International Conference on Respiratory Pathophysiology, Sleep

International Conference
on Respiratory Pathophysiology,
Sleep and Breathing
Rome - June 15-17, 2016
FINAL
PROGRAMME
FINALPROGRAMME
RAZIONALE
Sleep Medicine is considered as a multidisciplinary discipline involving numerous specialists. Sleep
related breathing disorders constitute a subset of the broad group of sleep disorders that include
many other disorders such as insomnia, hypersomnias, parasomnias, and sleep related movement
disorders. Sleep disorders cause continuous arousals, excessive daytime sleepiness with all related
effects on the capacity of concentration and attention; they can worsen cognitive function, and represent
a risk factor for cardiovascular and cerebrovascular events, arrhythmias and metabolic disorders.
Such disorders affect a huge percentage of the general population and often result in exacerbation of
underlying pathologies that tend to worsen considerably during sleep.
Individuals with chronic lung disease often have disturbed sleep associated with oxygen desaturations,
coughing, or dyspnoea. Patients with certains medical disorders, such as asthma, may suffer their
symptoms most severely during sleep. Both obstructive and restrictive lung diseases are associated with
poor quality of sleep. Chronic obstructive pulmonary disease (COPD) is a high and increasingly prevalent
disease; during wakefulness, abnormalities of respiratory function are demonstrated by standard pulmonary
function tests: among them, spirometry and arterial blood gas analysis are the most generally used to
define the degree of severity of COPD. A more complete evaluation of patients with this disease includes
the assessment of sleep gas exchanges, which worsen to a variable extent with respect to wakefulness.
Our ability to predict the prognosis of affected patients is improving, but is still imperfect. A better knowledge
of respiratory function during sleep could probably improve our approach to the disease. A similar approach
can be suggested for asthma considering the high relevance of its nocturnal exacerbation.
Sleep-disordered breathing (SDB) is a very common medical sleep problem; SDB is a group of disorders
that affect our breathing while we are asleep, and are characterized by disruptions of normal breathing
pattern. A short description of the physiological basis, main principles of treatment and the major
acute and chronic impact of treatment will be addressed.
The most common sleep related breathing disorders are snoring and sleep apnea. Obstructive sleep
apnea (OSA) is characterized by repetitive episodes of complete or partial interruption of ventilation
during sleep caused by a collapse of the upper airway. Obstructive apneas are associated with
ongoing increasing respiratory efforts, and cause intermittent arterial oxygen desaturation, systemic
and pulmonary arterial blood pressure fluctuations and sleep disruption.
The objective of this meeting is to review Respiratory Pathophysiology with a look at Pulmonary
Rehabilitation and the use of tele-health to increase access and capacity, dyspnea, exercise limitation and
nutrition; SLEEP DISORDERS going through sleep physiology and cognitive function, respiratory disorders
during sleep dealing with excessive daytime sleepiness and road safety and the diagnostic and therapeutic
approach; BREATHING DISORDERS with a look at control of breathing and neuromuscular disorders;
overlap syndrome and congestive heart failure and central sleep apnea and their treatment.
Prof. Francesco de Blasio
Prof. Giuseppe Insalaco
Prof. Mario Polverino
Scientific Committee
Francesco de Blasio, MD, FCCP
Giuseppe Insalaco, MD, FCCP
Barbara A. Phillips, MD, FCCP
Mario Polverino, MD, FCCP
Invited Faculty
P. Agostoni (Milano - Italy)
F. Andò, FCCP (Messina - Italy)
R. Antonelli Incalzi (Roma - Italy)
P. Banfi (Milano - Italy)
V. Bernhardt (Dallas, TX - USA)
A. Braghiroli (Veruno, NO - Italy)
M. Bruyneel (Bruxelles - Belgium)
C. Cajochen (Basel - Switzerland)
S. Carlone (Roma - Italy)
P. Carratù (Bari - Italy)
R. Casaburi, FCCP (Rancho Palos Verdes, CA - USA)
V. Castronovo (Milano - Italy)
A. Chetta (Parma - Italy)
F. Cirignotta (Bologna - Italy)
E.M. Clini, FCCP (Modena - Italy)
M. Contini (Milano - Italy)
U. Corrà (Veruno, NO - Italy)
D. Currow (Adelaide - Australia)
R. Cutrera (Roma - Italy)
R. Dahl (Brentford Middlesex - United Kingdom)
N. Dardes (Roma - Italy)
F. de Blasio, FCCP (Napoli - Italy)
F. Fanfulla (Pavia - Italy)
B. Fauroux (Paris - France)
L. Ferini Strambi (Milano - Italy)
F. Franssen (Horn - The Netherlands)
R. Goldstein, FCCP (Toronto - Canada)
G. Insalaco, FCCP (Palermo - Italy)
P. Laveneziana (Paris - France)
D.A. Mahler, FCCP (Hanover, NH - USA)
M. Manconi (Lugano - Switzerland)
D.M. Mannino, FCCP ((Lexington, KY - USA)
E. Muscianisi (Origgio, VA - Italy)
N. Netzer (Bad Aibling - Germany)
D.E. O’Donnell, FCCP (Kingston, ON - Canada)
O. Oldenburg (Bochum - Germany)
P. Paggiaro (Pisa - Italy)
P. Palange (Roma - Italy)
F. Pasqua (Roma - Italy)
J.L. Pepin (Grenoble - France)
P. Philip (Bordeaux - France)
B.A. Phillips, FCCP (Lexington, KY - USA)
S. Picciolo, FCCP (Messina - Italy)
F. Pizza (Bologna - Italy)
M. Polverino, FCCP (Scafati, SA - Italy)
W.J. Randerath, FCCP (Zurich - Germany)
S. Redolfi (Paris - France)
A. Rizzi (Verona - Italy)
P. Rogliani (Roma - Italy)
I. Rosenzweig (London - United Kingdom)
C.M. Sanguinetti, FCCP (Roma - Italy)
L. Scalfi (Napoli - Italy)
A. Schols (Maastricht - The Netherlands)
M. Steiner (Leicester - United Kingdom)
C. Tantucci (Brescia - Italy)
M.P. Villa (Roma - Italy)
M. Vitacca (Lumezzane, BS - Italy)
PROGRAMME
Wednesday, June 15th 2016
09.00-10.00 Participants registration
RESPIRATORY PATHOPHYSIOLOGY
10.00-11.30 Pulmonary rehabilitation
Chairmen: R. Goldstein - F. Pasqua
10.00-10.20 Using tele-health to increase access and capacity
M. Vitacca
10.20-10.40 Consequences and therapies of inactivity
R. Casaburi
10.40-11.00 Milestones in pulmonary rehabilitation
R. Goldstein
11.00-11.30 Discussion
11.30-13.00 Dyspnea
Chairmen: D.A. Mahler - C.M. Sanguinetti
11.30-11.50 Dyspnea domains and descriptors
D.A. Mahler
11.50-12.10 Mechanisms of dyspnea in chronic interstitial
and obstructive lung diseases: final common pathways
D.E. O’Donnell
12.10-12.30 Opioids and anxiolytics for refractory dyspnea
D. Currow
12.30-13.00 Discussion
13.00-13.30 Industry sponsored lecture
Right treatment to right patient:
GSK commitment to the respiratory research
R. Dahl - A. Rizzi
Chairman: F. de Blasio
13.30-14.00 Lunch
PROGRAMME
14.00-14.30 Opening remarks
F. de Blasio - B.A. Phillips
14.30-16.00 Exercise limitation
Chairmen: E.M. Clini - P. Rogliani
14.30-14.50 Cardiovascular response to exercise in COPD
A. Chetta
14.50-15.10 Performance of obese patients during exercise
V. Bernhardt
15.10-15.30 Respiratory mechanics and symptoms in pulmonary hypertension
P. Laveneziana
15.30-16.00 Discussion
16.00-17.30 Nutrition
Chairmen: F. Franssen - L. Scalfi
16.00-16.20 Assessment of body composition in COPD
M. Steiner
16.20-16.40 Metabolic phenotypes in COPD
A. Schols
16.40-17.00 Obesity in COPD
F. Franssen
17.00-17.30 Discussion
PROGRAMME
Thursday, June 16th 2016
SLEEP DISORDERS
09.00-10.30 Sleep physiology and cognitive function
Chairmen: R. Antonelli Incalzi - L. Ferini Strambi
09.00-09.20 Cognition and sleep loss
C. Cajochen
09.20-09.40 Sleep apnea and the brain: a complex relationship
I. Rosenzweig
09.40-10.00 Neurocognitive function and sleep apnea: the effects of therapy
V. Castronovo
10.00-10.30 Discussion
10.30-12.00 Respiratory disorders during sleep: diagnostic approach
Chairmen: G. Insalaco - M.P. Villa
10.30-10.50 When must we think to RDS
B.A. Phillips
10.50-11.10 Laboratoratory and ambulatory management for obstructive sleep apnea:
where and when
M. Bruyneel
11.10-11.30 Pediatric approach to sleep apnea
R. Cutrera
11.30-12.00 Discussion
12.00-12.30 Industry sponsored lecture
A new paradigm in the treatment of COPD:
results of the Flame Study
E. Muscianisi
Chairman: M. Polverino
12.30-13.00 Industry sponsored lecture
From the symptoms to the therapy.
Customized options for patients with COPD
C. Tantucci
Chairman: F. de Blasio
13.00-14.00 Lunch
PROGRAMME
14.00-15.30 Excessive daytime sleepiness
Chairmen: F. Cirignotta - P. Palange
14.00-14.20 How to measure sleepiness - A critical review
F. Pizza
14.20-14.40 Sleepiness at the weel
P. Philip
14.40-15.00 Determinants of sleepiness in OSAS
M. Manconi
15.00-15.30 Discussion
15.30-17.00 RDS: which therapeutic approach
Chairmen: G. Insalaco - S. Picciolo
15.30-15.50 RDS and CPAP therapy: just a pressure?
N. Netzer
15.50-16.10 Sleep apnea phenotypes and therapies choice for obstructive
sleep apnea
W.J. Randerath
16.10-16.30 Adaptive servo-ventilation for the treatment of CSR:
what’s going on
A. Braghiroli
16.30-17.00 Discussion
PROGRAMME
Friday, June 17th 2016
BREATHING DISORDERS
09.00-10.30 Control of breathing and neuromuscular disorders
Chairmen: F. Andò - P. Banfi
09.00-09.20 Controversies in the control of breathing
R. Casaburi
09.20-09.40 Sleep-disordered breathing in adult with neuromuscular disease
J.L. Pepin
09.40-10.00 Sleep-disordered breathing in children with neuromuscular disease
B. Fauroux
10.00-10.30 Discussion
10.30-12.00 Overlap syndrome
Chairmen: B.A. Phillips - N. Dardes
10.30-10.50 Overview, definitions and epidemiology
B.A. Phillips
10.50-11.10 OSAS and overlap syndrome affect both left and right heart
P. Carratù
11.10-11.30 Effect of treatment on COPD outcomes
D.M. Mannino
11.30-12.00 Discussion
12.00-13.00 Industry sponsored lecture
Drugs and patients: strategies for effective asthma therapy
M. Polverino
Chairman: G. Insalaco
12.30-13.00 Industry sponsored lecture
COPD double association therapy: which patients and when?
P. Paggiaro
Chairman: G. Insalaco
13.00-14.00 Lunch
PROGRAMME
14.00-15.30 Congestive heart failure
Chairmen: P. Agostoni - S. Carlone
14.00-14.20 Ventilation during exercise in heart failure, COPD and in patients
with both COPD and heart failure
P. Agostoni
14.20-14.40 Day-time, night-time and exercise periodic breathing in heart failure
U. Corrà
14.40-15.00 Gas exchange in heart failure
M. Contini
15.00-15.30 Discussion
15.30-17.00 Central sleep apnea
Chairmen: A. Braghiroli - F. Fanfulla
15.30-15.50 Central apneas: how to differentiate physiology from disease
C. Tantucci
15.50-16.10 Central sleep apnea and fluid dynamics
S. Redolfi
16.10-16.30 Treatment of central sleep apnea
O. Oldenburg
16.30-17.00 Discussion
INDUSTRY SPONSORED LECTURES
Wednesday, June 15th 2016
13.00-13.30
Right treatment to right patient: GSK commitment to the respiratory research
Supported by GlaxoSmithKline*
Thursday, June 16th 2016
12.00-12.30
A new paradigm in the treatment of COPD: results of the Flame Study
Supported by Biofutura-Novartis Farma*
Thursday, June 16th 2016
12.30-13.00
From the symptoms to the therapy. Customized options for patients with COPD
Supported by Laboratori Guidotti-Malesci*
Friday, June 17th 2016
12.30-13.00
COPD double association therapy: which patients and when?
Supported by AstraZeneca*
Friday, June 17th 2016
12.00-12.30
Drugs and patients: strategies for effective asthma therapy
Supported by an unrestricted educational grant by A. Menarini**
* Italian Ministry of Heath CME accreditation was not applied for
** Italian Ministry of Heath CME accreditation was applied for
REGISTRATION INFORMATION
Registration fee
All fees are requested in Euro.
Daily registration is not provided.
REGISTRATION FEE (VAT 22% included)
CHEST Member Physician
Non CHEST Member Physician
Physician younger than 35
Nurses, Physiotherapists
Euro 400,00
Euro 500,00
Euro 100,00
Euro 70,00
The registration fee includes:
• access to the scientific sessions
• access to the exhibition area
• congress kit
• coffee and lunch
• certificate of attendance
Payment
The registration fee payment should be made through:
• Cash
• Check non transferable made payable to Devital Service S.p.A.
• Credit card (Visa / Diners Club, Mastercard)
GENERAL INFORMATION
Organizing Secretariat and CME Provider
Devital Service SpA
Piazza Wagner 5 - 20145 Milan (Italy)
Tel. 0039 02 43319223 - Fax 02 48513353
E-mail: [email protected]
Congress Venue
Roma Eventi Fontana di Trevi
P.zza della Pilotta, 4 - 00187 Roma
Secretariat Opening Hours
Wednesday June 15 2016: 08.30-17.30
Thursday June 16 2016: 08.30-17.30
Friday June 17 2016: 08.30-17.30
Official Language
The official language of the Conference is English.
Simultaneaus translation is not provided.
Badge
Participants are kindly requested to wear their name badge during all the Conference activities.
The badge will admit to the scientific sessions, exhibition area, lunch and coffee break.
Lost badges are replaced against the payment of a handling fee of Euro 30,00 (local VAT included)
and upon proof of original registration.
Attendance Certificates
Attendance Certificates will be delivered on request to all regularly registered participants
at the end of the Conference.
WEB SITE
www.chest.it
CME
The conference has been accredited by the national agency for regional health services
(AGE.Na.S) for the professional figure of Medical Surgeon.
Topic areas: Allergy and Clinical Immunology, Cardiology, Geriatrics, Internal Medicine,
Pediatrics, Respiratory Diseases, General Practitioners (family doctors), Anesthesia and
Resuscitation, Neurology, Otolaryngology, Physical Medicine and Rehabilitation
CME Reference number: 159359 Ed. 1
Number CME credits obtained: 3,6
For acquisition of credits requires 80% presence of the actual duration of the
meeting and compilation of the CME requested documentation.
Organizing Secretariat and CME Provider
Devital Service SpA
Piazza Wagner 5 - 20145 Milan (Italy)
Tel. 0039 02 43319223 - Fax 02 48513353
E-mail: [email protected]