 2005 Jul; 5 (2):101-7. 220. Catalano G, Jereczek-Fossa BA, De Pas T, Leon ME, Cattani F, Spaggiari L, Veronesi G, de Braud F, Orecchia R. Three-Times-Daily Radiotherapy with Induction Chemotherapy in Locally Advanced Non-Small Cell Lung Cancer Feasibility and Toxicity Study. Strahlenther Onkol. 2005 Jun; 181(6):363-371. 221. Catalano V, Labianca R, Beretta GD, Gatta G, de Braud F, Van Cutsem E. Gastric Cancer. Crit Rev Oncol Hematol. 2005 Jun;54 (3):209-41 222. Veronesi G, Pelosi G, Sonzogni A, Leon ME, D’Aiuto M, Gasparri R, de Braud F, De Pas T, Sandri M, Spaggiari L. Tumor CEA as predictor of better outcome in squamous cell carcinoma of the lung. Lung Cancer. 2005 May; 48(2):233-40. 223. Allavena P, Signorelli M, Chieppa M, Erba E, Bianchi G, Marchesi F, Olimpio CO, Bonardi C, Garbi A, Dissoni A, de Braud F, Jimeno J, D’Incalci M. Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production. Cancer Res. 2005 Apr 1; 65(7):2964-71. 224. Mallik S, de Braud F, Fofana M, Humbert M, Clervil M, Blanchet P. Wich anaesthesia should be recommended for prostate biopsy? West Indian Med J. 2005 Mar; 54(2):135-8 225. Sessa C, de Braud F, Perotti A, Bauer J, Curigliano G, Noberasco C, Zanaboni F, Gianni L, Marsoni S, Jimeno J, D’Incalci M, Dall’o E, Colombo N. Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails. J Cli Oncol. 2005 Mar 20; 23 (9):1867-74. 226. de Braud F, De Pas T, Spaggiari L, Veronesi G, Curigliano G, Noberasco C, Pelosi G, Re: Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst. 2005 Mar 16; 97(6):461-2; author reply 462-3. 227. De Pas T, Sbanotto A, Catania C, Banfi MG, Curigliano G, Nole F, Fazio N, Formica V, Veronesi G, de Braud F. Oral administration of vinorelbine can overcome intractable endovenous-vinorelbine-associated acute tumor pain. Support Care Cancer. 2005 Mar; 13(3):194-5. 228. De Pas T, Colleoni M, Orlando L, Masci G, Rocca A, Catania C, Curigliano G, Manzoni S, Goldhirsch A, de Braud F. Reply to the artiche “Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity” by V.R. Rozados et al. (Ann Oncol 2004;15:1543-1550): and in humans? Ann Oncol. 2005 Apr; 16(4):673. 229. Noberasco C, De Pas T, Curigliano G, Manzoni S, Dodaro L, Pelosi G, Spaggiari L, de Braud F. Immunohistochemical detection of HER1/HER2 can be considered a predective marker of gefitinib activity in non-small-cell lung cancer? J Clin Oncol. 2005 Feb 1; 23(4):921-2; author reply 922. 230. Spaggiari L, D’Aiuto M, Veronesi G, Pelosi G, de Pas T, Catalano G, de Braud F. Extended pneumonectomy with partila resection of the left atrium, without cardiopulmonary bypass, for lung cancer. Ann Thorac Surg. 2005 Jan; 79 (1):234-40. 231. De Pas T, Pelosi G, de Braud F, Veronesi G, Curigliano G, Leon ME, Danesi R, Noberasco C, D’Aiuto M, Catalano G, Viale G, Spaggiari L. Modulation of epidermal growth factor receptor status by chemotherapy in patients with locally advanced non-smallcell lung cancer is rare. J Clin Oncol.2004 Dec 15;22 (24):4966-70. 232. Fazio N, De Pas T, de Braud F, Spaggiari L, Mazzarol G, Biffi R, Andreoni B, Zampino M, Curigliano G, Lorizzo K, Di Meglio G, Goldhirsch A. CDX-2 should be included in the work-up of patients with lung metastases from unknown primary. Ann Oncol. 2004 Dec;15 (12):1850. 233. Chiappa A, Zbar AP, Biffi R, Bellomi M, Orecchia R, Marsiglia H, Bertani E, de Braud F, Crotti C, Andreoni B. Primary and recurrent retroperitoneal sarcoma: factors affecting survival and long-term outcome. Hepatogastroenterology. 2004 Sep-Oct;51 (59):1304-9. 234. De Pas T, Curigliano G, Veronesi G, Catalano G, Catania C, Jereczek-Fossa B, Orecchia R, Spaggiari L, de Braud F. Optimization of the schedale of gemcitabinecisplatin combination as induction regimen for patients with biopsy-proven stage IIIa N2stage IIIb non-small-cell lung cancer: a prospective phase-II study. Bull Cancer. 2004 Sep 1; 91 (9):E273-7. Print 2004 Sep. 235. Gennari R, Curigliano G, Rotmensz N, Robertson C, Colleoni M, Zurrida S, Nole F, de Braud F, Orlando L, Leonardi MC, Galimberti V, Intra M, Veronesi P, Renne G, Cinieri S, Audisio RA, Luini A, Orecchia R, Viale G, Goldhirsch A. Breast carcinoma in elderly women: features of disease presentation, choice of local and systemic treatments compared with younger postmenopausal patients. Cancer. 2004 Sep 15; 101 (6):1302-10. 236. Jodrell DI, Evans TR, Steward W, Cameron D, Prendiville J, Aschele C, Noberasco C, Lind M, Carmichael J, Dobbs N, Camboni G, Gatti B, de Braud F. Phase II studies of BBR3464, a novel tri-nuclear platinum complex, in patients with gastric or gastrooesophageal adenocarcinoma. Eur J Cancer. 2004 Aug; 40 (12):1872-7 237. Labianca R, Beretta G, Gatta G, de Braud F, Wils J. Colon cancer Crit Rev Oncol Hematol. 2004 Aug; 51 (2):145-70. 238. Jereczek-Fossa BA, Morra A, de Braud F, Alterio D, Mazzetta C, Rocca A, Catalano G, Bianchi L, Pasetti M, Chiesa F, Bruschini R, Orecchia R. Hyperfractionated Radiotherapy in Locally Advanced Nasopharyngeal CancerAn Analysis of 43 Consecutive Patients. Strahlenther Onkol. 2004 Jul; 180 (7):425-33. 239. Cassidy J, Tabernero J, Twelves C, Brunet R, Butts C, Conroy T, de Braud F, Figer A, Grossmann J, Sawada N, Schoffski P, Sobrero A, Van Cutsem E, Diaz-Rubio E. XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol. 2004 Jun 1; 22 (11):2084-91. 240. Curigliano G, Cipolla C, de Braud F. Drug-induced prolongation of the QT interval. N Engl J Med. 2004 Jun 17; 350 (25):2618-21 241. de Braud F, Cascinu S, Gatta G. Cancer of pancreas.Crit Rev Oncol Hematol. 2004 May; 50 (2):147-55 242. Roth AD, Maibach R, Fazio N, Sessa C, Stupp R, Morant R, Herrmann R, Borner MM, Goldhirsch A, de Braud F. 5-Fluorouracil as protracted continuous intravenous infusion can be added to full-dose docetaxel (Taxotere)-cisplatin in advanced gastric carcinoma: a phase I-II trial. Ann Oncol. 2004 May; 15 (5):759-64. 243. Leo F, Solli P, Spaggiari L, Veronesi G, de Braud F, Leon ME, Pastorino U. Respiratory function changes after chemotherapy: an additional risk for postoperative respiratory complications? Ann Thorac Surg. 2004 Jan; 77 (1):260-5; discussion 265. 244. Loni L, de Braud F, Zinzani PL, Danesi R. Pharmacogenetics and proteomics of anticancer drugs in non-Hodgkin's lymphoma.Leuk Lymphoma. 2003;44 Suppl 3: S115-22. 245. Fazio N, Orsi F, Grasso RF, Ferretti G, Medici M, Rocca A, Zampino G, Curigliano G, De Pas T, Colleoni M, Bonomo G, Marrocco E, Lunghi L, de Braud F. Hepatic intraarterial chemotherapy using a percutaneous catheter in pretreated patients with metastatic colorectal carcinoma. Anticancer Res. 2003 Nov-Dec; 23 (6D):5023-30 246. Stahel R, Rossi A, Petruzelka L, Kosimidis P, de Braud F, Bernardo MM, Souquet PJ, Parra HS, Gridelli C, Lessons from the (“Iressa” Expanded Access Programme: gefitinib in special non-small-cell lung cancer patient populations. Br J Cancer. 2003 Dec; 89 Suppl 2:S19-23 247. De Pas T, Danesi R, Catania C, Curigliano G, de Braud F; Italia Sarcoma Group. Imatinib administration in two patients with liver metastases from GIST and severe jaundice Br J Cancer. 2003 Oct 20; 89 (8):1403-4 248. Danesi R, de Braud F, Fogli S, De Pas T, Di Paolo A, Curigliano G, Del Tacca M. Pharmacogenetics of anticancer drug sensitivity in non-small cell lung cancer. Pharmacol Rev 2003 Mar; 55(1): 57-103. 249. De Pas T, Bodei L, Pelosi G, de Braud F, Villa G, Capanna R, Paganelli G. Peptide receptor radiotherapy: a new option for the management of aggressive fibromatosis on behalf of the Italian Sarcoma Group. British Journal of Cancer 2003 Mar 10; 88 (5):645-7 250. de Braud F, Khayat D, Kroon BB, Valdagni R, Bruzzi P, Cascinelli N. melanoma Crit Rev Oncol Hematol. 2003 Jul; 47 (1):35-63. Review Malignant 251. Veronesi G, Spaggiari L, De Pas T, Solli PG, de Braud F, Catalano GP, Curigliano G, Leo F, Pastorino U. Preoperative chemotherapy is essential for conservative surgery of Askin tumors. Journal of Thoracic and Cardiovascular Surgery 2003 Feb; 125 (2): 428-9 252. Ravizza D, Fazio N, Fiori G, Crosta C, Orsi F, Grasso R, Medici M, Ferretti G, de Braud F. Iatrogenic gastroduodenal ulcers during hepatic intra-arterial chemotherapy. Hepatogastroenterology 2003 Jan-Feb; 50: 49-53 253. De Pas T, Casali PG, Toma S, Romanini A, Massidda B, Comandone A, Labianca R, Massacesi C, Tucci A, Antimi M, Biasco G, Agliettaq M, Apice G, de Braud F. Gastrointestinal stromal tumors: should they be treated with the same sistemic chemotherapy as other soft tissue sarcomas? Oncology 2003; 64 (2): 186-8 254. Orecchia R, Jereczek-Fossa BA, Catalano G, Chiesa F, De Pas T, Masci G, Krengli M, Vavassori A, De Paoli F, Robertson C, Marrocco E, de Braud F. Phase II trial of vinorelbine, cisplatin and continuous infusion of 5-fluorouracil followed by hyperfractionated radiotherapy in locally advanced head and neck cancer. Oncology 2002; 63 (2): 115-23 255. Curigliano G, Colleoni M, Renne G, Mazzarol G, Gennari R, Peruzzotti G, de Braud F, Robertson C, Maiorano E, Veronesi P, Nolè F, Mandalà M, Ferretti G, Viale G, Goldhirsch A. Recognizing features that are dissimilar in male and female breast cancer expression of p21Waf1 and p27Kip1 using an immunohistochemical assay. Annals of Oncology 2002 Jun; 13 (6): 895-902 256. De Pas T, Pastorino U, Spaggiari L, Curigliano G, de Braud F, Robertson C Preoperative chemotherapy in non-small-cell lung cancer: nothing new in N2 disease. Journal of Clinical Oncology 2002 May 15; 20 (10): 2603-4 257. Veronesi G, Solli PG, Leo F, D’Aiuto M, Leon ME, de Braud F, Spaggiari L, Pastorino U. Low morbidity of bronchoplastic procedures after chemotherapy for lung cancer. Lung Cancer 2002 Apr; 36 (1): 91-7 258. Curigliano G, Ferretti G, Mandala M, De Pas T, Calabro MG, Solli P, Noberasc C, de Braud F. GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis. Anticancer Research 2001 Sep-Oct; 21 (5): 3461-9 259. de Braud F, Maffezzini M, Vitale V, Bruzzi P, Gatta G, Hendry WF, Sternberg CN. Bladder cancer. Critical Review of Oncology and Hematology 2002 Jan; 41 (1): 89-106 260. De Pas T, Curigliano G, Franceschelli L, Catania C, Spaggiari L, de Braud F. Gemcitabine-induced systemic capillary leak syndrome. Annals of Oncology 2001 Nov; 12 (11): 1651-2 261. Fogli S, Danesi R, de Braud F, De Pas T, Curigliano G, Giovannetti G, Del Tacca M. Drug distribution and pharmacokinetic/pharmacodynamic relationship of paclitaxel and gemcitabine in patients with non-small-cell lung cancer. Annals of Oncology 2001 Nov; 12 (11): 1553-9 262. Pfister CU, Martoni A, Zamagni C, Lelli G, de Braud F, Souppart C, Duval M, Hornberger U. Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara) in breast cancer patients. Biopharmaceutics and Drug Disposition 2001 Jul; 22 (5): 191-7 263. Curigliano G, Ferretti G, Flamini G, Goldhirsch A, de Braud F, Calabro MG, Mandala M, Nole F, De Pas T, D'Addessi A, Cittadini A.Diagnosis of T1 bladder transitional cell carcinoma by denaturing gradient gel electrophoresis urinalysis. Anticancer Research 2001; 21: 3015-20 264. Biffi R, Pozzi S, Pace U, Cenciarelli S, Zambelli M, Orsi F, Grasso RF, de Braud F, Andreoni B. Is there a real advantage in utilizing central venous ports in oncology surgery? An analysis of the cost-effectiveness ratio. Tumori 2001; 87: S74-5 265. Biffi R, de Braud F, Orsi F, Pozzi S, Arnaldi P, Goldhirsch A, Rotmensz N, Robertson C, Bellomi M, Andreoni B. A randomized, prospective trial of central venous ports connected to standard open-ended or Groshong catheters in adult oncology patients. Cancer 2001; 92: 1204-12 266. Danesi R, de Braud F, Fogli S, Di Paolo A, Del Tacca M. Pharmacogenetic determinants of anti-cancer drug activity and toxicity. Trends in Pharmacological Sciences 2001; 22: 420-6 267. Paganelli G, Zoboli S, Cremonesi M, Bodei L, Ferrari M, Grana C, Bartolomei M, Orsi F, De Cicco C, Macke HR, Chinol M, de Braud F. Receptor-mediated radiotherapy with 90Y-DOTA-D-Phe1-Tyr3-octreotide. European Journal of Nuclear Medicine 2001; 28: 426-34 268. De Pas T, Catalano G, Pastorino U, de Braud F, Jereczek-Fossa B, Spaggiari L, Orecchia R. Very low acute toxicity of three fractions per day accelerated radiotherapy given after Induction chemotherapy and surgery in stage III non-small cell lung cancer. Lung Cancer 2000; 30: 149-50 269. Martinoni A, Cipolla CM, Civelli M, Cardinale D, Lamantia G, Colleoni M, DeBraud F, Susini G, Martinelli G, Goldhirsh A, Fiorentini C. Intrapericardial treatment of neoplastic pericardial effusions. Herz. 2000 Dec;25 (8):787-93. Review. 270. De Pas T, de Braud F, Mandala M, Curigliano G, Catania C, Ferretti G, Sozzi P, Solli P, Goldhirsch A.Cisplatin and vinorelbine as second-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) resistant to taxol plus gemcitabine. Lung Cancer 2001; 31: 267-70 271. Biffi R, Orsi F, Grasso F, De Braud F, Cenciarelli S, Andreoni B. Catheter rupture and distal embolisation: a rare complication of central venous ports. J Vasc Access. 2000 Jan-Mar;1 (1):19-22. 272. Orsi F, Grasso RF, Arnaldi P, Bonifacio C, Biffi R, De Braud F, Bellomi M. Ultrasound guided versus direct vein puncture in central venous port placement. J Vasc Access. 2000 Apr-Jun; 1 (2):73-7. 273. De Pas T, de Braud F, Danesi R, Sessa C, Catania C, Curigliano G, Fogli S, Del Tacca M, Zampino G, Sbanotto A, Rocca A, Cinieri S, Marrocco E, Milani A, Goldhirsch A. Phase I and pharmacologic study of weekly gemcitabine and paclitaxel in chemonaive patients with advanced non-small-cell lung cancer. Annals of Oncology 2000; 11: 821-7 274. Giavazzi R, Albini A, Bussolino F, de Braud F, Presta M, Ziche M, Costa A. biological basis for antiangiogenic therapy Eur J Cancer. 2000 Oct; 36 (15): 1913-8 The 275. de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. Journal of Clinical Oncology 2000; 18: 2938-47 276. Ferretti G, Curigliano G, Pastorino U, Cittadini A, Flamini G, Calabro MG, De Pas T, Orlando L, Mandala M, Colleoni M, Spaggiari L, Granone PL, Pagliari G, de Braud F, Fazio N, Goldhirsch A. Detection by denaturant gradient gel electrophoresis of tumorspecific mutations in biopsies and relative bronchoalveolar lavage fluid from resectable non-small cell lung cancer. Clinical Cancer Research 2000; 6: 2393-400 277. De Pas T, Curigliano G, Catania C, Comandone A, de Braud F. Ifosfamide in the elderly: clinical considerations for a better drug management. Critical Reviews in Oncology and Hematology 2000; 33: 129-35 278. Orlando L, Colleoni M, Nole F, Biffi R, Rocca A, Curigliano G, Ferretti G, Peruzzotti G, de Braud F, Masci G, Goldhirsch A. Incidence of venous thromboembolism in breast cancer patients during chemotherapy with vinorelbine, cisplatin, 5-fluorouracil as continuous infusion (ViFuP regimen): is prophylaxis required? Annals of Oncology 2000; 11: 117-8 279. Biffi R, Pozzi S, Orsi F, de Braud F, Cenciarelli S, Andreoni B. Catheter rupture and distal embolisation: a rare complication of central venous ports. Journal of Vascular Access 2000; 1: 19-22 280. De Pas T, Martinelli G, de Braud F, Peccatori F, Catania C, Aapro M, Goldhirsch A. Friedreich's ataxia and intrathecal chemotherapy in a patient with lymphoblastic lymphoma. Annals of Oncology 1999; 10: 1393 281. Brienza S, Bensmaine MA, Soulie P, Louvet C, Gamelin E, Francois E, Ducreux M, Marty M, Andre T, de Braud F, Bleiberg H, Segal V, Itzhaki M, Cvitkovic E. Oxaliplatin added to 5-fluorouracil-based therapy (5-FU +/- FA) in the treatment of 5-FU-pretreated patients with advanced colorectal carcinoma (ACRC): results from the European compassionate-use program. Annals of Oncology 1999; 10: 1311-6 282. Nole F, Minchella I, Colleoni M, Orvieto E, Munzone E, de Braud F, Peruzzotti G, Martinelli G, Zampino MG, Catania C, Pizzamiglio M, Veronesi P, Zurrida S, Galimberti V, Goldhirsch A, Veronesi U. Primary chemotherapy in operable breast cancer with favorable prognostic factors: a pilotstudy evaluating the efficacy of a regimen with a low subjective toxic burden containingvinorelbine, 5-fluorouracil and folinic acid (FLN). Annals of Oncology 1999; 10: 993-6 283. Casali P, Licitra L, Tondini C, de Braud F, Bruzzi P, Costa A, Cavalli F. START: a European state-of-the-art on-line instrument for clinical oncologists. Annals of Oncology 1999; 10: 769-73 284. Zampino MG, Colleoni M, Bajetta E, Stampino CG, Guenzi A and de Braud F. Pharmacokinetics of oral doxifluridine in patients with colorectal cancer. Tumori 1999; 85: 47-50 285. Paganelli G, Grana C, Chinol M, Cremonesi M, De Cicco C, de Braud F, Robertson C, Zurrida S, Casadio C, Zoboli S, Siccardi AG, Veronesi U. Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin. European Journal of Nuclear Medicine 1999; 26: 348-57 286. Crosta C, Fiori G, de Braud F. Endoscopic therapy of metastatic melanoma to the papilla of water: a case report. Giornale Italiano di Endoscopia Digestiva 1999; 22: 157-9 287. Colleoni M, Vicario G, Manente P, de Braud F, Fazio N, Liessi G. Activity and tolerability of courses of intra-arterial chemotherapy followed by chemoembolization in unresectable hepatocellular carcinoma. Tumori 1998; 84: 673-6 288. De Pas T, de Braud F, Orlando L, Nole F, Munzone E, Zampino MG, Fazio N, Aapro MS, Goldhirsch A. High-dose ifosfamide plus adriamycin in the treatment of adult advanced soft tissue sarcomas: is it feasible? Annals of Oncology 1998; 9: 917-9 289. Jereczek-Fossa B, de Braud F, Gasparetto M, De Pas T, Tradati N, Leonardi MC, Marsiglia HR, Orecchia R. Induction chemotherapy followed by simultaneous hyperfractionated radiochemotherapy in advanced head and neck cancer. A pilot study. Strahlenther Onkologie 1998; 174: 457-61 290. Biffi R, de Braud F, Orsi F, Pozzi S, Mauri S, Goldhirsch A, Nole F, Andreoni B. Totally implantable central venous access ports for long-term chemotherapy. A prospective study analyzing complications and costs of 333 devices with a minimum followup of 180 days. Annals of Oncology 1998; 9: 767-73 291. Paganelli G, Orecchia R, Jereczek-Fossa B, Grana C, Cremonesi M, de Braud F, Tradati N, Chinol M. Combined treatment of advanced oropharyngeal cancer with external radiotherapy and three-step radioimmunotherapy. European Journal of Nuclear Medicine 1998; 25: 1336-9 292. Audisio RA, de Braud F, Wils J. Hematology 1998; 27: 143-4 Gastric cancer. Critical Reviews in Oncology and 293. Diaz-Rubio E, Sastre J, Zaniboni A, Labianca R, Cortes-Funes H, de Braud F, Boni C, Benavides M, Dallavalle G, Homerin M. Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: a phase II multicentric study. Annals of Oncology 1998; 9: 105-8 294. Audisio RA, de Braud F, Wils J. Colorectal cancer. Critical Reviews in Oncology and Hematology 1998; 27: 139-41 295. De Pas T, de Braud F, Sessa C, Sbanotto A, Catania C, Zampino G, Minchella I, Cinieri S, Colleoni M, Nolè F, Ghilenzan S, Marrocco E and Goldhirsch A Phase I doseescalation study with weekly taxol and gemcitabine in patients with advanced non small cell lung cancer. Bulletin du Cancer 1998; 18 : 179-83 296. Fazio N, de Braud F, Colleoni M, Orsi F, Marenghi C, Oliva C, De Pas T, Locatelli M and Goldhirsch A Hepatic intra-arterial chemotherapy with fluorouracil, cisplatin and mitomycin-c in liver metastases from colorectal carcinoma by percutaneous catheter. Bulletin du Cancer 1998; 18: 120-3 297. Colleoni M, Audisio RA, de Braud F, Fazio N, Martinelli G, Goldhirsch A. Practical considerations in the treatment of hepatocellular carcinoma. Drugs 1998; 55: 367-82 298. de Braud F, Munzone E, Nole F, De Pas T, Biffi R, Brienza S, Aapro MS. Synergistic activity of oxaliplatin and 5-fluorouracil in patients with metastatic colorectal cancer with progressive disease while on or after 5-fluorouracil. American Journal of Clinical Oncology 1998; 21: 279-83 299. Nole F, de Braud F, Aapro M, Minchella I, De Pas M, Zampino MG, Monti S, Andreoni G, Goldhirsch A. Phase I-II study of vinorelbine in combination with 5fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden. Annals of Oncology 1997; 8: 865-70 300. Biffi R, Corrado F, de Braud F, de Lucia F, Scarpa D, Testori A, Orsi F, Bellomi M, Mauri S, Aapro M, Andreoni B. Long-term, totally implantable central venous access ports connected to a Groshong catheter for chemotherapy of solid tumours: experience from 178 cases using a single type of device. European Journal of Cancer 1997; 33: 1190-4 301. Colleoni M, Graffeo R, Martinelli G, Ghielmini M, de Braud F, Zampino G, Marini G, Cavalli F and Goldhirsch A Cisplatin, etoposide and bleomycin infusion (PEBi regimen) in good-risk patients with germ cell tumors. Oncology Reports 1997; 4: 913-6 302. de Braud F, Fazio N, Aapro M. Hormone replacement therapy and melanoma. CME Journal of Gynecology and Oncology 1997; 15-7 303. Peccatori F, de Braud F,Cocorocchio E, Aapro M Estrogen replacemnet therapy and colorectal cancer: suggestion of protection. CME Journal of Gynecology and Oncology 1997; 21-2 304. Janot F, Klijanienko J, Russo A, Mamet JP, de Braud F, El-Naggar AK, Pignon JP, Luboinski B, Cvitkovic E. Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: a prospective analysis. British Journal of Cancer 1996; 73: 531-8 305. de Braud F, De Pas T, Maffezzini M Immunoterapia del carcinoma renale avanzato. Urologia 1996: 451-7 306. Aapro MS, de Braud F, Tommasello G. 1996; 54, 35-8 Oncologie Médicale. Médicine et Hygiene 307. Munzone E, de Braud F, de Pas M, Zimatore M, Aapro MS. Le traitment adjuvant des tumeurs du colon et du rectum. Médicine et Hygiene 1996; 54, 1216-22 308. Klijanienko J, el-Naggar AK, de Braud F, Rodriguez-Peralto JL, Rodriguez R, Itzhaki M, Russo A, Janot F, Luboinski B, Cvitkovic E. Tumor vascularization, mitotic index, histopathologic grade, and DNA ploidy in the assessment of 114 head and neck squamous cell carcinomas. Cancer 1995; 75: 1649-56 309. Di Bartolomeo M, Bajetta E, de Braud F, Bochicchio AM, Gebbia V, Bozzetti F, Doci R, Bonfanti G, Cozzaglio L. Phase II study of the etoposide, leucovorin and fluorouracil combination for patients with advanced gastric cancer unsuitable for aggressive chemotherapy. Oncology 1995; 52: 41-4 310. de Braud F, Colleoni M, Noli F, Bajetta E. Home treatment with interleukin 2 and beta-interferon in patients with colorectal cancer and hepatocellular carcinoma. Oncology 1994; 51: 472-6 311. De Cesare M, Pratesi G, De Braud F, Zunino F, Stampino CG. Remarkable antitumor activity of 5'-deoxy-5-fluorouridine in human colorectal tumor xenografts. Anticancer Research 1994; 14: 549-54 312. Bajetta E, Di Bartolomeo M, de Braud F, Bozzetti F, Bochicchio AM, Comella P, Fagnani D, Farina G, Ferroni C, Franchi R, et al. Etoposide, doxorubicin and cisplatin (EAP) treatment in advanced gastric carcinoma: a multicentre study of the Italian Trials in Medical Oncology (I.T.M.O.) Group. European Journal of Cancer 1994; 30A: 596-600 313. de Braud F Le ròle de La thérapie medicale dans le traiment des tumeurs de l’etomac. Médicine et Hygiene 1994; 52, 2386-9 314. Klijanienko J, el-Naggar A, De Braud F, Micheau C, Janot F, Luboinski B, Gentile A, Russo A, Cvitkovic E. Keratins 6, 13 and 19. Differential expression in squamous cell carcinoma of the head and neck. Anal Quant Cytology and Histology 1993 Oct; 15 (5): 33540 315. Gasparini M, Zampino MG, Maffioli L, de Braud F, Bombardieri E, Buraggi GL. Enhancement of in vivo monoclonal antibody targeting with recombinant interferon a and cytokines. International Journal of Biological Markers. 1993; 8: 160-5 316. de Braud F, Bajetta E, Zampino MG, Zilembo N and Colleoni M. Systemic treatment of advanced malignant melanoma International Journal of Oncology 1993; 2: 245-52 317. de Braud F, Biganzoli L, Bajetta E, Colleoni M, Zampino MG. Subcutaneous lowdose interleukin-2 plus alpha interferon in advanced malignant melanoma. Tumori 1993; 79: 187-90 318. de Braud F, Al-Sarraf M. Diagnosis and management of squamous cell carcinoma of unknown primary tumor site of the neck. Seminars in Oncology 1993; 20: 273-8 319. Buzzoni R, Colleoni M, Bajetta E, Nole F, Nelli P, De Palma CA, de Braud F. Effective salvage chemotherapy in relapsed or refractory non-Hodgkin's lymphoma. Annals of Oncology 1993;4: 251-3 320. Zilembo N, Buzzoni R, Bajetta E, Di Bartolomeo M, de Braud F, Castellani R, Maffioli L, Celio L, Villa E, Lorusso V, et al. Salvage treatment after r-interferon alpha-2a in advanced neuroendocrine tumors. Acta Oncologica 1993; 32: 245-50 321. Di Bartolomeo M, Bajetta E, Zilembo N, de Braud F, Di Leo A, Verusio C, D'Aprile M, Scanni A, Barduagni M, et al, Barduagni A. Treatment of carcinoid syndrome with recombinant interferon alpha-2a. Acta Oncologica 1993; 32: 235-8 322. Colleoni M, Bajetta E, de Braud F, Zilembo N, Nole F, Nelli P. Reversal of resistance to doxifluridine and fluorouracil in metastatic colorectal cancer: the role of high-dose folinic acid. Tumori 1992; 78: 258-61 323. de Braud F, Bajetta E, Di Bartolomeo M, Colleoni M. Adjuvant chemotherapy for cancer of gastrointestinal tract: a critical review. Tumori 1992; 78: 228-34 324. Colleoni M, Nole F, Di Bartolomeo M, de Braud F, Bajetta E. Mitoxantrone in patients affected by hepatocellular carcinoma with unfavorable prognostic factors. Oncology 1992; 49: 139-42 325. Capri G, de Braud F, Lissoni P, Merson M, Santoro O, Stefanon B, Tana S, Tancini G Immunodepressione e tumori umani. NAM 1991; 7: 4-12 326. Ensley JF, Maciorowski Z, Pietraszkiewicz H, de Braud F, Sakr W. Methodology and clinical applications of cellular DNA content parameters determined by flow cytometry in squamous cell cancers of the head and neck. Cancer Treatment and Research 1990; 52: 22542 327. de Braud F, Heilbrun LK, Ahmed K, Sakr W, Ensley JF, Kish JA, Tapazoglou E, AlSarraf M Metastatic squamous cell carcinoma of an unknown primary localized to the neck. Advantages of an aggressive treatment. Cancer 1989; 64: 510-5 328. de Braud F Update on treatment of human neoplasia with interferons in combination with other agents. Folia Oncologica 1989; 12-26 329. de Braud F, Licitra L Diagnosi e trattamento dei carcinomi spinocellulare a sede primitiva ignota metastatici ai linfonodi cervicali Argomenti di Oncologia 1989; 10: 447-57 330. Orazi A, Sozzi G, Cattoretti G, de Braud F, Delia D. Acute leukemia with the (4;11) chromosome translocation following treatment for Hodgkin's disease: a case study. Haematologica 1988; 73: 279-83 331. Campagnari F, Bombardieri E, de Braud F, Baldini L, Maiolo AT. Terminal deoxynucleotidyl transferase, TdT, as a marker for leukemia and lymphoma cells. International Journal of Biological Markers 1987; 2: 31-42 332. Delia D, Bonati A, Giardini R, Villa S, de Braud F, Cattoretti G, Rilke F. Expression of the T1 (CD5, p67) surface antigen in B-CLL and B-NHL and its correlation with other B-cell differentiation markers. Hematological Oncology 1986; 4: 237-48 333. Delia D, Cattoretti G, Bonati A, Villa S, de Braud F, Buscaglia M. Detection of the common acute lymphoblastic leukaemia antigen (CALLA) on B cells from human fetal tissues. A multiple phenotypic characterization. Clinical and Experimental Immunology 1985; 59: 305-14 334. Delia D, Greaves M, Villa S, de Braud F. Characterization of the response of human thymocytes and blood lymphocytes to the synergistic mitogenicity of 12-Otetradecanoylphorbol-13-acetate (TPA)-ionomycin. European Journal of Immunology 1984; 14: 720-4 335. Bombardieri E, Campagnari F, de Braud F, Clerici L, Maiolo AT, Villa ML, Cappelletti V, Saccani Jotti G, Vezzoni P, Neri A, et al. Analysis of the enzyme terminal deoxyribonucleotidyl transferase in lymphoma and leukemia cells. Acta Biomedica Ateneo Parmense 1984; 55: 15-23 336. Campagnari F, Maiolo AT, Bombardieri E, de Braud F. Terminal deoxyribonucleotidyl transferase in malignant lymphoma and leukemia. Giornale di Clinica Medica 1982; 412