CV May 2012

Transcript

CV May 2012

Curriculum Vitae
Chryssostomos CHATGILIALOGLU
Biographical Sketch
Chryssostomos Chatgilialoglu (born 1952) is director
of research at the Consiglio Nazionale delle Ricerche
(Bologna) since 1991. He was the winner of the Fluka
Prize “Reagent of the Year 1990”. His research
interests lie in free radical reactions increasingly
addressed in the last decade to applications in
biomimetic chemistry and biomarkers discovery.
Author and editor of several books, including the 4
volumes of Encyclopedia of Radicals in Chemistry,
Biology and Materials published by Wiley in 2012. Author and co-author of over 240
papers, and invited speaker over 200 times at congresses and institutions. Supervisor of
international PhDs (>15) and post-doctorals (>30), including three Marie Curie IntraEuropean Fellowships and two Marie Curie Research Training Networks. He was the
Chairman of COST Action CM0603 on Free Radicals in Chemical Biology (2007-2011)
and the Proposer of the new COST Action on Biomimetic Radical Chemistry (20122016). He is President and co-founder of the spin-off company Lipinutragen.
Contents
Page
Short Curriculum Vitae
3
Research Activity
6
Research Quality
11
Reagent of the Year 1990
12
Publications in Journals
13
Publications in Books
46
Publications in Magazines and Online Resources
51
Publications as Meeting Abstract
53
Editorial Activities for Scientific Journals
55
Books
56
Patents
58
Conference and Visiting Activity
59
Invited Lectures at Congresses and Meetings
60
Invited Lectures at Institutions
72
Visiting Scientist at Foreign Istitutions
85
Managerial activity
87
International Appointments
91
Consulting Activity
95
2
Short Curriculum Vitae
Surname:
Chatgilialoglu
First name:
Chryssostomos
Date and place of birth:
Citizenship:
Nikea (Greece), 11-11-1952
Greek and Italian
Affiliation and official address:
ISOF - Consiglio Nazionale delle Ricerche (CNR),
Via Piero Gobetti 101, 40129 Bologna, Italy
phone: +39-0516398309
fax.: +39-0516398349
e-mail: [email protected]
http://www.isof.cnr.it/biofreeradicals/Home.html
Education
Laurea in Chimica Industriale (1976), University of Bologna
Career/Employment (employers, position, and dates)
University of York (UK)
Postdoctor
National Research Council of Canada (Ottawa) Research Associate
1977-1979
1979-1982
Consiglio Nazionale delle Ricerche (Bologna)
Professore Visitatore 1983-1985
Ricercatore
1985-1991
Dirigente di Ricerca
1991-
Specialties, Activities
Research:
- Free radical chemistry
- Chemical biology
- Radiation studies of biomolecular systems
- Omics of cell radical stress and related biomarkers
- Molecular design based on radical reactivity and biomimetic models
Management:
- Leader of BioFreeRadicals Group at ISOF, CNR
- Responsible of European and International projects
- President and co-founder of the spin-off company Lipinutragen srl
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Honours, Fellowships, Awards
- S.R.C. Postdoctoral Fellowship 1977 – 1979
- Visiting Scientist (National Research Council of Canada, summer 1986)
- Director of NATO Advanced Study Institute on Sulfur-Centered Reactive
Intermediates in Chemistry and Biology (June 1989)
- Visiting Scientist (University of Basel, February – July 1990)
- Fluka prize (Reagent of the Year 1990)
- NATO senior Fellowship (1991)
- Director of NATO Advanced Study Institute on Chemical Synthesis: Gnosis to
Prognosis (May 1994)
- Wilsmore Fellow (University of Melbourne, Australia, November 1999 – January
2000).
- Visiting Professor at Universitè Pierre et Marie Curie, France (April 2000)
- Guest Editor of Helvetica Chimica Acta (October 2006)
- Chair of COST Action CM0603: Free Radical in Chemical Biology (June 2007 –
June 2011)
- Visiting Professor at Ludwig-Maximilians-Universität München, Germany
(March, May and June 2008)
- Guest Editor of CHIMIA (September 2008)
- Visiting Professor at Universitè Pierre et Marie Curie, France (June 2009)
- The Cheves Walling Lecture 2009
- Chairman of the EUCHEM Conference on “Organic Free Radicals”, Bologna, 28
June - 2 July 2010
- Member of Editorial Board of Journal of Glycomics and Lipidomics since 2011.
- Co-Editor of the Encyclopedia of Radicals in Chemistry, Biology and Materials (4
volumes, 73 chapters, 2300 pages), 2012 John Wiley & Sons, Ltd.
- Proposer of COST Action CM01203: Biomimetic Radical Chemistry (Sept 2012 –
Sept 2016)
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Publications
- Number of papers:
240 (212 in refereed Journals + 32 chapters in Books)
- Books:
6 (2 as author and 4 edited)
- Patents:
6
- Citations:
> 6300 (h-index = 38)
Conferences and Seminars
- Invited speaker at congresses:
90
- Invited speaker at institutions:
114
5
Research Activity
The research activity of Dr. Chatgilialoglu concerns the theme of free radical chemistry,
embracing the structure-reactivity relationship of free radicals and their various
applications in synthetic methodologies, material science, and life sciences. The thus
acquired wide competence on free radical chemistry has been achieved and developed by
an interdisciplinary approach, using the fundamental knowledge of organic and physical
chemistry as basis for an extension into the fields of synthetic, bioorganic and biological
chemistry.
The scientific activity is presented here below in a chronological order from 1977 to
date, and pertains to the following fields:
-
Physical Organic Chemistry;
-
Synthetic Methodologies;
-
Polymeric Materials;
-
Biomimetic Chemistry for Technological Applications.
Physical Organic Chemistry
The studies in physical organic chemistry were predominant in the first ten years.
During this period Dr. Chatgilialoglu worked as post-doctoral fellow at the University of
York (England) in the group of Prof. R. O. C. Norman. Immediately after he served as
Research Associate for three years at the National Research Council of Canada (Ottawa)
with Prof. K. U. Ingold. The numerous publications of this period deal with studies of
organic and organometallic free radicals using laser flash photolysis and electron
paramagnetic resonance techniques, assisted by other analytical techniques, such as mass
spectrometry and nuclear magnetic resonance, and combined with theoretical and
synthetic models. The knowledge of kinetic methodologies and time-resolved
spectroscopies constituted a solid background for the expansion of his scientific activity.
In particular, the following subjects have been studied:
(i)
Structural properties and reactivity of sulfur-centered and nitrogen-centered
reactive species.
(ii)
Group 14 atom-centered radicals (Si, Ge, Sn). Within this topic the most
relevant result was the determination of absolute rate constants and Arrhenius
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parameters for the reaction of alkyl radicals with Group 14 metal hydrides by
means of laser flash photolysis. These data allowed, in particular, to examine
the reactivity of tributyltin hydride, that is a radical-based reagent largely
employed in organic chemistry, and to put the basis for the proposal of silicon
hydrides as an important class of reducing agents.
(iii)
Implementation of techniques for the acquisition of kinetic data (e.g., radical
clock methodology). The reactivity of several alkyl and aryl carbon-centered
radical species has been studied in the presence of hydrogen atom donors,
such as silicon or germanium hydrides and thiols. The radical cyclization
reaction has also been studied and applied in radical cascade synthetic
strategies starting from alkyl and acyl radicals.
(iv)
Chemical radiation studies in the last decade of the research activity using
gamma-irradiation and pulse radiolysis, for the individuation of fundamental
chemical mechanisms, such as the tautomerization of one-electron oxidation
of DNA bases, selective generation of radical centers on DNA sugar moieties
and free radical reactivity of lipids and proteins.
Free radical chemistry has become an important tool for organic synthesis, and its
success is mostly due to the basic work concerning free radical reactivity. In this respect,
the contribution given by Dr. Chatgilialoglu to fundamental discoveries and knowledge in
free radical chemistry is widely recognized in the scientific community at international
level.
Synthetic Methodologies
Starting from the late nineteen-eighties, studies in synthetic methodologies have been
carried out, focusing in particular on two subjects: radical-based reducing agents and
innovative radical-based synthetic strategies.
The studies on Group 14 hydride reactivity carried out in the previous years
highlighted a variety of triorganosilanes as interesting reducing agents in a free radical
mechanism. In fact, one of them, namely, tris(trimethylsilyl)silane was introduced as a
very versatile compound for carrying out several types of radical reactions, from
functional group reduction to deoxygenation, carbon-carbon bond formation, cyclization,
etc. This was an important discovery in a period when the reagent of choice for radical
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reduction was tributyltin hydride, which in the environment and particularly in humans
exhibits a strong toxicity. The regio-, chemo- and stereoselectivities of this reagent were
thoroughly investigated. For his achievements in this field Dr. Chatgilialoglu received the
prestigious Fluka prize “Reagent of the Year 1990” (see page 11). More than 1000
publications in chemical research deal with the use of this reagent from groups all over
the world. In the following years the class of organosilanes has been investigated
systematically, combining kinetic studies with synthetic applications, so that a complete
overview of the characteristics and applicability of the different silanes is now available.
Today, Dr. Chatgilialoglu is considered one of the most expert scientists in radical
reactivity of organosilanes. He is author of reviews on this subject, which appeared in the
most prestigious international scientific journals. He is also author of the book
“Organosilanes in Radical Chemistry” published by Wiley in 2004.
The scientific activity of the last 15-years was focused to synthetic strategies for
efficient, selective and environmental-friendly processes. During these studies, radical
chemistry has been successfully coupled with ionic processes. Elegant and efficient
syntheses have been realized for the preparation of molecular libraries of modified
nucleosides, lipids and proteins, which attract strong academic and industrial interests,
applicable to diverse fields, from biology and pharmacology to bio- and nanotechnology.
In the area of the macromolecule reactivity, the interest has been focused on free
radical mechanisms involving DNA and lipids. These macromolecules have received
attention from researchers from different fields, due to their peculiar molecular and
supramolecular characteristics that allow applications in biology and biotechnology fields
to be envisaged. In particular, Dr. Chatgilialoglu was the first to study the mechanism of
ribonolactone moiety and the formation of purine cyclonucleosides, which have been
further implemented in the area of biomimetic radical chemistry for technological
applications. The radical-based approach also involved phospholipids with the discovery
of thiyl radical catalyzed isomerization of unsaturated fatty acids. This reaction has been
applied to supramolecular organized systems such as liposomes, which have been then
implemented for biomimetic chemistry. The cis-trans isomerization has been thoroughly
studied in various conditions, establishing the effects of various factors (oxygen,
antioxidants, solvents) on the outcome. It is important to note that this conversion
changes deeply the properties of the lipid molecules, therefore, it becomes an important
tool for bio- and nano-technological applications. For example, in case of triglycerides,
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the isomerization can be useful to change the physical properties of oils, thus affording
new materials for various applications.
The experience in nucleoside and lipid chemistry led to the development of synthetic
processes in an aqueous environment. This is an ongoing project in Dr. Chatgilialoglu’s
group and it includes the “on water” methodology, where the effect of heterogeneous
systems coupled with the supramolecular organization of substrates can play an important
role for enhancing some selectivity features. The use of tris(trimethylsilyl)silane as
reagent in water was developed in this context.
Polymeric Materials
A further interdisciplinary research deals with polymeric materials, in particular with
the modification of commercially available polymers involving radical chemistry. This is
a field of enormous industrial interest, and Dr. Chatgilialoglu has been consultant for
important companies due to his well-known reputation as free radical expert. In
collaboration with the EniChem Company (Milan, Italy) the process of radical
carbonylation of 1,4-cis-polybutadiene was studied, and realized under mild conditions of
low temperature and moderate pressure. The formation and reactivity of an important
radical intermediate and the crucial species for the reaction mechanism, namely, the acyl
radical, was studied in detail. Since the polymer characteristics are driven by the
cyclization modes occurring in the material, the cyclization was also studied with several
appropriately synthesized monomeric models.
Dr. Chatgilialoglu was also consultant for six years of Ciba Geigy Ltd (Basel,
Switzerland) for organosilane chemistry. The research carried out on the oxidative
behavior of poly(hydrosilanes) highlighted the antioxidant activity of these chemicals and
the use as process stabilizers in the polyolefin extrusion, that has been world-patented.
Biomimetic Chemistry for Technological Applications
In the last decade the scientific activity has been increasingly addressed to the field of
radical processes under biomimetic conditions, as an extension of the previously
described synthetic and mechanistic studies on biomolecules. With a solid background on
physical organic chemistry and free radical reactivity, Dr. Chatgilialoglu has effectively
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contributed to the development of free radicals for nano- and bio-technological
applications, evaluating the effects of biomolecules such as DNA, proteins and lipids,
having specific supramolecular structures in aqueous systems. In particular, his approach
is to design biomimetic models which allow for a systematic study of all possible factors
influencing the reactivity of these macro- and supra-molecular systems, including
analytical protocols and complete characterization of reaction or transformation products.
The reactivity, as well as the library of products derived from the models, are an
important basis for starting bio- and nano-technological applications. An immediate
application of these achievements can be done in life sciences, due to the biological
impact of DNA and lipid molecules being involved in the free radical stress of
biosystems. Here we mention two processes which are promising for technological
development: the electron excess transfer in double stranded DNA and telomeric Gquadruplex, and the liposome cis-trans isomerization.
It is also important to evidence the connection of these studies with the
implementation of a strong analytical platform, made by molecular libraries and protocols
for the separation and characterization of a large variety of new biomolecular structures
including their properties. These libraries can have an enormous impact for a chemical
biology approach in the fields of proteomics, genomics and lipidomics, where the
knowledge of radical reactions and mechanisms can contribute to the understanding of
still unknown molecular bases for bio- and nano-technological applications.
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Research Quality
The quality of the research activity represents a strong commitment in the carrier of Dr.
Chatgilialoglu, either in the optimization of the research results to gain a firm leadership
in chemical sciences and in the choice of high impact subjects for attracting interest from
the scientific community. As a representative example Figure 1 shows that 84
publications out of 212 (40%) have been published in journals of the American Chemical
Society, which are well known for the accurate selection of the best subjects and the
severe peer review process. In particular, the four review articles published in Accounts of
Chemical Research and Chemical Reviews testify the international recognition given to
his research; the high number of papers appeared in the Journal of the American
Chemical Society represents an indirect measure of the interest of a general chemical
audience to the research subjects. The graphic also shows the wide range of chemical
publications in specialized areas going from physical chemistry to organic chemistry and
chemical biology.
Figure 1. 84 Pubblications in ACS journals
30
25
20
15
10
5
0
It is worth underlining the many scientific international collaborations of Dr.
Chatgilialoglu. He developed an expertise on free radical chemistry able to communicate
with a large variety of scientists. This experience has also allowed him to gather scientists
in free radical research, becoming an important reference person for this community, as
testified by the chairmanship of two COST Actions and the editing of the Encyclopedia
on Free Radicals in Chemistry, Biology and Materials published in 2012 by Wiley.
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12
Publications in Journals
Year 2012 (first five months)
205) Recent applications of the (TMS)3SiH radical-based reagent
Chatgilialoglu, C.; Lalevée, J.
Molecules 2012, 17, 527–555.
206) Revisiting the reaction of hydroxyl radicals with vicinal diols in water
Jiang, D.; Barata-Vallejo, S.; Golding, B. T.; Ferreri, C.; Chatgilialoglu, C.
Org. Biomol. Chem. 2012, 10, 1102–1107.
207) Rat liver mitochondrial membrane characteristics and mitochondrial functions are
more profoundly altered by dietary lipid quantity than by dietary lipid quality: effect
of different nutritional lipid patterns
Aoun, M; Feillet-Coudray, C.; Fouret, G.; Chabi, B. Crouzier, D.; Ferreri, C.;
Chatgilialoglu, C.; Cabello, C.; Cristol, J. P.; Carbonneau, M.-A.; Coudray, C.
Br. J. Nutr. 2012, 107, 647–659.
208) Trans fatty acids: chemical synthesis of eicosapentaenoic acid isomers and detection
in rats fed a deodorized fish oil diet
Ferreri, C.; Grabovskiy, S.; Aoun, M.; Melchiorre, M.; Kabal’nova, N.; FeilletCoudray, C.; Fouret, G.; Coudray, C.; Chatgilialoglu, C.
Chem. Res. Toxicol. 2012, 25, 687–694.
209) Biomimetic Models of Radical Stress and Related Biomarkers
Chatgilialoglu, C.; Ferreri, C.; Masi, A.; Melchiorre, M.; Sansone, A.; Terzidis, M.
A.; Torreggiani, A.
Chimia 2012, 66, 368–371.
210) Investigation of reactions postulated to occur during inhibition of ribonucleotide
reductases by 2'-azido-2'-deoxynucleotides
Dang, T. P.; Sobczak, A. J.; Mebel A.; Chatgilialoglu, C.; Wnuk, S. F.
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Tetrahedron 2012, 68, in press (doi:101016/j.tet.2012.04.050)
211) trans Arachidonic acid isomers inhibits NADPH-oxidase activity by direct
interaction with enzyme components
Souabni, H.; Thoma, V.; Bizouarn, T.; Chatgilialoglu, C.; Siafaka-Kapadai, A.;
Baciou, L.; Ferreri, C.; Houée-Lévin, C.; Ostuni, M.A.
Biochim. Biophys. Acta - Biomembr. 2012, 1818, in press (doi:
101016/j.bbamem.2012.04.018)
212) The role of functional lipidomics and the development of molecular diagnostic tools
Chatgilialoglu, C.; Ferreri, C.
Expert Rev. Mol. Diagn. 2012, 12, in press.
Year 2011
195) Investigation of excess electron transfer in DNA double-duplex systems allows
estimation of absolute excess electron transfer and CPD cleavage rates
Fazio, D.; Trindler, C.; Heil, K.; Chatgilialoglu, C.; Carell, T.
Chem. Eur. J. 2011, 17, 206–212.
196) Human serum albumin modifications associated with reducing radical stress
Salzano, A. M.; Renzone, G.; Scaloni, A.; Torreggiani, A.; Ferreri, C.;
Chatgilialoglu, C.
Mol. BioSyst. 2011, 7, 889–898.
197) Purine 5’,8-cyclonucleoside lesions: chemistry and biology
Chatgilialoglu, C.; Ferreri, C.; Terzidis, M. A.
Chem. Soc. Rev. 2011, 40, 1368–1382.
198) Radical-based alkylation of guanine derivatives in aqueous medium
Chatgilialoglu, C.; Caminal, C.; Mulazzani, Q. G.
Org. Biomol. Chem. 2011, 9, 3494–3498.
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199) Linoleic acid peroxidation vs cis–trans isomerization: a biomimetic model of free
radical reactivity in the presence of thiols
Mihaljević, B.; Tartaro, I.; Ferreri, C.; Chatgilialoglu, C.
Org. Biomol. Chem. 2011, 9, 3541–3548.
200) Combined Raman and IR spectroscopic studies on the radical-based modifications
of methionine
Torreggiani, A.; Barata-Vallejo, S.; Chatgilialoglu, C.
Anal. Bioanal. Chem. 2011, 401, 1231–1239.
201) Lipid markers of geometrical radical stress: synthesis of mono-trans cholesteryl
esters isomers and detection in human plasma
Melchiorre, M.; Torreggiani, A.; Chatgilialoglu, C.; Ferreri, C.
J. Am. Chem. Soc. 2011, 133, 15184–15190.
202) Radiation-induced reductive modifications of sulfur-containing amino acids within
peptides and proteins
Chatgilialoglu, C.; Ferreri, C.; Torreggiani, A.; Renzone, G.; Salzano, A. M.;
Scaloni, A.
J. Proteomics 2011, 74, 2264–2273.
203) Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin
secretion
Cohen, G.; Riahi, Y.; Shamni, O.; Guichardant, M.; Chatgilialoglu, C.; Ferreri, C.;
Kaiser, N.; Sasson, S.
Diabetes 2011, 60, 2830–2842.
204) New insights into the reaction paths of hydroxyl radicals with 2’-deoxyguanosine
Chatgilialoglu, C.; D’Angelantonio, M.; Kciuk, G.; Bobrowski, K.
Chem. Res. Toxicol. 2011, 24, 2200–2206.
Year 2010
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190) One-electron-reduction of 8-bromoisoguanosine and 8-bromoxanthosine in the
aqueous phase: sequential versus concerted proton-coupled electron routes
Chatgilialoglu, C.; D’Angelantonio, M.; Kaloudis, P.; Mulazzani, Q. G.; Guerra, M.
J. Phys. Chem. Lett. 2010, 1, 174–177.
191) Radiation chemical studies of methionine in aqueous solution: understanding the
role of molecular oxygen
Barata-Vallejo, S.; Ferreri, C.; Postigo, A.; Chatgilialoglu, C.
Chem. Res. Toxicol. 2010, 23, 258–263.
192) Separation of cis/trans geometrical fatty acid isomers by silver-exchanged zeolite Y
Lykakis, I. N.; Ferreri, C.; Grabovskiy, S. A.; Chatgilialoglu, C.
Tetrahedron 2010, 66, 2203–2209.
193) Radiation-induced formation of purine 5',8-cyclonucleosides in isolated and cellular
DNA: high stereospecificity and modulating effect of oxygen
Belmadoui, N.; Boussicault, F.; Guerra, M.; Ravanat, J. L.; Chatgilialoglu, C.;
Cadet, J.
Org. Biomol. Chem. 2010, 8, 3211–3219.
194) Base-promoted reaction of 5-hydroxyuracil derivatives with peroxyl radicals
Amorati, R.; Valgimigli, L.; Pedulli, G. F.; Grabovskiy, S. A.; Kabal’nova, N. N.;
Chatgilialoglu, C.
Org. Lett. 2010, 12, 4130–4133.
Year 2009
184) Reaction of hydrated electrons with guanine derivatives: tautomerism of
intermediate species
D’Angelantonio, M.; Russo, M.; Kaloudis, P.; Mulazzani, Q. G.; Wardman, P.;
Guerra, M.; Chatgilialoglu, C.
J. Phys. Chem. B 2009, 113, 2170–2176.
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185) A reevaluation of the ambident reactivity of guanine moiety towards hydroxyl
radicals
Chatgilialoglu, C.; D’Angelantonio, M.; Guerra, M.; Kaloudis, P.; Mulazzani, Q. G.
Angew. Chem. Int. Ed. 2009, 48, 2214–2217.
186) Rate constants and transition state geometry of reactions of alkyl, alkoxyl and
peroxyl radicals with thiols
Denisov, E. T.; Chatgilialoglu, C.; Shestakov, A. F.; Denisova, T. G.
Int. J. Chem. Kinet. 2009, 41, 284–293.
187) Hydrosilylation reactions of C-C multiple bonds using (Me3Si)3SiH in water.
Comparative study of the radical initiation step
Postigo, A.; Kopsov, S.; Zlotsky, S. S.; Ferreri, C.; Chatgilialoglu, C.
Organometallics 2009, 28, 3282–3287.
188) Zinc and cadmium complexes of a plant metallothionein under radical stress:
desulfurisation reactions associated with the formation of trans lipids in model
membranes
Torreggiani, A.; Domènech J.; Ferreri, C.; Orihuela, R.; Atrian, S.; Capdevila, M.;
Chatgilialoglu, C.
Chem. Eur. J. 2009, 15, 6015–6024.
189) Comparison of isoelectronic 8-HO-G and 8-NH2-G derivatives in redox processes
Kaloudis, P.; D’Angelantonio, M.; Guerra, M.; Spadafora, M.; Cismas, C.; Gimisis,
T.; Mulazzani, Q. G.; Chatgilialoglu, C.
J. Am. Chem. Soc. 2009, 131, 15895–15902.
Year 2008
171) Fatty acids profile of erythrocyte membranes as possible biomarker of longevity
Puca, A. A.; Andrew, P.; Novelli, V.; Viviani, C.; Somalvico, F.; Cirillo, N. A.;
Rejuv. Res. 2008, 11, 63–72.
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172) Solar one-way photoisomerisation of 5’,8-cyclo-2’-deoxyadenosine
Jimenez, L. B.; Encinas, S.; Chatgilialoglu, C.; Miranda, M. A.
Org. Biomol. Chem. 2008, 6, 1083–1086.
173) (Me3Si)3SiH: Twenty years after its discovery as a radical-based reducing agent
Chatgilialoglu, C.
Chem. Eur. J. 2008, 14, 2310–2320.
174) Lipid metabolism and diet: Possible mechanisms of slow aging
Puca, A.; Chatgilialoglu, C.; Ferreri, C.
Int. J. Biochem. Cell B. 2008, 40, 324–333.
175) One-electron reduction of 8-bromo-2-aminoadenosine in the aqueous phase:
Radiation chemical and DFT studies of the mechanism
Kaloudis, P.; D’Angelantonio, M.; Guerra, M.; Gimisis, T.; Mulazzani, Q. G.;
Chatgilialoglu, C.
J. Phys. Chem. B 2008, 112, 5209–5217.
176) The reductive desulfurization of Met and Cys residues in bovine RNAse A
associated with the trans lipid formation in a mimetic model of biological
membranes
Ferreri, C.; Chatgilialoglu, C.; Torreggiani, A.; Salzano, A. M.; Renzone, G.;
Scaloni, A.
J. Proteome Res. 2008, 7, 2007–2015.
177) The Fate of C5’ Radicals of Purine Nucleosides Under Oxidative Conditions
Boussicault, F.; Kaloudis, P.; Caminal, C.; Mulazzani, Q. G.; Chatgilialoglu, C.
J. Am. Chem. Soc. 2008, 130, 8377–8385.
178) Synthesis of all-trans anandamide: A substrate for fatty acid amide hydrolase with
dual effects on rabbit platelet activation
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Ferreri, C.; Anagnostopoulos, D.; Lykakis, I. N.; Chatgilialoglu, C.; SiafakaKapadai, A.
Bioorg. Med. Chem. 2008, 16, 8359–8365.
179) Silyl radicals in chemical synthesis
Chatgilialoglu, C.; Timokhin, V. I.
Adv. Organomet. Chem. 2008, 57, 117–181.
180) Biologically Relevant Small Radicals
Bauer, G.; Chatgilialoglu, C.; Gebicki, J. L.; Gebicka, L.; Gescheidt, G.; Golding,
B. T.; Goldstein, S.; Kaizer, J.; Merenyi, G.; Speier, G.; Wardman, P.
Chimia 2008, 62, 704–712.
181) Lipidomics and Free Radical Modifications of Lipids
Chatgilialoglu, C.; Ferreri, C.; Hermetter, A.; Lacote, E.; Mihaljević, B.; Nicolaides,
A.; Siafaka –Kapadai, A.
Chimia 2008, 62, 713–720.
182) Biomimetic chemistry on tandem protein/lipid damages under reductive radical
stress
Atrian, S.; Bobrowski, K.; Capdevila, M.; Chatgilialoglu, C.; Ferreri, C.; HouéeLevin, C.; Salzano, A. M.; Scaloni, A.; Torreggiani, A.
Chimia 2008, 62, 721–727.
183) DNA damage and radical reactions: mechanistic aspects, formation in cells and
repair studies
Cadet, J. Carell, T.; Cellai, L.; Chatgilialoglu, C.; Gimisis, T.; Miranda, M.; O'Neill,
P.; Ravanat, J.-L.; Robert, M.
Chimia 2008, 62, 742–749.
Year 2007
162) Reaction of Hydrogen Atom with Met-Enkephalin and Related Peptides
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Mozziconacci, O.; Bobrowski, K.; Ferreri, C.; Chatgilialoglu, C.
Chem. Eur. J. 2007, 13, 2029–2033.
163) Sulfhydryl Radical (HS•/S•–): A Contender for the Isomerization of Double Bonds in
Membrane Lipids
Lykakis, I. N.; Ferreri, C.; Chatgilialoglu, C.
Angew. Chem. Int. Ed. 2007, 46, 1914–1916.
164) Independent Generation of C-5’ Nucleosidyl Radicals in Thymidine and 2’Deoxyguanosine
Manetto, A.; Georganakis, D.; Gimisis, T.; Leondiadis, L.; Mayer, P.; Carell, T.;
Chatgilialoglu, C.
J. Org. Chem. 2007, 72, 3659–3666.
165) One-Electron Reduction of Methanesulfonyl Chloride. The Fate of (MeSO2Cl)•– and
MeSO2• Intermediates in Oxygenated Solutions and Their Role in the cis-trans
Isomerization of Monounsaturated Fatty Acids
Tamba, M.; Dajka, K.; Ferreri, C.; Asmus, K.-D.; Chatgilialoglu, C.
J. Am. Chem. Soc. 2007, 129, 8716–8723.
166) Radical Carbonylation with [11C]Carbon Monoxide Promoted by Oxygen-Centered
Radicals: Experimental and DFT Studies of the Mechanism
Itsenko, O.; Norberg, D.; Rasmussen, T; Långström, B.; Chatgilialoglu, C.
J. Am. Chem. Soc. 2007, 129, 9020–9031.
167) Trans Fatty Acids in Membranes: The Free Radical Path
Ferreri, C.; Panagiotaki, M.; Chatgilialoglu, C.
Mol. Biotechnol. 2007, 37, 19–25.
168) Ring-Opening of the Cyclobutane in Thymine Dimer Radical Anion
Chatgilialoglu, C.; Guerra, M.; Kaloudis, P.; Houée-Lévin, C.; Marignier, J.-L.;
Swaminathan, V. N.; Carell, T.
Chem. Eur. J. 2007, 13, 8979–8984.
20
169) Radical Reactions in Aqueous Medium Using (Me3Si)3SiH
Postigo, A.; Kopsov, S.; Ferreri, C.; Chatgilialoglu, C.
Org. Lett. 2007, 9, 5159–5162.
170) (5’S)- and (5’R)-5’,8-Cyclo-2’-deoxyguanosine: Mechanistic Insights on the 2'Deoxyguanosin-5'-yl radical Cyclization
Chatgilialoglu, C.; Bazzanini, R.; Jimenez, L. B.; Miranda, M. A.
Chem. Res. Toxicol. 2007, 20, 1820–1824.
Year 2006
148) Investigation of Radical-Based Damage of RNase A in Aqueous Solutions and
Lipid Vesicles
Torreggiani, A.; Tamba, M.; Manco, I.; Faraone-Mennella, M. R.; Ferreri, C.;
Chatgilialoglu, C.
Biopolymers 2006, 81, 39–50.
149) Complex Sequence Dependence by Excess Electron Transfer Through DNA with
Different Strength Electron Acceptors
Manetto, A.; Breeger, S.; Chatgilialoglu, C.; Carell, T.
Angew. Chem. Int. Ed. 2006, 44, 318–321.
150) A Facile One-Pot Synthesis of 8-Oxo-7,8-dehydro-(2’-deoxy)adenosine in Water
Chatgilialoglu, C.; Navacchia, M. L.; Postigo, A.
Tetrahedron Lett. 2006, 47, 711–714.
151) Probing the Influence of cis-trans Isomers on Model Lipid Membrane Fluidity Using
cis-Parinaric Acid and a Stop-Flow Technique
Ferreri, C.; Pierotti, S.; Chatgilialoglu, C.; Barbieri, A.; Barigelletti, F.
Chem. Commun. 2006, 529–531.
21
152) Comparison of Phosphatidylcholine Vesicle Properties Related to Geometrical
Isomerism
Ferreri, C.; Pierotti, S.; Barbieri, A.; Zambonin, L.; Landi, L.; Rasi, S.; Luisi, P. L.;
Barigelletti, F.; Chatgilialoglu, C.
Photochem. Photobiol. 2006, 82, 274–280.
153) Reductive Modification of Methionine Residue in Amyloid–β Peptide
Kadlcik, V.; Sicard-Roselli, C.; Houée-Levin, C.; Kodicek, M.; Ferreri, C.;
Chatgilialoglu, C.
Angew. Chem. Int. Ed. 2006, 45, 2595–2598.
154) Occurrence of Trans Fatty Acids in Rats Fed a Trans-Free Diet: A Free RadicalMediated Formation?
Zambonin, L.; Ferreri, C.; Cabrini, L.; Prata, C.; Chatgilialoglu, C.; Landi, L.
Free Radical Biol. Med. 2006, 40, 1549–1556.
155) C5’-Adenosinyl Radical Cyclization. A Stereochemical Investigation
Navacchia M. L.; Chatgilialoglu, C.; Montevecchi, P. C.
J. Org. Chem. 2006, 71, 4445–4452.
156) Trans Fatty Acids and Radical Stress: What Are the Real Culprits?
Chatgilialoglu, C.; Ferreri, C.; Lykakis, I. N.; Wardman, P.
Bioorg. Med. Chem. 2006, 14, 6144–6148.
157) Chemical Radiation Studies of 8-Bromo-2’-deoxyinosine and 8-Bromoinosine in
Aqueous Solutions
Russo, M.; Jimenez, L. B.; Mulazzani, Q. G.; D’Angelantonio, M.; Guerra, M.;
Miranda, M. A.; Chatgilialoglu, C.
Chem. Eur. J. 2006, 12, 7684–7693.
158) Tautomerism in the Guanyl Radicals
Chatgilialoglu, C.; Caminal C.; Altieri, A.; Vougioukalakis, G. C.; Mulazzani, Q.
G.; Gimisis, T.; Guerra, M.;
22
J. Am. Chem. Soc. 2006, 128, 13796–13805.
159) Epoxidation of Polyunsaturated Fatty Acid Double Bonds by Dioxirane Reagent:
Regioselectivity and Lipid Supramolecular Organization
Grabovskiy, S. A.; Kabal’nova, N. N.; Chatgilialoglu, C.; Ferreri, C.
Helv. Chim. Acta 2006, 89, 2243–2253.
160) The tris(trimethylsilyl)silane/thiol reducing system: A tool for measuring rate
constants for reactions of carbon-radicals with thiols
Chatgilialoglu, C.
Helv. Chim. Acta 2006, 89, 2387–2398.
161) The Reaction of Hydrogen Atoms with Methionine Residues: A Model of
Reductive Radical Stress Causing Tandem Protein-Lipid Damage
Ferreri, C.; Manco, I.; Faraone-Mennella, M. R.; Torreggiani, A.; Tamba, M.;
Manara, S.; Chatgilialoglu, C.
ChemBioChem 2006, 7, 1738–1744.
Year 2005
135) Reactions of Oxide Radical Ion (O•–) with Pyrimidine Nucleosides
Chatgilialoglu, C.; Ioele, M.; Mulazzani, Q. G.
Radiat. Phys. Chem. 2005, 72, 251–256.
136) The Kinetics of Z/E Isomerization of Methyl Oleate, Catalyzed by Photogenerated
Thiyl Radicals
Chatgilialoglu, C.; Samadi, A.; Guerra, M.; Fischer, H.
ChemPhysChem 2005, 6, 286–291.
137) The Reaction of Benzothiazole Sulfenamide with (TMS)3SiH: An Example of
Degenerated-Branched Chain Process
Varlamov, V. T.; Ferreri, C.; Chatgilialoglu, C.
J. Organomet. Chem. 2005, 690, 1756–1762.
23
138) Trans Lipids Formation Induced by Thiols in Human Monocytic Leukemia Cells
Ferreri, C.; Kratzsch, S.; Brede, O.; Marciniak, B.; Chatgilialoglu, C.
Free Radic. Biol. Med. 2005, 38, 1180–1187.
139) Radiation Damage of Lysozyme in a Biomimetic Model: Some Insights by Raman
Spectroscopy
Torreggiani, A.; Tamba, M.; Manco, I.; Faraone-Mennella, M. R.; Ferreri, C.;
Chatgilialoglu, C.
J. Mol. Struct. 2005, 744, 767–773.
140) Synthesis of All-trans Isomer of Arachidonic Acid and Its Effect on Rabbit Plateled
Aggregation
Anagnostopoulos, D.; Ferreri, C.; Samadi, A.; Chatgilialoglu, C.; Siafaka-Kapadai,
A.
Bioorg. Med. Chem. Lett. 2005, 15, 2766–2770.
141) The Influence of Solid–State Molecular Organization on the Reaction Paths of Thiyl
Radicals: EPR Experimental Evidence for Radiation Induced Reactions in
Clathrates, Polymer Matrices and Lysozyme
Faucitano, A.; Buttafava, A.; Mariani, A.; Chatgilialoglu, C.
ChemPhysChem 2005, 6, 1100–1107.
142) Trans Lipids: The Free Radical Path
Acc. Chem. Res. 2005, 38, 441–448.
143) Trans Fatty Acid and Atopic Eczema/Dermatitis Syndrome: The Relationship with a
Free Radical cis—trans Isomerization of Membrane Lipids
Ferreri, C.; Angelini, F.; Chatgilialoglu, C.; Dellonte, S.; Moschese, V.; Rossi, P.;
Chini, L.
Lipids 2005, 40, 661–667.
24
144) Tautomers of One-Electron Oxidized Guanosine
Chatgilialoglu, C.; Caminal C.; Guerra, M.; Mulazzani, Q. G.
Angew. Chem. Int. Ed. 2005, 44, 6030–6032.
145) Geometrical Trans Lipid Isomers: A New Target for Lipidomics
Ferreri, C.; Chatgilialoglu, C.
ChemBioChem 2005, 6, 1722–1734.
146) Radical Cyclization Approach to Cyclonucleosides
Navacchia, M. L.; Manetto, A.; Montevecchi, P. C.; Chatgilialoglu, C.
Eur. J. Org. Chem. 2005, 4640–4648.
147) The Radical-Based Reduction with (TMS)3SiH “on Water”
Postigo, A.; Ferreri, C.; Navacchia, M. L.; Chatgilialoglu, C.
Synlett 2005, 2854–2856.
Year 2004
123) Regioselective Cis-Trans Isomerization of Arachidonic Double Bonds by Thiyl
Radicals: The Influence of Phospholipid Supramolecular Organization
Ferreri, C.; Samadi, A.; Sassatelli, F.; Landi, L.; Chatgilialoglu, C.
J. Am. Chem. Soc. 2004, 126, 1063–1072.
124) Selective Generation and Reactivity of 5'-Adenosinyl and 2'-Adenosinyl Radicals
Chatgilialoglu, C.; Duca, M.; Ferreri, C.; Guerra, M.; Ioele, M.; Mulazzani, Q. G.;
Strittmatter, H.; Giese, B.
Chem. Eur. J. 2004, 10, 1249–1255.
125) Thermal Decomposition of tert-Butyl Perester of Thymidine-5’-carboxylic Acid.
Formation and Fate of the Pseudo C4’ Radical
Montevecchi, P. C.; Manetto, A.; Navacchia, M. L.; Chatgilialoglu, C.
Tetrahedron 2004, 60, 4303–4308.
25
126) Furanyl Nucleosides: Synthesis and Kinetics of Their Formation
Chatgilialoglu, C.; Vrantza, D.; Gimisis, T.
Tetrahedron Lett. 2004, 45, 4515-4517.
127) Liquid-Phase Oxidation of Pentamethyldisilane with Oxygen
Timokhin V. I.; Zaborovskii A. B.; Ferreri C.; Chatgilialoglu C.
Russ. J. Gen. Chem. 2004, 74, 469–469.
128) Excess Electron Transfer in G-Quadruplex
De Champdoré, M.; De Napoli, L.; Montesarchio, D.; Piccialli, G.; Caminal C.;
Mulazzani, Q. G.; Navacchia, M. L.; Chatgilialoglu, C.
Chem. Commun. 2004, 1756–1757.
129) A Mechanistic Investigation of (Me3Si)3SiH Oxidation
Zaborovskiy A. B.; Lutsyk D. S.; Prystansky R. E.; Kopylets V. I.; Timokhin V. I.;
Chatgilialoglu C.
J. Organomet. Chem. 2004, 689, 2912–2919.
130) Thiyl Radicals-Catalyzed Isomerization of Oils: An Entry to the Trans Lipid
Library
Samadi, A.; Andreu, I.; Ferreri, C.; Dellonte, S.; Chatgilialoglu, C.
J. Am. Oil Chem. Soc. 2004, 81, 753–758.
131) Synthesis and Biological Evaluation of Novel 1'- Branched and Spironucleoside
Analogues
Chatgilialoglu, C.; Ferreri, C.; Gimisis, T.; Roberti, M.; Balzarini, J.; De Clercq, E.
Nucleosides, Nucleotides & Nucleic Acids 2004, 23, 1565–1581.
132) Liquid–Phase Oxidation of tert-Buthyldimethylsilane
Lutsik-Maksim, D. S.; Timokhin V. I.; Zaborovskii, A. B.; Prystanskii, R. E.;
Turovskii, A.A.; Chatgilialoglu C.
Russ. J. Gen. Chem. 2004, 74, 1508–1512.
26
133) The Photochemistry of 8-Bromo-2’-deoxyadenosine. A Direct Entry to Cyclopurine
Lesions
Jimenez, L. B.; Encinas, S.; Miranda, M. A.; Navacchia, M. L.; Chatgilialoglu, C.
Photochem. Photobiol. Sci. 2004, 3, 1042–1046.
134) A Biomimetic Model of Tandem Radical Damage Involving Sulfur-Containing
Protein and Unsaturated Lipids
Ferreri, C.; Manco, I.; Faraone-Mennella, M. R.; Torreggiani, A.; Tamba, M.;
Chatgilialoglu, C.
ChemBioChem 2004, 5, 1710–1712.
Year 2003
120) Model Studies of DNA C5' Radicals. Selective Generation and Reactivity of 2'Deoxyadenosin-5'-yl Radical
Chatgilialoglu, C.; Guerra, M.; Mulazzani, Q. G.
J. Am. Chem. Soc. 2003, 125, 3839–3848.
121) Rate Constants for the β-Elimination of Tosyl Radical from a Variety of Substituted
Carbon-Centered Radicals
Timokhin, V. I.; Gastaldi, S.; Bertrand, M. P.; Chatgilialoglu, C.
J. Org. Chem. 2003, 68, 3532–3537.
122) Kinetics of Liquid–Phase Oxidation of Poly(phenylsilane)
Zaborovskiy A. B.; Timokhin V. I.; Chatgilialoglu C.
Polym. Sci. Ser. A 2003, 45, 612–616.
Year 2002
115) Kinetic and Product Studies of the Reaction of Triorganosilanes with
Dimethyldioxirane
Grabovskii, S. A.; Kabal’nova, N. N.; Shereshovets, V. V.; Chatgilialoglu, C.
27
116) 5-Endo-trig Radical Cyclizations: Disfavored or Favored Processes?
Chatgilialoglu, C.; Ferreri, C.; Guerra, M.; Timokhin, V.; Froudakis, G.; Gimisis, T.
J. Am. Chem. Soc. 2002, 124, 10765–10772.
117) The Kinetics of Thiyl Radical Induced Reactions of Monounsaturated Fatty Acid
Esters
Chatgilialoglu, C.; Altieri, A.; Fischer, H.
J. Am. Chem. Soc. 2002, 124, 12816–12823.
118) Arachidonate Geometrical Isomers Generated by Thiyl Radicals: The Relationship
with Trans Lipids detected in Biological Samples
Ferreri, C.; Faraone Mennella, M. R.; Formisano, C.; Landi, L.; Chatgilialoglu, C.
119) Geometrical Isomerism of Monounsaturated Fatty Acids: Thiyl Radical Catalysis
and Influence of Antioxidant Vitamins
Chatgilialoglu, C.; Zambonin, L.; Altieri, A.; Ferreri, C.; Mulazzani, Q. G.; Landi,
L.;
Year 2001
112) Cis–Trans Isomerization of Polyunsaturated Fatty Acid Residues in Phospholipids
Catalyzed by Thiyl Radicals
Ferreri, C.; Costantino, C.; Perrotta, L.; Landi, L.; Mulazzani, Q. G.; Chatgilialoglu,
C.
J. Am. Chem. Soc. 2001, 123, 4459–4468.
113) Free Radicals Associated with DNA Damage
Chatgilialoglu, C.; O’Neill, P.
Exp. Gerontol. 2001, 36, 1459–1471.
28
114) Reactivity of Tris(trimethylsilyl)silane Towards Diarylaminyl Radicals
Varlamov, V. T.; Denisov, E. T.; Chatgilialoglu, C.
J. Org. Chem. 2001, 66, 6317–6322.
Year 2000
106) Rate Constants for the Reaction of Cumylperoxyl Radicals with Group 14 Hydrides
Chatgilialoglu, C.; Timokhin, V. I.; Zaborovskiy, A. B.; Lutsyk, D. S.; Prystansky,
R. E.
J. Chem. Soc. Perkin Trans 2 2000, 577–581.
107) Radiation Chemical Studies of 8-Bromoguanosine in Aqueous Solution
Ioele, M.; Bazzanini, R.; Chatgilialoglu, C.; Mulazzani, Q. G.
J. Am. Chem. Soc. 2000, 122, 1900–1907.
108) Fate of the 2’-Deoxyadenosin-5’-yl Radical under Anaerobic Conditions
Flyunt, R.; Bazzanini, R.; Chatgilialoglu, C.; Mulazzani, Q. G.
J. Am. Chem. Soc. 2000, 122, 4225–4226.
109) cis–trans Isomerization of Monounsaturated Fatty Acid Residues in Phospholipids
by Thiyl Radicals
Chatgilialoglu, C.; Ferreri, C.; Ballestri, M.; Mulazzani, Q. G.; Landi, L.
J. Am. Chem. Soc. 2000, 122, 4593–4601.
110) Model of DNA C1’ Radicals. Structural, Spectral and Chemical Properties of the
Thyminylmethyl Radical and the 2’-Deoxyuridin-1’-yl Radical
Chatgilialoglu, C.; Ferreri, C.; Bazzanini, R.; Guerra, M.; Choi, S-Y.; Emanuel, C.
J.; Horner, J. H.; Newcomb,.M.
J. Am. Chem. Soc. 2000, 122, 9525–9533.
111) Radical-Based Reduction of Phosphine Sulfides and Phosphine Selenides by
(Me3Si)3SiH
Romeo, R.; Wozniak, L. A.; Chatgilialoglu, C.
29
Year 1999
94) The PdCl2/R3SiH System for the Silylation of Nucleosides
Ferreri, C.; Costantino, C.; Romeo, R.; Chatgilialoglu, C.
95) Rate Constants for the Reaction of Cumylperoxyl Radicals with Bu3SnH and
(TMS)3SiH
Chatgilialoglu, C.; Timokhin, V. I.; Zaborovskiy, A. B.; Lutsyk, D. S.; Prystansky,
R. E.
Chem. Commun. 1999, 405–406.
96) The Thiyl Radical-Mediated Isomerization of cis-Monounsaturated Fatty Acid
Residues in Phospholipids: A Novel Path of Membrane Damage?
Ferreri, C.; Costantino, C.; Landi, L.; Mulazzani, Q. G.; Chatgilialoglu, C.
Chem. Commun. 1999, 407–408.
97) Anionically Induced Formation of Anomeric Spironucleosides from 1’-C-Cyano-2’deoxyuridine
Chatgilialoglu, C.; Ferreri, C.; Gimisis, T.
98) Kinetics of 2’-Deoxyuridin-1’-yl Radical Reactions
Emanuel, C. J.; Newcomb, M.; Ferreri, C.; Chatgilialoglu, C.
J. Am. Chem. Soc. 1999, 121, 2927–2928.
99) Hydrogen Donor Abilities of the Germanium Hydrides
Chatgilialoglu, C.; Ballestri, M.; Escudié, J.; Pailhous, I.
100) Mechanistic and Synthetic Aspects of the C-1’ Radicals in Modified Nucleosides
30
Chatgilialoglu, C.
Nucleosides Nucleotides 1999, 18, 547–553.
101) Ex-novo and Revisum Procedures for the Preparation of C-1’ Branched Nucleosides
Chatgilialoglu, C.; Costantino, C.; Ferreri, C.; Gimisis, T.; Romagnoli, A.; Romeo,
R.
Nucleosides Nucleotides 1999, 18, 637–639.
102) C-1’ Radicals in Nucleosides
Chatgilialoglu, C.
Il Farmaco 1999, 54, 321–325.
103) Chemistry of Acyl Radicals
Chatgilialoglu, C.; Crich, D.; Komatsu, M.; Ryu, I.
Chem. Rev. 1999, 99, 1991–2069.
104) Hydrogen Donor Abilities of the Group 14 Hydrides
Chatgilialoglu, C.; Newcomb, M.
Adv. Organomet. Chem. 1999, 44, 67–112.
105) C-1’ Radical-Based Approaches for the Synthesis of Anomeric Spironucleosides
Chatgilialoglu, C.; Gimisis, T. Spada, G. P.
Chem. Eur. J. 1999, 5, 2866–2876.
Year 1998
85) Generation of C-1' Radicals Through a β-(Acyloxy)alkyl Rearrangement in
Modified Purines and Pyrimidine Nucleosides
Gimisis, T.; Ialongo, G; Chatgilialoglu, C.
Tetrahedron 1998, 54, 573–592.
86) One-Carbon Ring Expansion in Cyclopentanones as a Free-Radical Clock
Chatgilialoglu, C.; Timokhin, V. I.; Ballestri, M.
31
J. Org. Chem. 1998, 63, 1327–1329.
87) Homolytic reactivity of Group 14 Organometallic Hydrides Towards Nitroxides
Lucarini, M.; Marchesi, E.; Pedulli, G.F.; Chatgilialoglu, C.
J. Org. Chem. 1998, 63, 1687–1693.
88) The Versatile Behavior of the PdCl2/Et3SiH System. Conversion of Alcohols to the
Corresponding Halides and Alkanes
Ferreri, C.; Costantino, C.; Chatgilialoglu, C.; Boukherroub, R.; Manuel. G.
J. Organomet. Chem. 1998, 554, 135–137.
89) Autoxidation of Poly(hydrosilane)s
Chatgilialoglu, C.; Guerrini, A.; Lucarini, M.; Pedulli, G. F.; Carrozza, P.; DaRoit,
G.; Borzatta, V.; Lucchini, V.
90) Spectra and Structure of the 2'-Deoxyuridin-1'-yl Radical
Chatgilialoglu, C.; Gimisis, T.; Guerra, M.; Ferreri, C.; Emanuel, C. J.; Horner, J.
H.; Newcomb, M.; Lucarini, M.; Pedulli, G.F.
91) Fate of the C-1’ Peroxyl Radical in the 2’-Deoxyuridine System
Chatgilialoglu, C.; Gimisis, T.
Chem. Commun. 1998, 1249–1250.
92) Reactions of Oxide Radical Ion (•O–) with Pyrimidine and Purine Derivatives
Ioele, M.; Chatgilialoglu, C.; Mulazzani, G.
J. Phys. Chem. A 1998, 102, 6259–6265.
93) Catalytic Ferrier Rearrangement of Unsaturated Nucleosides
Linker, T.; Sommermann, T.; Gimisis, T.; Chatgilialoglu, C.
32
Year 1997
81) 5-exo-trig versus 6-endo-trig Cyclization of Alk-5-enoyl Radicals. The Role of OneCarbon Ring Expansion
Chatgilialoglu, C.; Ferreri, C.; Lucarini, M.; Venturini, A.; Zavitsas, A. A.
Chem. Eur. J. 1997, 3, 376–387.
82) A New Class of Anomeric Spironucleosides
Gimisis, T.; Castellari, C.; Chatgilialoglu, C.
Chem. Commun. 1997, 2089–2090.
83) Addition of Tris(trimethylsilyl)germyl Radicals to Unsaturated Compounds. An
EPR and Product Study
Bernardoni, S.; Lucarini, M.; Pedulli, G. F.; Valgimigli, L.; Gevorgyan, V.;
Chatgilialoglu, C.
J. Org. Chem. 1997, 62, 8009–8014.
84) Free Radical Chemistry Associated with H(RSiH)nH
Chatgilialoglu, C.; Ferreri, C.; Vecchi, D.; Lucarini, M.; Pedulli, G. F.
J. Organomet. Chem. 1997, 546, 475–481.
Year 1996
75) PdCl2-Catalyzed Reduction of Organic Halides by Triethylsilane
Boukherroub, R.; Chatgilialoglu, C.; Manuel. G.
76) 1,5-Radical Translocation Protocol for the Generation of C-1’ Radicals in
Nucleosides. Synthesis of Spiro Nucleosides through a Rare 5-endo-trig Cyclization
Gimisis, T.; Chatgilialoglu, C.
J. Org. Chem. 1996, 61, 1908–1909.
77) Free Radical Carbonylation of 1,4-cis-Polybutadiene
33
Chatgilialoglu, C.; Ferreri, C.; Sommazzi, A.
J. Am. Chem. Soc. 1996, 118, 7223–7224.
78) Synthesis of 2-Functionalized Allyl Tris(trimethylsilyl)silanes
Chatgilialoglu, C.; Ballestri, M.; Vecchi, D.; Curran, D. P.
79) 2-Functionalized Allyl Tris(trimethylsilyl)silanes as Radical-Based Allylating
Agents
Chatgilialoglu, C.; Ferreri, C.; Ballestri, M.; Curran, D. P.
80) Tris(trimethylsilyl)silane as Mediator in the Radical-Based Allylation Reactions of
Allyl and 2-Functionalized Allyl Phenyl Sulfones
Chatgilialoglu, C.; Alberti, A.; Ballestri, M.; Macciantelli, D.; Curran, D. P.
Year 1995
66) Rate Constant for the Reaction of Acyl Radicals with Bu3SnH and (TMS)3SiH
Chatgilialoglu, C.; Lucarini, M.
67) 5,10-Dihydro-Silanthrene as a Reagent for the Barton-McCombie Reaction
Gimisis, T.; Ballestri, M.; Ferreri, C.; Chatgilialoglu, C.; Boukherroub, R.; Manuel,
G.
68) Rate Constants and Arrhenius Parameters for the Reaction of Acyl Radicals with
Bu3SnH and (Me3Si)3SiH
Chatgilialoglu, C.; Ferreri, C.; Lucarini, M.; Pedrielli, P.; Pedulli, G. F.
34
69) (Z)–(E) Interconversion of Olefins by the Addition–Elimination Sequence of the
(TMS)3Si• Radical
Chatgilialoglu, C.; Ballestri, M.; Ferreri, C.; Vecchi, D.
J. Org. Chem. 1995, 60, 3826–3831.
70) Structural and Chemical Properties of Silyl Radicals
Chatgilialoglu, C.
Chem. Rev. 1995, 95, 1229–1251.
71) Radical Transformations of Nucleosides with (Me3Si)3SiH. Generation of a C-1’
Radical through 1,2-Migration of an Acyloxy Group
Gimisis, T.; Ialongo, G.; Zamboni, M.; Chatgilialoglu, C.
72) A Facile Entry to Secondary Cyclopropylcarbinols: Further Developments in the
Stereospecific Synthesis of (E)-Homoallylic Bromides
Ferreri, C.; Ambrosone, M.; Chatgilialoglu, C.
Synth. Commun. 1995, 25, 3351–3356.
73) Tris(trimethylsilyl)germane as a Radical-Based Reducing Agent
Chatgilialoglu, C.; Ballestri, M.
74) Energies of Activation. The Paradigm of Hydrogen Abstractions by Radicals
Zavitsas, A. A.; Chatgilialoglu, C.
J. Am. Chem. Soc. 1995, 117, 10645–10654.
Year 1994
65) Sulfur-Chlorine Bond Dissociation Enthalpies in Methane- and Benzene-sulfonyl
Chlorides
Chatgilialoglu, C.; Griller, D.; Kanabus-Kaminska, J. M.; Lossing, F. P.
J. Chem. Soc., Perkin Trans. 2 1994, 357–360.
35
Year 1993
61) A Comment on the Use of Triethylsilane as a Radical-Based Reducing Agent
Chatgilialoglu, C.; Ferreri, C.; Lucarini, M.
J. Org. Chem. 1993, 58, 249–251.
62) Organosilanes as Radical-Based Reducing Agents with Low Hydrogen Donating
Abilities
Ballestri, M.; Chatgilialoglu, C.; Guerra, M.; Guerrini, A.; Lucarini, M.; Seconi, G.
63) An Unexpected Stereochemical Control of Alkene Formation by the Choice of
Radical Initiator. The Reversible Addition of (Me3Si)3Si• Radicals to Alkenes
Ferreri, C.; Ballestri, M.; Chatgilialoglu, C.
64) Progress of the Barton-McCombie Methodology: From Tin Hydrides to Silanes
Chatgilialoglu, C; Ferreri, C.
Res. Chem. Intermed. 1993, 19, 755–775.
Year 1992
52) Reactions of Tris(trimethylsilyl)silyl Radicals with Nitroalkanes. EPR, Kinetic, and
Product Studies
Ballestri, M.; Chatgilialoglu, C.; Lucarini, M.; Pedulli, G. F.
J. Org. Chem. 1992, 57, 948–952.
53) The Reaction of Tris(trimethylsilyl)silane with Acid Chlorides
Ballestri, M.; Chatgilialoglu, C.; Cardi, N.; Sommazzi, A.
54) Autoxidation of Tris(trimethylsilyl)silane
36
Chatgilialoglu, C.; Guarini, A.; Guerrini, A.; Seconi, G.
J. Org. Chem. 1992, 57, 2207–2208.
55) A Study on the Reducing Abilities of Tris(alkylthio)silanes
Chatgilialoglu, C.; Guerra, M.; Guerrini, A.; Seconi, G.; Clark, K. B.; Griller, D.;
Kanabus-Kaminska, J. M.; Martinho-Simoes, J. A.
J. Org. Chem. 1992, 57, 2427–2433.
56) Organosilanes as Radical-Based Reducing Agents in Synthesis
Chatgilialoglu, C.
Acc. Chem. Res. 1992, 25, 188–194.
57) Homolytic Substitution Reaction at a Silicon Atom
Kulicke, K. J.; Chatgilialoglu, C.; Kopping, B.; Giese, B.
Helv. Chim. Acta 1992, 75, 935–939.
58) The Me3Si Substituent Effect on the Reactivity of Silanes. Structural Correlations
Between Silyl Radicals and Their Parent Silanes.
Chatgilialoglu, C.; Guerrini, A.; Lucarini, M.
J. Org. Chem. 1992, 57, 3405–3409.
59) (Me3Si)3SiH: An Efficient Hydrosilylating Agent of Alkenes and Alkynes
Kopping, B.; Chatgilialoglu, C.; Zehnder, M.; Giese, B.
J. Org. Chem. 1992, 57, 3994–4000.
60) Electron Impact Studies of Alkanesulfonyl Chorides. An Investigation of the Sulfur
Dioxide Radical Cation
Chatgilialoglu, C.; Guerra, M.; Hamdan, M.; Traldi, P.;
Int. J. Mass Spectrom. Ion Processes 1992, 116, 115–125.
Year 1991
48) Tris(trimethylsilyl)silane as a Radical-Based Reducing Agent in Synthesis
37
Ballestri, M.; Chatgilialoglu, C.; Clark, K.B.; Griller, D.; Giese, B.; Kopping, B.
J. Org. Chem. 1991, 56, 678–683.
49) An Approach to the Electronic Properties of Sulfonyl and Sulfinyl Compounds by
Means of Sulfur-33 and Oxygen-17 NMR
Barbarella, G.; Bongini, A.; Chatgilialoglu, C.; Zambianchi, M.
Phosphorus, Sulfur, and Silicon 1991, 58, 491–494.
50) (Me3Si)3SiSH: A New Radical-Based Reducing Agent
Ballestri, M.; Chatgilialoglu, C.; Seconi, G.
J. Organomet. Chem. 1991, 408, C1–C4.
51) Rate Constants and Arrherius Parameters for the Reaction of Some Carbon-Centered
Radicals with Tris(trimethylsilyl)silane
Chatgilialoglu, C.; Dickhaut , J.; Giese, B.
J. Org. Chem. 1991, 56, 6399–6403.
Year 1990
43) Tris(alkylthio)silanes as New Reducing Agents via Radicals
Chatgilialoglu, C.; Guerrini, A.; Seconi, G.
Synlett 1990, 219–220.
44) MSXα Study of Absorption Spectra of Free Radicals. Characterization of Rydberg
and Valence Transitions in Alkyl Derivatives of Group14 Centered Radicals
Chatgilialoglu, C.; Guerra, M.
J. Am. Chem. Soc. 1990, 112, 2854–2859.
45) Addition of Tris(trimethylsilyl)silyl Radicals to the Carbonyl Group
Alberti, A.; Chatgilialoglu, C.
Tetrahedron 1990, 46, 3963–3972.
38
46)
33
S and 17O NMR of Compounds Containing the SO2 Moiety. A Generalization of
the "Chlorine Effect"
Barbarella, G.; Chatgilialoglu, C.; Tugnoli, V.
J. Magn. Reson. 1990, 88, 277–283.
47) Alkyl Isocyanides as Precursors for the Formation of Carbon-Carbon Bonds
C. Chatgilialoglu, B. Giese and B. Kopping
Year 1989
38) Tris(trimethylsilyl)silane as Mediator in Organic Synthesis via Radicals
Giese, B.; Kopping, B.; Chatgilialoglu, C.
39) Rate Constants for the Reaction of Tris(trimethylsilyl)silyl Radicals with Organic
Halides
Chatgilialoglu, C.; Griller, D.; Lesage, M.
J. Org. Chem. 1989, 54, 2492–2494.
40) Amino- and Alkoxysulfonyl Radicals
Chatgilialoglu, C.; Griller, D.; Rossini, S.
J. Org. Chem. 1989, 54, 2734–2737.
41) Sulfonylium Ions in the Gas Phase
Chatgilialoglu, C.; Guerra, M.; Pelli, B.; Traldi, P.
Org. Mass Spectrom. 1989, 24, 455–460.
42) Tris(trimethylsilyl)silane: A Catalyst for Radical Mediated Reduction Reactions
Lesage, M.; Chatgilialoglu, C.; Griller, D.;
Year 1988
39
36) The Substituent Effect on the Reactivity of Silanes Towards tert-Butoxyl Radicals
Chatgilialoglu, C.; Rossini, S.
Bull. Chim. Soc. Fr. 1988, 298–300.
37) Tris(trimethylsilyl)silane. A New Reducing Agent
J. Org. Chem. 1988, 53, 3641–3642.
Year 1987
32) Absolute Rate Constants for the Reaction of Triethylsilyl Radicals with RingSubstituted Benzyl Chlorides
Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C.
J. Org. Chem. 1987, 52, 938–940.
33) Experimental and Theoretical Approaches to the Optical Absorption Spectra of
Sulfonyl Radicals
Chatgilialoglu, C.; Griller, D.; Guerra, M.
J. Phys. Chem. 1987, 91, 3747–3750.
34) Reduction of Silicon–Hydrogen Bond Strengths
Kanabus-Kaminska, J. M.; Hawari, J. A.; Griller, D.; Chatgilialoglu, C.
J. Am. Chem. Soc. 1987, 109, 5267–5268.
35) Sulfur-33 NMR of Cyclic Sulfides, Sulfoxides and Sulfones
Barbarella, G.; Bongini, A.; Chatgilialoglu, C.; Rossini, S.; Tugnoli, V.
J. Org. Chem. 1987, 52, 3857–3860.
Year 1986
27) Absolute Rate Constants for the Reactions of α-Toluenesulfonyl Chloride with
Carbon-Centered Radicals
40
Chatgilialoglu, C.
J. Org. Chem. 1986, 51, 2871–2873.
28) An Investigation of Structure and Conformation of Thiophene-2-sulphonyl Radicals
Alberti, A.; Chatgilialoglu, C.; Guerra, M.
29) On the Addition of Silyl Radicals to Unsaturated Carbonyl Compounds:
Regioselectivity of the Attack and 1,3 Carbon to Oxygen Silicon Migration
Alberti, A.; Chatgilialoglu, C.; Pedulli, G. F.; Zanirato, P.
J. Am. Chem. Soc. 1986, 108, 4993–4998.
30) Arrhenius Parameters for the Reaction of tert-Butoxyl Radicals with Triethylsilane
Chatgilialoglu, C.
Gazz. Chim. Ital. 1986, 116, 511–513.
31)
33
S and 17O NMR of Compounds Containing the SO2 Moiety. The Chlorine Effect
Barbarella, G.; Chatgilialoglu, C.; Rossini, S.; Tugnoli, V.
J. Magn. Reson. 1986, 70, 204–212.
Year 1985
26) Structural and Optical Absorption Spectra of Some Sulfuranyl Radicals in Solution
Chatgilialoglu, C.; Castelhano, A. L.; Griller, D.
J. Org. Chem. 1985, 50, 2516–2518.
Year 1984
24) Conformational Studies by Dynamic Nuclear Magnetic Resonance. Part 26.
Interconversion Barriers between syn- and anti- Conformers of Isomeric
Thiophenecarbaldehydes
Lunazzi, L.; Placucci, G.; Chatgilialoglu, C.; Macciantelli, D.
41
25) Absolute Rate Constants for Hydrogen Abstraction from Aldehydes and
Conformational Studies of the Corresponding Aromatic Acyl Radicals
Chatgilialoglu, C.; Lunazzi, L.; Macciantelli, D.; Placucci, G.
J. Am. Chem. Soc. 1984, 106, 5252–5256.
Year 1983
18) Intramolecular and Intermolecular Reactions of Alkenylsilyl Radicals
Chatgilialoglu, C.; Woynar, H.; Ingold, K. U.; Davies, A. G.
19) Absolute Rate Constants for the Addition of Triethylsilyl Radicals to Various
Unsaturated Compounds
J. Am. Chem. Soc. 1983, 105, 3292–3296.
20) A Homoallyl Radical Rearrangement. Kinetics of the Isomerization of the 2,2Dimethyl-3-buten-1-yl Radical to the 1,1-Dimethyl-3-buten-1-yl Radical
Chatgilialoglu, C.; Ingold, K. U.; Tse-Sheepy, I.; Warkentin, J.
Can. J. Chem. 1983, 61, 1077–1081.
21) Formation, Decay, and Spectral Characterization of Some Alkyl- and ArylSubstituted Carbon-, Silicon-, Germanium-, and Tin-Centered Radicals
Chatgilialoglu, C.; Ingold, K. U.; Lusztyk, J.; Nazran, A. S.; Scaiano, J. C.
22) Kinetic Studies on the Formation and Decay of Some Sulfonyl Radicals
Chatgilialoglu, C.; Lunazzi, L.; Ingold, K. U.
J. Org. Chem. 1983, 48, 3588–3589.
23) Reaction of Bis(trifluoromethyl)aminoxyl with Cyclopropane
Anpo, M.; Chatgilialoglu, C.; Ingold, K. U.
42
J. Org. Chem. 1983, 48, 4104–4106.
Year 1982
13) Absolute Rate Constants for the Reactions of tert-Butoxyl Radicals and Some
Ketone Triplets with Silanes
Chatgilialoglu, C.; Scaiano, J. C.; Ingold, K. U.
14) Absolute Rate Constants for the Addition of Triethylsilyl Radicals to the Carbonyl
Group
J. Am. Chem. Soc. 1982, 104, 5119–5123.
15) Absolute Rate Constants for the Reaction of Triethylsilyl Radicals with Organic
Halides
J. Am. Chem. Soc. 1982, 104, 5123–5127.
16) Attempted Spin Trapping of tert-Butylperoxyl Radicals by Trifluoronitrosomethane
Chatgilialoglu, C.; Howard, J. A.; Ingold, K. U.
J. Org. Chem. 1982, 47, 4361–4362.
17) Hindered Rotation of the CF3 Group in tert-Butoxy Trifluoromethyl Nitroxide
Chatgilialoglu, C.; Ingold, K. U.
J. Phys. Chem. 1982, 86, 4372–4375.
Year 1981
8)
Absolute Rate Constants for Some Reactions Involving Triethylsilyl Radicals in
Solution
Chatgilialoglu, C.; Ingold, K. U.; Scaiano, J. C.; Woynar, H.
J. Am. Chem. Soc. 1981, 103, 3231–3232.
43
9)
Configuration and Conformation of Alkoxyalkyl and Hydroxyalkyl Trifluoromethyl
Nitroxides. Anomeric Effects and Nitroxide Conformations
Can. J. Chem. 1981, 59, 1745–1752.
10) "Spontaneous" Formation of Radicals from Nitroso Compounds. Inadvertent
Photolysis vs. Molecule Assisted Homolysis
J. Am. Chem. Soc. 1981, 103, 4833–4837.
11) Infrared and Raman Spectra of N,N-Bis(trifluoromethyl)hydroxylamine and
Bis(trifluoromethyl) Nitroxide
Compton, D. A. C.; Chatgilialoglu, C.; Mantsch, H. H.; Ingold, K. U.
J. Phys. Chem. 1981, 85, 3093–3100.
12) Rate Constants and Arrhenius Parameters for the Reactions of Primary, Secondary,
and Tertiary Alkyl Radicals with Tri-n-butyltin Hydride
J. Am. Chem. Soc. 1981, 103, 7739–7742.
Year 1980
4)
Electron Spin Resonance Studies of Radicals formed during the Thermolysis and
Photolysis of Sulphoxides and Thiosulphonates
Chatgilialoglu, C.; Gilbert, B. C.; Gill, B.; Sexton, M. D.
5)
E.s.r. Studies of the Generation and Structure of Aminosulphonyl (Sulphamoyl)
Radicals, R2NSO2•
Chatgilialoglu, C.; Gilbert, B. C.; Norman, R. O. C.; Symons, M. C. R.
J. Chem. Res. 1980, (S) 185, (M) 2610–2623.
44
6)
Investigations of Structure and Conformation. Part 14. INDO and Electron Spin
Resonance Studies of Aliphatic Sulphonyl Radicals
Chatgilialoglu, C.; Gilbert, B. C.; Norman, R. O. C.
7)
Bis(trifluoromethyl)aminyl and Bis(trifluoromethyl) Nitroxide
Chatgilialoglu, C.; Malatesta, V.; Ingold, K. U.
J. Phys. Chem. 1980, 84, 3597–3599.
Year 1979
2)
Investigations of structure and conformation. Part 12. The structure of aromatic
sulphonyl radicals: an e.s.r. and INDO molecular orbital study
Chatgilialoglu, C.; Gilbert, B. C.; Norman, R. O. C.
3)
Electron spin resonance studies. Part 57. Alkane- and arene-sulphinate esters: an
investigation of their photochemical decomposition and reactions with the t-butoxyl
radical
Chatgilialoglu, C.; Gilbert, B. C.; Kirk, C. M.; Norman, R. O. C.
Year 1977
1)
Addition of some 1,3-diaryltriazenes to tetracyanoethylene
Camaggi, C. M.; Leardini, R.; Chatgilialoglu, C.
J. Org. Chem. 1977, 42, 2611–2614.
45
Publications in Books
1)
Quantum Mechanical Tunneling in Free Radical Reactions.
Malatesta, V.; Ingold, K. U.; Chatgilialoglu, C.
Fast Reactions in Energetic Systems; Capellos, C.; Walker, R. F., Eds; D. Reidel:
Dordrecht, 1981; pp. 541–551.
2)
Studies on Some Trifluoromethyl Nitroxide Radicals by EPR Spectroscopy.
Chatgilialoglu, C.; Ingold, K. U.; Malatesta, V.
Fast Reactions in Energetic Systems; Capellos, C.; Walker, R. F., Eds; D. Reidel:
Dordrecht, 1981; pp. 553–559.
3)
Radical Reaction: Part 1.
Organic Reaction Mechanisms; Knipe, A. C.; Watts, W. E., Eds; Wiley: Chichester,
1984; pp. 73–108.
4)
1985; pp. 83–127.
5)
1986; pp. 87–137.
6)
Formation, Decay, and Spectral Characterization of Some Sulfonyl Radicals.
Chatgilialoglu, C.
Advances in Chemical Reaction Dynamics; Rentzepis, P. M.; Capellos, C., Eds; D.
Reidel: Dordrecht, 1986; pp. 571–579.
7)
46
1987; pp. 85–128.
8)
Sulfinyl Radicals.
Chatgilialoglu, C.
The Chemistry of Sulfones and Sulfoxides; Patai, S.; Rappoport, Z.; Stirling, C. J.
M., Eds; Wiley: London, 1988; pp. 1081–1087.
9)
Sulfonyl Radicals.
Chatgilialoglu, C.
The Chemistry of Sulfones and Sulfoxides; Patai, S.; Rappoport, Z.; Stirling, C. J.
M., Eds; Wiley: London, 1988; pp. 1089–1113.
10) Recent Advances in the Chemistry of Silyl radicals.
Chatgilialoglu, C.
Paramagnetic Organometallic Species in Activation/Selectivity, Catalysis; Chanon,
M.; Julliard, M.; Poite, J. C., Eds; Kluwer: Dordrecht, 1989; pp. 119–129.
11) Silanes as New Reducing Agents in Organic Synthesis.
Chatgilialoglu, C.
Free Radicals in Synthesis and Biology; Minisci, F., Ed.; Kluwer: Dordrecht, 1989;
pp. 115–123.
12) Electronic Absorption Spectra of Free Radicals.
Chatgilialoglu, C.
Handbook of Organic Photochemistry; Scaiano, J. C., Ed.; CRC Press: Boca Raton,
1989; Vol. II; pp. 3–11.
13) Free Radical Chemistry of Sulfenic Acids and Their Derivatives.
Chatgilialoglu, C.
The Chemistry of Sulfenic Acids and Their Derivatives; Patai, S., Ed.; Wiley:
London, 1990; pp. 549–569.
47
14) Alkanethiylperoxyl Radicals.
Chatgilialoglu, C.; Guerra, M.
Sulfur–Centered Reactive Intermediates in Chemistry and Biology; Chatgilialoglu,
C.; Asmus, K.-D., Eds; Plenum Press: New York, 1990; pp. 31–36.
15) Recent Advances in the Chemistry of Compounds Containing S-Si Moiety.
Ballestri, M.; Chatgilialoglu, C.; Dembech, P.; Guerrini, A.; Seconi, G.
Sulfur–Centered Reactive Intermediates in Chemistry and Biology; Chatgilialoglu,
C.; Asmus, K.-D., Eds; Plenum Press: New York, 1990; pp. 319–325.
16) Proprietà Strutturali e Chimiche di Alcuni Radicali Centrati allo Zolfo.
Chatgilialoglu, C.
V Convegno Nazionale della Società Italiana per le Ricerche sulle Radiazioni; Serie
Simposi (ENEA): Roma, 1991; pp. 247–257.
17) Thiyl Radicals.
Chatgilialoglu, C; Guerra, M.
Supplement S: The Chemistry of Sulfur-containing Functional Groups; Patai, S.;
Rappoport, Z., Ed.; Wiley: London, 1993; pp. 363–394.
18) Free Radical Addition Involving C-C Triple Bonds.
Supplement C: The Chemistry of Triple-bonded Functional Groups; Patai, S., Ed.;
Wiley: London, 1994; pp. 917–944.
19) The Advancement of Radical-Based Synthetic Strategies: From Reagent Design to
Polymer Modification
Chatgilialoglu, C.
Chemical Synthesis: Gnosis to Prognosis; Chatgilialoglu, C.; Snieckus, V., Eds;
Kluwer: Dordrecht, 1996; pp. 263–276.
48
20) Free Radical Chemistry Associated with C-1’ Position of Nucleosides and Nucleic
Acids.
Chatgilialoglu, C.; Gimisis, T.
Free Radicals in Biology and Enviroment; Minisci, F., Ed.; Kluwer: Dordrecht,
1997; pp. 281–292.
21) Tris(trimethylsilyl)silane in Organic Synthesis
Chatgilialoglu, C.; Ferreri, C.; Gimisis, T.
The Chemistry of Organic Silicon Compounds, Vol 2; Rappoport, S.; Apeloig, Y.,
Eds.; Wiley: Chichester, 1998; pp. 1539–1579.
22) Sulfur-Centered Radicals in Organic Synthesis
Chatgilialoglu, C.; Bertrand, M. P.; Ferreri, C.
S-Centered Radicals; Alfassi, Z. B., Ed.; Wiley: Chichester, 1999; pp. 311–354.
23) Organic Synthesis by Radical Reactions
Chatgilialoglu, C.; Renaud, P.
General Aspects of Free Radical Chemistry; Alfassi, Z. B., Ed.; Wiley: Chichester,
1999; pp. 501–538.
24) Tin Silicon and Related Reducing Agents
Chatgilialoglu, C.
Radicals in Organic Synthesis, Vol 1; Renaud, P.; Sibi, M. P., Eds; Wiley-VCH:
Weinheim, 2001; pp. 28–49.
25) Silyl Radicals
Chatgilialoglu, C.; Schiesser, C. H.
The Chemistry of Organic Silicon Compounds, Vol 3; Rappoport, S.; Apeloig, Y.,
Eds.; Wiley: Chichester, 2001; pp. 341–390.
26) Fatty Acids and Phospholipids
Chatgilialoglu, C.; Ferreri, C.;
49
Cis-Trans Isomerization: From Biology to Supramolecular Chemistry; Dugave, C.,
Ed.; Wiley-VCH: Weinheim, 2006; pp. 95–12.
27) Membrane Lipidomics and the Geometry of Unsaturated Fatty Acids: From
Biomimetic Models to Biological Consequences
Lipidomics. Vol. 1: Methods and Protocols; Armstrong, D., Ed.; Humana Press:
New York, 2009; pp. 391–412.
28) Reactivity of nucleic acid sugar radicals
Chatgilialoglu, C.
Radical and Radical Ion Reactivity in Nucleic Acid Chemistry; Greenberg, M. M.,
Ed.; Wiley: New Jersey 2009; Chapter 4; pp. 99–133.
29) Biomimetic chemistry: radical reactions in vesicle suspensions
Biomimetics, Lerning from Nature; Mukherjee, A., Ed.; IN-TECH: Vienna, 2010;
Ch. 6; pp. 117–135.
30) Silanes as Reducing Reagents in Radical Chemistry
Chatgilialoglu, C.; Timokhin, V. I.
Encyclopedia of Radical in Chemistry, Biology & Materials; Chatgilialoglu, C.;
Studer, A., Eds.; Wiley: Chichester, 2012; Vol. 2; Ch. 22; pp. 561–600.
31) Oxidatively Formed Sugar Radicals in Nucleic Acids
Gimisis, T.; Chatgilialoglu, C.
32) Lipid Isomerization
50
Publications in Magazines and Online Resources
1)
(TMS)3SiH in organic synthesis: Part 1
Chatgilialoglu, C.
Organic Chemistry Highlights 2004 (article online posting date October 5, 2004).
http://www.organic-chemistry.org/Highlights/2004/05October.shtm
2)
(TMS)3SiH in organic synthesis: Part 2
Chatgilialoglu, C.
Organic Chemistry Highlights 2004 (article online posting date November 5, 2004).
http://www.organic-chemistry.org/Highlights/2004/05November.shtm
3)
Free radical pathway to geometrical trans lipids
Inform 2006, 17, 435–437.
4)
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
Chatgilialoglu, C.; Navacchia M. L.; Perchyonok, T. V.
Encyclopedia of Reagents for Organic Synthesis [Online]; John Wiley & Sons Ltd.,
2006; DOI: 10.1002/047084289X.rd135.pub2 (article online posting date
September 15, 2006).
5)
Tris(trimethylsilyl)silane
Chatgilialoglu, C.
Encyclopedia of Reagents for Organic Synthesis [Online]; John Wiley & Sons Ltd.,
2007; DOI: 10.1002/047084289X.rt420.pub2 (article online posting date March 15,
2007)
6)
Fats of life… explaining the villainous properties of trans fats
Chatgilialoglu, C.
Optimum Nutrition 2007 (Issue 2), 40–43.
51
7)
The lipidomic approach: Transfer chemical research to a spin-off initiative in health
care
Ferreri, C.; Chatgilialoglu C.; Ferreri, R.
Industry & Higher Education 2008, 22, 403–409.
52
Publications as Meeting Abstracts
1)
Trans-Phospholipids in Membranes: Methods of Formation and Properties
Chatgilialoglu, C.; Ferreri, C.; Dellonte, S.; Altieri, A.; Sassatelli, F.; Zambonin, L.;
Landi, L.
Chem. Phys. Lipids 2002, 118, 44–45.
2)
Trans-Lipids Formed by a Thiyl Radical Catalyzed Process and Their Relevance in
Skin Disorders
Ferreri, C.; Chatgilialoglu, C.; Dellonte, S.; Samadi, A.; Manco, I; FaraoneMennella, R.; Neri, I.; Maranini, A. R.
Chem. Phys. Lipids 2002, 118, 90–91.
3)
All-trans PUFA Synthesis by the Thiyl Radical–Catalysed Methodology and Their
Effects on Rabbit Platelet Aggregation
Anagnostopoulos, D.; Chatgilialoglu C.; Ferreri C.; Samadi, A.; Siafaka–Kapadai,
A.
Chem. Phys. Lipids 2004, 130, 67–67.
4)
Trans Fatty Acid and Atopic Eczema/Dermatitis Syndrome: The relationship with a
free radical cis-trans isomerization of membrane lipids trans LIPIDS in atopic
dermatitis.
Chini, L.; Angelini, F.; Chatgilialoglu, C.; Dellonte, S.; Moschese, V.; Corrente, S.;
Iannini, R.; Chianca, M.; Rossi, P.; Ferreri, C.
Clin. Immunol. 2005, 115, S54–S55.
5)
Endogenous formation of trans fatty acids in rats fed a trans-free diet
Zambonin, L.; Cabrini, L.; Prata, C.; Ferreri, C.; Chatgilialoglu, C.; Landi, L.
Chem. Phys. Lipids 2005, 136, 165–166.
6)
Trans Lipids and Radical Stress
Chem. Phys. Lipids 2006, 143, 80–81.
53
7)
Thiyl and sulphonyl radicals as catalytic agents for the cis-trans isomerization of
unsaturated fatty acid residues in liposomes
Tamba, M.; Mozziconacci, O.; Chatgilialoglu, C.; Ferreri, C
Free Radic. Res. 2007, 41, S57–S57.
8)
Bleomycin increases trans lipid isomers in human testicular cancer cell membrane
Cort, A.; Ozben, T.; Kucuksayan, E.; Melchiorre, M.; Chatgilialoglu, C.; Ferreri, C.
FEBS J. 2011, 278, 201–201.
54
Editorial Activities for Scientific Journals
Guest Editor
1)
Special issue of Helvitica Chimica Acta dedicated to the memory of Professor Hanns
Fischer
Chatgilialoglu, C.; Gescheidt, G. (Guest Editors)
Helvitica Chimica Acta 2006, volume 89, issue 10, pp. 2059 – 2589.
2)
Special Issue of CHIMIA dedicated to “Free Radicals in Chemical Biology”
Chatgilialoglu, C. (Guest Editor)
Chimia 2008, volume 62, issue 9, pp. 703 – 749.
Member of Editorial Board
1)
For the Journal of Glycomics and Lipidomics since 2011.
55
Books
As Author
1)
Organosilanes in Radical Chemistry
Author: Chryssostomos Chatgilialoglu
John Wiley & Sons Ltd, Chichester (UK), 2004.
Hardcover, 227 pages; ISBN: 0-471-49870-X
http://eu.wiley.com/WileyCDA/WileyTitle/productCd-047149870X.html
2)
Membrana Cellulare e Lipidomica: La salute dalla medicina molecolare
Authors: Carla Ferreri and Chryssostomos Chatgilialoglu
Publisher: CNR Edizioni, Roma, October 2011.
http://www.edizioni.cnr.it/
56
As Editor
1) Sulfur-Centered Reactive Intermediates in Chemistry and Biology
Edited by C. Chatgilialoglu and K.-D. Asmus,
Plenum Press, New York, 1990.
2) Chemical Synthesis: Gnosis to Prognosis
Edited by C. Chatgilialoglu and V. Snieckus,
Kluwer Academic Publishers, Dordrecht, 1996.
3314-2 copertina.qxp:A 170 mastro copertine 15/06/10 14:51 Pagina 1
51
C
hryssostomos Chatgilialoglu is Research Director at Consiglio Nazionale delle Ricerche, Bologna (Italy).
His research interests lie in free radical reactions and in the last decade have been increasingly addressed
to applications in life sciences, such as biomimetic chemistry of radical stress and related biomarkers.
Edited by Chryssostomos Chatgilialoglu
Publisher: Arcane editrice S.r.l., Roma, Italy,
June 2010.
Proceedings of
EUCHEM Conference on
Organic Free Radicals
edited by C. Chatgilialoglu
T
his volume covers the proceedings of the 12th EUCHEM Conference on Organic Free Radicals
in Bologna, June 28 – July 2, 2010. It covers the main fields of free radical chemistry from
organic synthesis to chemical biology and from polymers to materials. Numerous experts from all
over the world have contributed with their lectures and papers. The variety of subjects demonstrates the attractiveness of free radical research, foreseeing a period of further growth for this field.
COVER: STUDIO BG
3) Proceendings of of EUCHEM Conference on
Chryssostomos Chatgilialoglu
JUNE
28 – JULY 2, 2010, BOLOGNA, ITALY
edited by
ISBN 978-88-548-2214-2
9 788854 833142
ARACNE
ISBN 978-88-548-3314-2
4) Encyclopedia of Radicals in Chemistry, Biology
and Materials
(4 volumes, 73 Chapters and over 2300 pages)
Edited by Chryssostomos Chatgilialoglu and
Armido Studer
Publisher: Wiley, Chichester, UK, Ferbuary 2012.
ISBN: 978-0-470-97125-3
57
Patents
1) Procedimento per la riduzione di alogenuri organici ai corrispodenti composti
dealogenati
IT Patent 48150A87 (1987).
2) Polymers containing repeating cycloketonic units, and method for obtaining them
Sommazzi, A.; Cardi, N.; Garbassi, F.; Chatgilialoglu, C.
US Patent 5,369,187 (1994).
3) Polyhydrosilanes as process stabilizers
Carrozza, P.; Borzatta, V.; Chatgilialoglu, C.
PCT Int. Appl. WO97/02322 (1997).
US Patent 6,005,036 (21.12.1999);
TW Patent 122742NI (23.03.2001); JP pending;
EP (BE, DE, FR, IT, NL) Patent 836635 (05.12.2001).
4) Polysilane stabilizer containing sterically hindered amine groups
Carrozza, P.; Borzatta, V.; Chatgilialoglu, C.; Da Roit, G.
PCT Int. Appl. WO00/64965 (2000).
US Patent 6,538,055 (25.03.2003);
JP pending; KR pending;
EP (BE, DE, ES, FR, GB, IT, NL) Patent 1185577 (21.05.2003).
5) Processo per l’isomerizzazione cis/trans di mono-, di-, e tri-gliceridi o loro miscele
IT Patent 13227121 (27.04.2005).
6) Metodo analitico per l’identificazione di componenti lipidiche contenenti doppi
legami con isomeria trans
IT Patent 1327120 (27.04.2005).
58
Conference and Visiting Activity
The conference and visiting activity of Dr. Chatgilialoglu is very intense and includes
invitations to scientific institutions and to international meetings, as well as several
visiting professorships spent in foreign Universities. This activity correlates with the high
reputation of the international scientific community that Dr. Chatgilialoglu has achieved,
and it can be a clear advantage for establishing firm relationship between Italy and
foreing countries. Lists of the commitments are reported in the following pages.
In the graph below, the over 114 invited lectures at institutions are distributed
geographically. It shows the worldwide recognition of Dr. Chatgilialoglu’s research.
Figure 2. Geographical Distribution of Invited Lectures at Institutions
Italy (17.5%)
Rest of Europe (42.1%)
USA (21.1%)
Rest of Americas (5.3)
Russia, Japan &
Australia (14.0%)
59
Invited Lectures at Congresses and Meetings
1)
Scuola GDRM. Fenomeni e tecniche emergenti delle risonanze magnetiche: epr e
nmr. (Roma, Italy, 19-24 May 1986).
Title: Misure di costanti di velocità di process radicali unimolecolari mediante
spettroscopia epr
2)
Gordon Research Conference on Free Radical Reactions (Newport, USA, 24-28
August 1987).
Title: Novel silanes as radical reducing agents
3)
NATO Advanced Research Workshop on “Paramagnetic organometallic species in
activation, selectivity, catalysis” (Saint-Maximin, France, 4 – 8 October 1987).
Title: Recent advances in the chemistry of silyl radicals
4)
NATO Advanced Research Workshop on “Free radicals in synthesis and biology”
(Bardolino, Italy, 8-13 May 1988).
Title: Silanes as new reducing agents in organic synthesis
5)
COFEM 88 (Frascati, Italy, 17-20 July 1988).
Title: Nuovi agenti riducenti per via radicalica
6)
NATO Advanced Study Institute on “Sulfur-centered reactive ointermediates in
chemistry and biology (Maratea, Italy, 18-30 June 1989).
Title: Novel free radical chain reactions involving organosulfur compounds
7)
V Convegno Nazionale della Società Italiana per le Ricerche sulle Radiazioni
(Roma, Italy, 12-14 October 1989)
Title: Caratterizzazione e reazioni di radicali centrati allo zolfo
8)
EUCHEM Conference on Organic Free Radicals (Arles, France, 21-26 August
1990)
Title: Organosilanes as radical-based reducing agents in synthesis
60
9)
NATO ASI on "Chemical Synthesis: Gnosis to Prognosis" (Ravello, Italy, 8-19 May
1994).
Title: The advancement of radical-based synthetic strategies: From reagent design
to polymer modification
10) EUCHEM Conference on Organic Free Radicals (Champery, Switzerland, 21-26
August 1994)
Title: Acyl radicals as intermediates in the synthesis of new materials
11) NATO Advanced Research Workshop on “Free Radicals in Biology and
Environment” (Bardolino, Italy, 25 June 1996)
Title: Free radical chemistry associated with the C-1’ position of nucleosides
12) 3rd Winter Research Conferences on “Oxidative Effects of Radiations on
Biomolecules and Cells” (Les Arcs, France, 11 May 1997)
Title: Reaction of the O•- radical with nucleosides and related compounds
13) 30th Organosilicon Symposium, (London, Canada, 30-31 May 1997)
Title: Free radical chemistry associated with organosilanes: from reagent design to
polymer application
14) VIII Meeting: Strutture Eterocicliche nella Ricerca Farmaceutica, (Palermo, Italy,
17-20 May 1998).
Title: Free radical chemistry associated with the C1' position of nucleosides
15) XIII International Round Table: Nucleosides, Nucleotides, and Their Biological
Applications (Montpellier, France 6-10 September 1998).
Title: Mechanistic and synthetic aspects of the C-1’ radicals in modified nucleosides
16) Gordon Research Conference on Free Radical Reactions (Plymouth, USA, 11-16
July 1999).
Title: What’s new about thiols in free radical chemistry
61
17) 37th IUPAC Congress “Frontiers in Chemistry: Molecular Basis of the Life
Sciences” (Berlin, Germany, 14-19 August 1999)
Title: Structural Characteristics of C1’ Radical Nucleosides and Their Fate in the
Presence of Glutathione Under Anoxic or Aerobic Conditions
18) XXVI Convegno Naz. della Divisione di Chimica Organica (Giardini Naxos, Italy,
1-5 September 1999).
Title: Radicali in posizione anomerica di nucleosidi: aspetti sintetici e biologici
19) 2nd COST meeting on Radical Cascade Reactions (Glasgow, UK, 9 September,
1999).
Title: 5’,8-cyclopurines: Synthesis and mechanistic aspects
20) The 13th Brisbane Organic Chemistry Symposium (Brisbane, Australia, Nov. 26,
1999)
21) RACI NSW Organic Group. 20th Annual One Day Symposium (Wollongong,
Australia, Nov. 30, 1999)
22) 24th Annual Synthesis Symposium (Melbourne, Australia, 3 December 1999)
23) Adelaide Organic Chemistry Symposium (Adelaide, Australia 6 December 1999)
24) Gomberg 2000, the 8th International Symposium on Organic Free Radicals (Ann
Arbor, USA, June 25-29, 2000).
Title: Free Radicals in Nucleosides: Serendipity and Planning
62
25) XVIth International Symposium on Medicinal Chemistry (Bologna, Italy, 18-22
September, 2000).
Title: Synthesis of conformationally fixed nucleosides via radical cascade reactions
26) 3rd COST meeting on Radical Cascade Reactions (Fribourg, Switzerland, 20-22
October 2000)
Title: One-pot Synthesis of 5’,8-cyclopurines
27) Pacifichem 2000. Symposium No. 29: New Developments in Organic Radical
Chemistry (Honolulu, USA, 14-19 December 2000).
28) 22nd Miller Conference on Radiation Chemistry (Bowness on Windermere, UK, 712 April 2001).
Title: The cis-trans isomerization of unsaturated fatty acid residues in lipids
catalyzed by thiyl radicals
29) 4th COST meeting on Radical Cascade Reactions (Madrid, Spain, 4-6 October 2001)
Title: Radical cascade reactions in aqueous solutions
30) International Conference on Reactive Intermediates and Reaction Mechanisms
(Ascona, Switzerland, 7-12 July 2002)
Title: The fate of C5’ radicals in purinef nucleosides
31) 6th Winter Research Conferences on “Oxidative Damage of DNA: Formation and
Biological Features” (Les Houches, Francia, 25-26 March 2003)
Title: Free radical chemistry in the carbohydrate moiety of nucleosides and
nucleostides
32) EYICS 2003 // SULFRAD Conference (Slubice, Poland, 7-11 May 2003)
Title: Free radical chemistry in the carbohydrate moiety of nucleosides
63
33) 9th International Symposium on Organic Free Radicals (Porto-Vecchio, France, 611 June 2004)
Title: Paradoxical Generation of One-Electron Oxidized 2’-Deoxyguanosine Under
Reducing
Conditions.
Application
to
Excess
Electron
Transfer
in
Oligodeoxyribonucleosides
34) COST P9 on Radiation Damage in Biomelecular Systems (Lyon, France, 24-27 June
2004)
Title: Interaction of Electrons with 8-Bromoadenine and 8-Bromoguanine
Derivatives
35) 1st Hellenic Symposium on Organic Synthesis (Athens, Greece, 4-6 November
2004)
Title: Trans lipids: The Free Radical Path
36) 1st Pacific Symposium on Radical Chemistry (Kanazawa, Japan, 15-16 November
2004)
37) Gordon Research Conference on Free Radical Reactions (Plymouth, USA, 3-8 July
2005)
38) 7th Winter Research Conferences on “Oxidatively Generated Damage to DNA:
Formation, Repair and Biological Features” (Les Houches, France, 19-22 March
2006)
Title: Radicals for sugar moieties of DNA and RNA models
39) EUCHEM Conference on Organic Free Radicals (Bergen, Norway, 9-13 July 2006)
Title: Radical reactions in water, on water and in vescicles
40) 6th CLUSTOXDNA meeting (Valencia, Spain, 29 October - 1 November 2006)
Title: Tautomerism in the guanyl radical
64
41) 4th SANIT: Il ruolo della ricerca nella sanità (Rome, Italy, 18-21 April 2007)
Title: Spin-off LIPINUTRAGEN
42) 2nd Greek Lipid Forum (Athens, Greece, 7-8 June 2007)
Title: Trans Fatty Acids and Radical Stress
43) Melusyn Workshop: Synchrotron Radiation Based Radiobiology (Saint-Aubin,
France, 25-26 June 2007)
Title: Trans Fatty Acids and Radical Stress
44) 9th Latin American Conference on Physical Organic Chemistry (Córdoba,
Argentina, 30 Sept. - 05 Oct. 2007)
Title: Biomimetic Chemistry: Radical Reactions in Vesicles Suspensions
45) Oxygen, Stress and Lipids (Dubrovnik, Croatia, 25-27 October 2007)
Title: Trans fatty acids and radical stress
46) ESOF 2008. Workshop on “Fats: the bad, the good and the ugly” (Barcelona, Spain,
19 July 2008)
Title: Trans fatty acids: From nutrition to radical stress
47) 8th International Conference on Pulse Investigations in Chemistry, Biology and
Physics PULS'2008 (Kraków, Poland, 6-12 September, 2008)
Title: One-electron reduction of 8-bromopurine nucleosides and excess electron
transfer through DNA
48) COST Action CM0603: WG1 Meeting, Consiglio Nazionale delle Ricerche
(Bologna, Italy, 11-12 February 2008)
Title: Common Antioxidant as Inhibitors of the Radical-Based Lipid Isomerization
49) COST Action CM0603: WG4 Meeting, Hotel Stefanie (Vienna, Austria, 29 Feb. - 1
March 2008)
65
Title: Biomimetic Chemistry: Radical Reactions in Vesicle Suspensions
50) COST Action CM0603: WG2 Meeting, Facultat de Biologia, Universitat de
Barcelona (Barcelona, Spain, 6-7 March 2008).
Title: Reductive Modification of Methionine and Cysteine Residues in Peptides and
Proteins
51) COST Action CM0603: WG3 Meeting. Department of Chemistry and Pharmacy,
LMU Munich (Munich, Germany, 14-15 March 2008)
Title: 5’,8-Cyclopurine Lesions
52) COST Action CM0603: WG3 Meeting. Centre de l’Ecole de Physique (Les
Houches, France, 17-19 January 2009)
Title: The Chemistry 5’,8-Cyclopurine Lesions
53) 8th Winter Research Conferences on “Oxidatively DNA Damage (Les Houches,
France, 19-23 January 2009)
Title: Revising the Reactions of Hydroxyl Radicals and Hydrated Electrons with
Guanine Derivatives
54) Conferenza di DPM, Federchimica (Milan, Italy, 25 February 2009)
Title: La promozione dell’impresa Spin-off Lipinutragen
55) FEBS Advanced Lecture Course: Mechanisms and Consequences of Free RadicalMediated Oxidative Protein Modification (Antalya, Turkey, 15-20 April 2009).
Title: Desulfurization reactions of Met and Cys residues under reductive radical
stress
56) FEBS Advanced Lecture Course: Mechanisms and Consequences of Free RadicalMediated Oxidative Protein Modification (Antalya, Turkey, 15-20 April 2009).
Title: Free radical-mediated oxidative modifications of Met and Cys residues
66
57) COST Action CM0603: Joint WG1/WG2 meeting, Lordos Beach Hotel (Larnaca,
Cyprus, 4 – 6 May 2009)
Title: The reaction of thiyl radicals with PUFA: time-resolved experiments and
product studies
58) COST Action CM0603: Joint WG4/WG2 meeting, Ramada Hotel, (Balaton Lake,
Hungary, 22 – 24 May 2009).
Title: The reaction of thiyl radicals with PUFA: completing the picture
59) Organic Free Radicals Ottawa 2009 (OFRO-2009), Ottawa University (Ottawa,
Canada, 26 – 30 July 2009)
Title: Tautomerism in the Guanyl Radical
60) 26th Miller Conference on Radiation Chemistry (Keszthely, Hungary, 28 Aug. – 2
Sept. 2009)
Title: Tautomerism in the Guanyl Radical
61) 1st International Congress of Fatty Liver and Metabolic Syndrome (Budapest,
Hungary, 12-14 November 2009).
Title: Trans fatty acids in membranes: from nutrition to radical stress
62) NUTRACEUTICA: svipuppo e prospettive (CNR, Roma, Italy, 18 Novemver 2009)
Title: Dalla ricerca chimica ad un'impresa spin-off nel campo
Lipidomico/Nutraceutico
63) Cellular radical stress and related biomarkers – COST Action CM0603 (University
of Athens, Greece, 22 –24 February 2010)
Title: Radiation Chemical Studies of Methionine in Aqueous Solution:
Understanding the Role of Molecular Oxygen
64) Damages induced in biomolecules by low and high energy radiations – COST
Action CM0603 & MELUSYN (FIAP Jean Monnet - Paris, France, 9-12 March
2010)
67
Title: The Reaction of Hydroxyl Radicals with Guanine Derivatives
65) BioInItaly Investiment Forum 2010 (Milano, Italy, 19 – 20 April 2010)
Title: Lipinutragen spin-off del CNR
66) Obesità giovanile: alimentazione e sport insieme per la salute (Tenuta di
Sarramarina, Matera, Italy, 22 Maggio 2010)
Title: Acidi grassi trans: dall’alimentazione allo stress ossidativo
67) 4th Annual Progress Conference, COST–Chemistry and Molecular Sciences and
Technologies (Mediterranean Beach Hotel, Limassol, Cyprus, 3 – 5 June 2010).
Title: Free Radicals in Chemical Biology – CM0603
68) Lipid Oxidation, Human Diseases and Aging (University of Turin, Italy, 16 – 18
June, 2010)
Title: Lipid modification and radical stress in membranes
69) Topical issues of physical-organic, synthetic and medicinal chemistry (Ufa State
Petrolium Technological University, Ufa, Russia, 21 – 24 September 2010)
Title: Biomimetic models of free radical stress and related biomarkers
70) Workshop: Natural products as drugs and lead for drugs (Orthodox Academy of
Crete, Greece, 12 – 15 October 2010)
Title: Synthetic and mechanistic pathways of purine 5’,8-cyclonucleoside: The role
in DNA
71) XV Congresso Annuale della Società Italiana per le Ricerche sulle Radiazioni
(l’Istituto Superiore di Sanità, Roma, Italy, 27 – 29 October 2010)
Title: Modelli biomimetici di stress radicalico e biomarcatori correlati
72) Corso ECM: Lipidomica, Nutrizione e Stress (Bologna, Italy, 20 November 2010)
Title: Acidi grassi trans nella nutrizione e nello stress cellulare
68
73) Workshop: Epigenetics - Bench to Bedside (Institute of Biophysics, Brno, Czech
Republic, 22 – 24 November 2010)
Title: Biomarkers of free radical stress
74) Radical stress and defenses – COST Action CM0603 (Boğaziçi University,
Istanbul, Turkey, 2 – 3 December 2010)
Title: The Reaction of Hydroxyl Radicals with Guanine Derivatives
75) SIRR Workshop on Stress Ossidativo: Danni, Conseguenze e Rimedi (Univerity of
Bologna, Italy, 27 May 2011)
76) Corso ECM: Lipidomica, Nutrizione e Nutraceutica (Bologna, Italy, 21 May 2011)
Title: Oli nella nutrizione e formazione di acidi grassi trans
77) 5th Annual Progress Conference, COST–Chemistry and Molecular Sciences and
Technologies (Ma’ale Hachamisha Hotel, Judean Hills, Israel, 2 – 4 June 2011).
Title: Free Radicals in Chemical Biology – CM0603
78) Free Radicals in Chemical Biology (Rudjer Boskovic Institute, Zagreb, Croatia, 14
– 17 June 2011)
Title: Biomimetic models of radical stress and related biomarkers
79) 17th European Symposium on Organic Chemistry (ESOC) (Creta Maris Hotel,
Crete, Greece, 10 – 15 July 2011)
80) 16th International Symposium On Silicon Chemistry (ISOS) (McMaster University,
Hamilton, Canada, 14 – 18 August 2011)
Title: The (TMS)3SiH reagent in recent applications
81) 14th International Congress of Radiation Research (ICRR) (The Palace of Culture
and Science, Warsaw, Poland, 28 August – 1 September 2011)
69
Title: Chemical radiation studies related to radical-based DNA damage
82) 14th European Conference on the Spectroscopy of Biological Molecules (ECSBM)
(University of Coimbra, Portugal, 29 August – 3 September 2011)
83) 3rd International MELODI Workshop (Istituto Superiore di Sanità, Rome, Italy, 2 –
4 November 2011)
Title: Biomimetic models of radiation-induced radical stress and biomarker
discovery
84) International Conference on Metabolomics & System Biology (San Francisco
Airport Marriott, USA, 20 – 22 February 2012)
Title: Geometrical isomers of unsaturated fatty acids as markers of free radical
stress
85) COST-Chemistry and Molecular Science and Technologies, Domain Committee
Meeting (Seville, Spain, 15 March 2012)
Title of the proposal: Biomimetic Radical Chemistry
86) Emerging Companies: meet the innovation (CNR, Roma, Italy, 23 – 24 May 2012)
87) Corso ECM: Lipidomica e Sovrappeso (Bologna, Italy, 26 May 2012)
Title: Acidi grassi trans: biomarcatori di stress e ruolo nell’obesità
88) Congresso Nazionale della Divisione di Chimica Industriale (Firenze, Italy, 11 – 14
June 2012)
89) 11th International Symposium on Organic Free Radicals (Bern, Switzerland, 1 – 5
July 2012)
70
90) 244th National of the American Chemical Society (Philadelphia, USA, 19 – 23
August 2012)
Title: Bio-inspired synthetic strategies of purine 5’,8-cyclonucleoside derivatives
71
Invited Lectures at Institutions
(The list of conferences prior to 1991 is not available)
1)
1 March 1991. Facultè des Sciences saint-Jerome, Université D' Aix-Marseille III
(France).
Title: The design of silanes with different hydrogen donating abilities
2)
4 March 1991. Institut de Chimie Fine, Université Montpellier II (France).
3)
24 April 1991. Dipartimento di Chimica e Chimica Industriale, Università di Pisa
(Italy).
Title: Organosilani come agenti riducenti per via radicalica
4)
27 May 1991. Institut für Organische Chemie der Universität Basel (Switzerland).
Title: Recent advances in the chemistry of tris(trimethylsilyl)silane.
5)
18 June 1991. In occassione delle lezioni tenute dal Prof. D. H. R. Barton per
l' Accademia Nazionale dei Lincei, Sala Congressi del CNR (Milan, Italy).
6)
24 November 1991. Istituto di Chimica Farmaceutica e Tecnica Farmaceutica,
Università di Perugia (Italy).
Title: Organosilani come agenti riducenti per via radicalica.
7)
26 November 1992. Istituto per la Chimica di Molecole d' interesse Biologico, CNR,
Arco Felice (Italy).
Title: Organosilani come agenti riducenti per via radicalica
8)
5 February 1993. Additives Division, Ciba-Geigy Limited, Marly (Switzerland).
Title: Organosilanes as radical-based reagents in organic synthesis
9)
10 March 1993. Ciba-Geigy S.p.A., Pontecchio Marconi, Bologna (Italy).
72
10) 22 April 1993. Menarini Industrie Farmaceutiche Riunite S. r. l., Firenze (Italy).
11) 20 October 1993. Dipartimento di Chimica Organica, Università di Ferrara (Italy).
12) 7 December 1993. Centre de Recherches Pierre Fabre, Castres (France)
13) 29 March 1994. Department of Chemistry, University of Pittsburgh (USA)
Title: Acyl Radicals: Theory, Kinetics and New Synthetic Strategies
14) 31 March 1994. Department of Chemistry, University of Pittsburgh (USA)
15) 19 January 1995. Chemistry Department, University of Ioannina (Greece).
Title: Organosilanes as radical-based reagents in synthesis
16) 4 April 1995. Institut de chimie organique, Université de Fribourg (Switzerland).
Title: Organosilicon reagents designed for radical chain reactions
17) 3 January 1996. Department of Chemistry, University of California, Berkeley
(USA).
Title: Design of organosilanes for radical-based synthetic applications
18) 9 January 1996. Department of Chemistry, University of Stanford (USA).
Title: Design of organosilanes for radical-based synthetic applications
19) 23 April 1996. Department of Chemistry, University of Pittsburgh (USA).
Title: Poly(hydrosilane)s
73
20) 24 April 1996. Department of Chemistry, University of Pittsburgh (USA).
21) 26 April 1996. Radiation Laboratory, University of Notre Dame (USA).
22) 29 April 1996. Department of Chemistry, Wayne State University, Detroit (USA).
23) 3 May 1996. Additives Division, Ciba-Geigy, Ardslaey (NY) (USA).
24) 20 May 1996. Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia
(Italy).
Title: Chimica dei radicali liberi correlata alla posizione anomerica di nucleosidi
25) 17 July 1996. Dipartimento di Chimica, Università degli Studi di Pisa (Italy).
Title: Poli(sililidruri) compatibili con l’ambiente
26) 4 November 1996. Additives Division, Ciba-Geigy, Marly (Switzerland).
27) 28 May 1997. Department of Chemistry, University of Waterloo (Canada).
Titolo: Free radical chemistry associated with the C1' position of nucleosides
28) 3 October 1997. Ciba Specialty Chemicals, Marly (Switzerland).
Title: Acyl radicals: from elementary reactions to their role in polymer modification
29) 4 December 1997. Laboratoire de Chimie Moleculaire Organique, Universite d'AixMarseille 3 (France).
30) 8 June 1998. Ciba Specialty Chemicals, Marly (Switzerland).
74
Title: Chemistry of acyl radicals
31) 8 June 1998. Societè Fribourgeoise de Chimie, Université de Fribourg
(Switzerland).
32) 3 July 1998. Highlights on Radical Reactivity, Area delle Ricerche CNR, Bologna
(Italy).
Title: How the radical clock methodology can be applied for determining the rate
constants of the reactions of alkyl radicals with thiols
33) 8 October 1998. Department of Chemistry, Northwestern University, Evanston
(USA).
Titolo: Free radical chemistry associated with the C1' position of nucleosides
34) 9 October 1998. Chemistry Department, University of Illinois, Chicago (USA).
polymer application
35) 13 October 1998. Department of Chemistry, Wayne State University, Detroit
(USA).
polymer application
36) 4 December 1998. Laboratoire de Chimie Organique de Synthèse, Université Pierre
et Marie Curie - Paris VI, (France).
37) 11 March 1999. Chemistry Department, University of Wisconsin (USA).
Title: Recent advances in free-radical chemistry of organosilanes
38) 15 March 1999. Chemistry Department, University of Illinois (USA).
75
39) 17 March 1999. Chemistry Department, Ohio State University (USA).
Title: Free radical chemistry associated with organosilanes: From reagent design to
polymer application
40) 27 September 1999. Institute of Organic Chemistry, Russian Academy of Science,
Ufa (Russia).
Title: Free radical chemistry associated with organosilanes: From reagent design to
polymer application
41) 4 October 1999. Institute of Chemical Physics, Russian Acad. of Science,
Chernogolovka (Russia).
Title: Free radical chemistry associated with organosilanes
42) 25 November 1999. Chemistry Griffith University, Brisbane (Australia).
43) 29 November 1999. Heart Research Institute, Sydney (Australia).
Title: The thiyl radical mediated cis/trans isomerization of fatty acid residues in
lipids
44) 9 December 1999. Research School of Chemistry, Australian National University,
Canberra (Australia).
45) 16 December 1999. CSIRO Molecular Sciences, Melbourne (Australia).
46) 13 April 2000. Departement de Synthese Organique, Ecole Polytechnique, (France).
lipids
47) 17 April 2000. Université Pierre et Marie Curie (Paris VI) (France).
76
lipids
48) 18 April 2000. Institute de Chimie Moléculaire d'Orsay, Université Paris-sud
(France).
lipids
49) 13 February 2001. Institut für Polymere, ETH-Zentrum, Zürich (Switzerland).
Title: The cis-trans isomerization of unsaturated fatty acid residues in lipids
catalyzed by thiyl radicals
50) 15, February 2001. Dipartimento di Chimica Organica e Biochimica, Università
degli Studi di Napoli “Federico II” (Italy).
Title: Studi modello del danneggiamento del DNA per via radicalica
51) 10 May 2001. Laboratorio di Immunologia e Biotecnologia Pediatrica, Università di
Roma “Tor Vergata” (Italy).
Title: Aspetti chimici e biologici di acidi grassi a configurazione trans come
costituenti dei lipidi
52) 24 May 2001. Institute of Organic Chemistry, Polish Academy of Sciencies,
Warsaw (Poland).
Title: Organosilanes as radical based reducing agents
53) 28 May 2001. Department of Organometallic Chemistry, Adam Mickiewicz
University, Poznan, (Poland).
54) 29 May 2001. Department of Bioorganic Chemistry, Polish Academy of Sciencies,
Lodz (Poland).
Title: Synthesis of conformationally fixed nucleosides
77
55) 30 May 2001. Centre of Molecular and Macromolecular Studies, Polish Academy of
Sciencies, Lodz (Poland).
56) 11 December 2001. Institute de Tecnologia Quimica UPV-CSIC, Universidad
Politécnica de Valencia (Spain).
Title: Mechanistic aspects of C1' and C5' radicals in nucleosides
57) 18 December 2001. Centre de Biophysique Moléculaire, CNRS, Orléans (France).
Title: Mechanistic aspects of C1' and C5' radicals in nucleosides
58) 20 December 2001. Institut de Chimie des Substances Naturelles, CNRS, Gif-surYvette (France).
59) 13 May 2002. Department of Chemistry, University of Athens (Greece).
Title: Mechanistic aspects of C1' and C5' nucleosidyl radicals
60) 20 October 2003. Department of Biochemistry, M. V. Lomonosov Moscow State
University (Russia).
Title: Cis-trans isomerization of unsaturated fatty acid residues by thiyl radicals:
The influence of phospholipid supramolecular organization.
61) 22 October 2003. Moscow Institute of Biochemical Physics, Russian Academy of
Science (Russia).
Title: Model studies of DNA damage: Selective generation and reactivity of sugar
carbon-centered radical.
62) 24 October 2003. Institute of Organic Chemistry, Russian Academy of Science, Ufa
(Russia).
Title: Cis-trans isomerization of unsaturated fatty acid residues by thiyl radicals:
The influence of phospholipid supramolecular organization.
78
63) 14 September 2004. Chemistry of Department, University of Munchen (Germany).
Title: Interaction of Hydrated Electrons with 8-Bromoadenine and 8Bromoguanine Derivatives
64) 15 September 2004. Chemistry of Department, University of Uppsala (Sweden).
Title: (TMS)3SiH in Consecutive Radical Reactions: Synthesis of Cyclonucleosides
65) 11 November 2004. Division of Molecular Material Science, Osaka City University
(Japan).
66) 12 November 2004. Institute of Scientific and Industrial Research, Osaka University
(Japan).
Title: Free Radical Chemistry in the Carbohydrate Moiety of Nucleosides. Model
Studies of DNA Damage
Derivatives. Application to the Excess Electron Transfer in Oligonucleostides
67) 13 November 2004. Department of Applied Chemistry, Osaka Prefecture University
(Japan).
Title: Organosilanes in Radical Chemistry: Principles, Methods and Applications
68) 18 November 2004. Department of Chemistry, Osaka Prefecture University (Japan).
69) 19 November 2004. Department of Chemistry, Kyoto University (Japan).
Derivatives. Application to the Excess Electron Transfer in Oligonucleostides
70) 14 January 2005. Institut für Anorganische Chemie, Technische Universität Graz
(Austria).
79
71) 27 May 2005. Dipartimento di Patologia Generale, Seconda Università degli Studi
di Napoli (Italy).
Title: Lipidi Trans e Stress Radicalico
72) 2 December 2005. Department of Chemistry, University of Aarhus (Denmark).
Title: Lipidi Trans: The Free Radical Path
73) 21 December 2005. Dipartimento di Chimica Generale, Università di Pavia (Italy).
Titolo: Lipidi trans: formazione per via radicalica e significato biologico
74) 15 June 2006. Institute of Biochemical Physics, Russian Academy of Science,
Moscow (Russia).
Title: Trans Lipids: the Free Radical Path
75) 19 June 2006. Institute of Problems in Chemical Physics, Russian Academy of
Science, Chernogolovka (Russia).
Title: Trans Lipids: the Free Radical Path
76) 9 October 2006. COST office, Brussels (Belgium)
Title: Free Radicals in Chemical Biology
77) 9 May 2007. Technische Universität Graz (Austria).
Title: Biomimetic Chemistry: Radical Reactions in Vesicles Suspensions
78) 28 September 2007. Universidad Nacional de Córdoba (Argentina)
79) 8 October 2007. Universidad de Belgrano (Buenos Aires, Argentina)
Title: Trans fatty acids and radical stress
80) 9 October 2007. Universidad de Belgrano (Buenos Aires, Argentina)
Title: Fate of C5’ radicals in DNA and 5’,8-cyclopurine lesions
80
81) 10 October 2007. Universidad de Buenos Aires (Argentina)
82) 25 February 2008. Istituto di Scienze e Tecnologie Molecolari, CNR, Milano (Italy)
Title: Acidi Grassi Trans e Stress Radicalico
83) 06 March 2008. Institute for Research in Biomedicine (IRB Barcelona), Parc
Científic de Barcelona (Spain).
Title: 5’,8-Cyclopurine Lesions: Chemistry and Biology
84) 17 March 2008. Université Pierre et Marie Curie (Paris, France).
Title: Free Radical Chemistry for Understanding Biologically Related Mechanisms
85) 17 April 2008. Department of Chemistry and Biochemistry, Florida State University
(Tallahassee, USA)
Title: One-Electron-Reduction of 8-Bromopurine Derivatives: A Palette of
Chemical Behavior Related to DNA
86) 21 April 2008. Chemistry Department, New York University (USA)
87) 24 April 2008. Department of Chemistry, Johns Hopkins University (Barltimore,
USA)
88) 19 May 2008. Organische Chemie, Technisch Universität Kaiserslautern
(Germany).
Title: Free Radical Chemistry for Understanding Biologically Related Mechanisms
89) 20 May 2008. Department of Chemistry and Pharmacy, LMU Munich (Germany)
81
Title: One-Electron-Reduction of 8-Bromopurine Derivatives and Related Systems
(Part 1)
90) 29 May 2008. Organisch-Chemisches Institut, Universität Münster (Germany).
Title: One-Electron-Reduction of 8-Bromopurine Derivatives: A Palette of
Chemical Behavior Related to DNA
91) 02 June 2008. Department of Chemistry and Pharmacy, LMU Munich (Germany)
Title: Biomimetic Chemistry: Radical Reactions in Vesicle Suspensions
92) 17 June 2008. Department of Chemistry and Pharmacy, LMU Munich (Germany)
Title: One-Electron-Reduction of 8-Bromopurine Derivatives and Related Systems
(Part 2)
93) 25 June 2008. Department of Chemistry, Aarhus University (Aarhus, Denmark)
94) 09 June 2009. Université Pierre et Marie Curie - Paris 6, (France)
Title: (Part A) Trans fatty acids: From nutrition to radical stress; (Part B) Trans
fatty acids: Radical reactions in solution and in vesicle suspensions
95) 16 June 2009. Université Pierre et Marie - Paris 6, (France)
Title: (Part A) Free radical-mediated oxidative modifications of Met and Cys
residues;
(Part B) Desulfurization of Met and Cys Residues under Reductive Radical Stress
96) 23 June 2009. Université Pierre et Marie Curie - Paris 6, (France)
Title: Mechanistic studies related to radical-based DNA damage
97) 10 June 2009. University Paris 7 - Diderot (France)
98) 19 June 2009. Université Paris-Sud, Orsay (France)
82
Title: Desulfurization of Met and Cys residues under reductive radical stress
99) 23 September 2009. Semenov Institute of Chemical Physics RAS, Moscow (Russia)
Title: Tandem protein/lipid damage and Protection for lipid geometric integrity
100) 30 September 2009. Chimica Industriale, University of Bologna (Italy)
Title: Ricerca su radicali liberi: un omaggio al professore Gian Franco Pedulli
101) 27 October 2009. Biochemistry Dept., Faculty of Pharmacy, University of Buenos
Aires (Argentina)
102) 26 November 2010. Dipartimento di Chimica, Università di Salerno, (Italy)
103) 5 April 2011. Laboratoire Lésions des Acides Nucléiques, CEA Grenoble (France).
104) 16 May 2011. Dipartimento di Scienze Farmaceutiche, University of Bologna
(Italy)
105) 19 May 2011. Dipartimento di Scienze Farmaceutiche, University of Napoli
“Federico II” (Italy)
106) 26 October 2011. UMR NutrPass, Montpellier (France).
Title: Geometrical isomers of unsaturated fatty acids as markers of free radical
stress
107) 18 November 2011. Department of Chemistry and Biochemistry, Florida
International University, Miami (USA)
83
108) 21 November 2011. Chemistry Department, New York University, New York, NY
(USA)
109) 22 November 2011. Chemistry Department, Brookhaven National Laboratory,
Upton, NY (USA)
110) 6 December 2011. School of Chemistry, Newcastle University (UK)
111) 13 February 2012. Department of Chemistry and Biochemistry, University of
California, San Diego, CA (USA)
112) 15 February 2012. Department of Chemistry, The Scripps Research Institute, La
Jolla, CA (USA)
113) 17 February 2012. Department of Chemistry and Biochemistry, University of
California, Reverside, CA (USA)
114) 19 April 2012. Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette
(France)
84
Visiting Scientist at Foreign Institutions
1)
Division of Chemistry, National Research Council of Canada, Ottawa (Canada).
July – August 1986
Invited by Dr. David Griller
2)
Department für Chemie der Universität Basel, (Svizzera).
February – July 1990
Invited by Prof. Bernd Giese
3)
Department für Chemie der Universität Basel, (Svizzera).
May – June 1991 (NATO Senior Fellowship)
Invited by Prof. Bernd Giese
4)
Visit at Russisn Academy of Sciences (RAS) in Ufa e Chernogolovka in the frame
of the bilateral agreement CNR / RAS.
September 27 - October 6, 1999
Invited by Prof. V. V. Shereshovets e Prof. E. T. Denisov
5)
Wilsmore Fellow to the School of Chemistry, University of Melbourne (Australia).
November 1999 – January 2000
Invited by Prof. Carl. H. Schiesser
6)
Laboratoire de Chimie Organique de Synthèse, Université Pierre et Marie Curie
(Francia).
April 2000
Invited by Prof. Max Malacria
7)
Visit at Polish Academy of Sciences (PAN) in Varsavia, Posnan e Lodz in the frame
of the bilateral agreement CNR / PAN.
May 24 – June 1, 2001
Invited by Prof. W. J. Stec
85
8)
Center for Integrated Protein Science Munich, LMU Munich (Germany).
March, May and June 2008
Invited by Prof. Thomas Carell
9)
Laboratoire de Chimie Organique de Synthèse, Université Pierre et Marie Curie
(France).
June 2009
Invited by Prof. Max Malacria
86
Managerial Activity
The managerial activity of Dr. Chatgilialoglu concerns various functions, summarized
as follows:
a) Leader of the BioFreeRadicals group at CNR, ISOF in Bologna, with the task of
research planning and supervising, fund raising, strategy and decision making
b) Consulting and refereeing activities for companies and institutions
c) Responsible functions within European and international projects
d) President of the spin-off company Lipinutragen Srl (Bologna)
Team leader of the BioFreeRadicals group
The BioFreeRadicals group at ISOF (CNR) includes 5 permanent researchers and
temporary staff, consisting of pre- and post-doctoral fellows. In 2012 it counts a total of 9
people. The group works on a research project, approved by the CNR, concerning
“Biomimetic models of radical stress and related biomarkers”. The financial and human
resources for this project are based on the matching fund criteria. Therefore, the
managerial activity and group leadership of Dr. Chatgilialoglu are focused on: (i) high
level productivity, in terms of research results and publications; (ii) optimal fund raising,
in order to create the budget for satisfactory research and human resources.
A constant growth of scientific productivity has been maintained during the scientific
career of Dr. Chatgilialoglu, as depicted in the diagram of Figure 3. The impressive
quantity of the scientific peer-reviewed publications clearly reflects a strong and constant
focus on all research subjects of interest. The excellent standard of the research is
demonstrated by the fact that the papers appear in high impact journals and receive a
remarkable number of citations. The yearly distribution of citations is depicted in Figure
4. The unremitting efforts of cultural renovation and acquisition of multidisciplinary
competences have certainly contributed to these achievements. Also, great attention has
been devoted to maintaining active international scientific collaborations and
participation in exchange visiting programs, for establishing contacts among research
groups of different countries. This has been a great strategic help for the set-up of
efficient partnerships for increasing productivity and preparing network for research grant
applications.
87
Figure 3. Published items in each year up to April 2012 (Web of Science Citation Report)
Figure 4. Citations in each year up to April 2012 (Web of Science Citation Report).
Sum of the Times Cited: 6325; h-index: 38
The fund raising has also been an important part of the managerial activity, and in the
last years this aspect has become more and more crucial. Dr. Chatgilialoglu participated
to several research projects within the “V, VI and VII Framework Programs” of the
European Commission. He received financial support for the COST Action “Free
Radicals in Chemical Biology” for the period June 2007 – June 2011 and he has recently
been granted with a four year support for the COST Action “Biomimetic Radical
88
Chemistry” starting September 2012. He managed several European grants over the last
three Framework Programs and at the present is the scientist-in-charge of a two years
Marie Curie IEF (started April 2012). The role of Dr. Chatgilialoglu has nowadays
reached a wide recognition from the free radical chemistry community and from a
multidisciplinary context of European research.
Consulting and refereeing activity for institutions and companies
Dr. Chatgilialoglu also carried out consulting activity, especially with companies
involved in applications of free radical reactivity. These contracts were carried our
bringing financial resources for the CNR research group. The longest consulting period
concerned a six years contact with Ciba Geigy Ltd., with the results from this cooperative
endeavor in the field of polysilanes having been world-patented.
Dr. Chatgilialoglu plays a significant role in the scientific community as referee for
institutions and companies. The most important journals of the chemical field (i.e., J. Am.
Chem. Soc. and Angewandte Chemie) are constantly asking him for peer reviewing of
manuscripts submitted to them. He acted as Guest Editor for the journals Helvetica
Chimica Acta and Chimia. He was also nominated as foreign referee or opponent in
public dissertations for PhD degrees at several European universities (e.g., Uppsala,
Marseille, Paris, Valencia, Munich, Athens, Montpellier). In 2002 the Greek Ministry of
National Education and Religious Affairs appointed him to an international committee for
the evaluation of the “Post Graduate Curriculum Programs” offered by the Greek
Institution of Higher Education (AEI).
Responsible functions within European and international projects
Dr. Chatgilialoglu is very active in the relationship with foreign institutions and
research groups, in the firm belief that the strong interaction with several countries can
reinforce the scientific visibility of the Italian groups and create a critical mass for
important advances in science. The managerial activity involved leadership of several
projects at international levels concerning collaborative research grants and bilateral
scientific cooperation agreements. Among others, he was director of Summer Schools
within the frame of NATO Advanced Study Institutes in 1989 and 1994. He was also
responsible for three NATO Collaborative Research Grants (3-years-time duration each)
89
with American institutions. In all cases, he acted as both scientific and administrative
supervisor. He was the supervisor of two Individual Marie Curie Fellowship in 1996 and
2002, and one ongoing started April 2012. From 2002 to 2007 he participated to two
Marie Curie Research Training Networks. For the period 2007-2011 he acted as the chair
of the COST Action “Free Radicals in Chemical Biology” and a new COST Action on
“Biomimetic Radical Chemistry” is approved starting from September 2012 for four
years.
President of the spin-off company Lipinutragen Srl
The managerial activity in the last five years focused on the creation of a spin-off
company based on the research results in lipidomics strongly connected with health,
nutrition and quality of life. The research on the
lipidomics of radical stress and the formation of trans
lipids led to the setting up of an innovative analysis of
erythrocyte membranes, which is commercialized as a
preventive tool in medicine for ameliorating metabolic
status and quality of life. On December 2005,
Lipinutragen Srl (http://www.lipinutragen.it) was founded and Dr. Chatgilialoglu was
nominated President of this company. The marketing concerns the commercialization of
the lipidomic analysis, denominated FAT PROFILE® (European trade mark) to clients in
the sector of health care (medical doctors, medical centers, hospitals etc). Recently a new
product named FAT PHARMACY® has been launched in the pharmacies. The company
also produces a nutraceutical line, named Nutragenika, which represents the first
membrane-targeted nutraceuticals available in the market, and it is sold in the Italian
pharmacies. This entrepreneurial experience enriches his multidisciplinary skills
contributing to improve his formation in the field of science for business.
90
International Appointments
1)
NATO Collaborative Research Grant n. 860678.
Title: Structural and chemical properties of some sulfur-containing intermediates
Common research project between Dr. C. Chatgilialoglu (ICoCEA, CNR) e Dr. D.
Griller (Division of Chemistry, National Research Council of Canada).
Period: April 1986 - March 1989
2)
Progetto Finalizzato Chimica Fine
Sottoprogetto Nuove sintesi: Metodologie e campi avanzati di sintesi organica
Title: Nuovi processi radicalici a catena selettivi
Period: 1989 – 1993
3)
Director of NATO Advanced Study Institute
Title: Sulfur-Centered Reactive Intermediates in Chemistry and Biology
Maratea (Italy), 18 – 30 June 1989
4)
Title: New Reagents for Radical Allylation.
Common research project between Dr. C. Chatgilialoglu (ICoCEA, CNR) e Prof. D.
P. Curran (Department of Chemistry, University of Pittsburg, USA)
Period: April 1993 – March 1996
5)
Director of NATO Advanced Study Institute
Title: Chemical Synthesis: Gnosis to Prognosis
Ravello (Italy), 8 – 19 May 1994
6)
Marie Curie Individual Fellowships: Model studies on radical induced DNA
cleavage associated with the C-1’ position
Scientist in charge: Chatgilialoglu, C. Fellow: Gimisis, T.
Contracts No: ERBFMBICT950336
Period: February 1996 – January 1998.
91
7)
Title: Free Radical Chemistry of the C1’ Position of Nucleosides.
Common research project between Dr. C. Chatgilialoglu (ICoCEA, CNR) e Prof. M.
Newcomb (Chemistry Department, Wayne State University, USA)
Period: April 1997 - March 1999
8)
COST Programme of European Commission.
Title: Radical Cascade Reactions (D12/0005/98)
Period: June 1998 – December 2002
9)
Scientific cooperation agreement CNR/RAS (Russia).
Title: Nuovi sviluppi sulla reattività dei silani in reazioni radicaliche
Period: 1999–2001
10) Scientific cooperation agreement CNR/PAN (Poland).
Title: Riduzioni di composti organofosforici mediante reattivi organometallici.
Nuovi applicazioni.
Period: 2000–2002
11) Scientific cooperation agreement CNR/RAS (Russia).
Title: Studio del meccanismo e dei prodotti dell’ossidazione di nucleosidi con ozono
Period: 2002–2004
12) Marie Curie Individual Fellowships: Trans-unsaturated fatty acid residues in
phospholipids: chemical and biological aspects
Scientist in charge: Chatgilialoglu, C. Fellow: Samadi, A.
Contract No: HPMF-CT-2001-01313
Period: 01.01.2002 – 31.12.2003
13) Research Training Network: Sulfur radical chemistry and biological significance:
the protective and damaging roles of thiol and thioether radicals [SULFRAD]
Contract No: HPRN-CT-2002-00184
92
Period: 01.09.2002 — 28.02.2006
14) Research Training Network: Selective formation and biochemistry of oxidative
clustered DNA damage [CLUSTOXDNA]
Contract No: MRTN-CT-2003-505086
Period: 01.02.2004 – 31.07.2007
Title: Model studies of DNA radicals repair: H-atom abstraction from thiols
Period: 2005–2007
16) Chair of COST Action CM0603
Domain: Chemistry and Molecular Sciences and Technologies
Action Title: Free Radical in Chemical Biology (CHEMBIORADICAL)
Period: June 2007 – June 2011
Title: Markers of radical stress for membrane lipidomics
Period: 2008–2010
18) Scientific cooperation agreement CNR/CONICET (Argentina).
Title: Modified unsaturated lipids, radical-based tandem damage and their
applications
Period: 2009–2010
19) Chair of the 12th EUCHEM Conference on “Organic Free Radicals”
Bologna (Italy), June 28 – July 2, 2010
20) Management Committee Member of the Trans-Domain COST Action
CMST-TD0905
Action Title: Epigenetics: Bench to Bedside
Period: June 2010 – June 2014
93
21) MIUR – PRIN 2009
Title: Oxidative DNA damage: mechanisms and physico-chemical properties of
intermediates and products
Contract No: 2009K3RH7N
Period: 2011 – 2013
22) Marie Curie Actions – Intra European Fellowships (IEF): Formation and roles of
the 5',8-cyclo-2'-deoxyguanosine lesion (CYCLOGUO)
Scientist in charge: Chatgilialoglu, C. Fellow: Terzidis, M. A.
Contract No: PIEF-GA-2011-298555
Period: 01.04.2012 – 31.03.2014
23) Proposer of COST Action CM1203
Domain: Chemistry and Molecular Sciences and Technologies
Action Title: Biomimetic Radical Chemistry
Period: September 2012 – September 2016
94
Consulting activity
1)
Guido Donegani (EniChem), Novara. Italy
January 1991 – March 1992
2)
Ciba-Geigy Limited, Basel (Switzerland).
February 1994 – January 1996
3)
CTU consulting for Tribunale di Milano, in the suit ELF Atochem Italia srl vs ICI
Imperial Chemical Industries LTD (1994-1996).
4)
Ciba-Geigy Limited, Basel (Switzerland).
Mau 1996 – April 2000
5)
BIOCHIMICI PSN DERMA SpA, Bologna (Italy).
June 2000 – December 2001
6)
BIORAMA 2000 srl, Bologna (Italy).
January 2001 – December 2002
95

CV May 2012

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