Scientific Program

UNDER THE AUSPICES OF
SIE
Società Italiana di Ematologia
ACKNOWLEDGEMENTS
THE EBMT CELLULAR
THERAPY AND
IMMUNOBIOLOGY
WORKING PARTY
SYMPOSIUM
From Transplantation
to Gene Therapy:
Cellular therapy in evolution
November 11th -13th, 2015
Milano,
San Raffaele Hospital
SCIENTIFIC PROGRAM
EBMT-CTIWP BOARD
Chairman
Secretary
Prof. Chiara Bonini
Prof. Christian Chabannon
Vita-Salute San Raffaele University
Milano, Italy
FACULTY
Prof. Francesco Dazzi
King’s College
London, UK
Paoli Calmettes Institute
Marseille, France
Dr. Paolo Dellabona
San Raffaele Hospital
Milano, Italy
Prof. Gianpietro Dotti
The University of
North Carolina
Chapel Hill, USA
LOCAL SCIENTIFIC COMMITTEE
Dr. Attilio Bondanza
San Raffaele Hospital
Milano, Italy
Prof. Fabio Ciceri
Vita-Salute San Raffaele University
Milano, Italy
Dr. Sara Mastaglio
San Raffaele Hospital
Milano, Italy
Prof. Hermann Einsele
University Hospital
Würzburg, Germany
Dr. Luca Vago
San Raffaele Hospital
Milano, Italy
Vita-Salute San Raffaele
University
Milano, Italy
Prof. Ettore Biagi
Milano-Bicocca University
San Gerardo Hospital
Monza, Italy
Prof. Isabelle André-Schmutz Prof. Andrea Biondi
Institut Imagine – INSERM
Paris, France
Milano-Bicocca University
Milano, Italy
Dr. Manuela Battaglia
Prof. Claudio Bordignon
Dr. Giulia Casorati
San Raffaele Hospital
Milano, Italy
Dr. Nicoletta Cieri
San Raffaele Hospital
Milano, Italy
Prof. Massimo Clementi
San Raffaele Hospital
Milano, Italy
MolMed Spa
Milano, Italy
Vita-Salute San Raffaele
University
Milano, Italy
Dr. Maria Ester Bernardo
Dr. Marco Bregni
Dr. Patrizia Comoli
San Raffaele Hospital
Milano, Italy
Ospedale di Circolo
Busto Arsizio (VA), Italy
University of Washington
Fred Hutchinson
Cancer Research Center
Seattle, USA
Dr. Silvia Gregori
San Raffaele Hospital
Telethon Institute for
Gene Therapy
Milano, Italy
Dr. Michael Hudecek
University Hospital
Würzburg, Germany
Prof. Ulrike Köhl
FACULTY
Prof. Alessandro Aiuti
Prof. Phil Greenberg
Policlinico San Matteo Hospital
Pavia, Italy
Dr. Ivana Ferrero
Università degli Studi
Torino, Italy
Hannover Medical
School (MHH)
Hannover, Germany
Dr. Willem E. Fibbe
Prof. Franco Locatelli
Leiden University
Medical Center
Leiden, The Netherlands
Pediatric Hospital
Bambino Gesù
Roma, Italy
Prof. Katharina Fleischhauer
Dr. Anna Mondino
Essen University Hospital
Essen, Germany
San Raffaele Hospital
Milano, Italy
Dr. Maria Cristina Galli
Prof. Luigi Naldini
Istituto Superiore di Sanità
Roma, Italy
Dr. Eliane Gluckman
Eurocord International
Registry
Hôpital Saint Louis
Paris, France
Vita-Salute San Raffaele
University
Milano, Italy
Prof. Richard O’Reilly
Memorial Sloan Kettering
Cancer Center
New York, USA
Dr. Paolo Pedrazzoli
Policlinico San Matteo Hospital
Pavia, Italy
Prof. Karl Peggs
University College Hospital
London, UK
Dr. Jan Richter
Novartis Pharma AG
Basel, Switzerland
Prof. Vanderson Rocha
Oxford University Hospitals
Oxford, UK
Dr. Annalisa Ruggeri
Eurocord International Registry
Hôpital Saint Louis
Paris, France
Dr. Carmen Ruiz de Elvira
EBMT Central Registry Office
London, UK
Prof. Jaime Sanz Caballer
University Hospital La Fe
Valencia, Spain
Prof. Antoine Toubert
Paris Diderot University
Paris, France
Dr. Marcel van den Brink
Memorial Sloan Kettering
Cancer Center
New York, USA
Prof. Andrea Velardi
University of Perugia
Perugia, Italy
SCIENTIFIC PROGRAM
14.00-17.30
Wednesday, November 11th 2015
The CTIWP Business meeting
18.00-19.30 Symposium Opening Lectures
Chairs: C. Bonini, C. Chabannon
Session II
Cellular therapy to improve transplantation outcome
11.40 12.00
Chairs: M. Bregni, P. Comoli
MSCs: does source matter?
M.E. Bernardo, Italy
NK cell therapy in allo-SCT
Immune players in BMT
R. O’Reilly, USA
From bench to GMP
C. Bordignon, Italy
12.20
Cellular therapy for tolerance induction:
MSC vs Tregs in HSCT
19.30
Light buffet
Thursday, November 12th 2015
09.00 Keynote Lecture
Chair: M. Clementi
Microbiome and GvHD
M. van den Brink, USA
Session I
Cord Blood Transplantation: current challenges
Chairs: F. Locatelli, V. Rocha
09.40
Do we need to collect more CBU?
10.00
10.20
C. Chabannon, France
F. Dazzi, UK
12.40
Cell therapy for cytomegalovirus
K. Peggs, UK
13.00
Lunch break
14.00 14.20
14.40
15.00
Pathogen specific T cells
H. Einsele, Germany
Alfabeta depletion in haplo-HSCT
F. Locatelli, Italy
Targeting leukemia by lipid specific T cells
G. Casorati, Italy
Keynote Lecture
Chair: F. Locatelli
Harnessing mesenchymal stromal cells for
immune modulatory treatment
J. Sanz Caballer, Spain
W. Fibbe, The Netherlands
Immune reconstitution after CBT
15.40
Break
A. Ruggeri, France
Open questions in clinical CBT
E. Gluckman, France
10.40
Keynote Lecture
Chairs: M. Battaglia, S. Gregori
Cellular therapy to improve outcome of haplo-HSCT
A. Velardi, Italy
11.20
Break
Session III
The use of genetically redirected T cells:
Improving SCT or replacing SCT?
Chairs: P. Dellabona, P. Pedrazzoli
16.00
Targeting AML and MM with CD44v6-CAR T cells:
synergy with allo-SCT?
A. Bondanza, Italy
SCIENTIFIC PROGRAM
16.20
Targeting MM with CAR T cells
M. Hudecek, Germany
16.40
CAR-T cells from lymphoid malignancies to solid tumors
11.00 11.20 A sustainable cellular therapy approach: CAR-based CIK
E. Biagi, Italy
Regulatory framework from ATMP
G. Dotti, USA
M.C. Galli, Italy
CAR expressing NK cells
U. Köhl, Germany
11.40
Round Table
17.20 Keynote Lecture
C. Bordignon, M.C. Galli, M. Introna, J. Richter
P. Greenberg, USA
12.45
Lunch break
18.00 Round Table
A. Aiuti, F. Ciceri, G. Dotti, P. Greenberg, R. O’Reilly
17.00
TCR redirected T cells for myeloid leukemia
ellular Therapy: improving the outcome of SCT
C
or replacing SCT?
rom HSCT to cell therapy and gene therapy:
F
regulatory hurdles and innovative business models
Session V
Cellular Therapy and allo-SCT:
guidelines for patients’ follow-up
Chairs: A. Bondanza, A. Toubert
Friday, November 13th 2015
13.40
How to improve post-transplant immunological
reconstitution
Keynote Lecture
I. André-Schmutz, France
09.00 14.00
ssessing lymphocyte generation by DNA rearrangement
A
excision circles in allo-HSCT
Lentiviral vectors and nucleases: clinical applications and
future directions
A. Toubert, France
Chairs: A. Biondi, C. Bordignon
L. Naldini, Italy
14.20
14.40 Session IV
Regulation, harmonization and sustainability
of cellular therapy: what can we learn from SCT?
Chairs: A. Aiuti, F. Ciceri
10.00
Cell therapy in Jacie standards
I. Ferrero, Italy
10.20
A European Registry for cellular therapy
The concept of permissiveness in HSCT and cell therapy
K. Fleischhauer, Germany
Leukemia immune editing
L. Vago, Italy
15.00
Memory stem T cells in transplantation and
cellular therapy
15.20 N. Cieri, Italy
Keynote Lecture
Chair: C. Bonini
C. Ruiz de Elvira, UK
When allogeneic hematopoietic cell transplantation
meets adoptive T cell Therapy
A. Mondino, Italy
10.40
Break
16.00 Closing remarks