Carmelo Rizzari - EMA

Transcript

Curriculum vitae
PERSONAL INFORMATION
Carmelo Rizzari
WORK EXPERIENCE
June 1999–Present
Head of the Pediatric Hematology-Oncology Unit
University of Milano Bicocca, Hospital S. Gerardo of Monza (Italy)
Pediatric Hematology Oncology
June 2002–June 2009
Staff Associate Member - High Specialization
Pediatric Hematology Oncology
October 1990–June 2002
Staff Assistant Member
Pediatric Hematology-Oncology
March 1989–October 1990
Pediatrician
Cinisello Balsamo, Milano (Italy)
Pediatrics
July 1988–September 1988
Medical Service in the public area of care continuity
Italian Health Service (Italy)
Pediatrics
January 1988–May 1988
Medical activity of substitution for General Practitioners or Pediatricians
Italian Health Service (Italy)
Internal and Emergency Medicine
May 1986–September 1988
Permanent Member of the 23rd Commission (ASL Catania) for the evaluation of
Civil Invalidity
ASL Catania (Italy)
Legal medicine and Forensic Sciensces
April 1984–October 1985
Medical Officer
Italian Military Navy (Italy)
Military and Emergency Medicine
EDUCATION AND TRAINING
November 1977–July 1983
Degree in Medicine and Surgery (Mentor: Prof. G. Russo, Catania)
110/110 cum laude
Univerisyt of Catania, School of Medicine and Surgery (Italy)
Medicine and Surgery
July 1983–November 1983
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National abilitation to professional medical activities
© European Union, 2002-2015 | http://europass.cedefop.europa.eu
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Curriculum vitae
Carmelo Rizzari
University of Catania, School of Medicine (Italy)
Medicine and Surgery
July 1984–August 1984
Stage in pediatric hematology-oncology, Department of Pediatrics,
Pediatric hematology- Oncology Unit (Mentors: Prof. Martii Siimes,
Prof. Mikko Perkkio) University of Helsinki
University of Helsinki (Finland)
February 1985–December 1985
Employment as staff assistant member while resident in Pediatrics
at the Department of Pediatrics
University of Catania (Italy)
January 1987–September 1988
Stage in pediatric hematology-oncology, Department of Pediatrics,
University of Milano, Hospital S. Gerardo of Monza (Mentor: Prof.
Giuseppe Masera) .
November 1984–July 1988
Specialization in Pediatrics (Mentor: Prof. G. Schilirò) 50/50 cum
laude
(Italy)
April 1997–October 1997
Visiting Scientist, Department of Clinical Pharmacology, St. Jude
Childrens’ Research Hospital (Mentors: Dr. Mary V. Relling, Dr.
William E. Evans), Memphis, TN, USA
University of Tennessee, Memphis (United States)
Pediatric Hematology-Oncology, Clinical Pharmacology
ADDITIONAL INFORMATION
Expertise
Involved since the late 80ies in the field of pediatric leukemias with special expertise developed in the
field of cancer chemotherapy. Currently he is the full Responsible of the Pediatric HematologyOncology Unit in Monza, which is the largest and first recruiting center for hematological malignancies
in Italy.
His main professional and scientific achievements are listed below:
Participation in the development and drafting of the chemotherapy protocols adopted in Italy since the
late 80ies by the AIEOP for the first-line (AIEOP LLA 91, 95, 2000) and second line (REC 98, REC 98,
INTREALL) treatment of Acute Lymphoblastic Leukemia.
Participation in the development and drafting of the chemotherapy protocols adopted in Italy since the
late 90ies by the AIEOP for the first-line (AML AIEOP 2002/01-02) and second line (IBFMSG
Relapsed AML 2002 study) treatment of Acute Myeloid Leukemia.
Member of the Trial Steering Committee of the currently ongoing international AIEOP-BFM ALL 2009
Study and coordinator for the pharmacological studies conducted in this trial for E.Coli PEG-ASP and
Erwinia C. ASP. Major efforts have been aimed at a better management and understanding on this
drug.
Member of the AIEOP Trial Steering Committee for the AIEOP ALL and AML front-line and relapsed
trials. He is also a member of the AIEOP committee for Myelodisplastic Syndromes.
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Curriculum vitae
Carmelo Rizzari
Co-cordinator since 2007 of the national protocol AIEOP ALL REC 2003 for relapsed acute
lymphoblastic leukemia. Co-Principal Investigator for Italy in the European protocol IntReALL 2010
funded under the FP7 project for the European Community. In the frame of this trial he has been
appointed coordinator of the european working group on studies for ASP.
Principal investigator of the Italian international randomized studies AML 2001/01 (FLAG ±
DaunoXome) of the International BFM Study Group.
Member of the Trial Steering Committe for the upcoming european study for Relapsed AML I-BFMSG AML Relapsed 2014.
Member of the European Working Group for the design and implementation of a common european
protocol to be started in 2017-2018.
Coordinator of the Working Group for surveillance studies of complications and toxic events in AIEOP
protocols for acute lymphoblastic leukemia.
Italian Principal Investigator and member of the 'European Advisory Board of the international
randomized EPO-INT-51 on the role of erythropoietin Alfa in the treatment of pediatric patients with
acute lymphoblastic leukemia or solid tumors.
Local Principal Investigator of several Phase I-II studies on Clofarabine (Amgen), Dasatinib (Bristol
Myers Squibb) Forodesine (Mundipharma), Midostaurine (Novartis), Nilotinib (Novartis),
Blinatumomab (Amgen), Bortezomib (Academic Trial), NI-0501-04 (Novimmune), Volasertib
(Boehringer Ingelheim), Azacytidine (Celgene). Currently he is the local PI of several additional studies
with innovative drugs or strategies.
"Expert Consultant" independent outside of the "Therapeutic Expert Group "for the part relating to
leukemias and lymphomas" within the project called "TEDDY" (acronym for Task-force in Europe for
Drug Development for the Young)
Since June 2010 member on behalf of the Italian centers, of the International Quality and Accreditation
Committee of the european ITCC (Innovative Therapies in Children with Cancer) consortium.
Since May 2012 coordinator of the AIEOP working group for Clinical Pharmacology and
Pharmacovigilance.
In 2013 enabled to hold the position of associate professor in the national academic selection for the
General and Specialistic areas of Pediatrics (MED38).
Author and coauthor of 80 publications (see attached list) in relevant, high IF scored, peer reviewed
journals (Lancet, JCO, Blood, BJH, BJC, Cancer, Haematologica, Leukemia) and author of the
follwinfg chapters in scientific books:
“Asparaginase Treatment” on “Treatment of acute leukemias – new directions for clinical research”,
edited by CH Pui, Humana Press, New Jersey, 2002.
“Le leucemie acute in età pediatrica” in Fondamenti di Oncologia Clinica, Editors. F. Cavalli, F.
Cognetti A. Costa, R. Orecchia, Elsevier Italia, 2005
Chairman and speaker at several international scientific conferences and meetings (AIEOP, ASH,
SIOP, IBFMSG).
Data Monitoring Committee Member or Chairman for phase I-II pediatric clinical trials regarding
anticancer agents and supportive therapy drugs in the field of pediatric hematology and oncology.
Lecturer for students of the Medical School and for post-graduates and residents of the School of
Specialization in Paediatrics
Tutor, supervisor and co-rapporteur of several theses of the Medical School and of the Residency
School in Pediatrics of the University of Milano Bicocca.
Peer-reviewer for several scientific journals in the field of Hematology-Oncology (Haematologica,
Cancer, Pediatric Blood and Cancer, Journal of Pediatric Hematology Oncology, International Journal
of Pediatric Hematology and Oncology, Blood, Leukemia, Lancet Oncology, Lancet Haematology).
Publications
1: Paganin M, Buldini B, Germano G, Seganfreddo E, Meglio AD, Magrin E, Grillo F,
Pigazzi M, Rizzari C, Cazzaniga G, Khiabanian H, Palomero T, Rabadan R, Ferrando
AA, Basso G. A Case of T-cell Acute Lymphoblastic Leukemia Relapsed As Myeloid
Acute Leukemia. Pediatr Blood Cancer. 2016 May 3. doi: 10.1002/pbc.26054. [Epub
ahead of print] PubMed PMID: 27149388.
2: van der Sluis IM, Vrooman LM, Pieters R, Baruchel A, Escherich G, Goulden N,
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Carmelo Rizzari
Mondelaers V, de Toledo JS, Rizzari C, Silverman LB, Whitlock JA. Consensus
expert recommendations for identification and management of asparaginase
hypersensitivity and silent inactivation. Haematologica. 2016 Mar;101(3):279-85.
doi: 10.3324/haematol.2015.137380. PubMed PMID: 26928249; PubMed Central PMCID:
PMC4815719.
3: Conter V, Valsecchi MG, Buldini B, Parasole R, Locatelli F, Colombini A,
Rizzari C, Putti MC, Barisone E, Nigro LL, Santoro N, Ziino O, Pession A, Testi
AM, Micalizzi C, Casale F, Pierani P, Cesaro S, Cellini M, Silvestri D, Cazzaniga
G, Biondi A, Basso G. Early T-cell precursor acute lymphoblastic leukaemia in
children treated in AIEOP centres with AIEOP-BFM protocols: a retrospective
analysis. Lancet Haematol. 2016 Feb;3(2):e80-6. doi:
10.1016/S2352-3026(15)00254-9. Epub 2016 Jan 26. PubMed PMID: 26853647.
4: Rizzari C. Still trying to pick the best asparaginase preparation. Lancet
Oncol. 2015 Dec;16(16):1580-1. doi: 10.1016/S1470-2045(15)00451-9. Epub 2015 Nov
6. PubMed PMID: 26549585.
5: Zwaan CM, Kolb EA, Reinhardt D, Abrahamsson J, Adachi S, Aplenc R, De Bont ES,
De Moerloose B, Dworzak M, Gibson BE, Hasle H, Leverger G, Locatelli F, Ragu C,
Ribeiro RC, Rizzari C, Rubnitz JE, Smith OP, Sung L, Tomizawa D, van den
Heuvel-Eibrink MM, Creutzig U, Kaspers GJ. Collaborative Efforts Driving Progress
in Pediatric Acute Myeloid Leukemia. J Clin Oncol. 2015 Sep 20;33(27):2949-62.
doi: 10.1200/JCO.2015.62.8289. Epub 2015 Aug 24. Review. PubMed PMID: 26304895;
PubMed Central PMCID: PMC4567700.
6: Quarello P, Fagioli F, Basso G, Putti MC, Berger M, Luciani M, Rizzari C,
Menna G, Masetti R, Locatelli F. Outcome of children with acute myeloid leukaemia
(AML) experiencing primary induction failure in the AIEOP AML 2002/01 clinical
trial. Br J Haematol. 2015 Nov;171(4):566-73. doi: 10.1111/bjh.13611. Epub 2015
Jul 30. PubMed PMID: 26223157.
7: Togni M, Masetti R, Pigazzi M, Astolfi A, Zama D, Indio V, Serravalle S,
Manara E, Bisio V, Rizzari C, Basso G, Pession A, Locatelli F. Identification of
the NUP98-PHF23 fusion gene in pediatric cytogenetically normal acute myeloid
leukemia by whole-transcriptome sequencing. J Hematol Oncol. 2015 Jun 12;8:69.
doi: 10.1186/s13045-015-0167-8. PubMed PMID: 26066811; PubMed Central PMCID:
PMC4467064.
8: Asselin B, Rizzari C. Asparaginase pharmacokinetics and implications of
therapeutic drug monitoring. Leuk Lymphoma. 2015;56(8):2273-80. doi:
10.3109/10428194.2014.1003056. Epub 2015 Mar 11. Review. PubMed PMID: 25586605;
9: Magnani C, Mattioli S, Miligi L, Ranucci A, Rondelli R, Salvan A, Bisanti L,
Masera G, Rizzari C, Zambon P, Cannizzaro S, Gafà L, Luzzatto LL, Benvenuti A,
Michelozzi P, Kirchmayer U, Cocco P, Biddau P, Galassi C, Celentano E, Guarino E,
Assennato G, de Nichilo G, Merlo DF, Bocchini V, Pannelli F, Mosciatti P, Minelli
L, Chiavarini M, Cuttini M, Casotto V, Torregrossa MV, Valenti RM, Forastiere F,
Haupt R, Lagorio S, Risica S, Polichetti A. SETIL: Italian multicentric
epidemiological case-control study on risk factors for childhood leukaemia, non
hodgkin lymphoma and neuroblastoma: study population and prevalence of risk
factors in Italy. Ital J Pediatr. 2014 Dec 24;40:103. doi:
10.1186/s13052-014-0103-5. PubMed PMID: 25539823; PubMed Central PMCID:
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Carmelo Rizzari
PMC4310183.
10: Pigazzi M, Manara E, Buldini B, Beqiri V, Bisio V, Tregnago C, Rondelli R,
Masetti R, Putti MC, Fagioli F, Rizzari C, Pession A, Locatelli F, Basso G.
Minimal residual disease monitored after induction therapy by RQ-PCR can
contribute to tailor treatment of patients with t(8;21) RUNX1-RUNX1T1
rearrangement. Haematologica. 2015 Mar;100(3):e99-101. doi:
10.3324/haematol.2014.114579. Epub 2014 Dec 5. PubMed PMID: 25480496; PubMed
Central PMCID: PMC4349288.
11: Guenat D, Quentin S, Rizzari C, Lundin C, Coliva T, Edery P, Fryssira H,
Bermont L, Ferrand C, Soulier J, Borg C, Rohrlich PS. Constitutional and somatic
deletions of the Williams-Beuren syndrome critical region in non-Hodgkin
lymphoma. J Hematol Oncol. 2014 Nov 7;7:82. doi: 10.1186/s13045-014-0082-4.
PubMed PMID: 25388916; PubMed Central PMCID: PMC4228180.
12: Rizzari C, Putti MC, Colombini A, Casagranda S, Ferrari GM, Papayannidis C,
Iacobucci I, Abbenante MC, Sartor C, Martinelli G. Rationale for a
pediatric-inspired approach in the adolescent and young adult population with
acute lymphoblastic leukemia, with a focus on asparaginase treatment. Hematol
Rep. 2014 Sep 30;6(3):5554. doi: 10.4081/hr.2014.5554. eCollection 2014 Aug 26.
Review. PubMed PMID: 25317319; PubMed Central PMCID: PMC4194384.
13: Parodi S, Merlo DF, Ranucci A, Miligi L, Benvenuti A, Rondelli R, Magnani C,
Haupt R; SETIL Working Group. Risk of neuroblastoma, maternal characteristics and
perinatal exposures: the SETIL study. Cancer Epidemiol. 2014 Dec;38(6):686-94.
doi: 10.1016/j.canep.2014.09.007. Epub 2014 Oct 1. PubMed PMID: 25280392.
14: Bachas C, Schuurhuis GJ, Reinhardt D, Creutzig U, Kwidama ZJ, Zwaan CM, van
den Heuvel-Eibrink MM, De Bont ES, Elitzur S, Rizzari C, de Haas V, Zimmermann M,
Cloos J, Kaspers GJ. Clinical relevance of molecular aberrations in paediatric
acute myeloid leukaemia at first relapse. Br J Haematol. 2014 Sep;166(6):902-10.
doi: 10.1111/bjh.12989. Epub 2014 Jun 25. PubMed PMID: 24962064.
15: Creutzig U, Zimmermann M, Dworzak MN, Gibson B, Tamminga R, Abrahamsson J, Ha
SY, Hasle H, Maschan A, Bertrand Y, Leverger G, von Neuhoff C, Razzouk B, Rizzari
C, Smisek P, Smith OP, Stark B, Reinhardt D, Kaspers GL. The prognostic
significance of early treatment response in pediatric relapsed acute myeloid
leukemia: results of the international study Relapsed AML 2001/01. Haematologica.
2014 Sep;99(9):1472-8. doi: 10.3324/haematol.2014.104182. Epub 2014 Apr 24.
PubMed PMID: 24763401; PubMed Central PMCID: PMC4562536.
16: Rizzari C. Shedding light on the asparaginase galaxy. Blood. 2014 Mar
27;123(13):1976-8. doi: 10.1182/blood-2014-02-553040. PubMed PMID: 24677398.
17: Conter V, Valsecchi MG, Parasole R, Putti MC, Locatelli F, Barisone E, Lo
Nigro L, Santoro N, Aricò M, Ziino O, Pession A, Testi AM, Micalizzi C, Casale F,
Zecca M, Casazza G, Tamaro P, La Barba G, Notarangelo LD, Silvestri D, Colombini
A, Rizzari C, Biondi A, Masera G, Basso G. Childhood high-risk acute
lymphoblastic leukemia in first remission: results after chemotherapy or
transplant from the AIEOP ALL 2000 study. Blood. 2014 Mar 6;123(10):1470-8. doi:
10.1182/blood-2013-10-532598. Epub 2014 Jan 10. PubMed PMID: 24415536.
18: Badaloni C, Ranucci A, Cesaroni G, Zanini G, Vienneau D, Al-Aidrous F, De
Hoogh K, Magnani C, Forastiere F; SETIL Study Group. Air pollution and childhood
leukaemia: a nationwide case-control study in Italy. Occup Environ Med. 2013
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Carmelo Rizzari
Dec;70(12):876-83. doi: 10.1136/oemed-2013-101604. Epub 2013 Sep 18. PubMed PMID:
24142970.
19: Masetti R, Togni M, Astolfi A, Pigazzi M, Manara E, Indio V, Rizzari C,
Rutella S, Basso G, Pession A, Locatelli F. DHH-RHEBL1 fusion transcript: a novel
recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute
myeloid leukemia. Oncotarget. 2013 Oct;4(10):1712-20. PubMed PMID: 24127550;
20: Chiu M, Franchi-Gazzola R, Bussolati O, D'Amico G, Dell'Acqua F, Rizzari C.
Asparagine levels in the bone marrow of patients with acute lymphoblastic
leukemia during asparaginase therapy. Pediatr Blood Cancer. 2013 Nov;60(11):1915.
doi: 10.1002/pbc.24663. Epub 2013 Jul 30. PubMed PMID: 23900737.
21: Ruggiero A, Triarico S, Trombatore G, Battista A, Dell'acqua F, Rizzari C,
Riccardi R. Incidence, clinical features and management of hypersensitivity
reactions to chemotherapeutic drugs in children with cancer. Eur J Clin
Pharmacol. 2013 Oct;69(10):1739-46. doi: 10.1007/s00228-013-1546-0. Epub 2013 Jun
14. Review. PubMed PMID: 23765411.
22: Zwaan CM, Rizzari C, Mechinaud F, Lancaster DL, Lehrnbecher T, van der Velden
VH, Beverloo BB, den Boer ML, Pieters R, Reinhardt D, Dworzak M, Rosenberg J,
Manos G, Agrawal S, Strauss L, Baruchel A, Kearns PR. Dasatinib in children and
adolescents with relapsed or refractory leukemia: results of the CA180-018 phase
I dose-escalation study of the Innovative Therapies for Children with Cancer
Consortium. J Clin Oncol. 2013 Jul 1;31(19):2460-8. doi:
10.1200/JCO.2012.46.8280. Epub 2013 May 28. PubMed PMID: 23715577.
23: Pession A, Masetti R, Rizzari C, Putti MC, Casale F, Fagioli F, Luciani M, Lo
Nigro L, Menna G, Micalizzi C, Santoro N, Testi AM, Zecca M, Biondi A, Pigazzi M,
Rutella S, Rondelli R, Basso G, Locatelli F; AIEOP AML Study Group. Results of
the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children
with acute myeloid leukemia. Blood. 2013 Jul 11;122(2):170-8. doi:
10.1182/blood-2013-03-491621. Epub 2013 May 14. PubMed PMID: 23673857.
24: Lo Nigro L, Mirabile E, Tumino M, Caserta C, Cazzaniga G, Rizzari C,
Silvestri D, Buldini B, Barisone E, Casale F, Luciani M, Locatelli F, Messina C,
Micalizzi C, Pession A, Parasole R, Santoro N, Masera G, Basso G, Aricò M,
Valsecchi M, Biondi A, Conter V; AIEOP—Scientific Committee of ALL. Detection of
PICALM-MLLT10 (CALM-AF10) and outcome in children with T-lineage acute
lymphoblastic leukemia. Leukemia. 2013 Dec;27(12):2419-21. doi:
10.1038/leu.2013.149. Epub 2013 May 14. PubMed PMID: 23670296.
25: Santoro N, Colombini A, Silvestri D, Grassi M, Giordano P, Parasole R,
Barisone E, Caruso R, Conter V, Valsecchi MG, Masera G, Rizzari C. Screening for
coagulopathy and identification of children with acute lymphoblastic leukemia at
a higher risk of symptomatic venous thrombosis: an AIEOP experience. J Pediatr
Hematol Oncol. 2013 Jul;35(5):348-55. doi: 10.1097/MPH.0b013e31828dc614. PubMed
PMID: 23619106.
26: Cianci P, Tono V, Sala A, Locatelli L, Carta C, Rizzari C, Biondi A,
Selicorni A. A boy with Burkitt lymphoma associated with Noonan syndrome due to a
mutation in RAF1. Am J Med Genet A. 2013 Jun;161A(6):1401-4. doi:
10.1002/ajmg.a.35875. Epub 2013 Apr 23. PubMed PMID: 23613113.
27: Rizzari C, Conter V, Starý J, Colombini A, Moericke A, Schrappe M. Optimizing
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Carmelo Rizzari
asparaginase therapy for acute lymphoblastic leukemia. Curr Opin Oncol. 2013
Mar;25 Suppl 1:S1-9. doi: 10.1097/CCO.0b013e32835d7d85. Review. PubMed PMID:
23380829.
28: Kaspers GJ, Zimmermann M, Reinhardt D, Gibson BE, Tamminga RY, Aleinikova O,
Armendariz H, Dworzak M, Ha SY, Hasle H, Hovi L, Maschan A, Bertrand Y, Leverger
GG, Razzouk BI, Rizzari C, Smisek P, Smith O, Stark B, Creutzig U. Improved
outcome in pediatric relapsed acute myeloid leukemia: results of a randomized
trial on liposomal daunorubicin by the International BFM Study Group. J Clin
Oncol. 2013 Feb 10;31(5):599-607. doi: 10.1200/JCO.2012.43.7384. Epub 2013 Jan
14. PubMed PMID: 23319696.
29: Romaniello R, Arrigoni F, Citterio A, Tonelli A, Sforzini C, Rizzari C,
Pessina M, Triulzi F, Bassi MT, Borgatti R. Cerebroretinal microangiopathy with
calcifications and cysts associated with CTC1 and NDP mutations. J Child Neurol.
2013 Dec;28(12):1702-8. doi: 10.1177/0883073812467849. Epub 2012 Dec 5. PubMed
PMID: 23220793.
30: Rizzari C, Cazzaniga G, Coliva T, De Angelis C, Conter V. Predictive factors
of relapse and survival in childhood acute myeloid leukemia: role of minimal
residual disease. Expert Rev Anticancer Ther. 2011 Sep;11(9):1391-401. doi:
10.1586/era.11.37. Review. PubMed PMID: 21929313.
31: Pigazzi M, Masetti R, Bresolin S, Beghin A, Di Meglio A, Gelain S, Trentin L,
Baron E, Giordan M, Zangrando A, Buldini B, Leszl A, Putti MC, Rizzari C,
Locatelli F, Pession A, Te Kronnie G, Basso G. MLL partner genes drive distinct
gene expression profiles and genomic alterations in pediatric acute myeloid
leukemia: an AIEOP study. Leukemia. 2011 Mar;25(3):560-3. doi:
10.1038/leu.2010.316. Epub 2011 Feb 18. PubMed PMID: 21331072.
32: Chiapparini L, Uziel G, Vallinoto C, Bruzzone MG, Rovelli A, Tricomi G, Bizzi
A, Nardocci N, Rizzari C, Savoiardo M. Hemophagocytic lymphohistiocytosis with
neurological presentation: MRI findings and a nearly miss diagnosis. Neurol Sci.
2011 Jun;32(3):473-7. doi: 10.1007/s10072-010-0467-2. Epub 2011 Jan 14. PubMed
PMID: 21234777.
33: Pieters R, Hunger SP, Boos J, Rizzari C, Silverman L, Baruchel A, Goekbuget
N, Schrappe M, Pui CH. L-asparaginase treatment in acute lymphoblastic leukemia:
a focus on Erwinia asparaginase. Cancer. 2011 Jan 15;117(2):238-49. doi:
10.1002/cncr.25489. Epub 2010 Sep 7. Review. PubMed PMID: 20824725; PubMed
Central PMCID: PMC3000881.
34: Conter V, Aricò M, Basso G, Biondi A, Barisone E, Messina C, Parasole R, De
Rossi G, Locatelli F, Pession A, Santoro N, Micalizzi C, Citterio M, Rizzari C,
Silvestri D, Rondelli R, Lo Nigro L, Ziino O, Testi AM, Masera G, Valsecchi MG;
Associazione Italiana di Ematologia ed Oncologia Pediatrica. Long-term results of
the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82,
87, 88, 91 and 95 for childhood acute lymphoblastic leukemia. Leukemia. 2010
Feb;24(2):255-64. doi: 10.1038/leu.2009.250. Epub 2009 Dec 17. PubMed PMID:
20016536.
35: Locatelli F, Testi AM, Bernardo ME, Rizzari C, Bertaina A, Merli P, Pession
A, Giraldi E, Parasole R, Barberi W, Zecca M. Clofarabine, cyclophosphamide and
etoposide as single-course re-induction therapy for children with
refractory/multiple relapsed acute lymphoblastic leukaemia. Br J Haematol. 2009
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Nov;147(3):371-8. doi: 10.1111/j.1365-2141.2009.07882.x. Epub 2009 Aug 29. PubMed
PMID: 19747360.
36: Rizzari C, Biondi A. Tailoring treatment strategy for acute promyelocytic
leukemia in low-income countries. Pediatr Blood Cancer. 2009 Sep;53(3):303-5.
doi: 10.1002/pbc.22087. PubMed PMID: 19544375.
37: Paganin M, Zecca M, Fabbri G, Polato K, Biondi A, Rizzari C, Locatelli F,
Basso G. Minimal residual disease is an important predictive factor of outcome in
children with relapsed 'high-risk' acute lymphoblastic leukemia. Leukemia. 2008
Dec;22(12):2193-200. doi: 10.1038/leu.2008.227. Epub 2008 Aug 28. PubMed PMID:
18754029.
38: Marangon E, Citterio M, Sala F, Barisone E, Lippi AA, Rizzari C, Biondi A,
D'Incalci M, Zucchetti M. Pharmacokinetic profile of imatinib mesylate and
N-desmethyl-imatinib (CGP 74588) in children with newly diagnosed Ph+ acute
leukemias. Cancer Chemother Pharmacol. 2009 Feb;63(3):563-6. doi:
10.1007/s00280-008-0764-0. Epub 2008 Jun 3. PubMed PMID: 18521606.
39: Aricò M, Valsecchi MG, Rizzari C, Barisone E, Biondi A, Casale F, Locatelli
F, Lo Nigro L, Luciani M, Messina C, Micalizzi C, Parasole R, Pession A, Santoro
N, Testi AM, Silvestri D, Basso G, Masera G, Conter V. Long-term results of the
AIEOP-ALL-95 Trial for Childhood Acute Lymphoblastic Leukemia: insight on the
prognostic value of DNA index in the framework of Berlin-Frankfurt-Muenster based
chemotherapy. J Clin Oncol. 2008 Jan 10;26(2):283-9. doi:
10.1200/JCO.2007.12.3927. PubMed PMID: 18182669.
40: Einaudi S, Bertorello N, Masera N, Farinasso L, Barisone E, Rizzari C,
Corrias A, Villa A, Riva F, Saracco P, Pastore G. Adrenal axis function after
high-dose steroid therapy for childhood acute lymphoblastic leukemia. Pediatr
Blood Cancer. 2008 Mar;50(3):537-41. PubMed PMID: 17828747.
41: Pigullo S, Haupt R, Dufour C, Di Michele P, Valsecchi MG, Basso G, Rizzari C,
Biondi A, Lanciotti M. Are genotypes of glutathione S-transferase superfamily a
risk factor for childhood acute lymphoblastic leukemia? Results of an Italian
case-control study. Leukemia. 2007 May;21(5):1122-4. Epub 2007 Feb 22. PubMed
PMID: 17315021.
42: Kishi S, Cheng C, French D, Pei D, Das S, Cook EH, Hijiya N, Rizzari C,
Rosner GL, Frudakis T, Pui CH, Evans WE, Relling MV. Ancestry and
pharmacogenetics of antileukemic drug toxicity. Blood. 2007 May
15;109(10):4151-7. Epub 2007 Jan 30. PubMed PMID: 17264302; PubMed Central PMCID:
PMC1885506.
43: Biondi A, Rizzari C, Valsecchi MG, De Lorenzo P, Aricò M, Basso G, Locatelli
F, Lo Nigro L, De Rossi G, Masera G. Role of treatment intensification in infants
with acute lymphoblastic leukemia: results of two consecutive AIEOP studies.
Haematologica. 2006 Apr;91(4):534-7. Epub 2006 Mar 15. PubMed PMID: 16537119.
44: Rizzari C, Citterio M, Zucchetti M, Conter V, Chiesa R, Colombini A, Malguzzi
S, Silvestri D, D'Incalci M. A pharmacological study on pegylated asparaginase
used in front-line treatment of children with acute lymphoblastic leukemia.
Haematologica. 2006 Jan;91(1):24-31. PubMed PMID: 16434367.
45: Pession A, Valsecchi MG, Masera G, Kamps WA, Magyarosy E, Rizzari C, van
Wering ER, Lo Nigro L, van der Does A, Locatelli F, Basso G, Aricò M. Long-term
results of a randomized trial on extended use of high dose L-asparaginase for
21/5/16
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Curriculum vitae
Carmelo Rizzari
standard risk childhood acute lymphoblastic leukemia. J Clin Oncol. 2005 Oct
1;23(28):7161-7. PubMed PMID: 16192600.
46: Aricò M, Conter V, Valsecchi MG, Rizzari C, Boccalatte MF, Barisone E,
Messina C, De Rossi G, Lo Nigro L, Pession A, Locatelli F, Micalizzi C, Basso G.
Treatment reduction in highly selected standard-risk childhood acute
lymphoblastic leukemia. The AIEOP ALL-9501 study. Haematologica. 2005
Sep;90(9):1186-91. PubMed PMID: 16154841.
47: Pession A, Rondelli R, Basso G, Rizzari C, Testi AM, Fagioli F, De Stefano P,
Locatelli F; AML Strategy & Study Committee of the Associazione Italiana di
Ematologia e Oncologia Pediatrica (AIEOP). Treatment and long-term results in
children with acute myeloid leukaemia treated according to the AIEOP AML
protocols. Leukemia. 2005 Dec;19(12):2043-53. PubMed PMID: 16107897.
48: Santoro N, Giordano P, Del Vecchio GC, Guido G, Rizzari C, Varotto S, Masera
G, De Mattia D. Ischemic stroke in children treated for acute lymphoblastic
leukemia: a retrospective study. J Pediatr Hematol Oncol. 2005 Mar;27(3):153-7.
PubMed PMID: 15750448.
49: Frascella E, Rondelli R, Pigazzi M, Zampieron C, Fagioli F, Favre C, Lippi
AA, Locatelli F, Luciani M, Menna G, Micalizzi C, Rizzari C, Testi AM, Pession A,
Basso G. Clinical features of childhood acute myeloid leukaemia with specific
gene rearrangements. Leukemia. 2004 Aug;18(8):1427-9. PubMed PMID: 15201852.
50: Beretta C, Gaipa G, Rossi V, Bernasconi S, Spinelli O, Dell'Oro MG, Rizzari
C, Rambaldi A, Biondi A, Cazzaniga G. Development of a quantitative-PCR method
for specific FLT3/ITD monitoring in acute myeloid leukemia. Leukemia. 2004
Aug;18(8):1441-4. PubMed PMID: 15201851.
51: Rizzari C, Valsecchi MG, Aricò M, Miniero R, Messina C, De Rossi G, Testi AM,
Mura R, Galimberti S, Biondi A, Locatelli F, Conter V. Outcome of very late
relapse in children with acute lymphoblastic leukemia. Haematologica. 2004
Apr;89(4):427-34. PubMed PMID: 15075076.
52: Giordano P, Santoro N, Del Vecchio GC, Rizzari C, Masera G, De Mattia D.
T-immunophenotype is associated with an increased prevalence of thrombosis in
children with acute lymphoblastic leukemia. A retrospective study. Haematologica.
2003 Sep;88(9):1079-80. PubMed PMID: 12969822.
53: Sala A, Lanciotti M, Valsecchi MG, di Michele P, Dufour C, Haupt R, Basso G,
Rizzari C, Biondi A. Genotypes of the glutathione S-transferase superfamily do
not correlate with outcome of childhood acute lymphoblastic leukemia. Leukemia.
2003 May;17(5):981-3. PubMed PMID: 12750715.
54: Arrigoni P, Beretta C, Silvestri D, Rossi V, Rizzari C, Valsecchi MG,
Cazzaniga G, Biondi A. FLT3 internal tandem duplication in childhood acute
myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic
leukaemia. Br J Haematol. 2003 Jan;120(1):89-92. PubMed PMID: 12492581.
55: Aricò M, Valsecchi MG, Conter V, Rizzari C, Pession A, Messina C, Barisone E,
Poggi V, De Rossi G, Locatelli F, Micalizzi MC, Basso G, Masera G. Improved
outcome in high-risk childhood acute lymphoblastic leukemia defined by
prednisone-poor response treated with double Berlin-Frankfurt-Muenster protocol
II. Blood. 2002 Jul 15;100(2):420-6. PubMed PMID: 12091331.
56: Rizzari C, Valsecchi MG, Aricò M, Conter V, Testi A, Barisone E, Casale F, Lo
Nigro L, Rondelli R, Basso G, Santoro N, Masera G; Associazione Italiano
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Curriculum vitae
Carmelo Rizzari
Ematologia Oncologia Pediatrica. Effect of protracted high-dose L-asparaginase
given as a second exposure in a Berlin-Frankfurt-Münster-based treatment: results
of the randomized 9102 intermediate-risk childhood acute lymphoblastic leukemia
study--a report from the Associazione Italiana Ematologia Oncologia Pediatrica. J
Clin Oncol. 2001 Mar 1;19(5):1297-303. PubMed PMID: 11230471.
57: Conter V, Aricò M, Valsecchi MG, Basso G, Biondi A, Madon E, Mandelli F,
Paolucci G, Pession A, Rizzari C, Rondelli R, Zanesco L, Masera G. Long-term
results of the Italian Association of Pediatric Hematology and Oncology (AIEOP)
acute lymphoblastic leukemia studies, 1982-1995. Leukemia. 2000
Dec;14(12):2196-204. PubMed PMID: 11187911.
58: Rizzari C, Zucchetti M, Conter V, Diomede L, Bruno A, Gavazzi L, Paganini M,
Sparano P, Lo Nigro L, Aricò M, Milani M, D'Incalci M. L-asparagine depletion and
L-asparaginase activity in children with acute lymphoblastic leukemia receiving
i.m. or i.v. Erwinia C. or E. coli L-asparaginase as first exposure. Ann Oncol.
2000 Feb;11(2):189-93. PubMed PMID: 10761754.
59: Riva L, Conter V, Rizzari C, Jankovic M, Sala A, Milani M. Successful
treatment of intrathecal methotrexate overdose with folinic acid rescue: a case
report. Acta Paediatr. 1999 Jul;88(7):780-2. Review. PubMed PMID: 10447141.
60: Rizzari C, Malberti R, Dell'Orto M, Milani M, Jankovic M, Ferrari E, Conter
V. Transient myeloproliferative disorder associated with trisomy 21: is a short
course of chemotherapy indicated in patients with liver impairment and severe
clinical problems? Med Pediatr Oncol. 1999 Jun;32(6):453-4. PubMed PMID:
10358708.
61: Conter V, Aricò M, Valsecchi MG, Rizzari C, Testi A, Miniero R, Di Tullio MT,
Lo Nigro L, Pession A, Rondelli R, Messina C, Santoro N, Mori PG, De Rossi G,
Tamaro P, Silvestri D, Biondi A, Basso G, Masera G. Intensive BFM chemotherapy
for childhood ALL: interim analysis of the AIEOP-ALL 91 study. Associazione
Italiana Ematologia Oncologia Pediatrica. Haematologica. 1998 Sep;83(9):791-9.
62: Rizzari C, Conter V. Bone marrow biopsy as prognostic indicator in childhood
acute lymphoblastic leukemia--another opinion. Med Pediatr Oncol. 1998
May;30(5):315-7. PubMed PMID: 9544233.
63: Rizzari C, Valsecchi MG, Conter V. MTHFR 677C-->T mutation and neural-tube
defects. Lancet. 1997 Nov 15;350(9089):1479-80. PubMed PMID: 9371193.
64: Conter V, Schrappe M, Aricó M, Reiter A, Rizzari C, Dördelmann M, Valsecchi
MG, Zimmermann M, Ludwig WD, Basso G, Masera G, Riehm H. Role of cranial
radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC
count and good response to prednisone. Associazione Italiana Ematologia Oncologia
Pediatrica and the Berlin-Frankfurt-Münster groups. J Clin Oncol. 1997
Aug;15(8):2786-91. PubMed PMID: 9256120.
65: Gentili D, Conter V, Rizzari C, Tschuemperlin B, Zucchetti M, Orlandoni D,
D'Incalci M, Masera G. L-Asparagine depletion in plasma and cerebro-spinal fluid
of children with acute lymphoblastic leukemia during subsequent exposures to
Erwinia L-asparaginase. Ann Oncol. 1996 Sep;7(7):725-30. PubMed PMID: 8905031.
66: Rizzari C, Conter V. Rothmund-Thomson syndrome, malignant diseases, and
treatment opportunities. Pediatr Hematol Oncol. 1996 Mar-Apr;13(2):195-6. PubMed
PMID: 8721038.
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Curriculum vitae
Carmelo Rizzari
67: Conter V, D'Angelo P, Rizzari C, Jankovic M, Dampier C, Masera G, Johnson FL.
High-dose cytosine arabinoside and fractionated total body irradiation as a
preparative regimen for the treatment of children with acute lymphoblastic
leukemia and Down syndrome by allogeneic bone marrow transplantation. Bone Marrow
Transplant. 1996 Feb;17(2):287-9. PubMed PMID: 8640182.
68: Rizzari C, Bacchiocchi D, Rovelli A, Biondi A, Cantu'-Rajnoldi A, Uderzo C,
Masera G. Myelodysplastic syndrome in a child with Rothmund-Thomson syndrome: a
case report. J Pediatr Hematol Oncol. 1996 Feb;18(1):96-7. PubMed PMID: 8556381.
69: Conter V, Aricò M, Valsecchi MG, Rizzari C, Testi AM, Messina C, Mori PG,
Miniero R, Colella R, Basso G, et al. Extended intrathecal methotrexate may
replace cranial irradiation for prevention of CNS relapse in children with
intermediate-risk acute lymphoblastic leukemia treated with
Berlin-Frankfurt-Münster-based intensive chemotherapy. The Associazione Italiana
di Ematologia ed Oncologia Pediatrica. J Clin Oncol. 1995 Oct;13(10):2497-502.
70: Rizzari C, Conter V. "Childhood ALL and cystic fibrosis--treatment and
outcome". Med Pediatr Oncol. 1995 Sep;25(3):223. PubMed PMID: 7623733.
71: Barzaghi A, Dell'Orto M, Rovelli A, Rizzari C, Colombini A, Uderzo C. Central
venous catheter clots: incidence, clinical significance and catheter care in
patients with hematologic malignancies. Pediatr Hematol Oncol. 1995
May-Jun;12(3):243-50. PubMed PMID: 7640177.
72: Aricò M, Basso G, Mandelli F, Rizzari C, Colella R, Barisone E, Zanesco L,
Rondelli R, Pession A, Masera G. Good steroid response in vivo predicts a
favorable outcome in children with T-cell acute lymphoblastic leukemia. The
Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). Cancer. 1995 Apr
1;75(7):1684-93. PubMed PMID: 8826928.
73: Rizzari C, Conter V, D'Angelo P, Cantù-Rajnoldi A, Masera G. Efficacy of
prolonged low-dose steroid treatment in a child with idiopathic hypereosinophilic
syndrome: a case report. Pediatr Hematol Oncol. 1995 Mar-Apr;12(2):209-12. PubMed
PMID: 7626393.
74: D'Angelo P, Mura R, Rizzari C, Conter V, Bellini F, Valsecchi MG, Manganini
C, Silvestri D, Masera G. Prognostic value of nephromegaly at diagnosis of
childhood acute lymphoblastic leukemia. Acta Haematol. 1995;94(2):84-9. PubMed
PMID: 7484018.
75: D'Angelo P, Conter V, Di Chiara G, Rizzari C, Memeo A, Barigozzi P. Severe
osteoporosis and multiple vertebral collapses in a child during treatment for
B-ALL. Acta Haematol. 1993;89(1):38-42. PubMed PMID: 8480485.
76: Rovelli A, Biondi A, Cantù Rajnoldi A, Conter V, Giudici G, Jankovic M,
Locasciulli A, Rizzari C, Romitti L, Rossi MR, et al. Microgranular variant of
acute promyelocytic leukemia in children. J Clin Oncol. 1992 Sep;10(9):1413-8.
77: Rizzari C, Conter V, Jankovic M, D'Angelo P, Masera G, Costantini D,
Bettinelli ME, Giunta AM. Acute lymphoblastic leukaemia in a child with cystic
fibrosis. Haematologica. 1992 Sep-Oct;77(5):427-9. Review. PubMed PMID: 1483594.
78: Mura R, D'Angelo P, Rizzari C, Biondi A, Giudici G, Crosti L, Castagni M,
Cantu'-Rajnoldi A. Lineage switch in a childhood T-cell acute lymphoblastic
leukemia. Pediatr Hematol Oncol. 1992 Jul-Sep;9(3):281-8. PubMed PMID: 1525008.
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Curriculum vitae
Carmelo Rizzari
79: Rizzari C, Palamone G, Corbetta A, Uderzo C, Viganò EF, Codecasa G. Central
venous catheter-related infections in pediatric hematology-oncology patients:
role of home and hospital management. Pediatr Hematol Oncol. 1992
Apr-Jun;9(2):115-23. PubMed PMID: 1524988.
80: Uderzo C, D'Angelo P, Rizzari C, Viganò EF, Rovelli A, Gornati G, Codecasa G,
Locasciulli A, Masera G. Central venous catheter-related complications after bone
marrow transplantation in children with hematological malignancies. Bone Marrow
Transplant. 1992 Feb;9(2):113-7. PubMed PMID: 1571709.
81: Rizzari C, Conter V, Jankovic M, Uderzo C, Masera G, Cappellini A, Rajnoldi
AC. Isolated muscular relapse in a child with B-acute lymphoblastic leukemia, off
therapy. Pediatr Hematol Oncol. 1991 Jul-Sep;8(3):263-7. PubMed PMID: 1742186.
82: Schiliro G, Rizzari C, Testa R, Lo Faro F, Comisi FF, Russo A. Association of
Hb S [beta 6(A3)Glu----Val] and Hb I-interlaken [alpha 15(A13)Gly----Asp] in a
Sicilian man; review of the occurrence of Hb I-interlaken in Sicily. Hemoglobin.
1989;13(4):403-10. Review. PubMed PMID: 2666359.
83: Rizzari C, Santamaria M, Galli MA, Jankovic M, Uderzo C. [Early daunorubicin
cardiotoxicity and fatal outcome in a child with acute myeloblastic leukemia
(M2)]. Pediatr Med Chir. 1987 Nov-Dec;9(6):749-50. Italian. PubMed PMID: 3481847.
84: Russo A, Di Bella D, Lo Bianco M, Rizzari C, Schilirò G. Convulsions and
intracranial calcifications in a leukemic infant receiving only intrathecal
methotrexate as central nervous system prophylaxis. Pediatr Hematol Oncol.
1987;4(3):269-72. PubMed PMID: 3152931.
85: Russo A, Tomarchio S, Pero G, Consoli G, Marina R, Rizzari C, Schilirò G.
Abnormal visual-evoked potentials in leukemic children after cranial radiation.
Med Pediatr Oncol. 1985;13(6):313-7. PubMed PMID: 3862934.
Projects
Memberships
Other Relevant Information
21/5/16
See the expertise section for a thorough description
Active member of the following scientific societies/networks/consortia: AIEOP, IBFMSG, ITCC, SIOP.
All information is included in the Expertise section
Page12 / 12

Carmelo Rizzari - EMA

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