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BIOGRAPHICAL SKETCH NAME Francesca D’Addio MD, PhD POSITION TITLE Research Associate/ Transplant Medical Consultant San Raffaele Hospital Research Associate Nephrology Division Boston Children’s Hospital-Harvard Medical School EDUCATION/TRAINING Liceo Classico G. Nolfi, Fano, Italy Universita’ Degli Studi Bologna, Italy Universita’ Degli Studi Bologna, Italy DEGREE (if applicable) B.S. M.D. Residency Universita’ Degli Studi Bologna, Italy PhD 2009 Harvard Medical School, Boston, USA PhD/Fellowship 2008 San Raffaele Hospital/ Boston Children's Hospital, Harvard Medical School, Boston Research Associate/ Transplant Consultant 2010 INSTITUTION AND LOCATION MM/YY 1995 2000 2005 FIELD OF STUDY Medicine Nephrology Nephrology and Transplantation Immunology Nephrology and Transplantation Immunology Immunology in Transplantation and Diabetes Personal Statement During my education and training at the Medical School of the University of Bologna, Italy, I learned what was the real meaning of being a physician and how challenging it can be when dealing with clinical patients and their diseases. I have taken-on this challenge and have committed myself for the betterment of the care of my patients through research and discovery. Until 2005, all of my training has been based in clinical settings. My training at the Boston Children’s Hospital and at the San Raffaele Hospital allowed me to expand my research interest to the field of immunobiology and autoimmune diabetes. My long-term goal is to combine my scientific experience in research with my clinical background in developing my future career and becoming an independent investigator in the field of diabetes. Positions and Employment 2000-2005 Residency in Nephrology, S. Orsola Hospital, University of Bologna-Italy 2006- 2010 Nephrology Research Fellow, Boston Children's Hospital, Harvard Medical School, Boston 2008-2010 Basic Science American Society Transplantation Fellowship 2008Scientific Consultant Transplant Immunology, Transplantation Division, OSR-Milan Italy 2010 Scientific Consultant Transplant Immunology, Mario Negri Institute, Bergamo 2010- 2012 ERA EDTA Long Term Fellowship (Department of Transplantation, OSR-Milan Italy 2010Transplantation Medical Consultant,Transplant Medicine Division, OSR-Milan Italy 2012 SISQT-Biotest Fellowship (Società Italiana per la Qualità e Sicurezza dei Trapianti) 2013ISSNAF-Fondazione Marche PostDoctoral Fellowship, Boston Children’s Hospital, Boston Other Experience and Professional Memberships 2006 American Society of Transplantation Membership 2010 Executive Committee member Annual Scientific Exchange Conference 2013 Academic Editor PLOS ONE Honors and Prizes 2008 American Society Transplantation Distinguished Fellow, San Diego United States 2008 Basic Science American Society Transplantation Fellowship 2008 Young Investigator Award –ATC Conference Toronto Canada 2009 Young Investigator Award –ATC Conference Boston United States 2009 Young Innovator Award –ASE Orlando United States 2010 Young Investigator Award–ATC Conference San Diego United States 1 2010 2010 2010 2011 2012 2013 ERA-EDTA Long-Term Fellowship SIN Best Oral Presentation Award in Translational Research, SIN Conference Rimini Italy Premio di studio in Diabetologia “ANGELA BERTIN” Biotest ESOT Award – ESOT Conference Glasgow Scotland SISQT-Biotest Fellowship (Società Italiana per la Qualità e Sicurezza dei trapianti) Italian Scientists and Scholars North America Foundation-Fondazione Marche Postodctoral Fellowship Grant Selected peer-reviewed publications (in chronological order, n=19 out of 33, H index=13). 1. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D'Addio F, Mfarrej B, Donnarumma M, Habicht A, Clarkson MR, Iacomini J, Glimcher LH, Sayegh MH, Ansari MJ. J Exp Med. 2008 Dec 22;205(13):3133-44. 2. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Popoola J, Clarkson M, Yagita H, Akiba H, Freeman G, Iacomini J, Turka L, Glimcher L, Sayegh MH. Proc Natl Acad Sci USA 2009 Jun 30;106(26):10734-9. 3. A Novel clinically relevant approach to promote regulation in transplantation. D’Addio F, Habicht A, Yuan X , Williams J, Ruzek M, iacomini J, Najafian N, Sayegh MH, Ansari MJ. Transplantation. 2010 Aug 15;90(3):260-9. 4. A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice. Vergani A, D’Addio F, Jurewicz M, Watanebe T, Law k, Schuetz C, Orsenigo E, Shaoping D, Rodig S, Staudacher C, Abdi R, Williams J, Markmann J, Atkinson M, Sayegh MH, Fiorina P. Diabetes. 2010 Sep;59(9):2253-64. 5. Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival through a PD-L1-mediated mechanism. Fiorina P, Jurewicz M, Vergani A, D’Addio F, Godwin J, Law K, Thoma G, Kovarik J, La Rosa S, Capella C, Rodig S, Zerwes H, Sayegh MH, and Abdi R. J Immunol. 2010 Nov 1;187(9):4530-41. 6. TIM-3: A Novel Regulatory Molecule of Alloimmune Activation. Boenisch O*, D’Addio F*, Watanabe T, Elyaman W, Padera RF, Rodig S, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N. J Immunol. 2010 Nov 15;185(10):5806-19. 7. Kidney-Pancreas Transplantation Is Associated With Near-Normal Sexual Function in Uremic Type 1 Diabetic Patients. Salonia A, D’Addio F, Gremizzi C, Briganti A, Dehò F, Caldara R, Orsenigo E, Staudacher C, Socci C, Rigatti P, Secchi A, Montorsi F, Fiorina P. Transplantation. 2011 Oct 15;92(7):802-808. 8. The Link between the PDL1 Costimulatory Pathway and Th17 in Fetomaternal Tolerance. D'Addio F, Riella LV, Mfarrej BG, Chabtini L, Adams LT, Yeung M, Yagita H, Azuma M, Sayegh MH, Guleria I. J Immunol. 2011. 9. Prolonged, Low-Dose Anti-Thymocyte Globulin, Combined with CTLA4-Ig, Promotes Engraftment in a Stringent Transplant Model. D'Addio F, Boenisch O, Magee CN, Yeung MY, Yuan X, Mfarrej B, Vergani A, Ansari MJ, Fiorina P, Najafian N. PLoS One. 2013;8(1):e53797. 10. Effect of the Purinergic Inhibitor Oxidized-ATP in a Model of Islet Allograft Rejection. Vergani A, Fotino C, D'Addio F, Tezza S, Podetta M, Gatti F, Chin M, Bassi R, Molano RD, Corradi D, Gatti R, Ferrero ME, Secchi A, Grassi F, Ricordi C, Sayegh MH, Maffi P, Pileggi A, Fiorina P. Diabetes. 2013 Jan 11. 11. Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7. Vergani A, Tezza S, D'Addio F, Fotino C, Liu K, Niewczas M, Bassi R, Molano RD, Kleffel S, Petrelli A, Soleti A, Ammirati E, Frigerio M, Visner G, Grassi F, Ferrero ME, Corradi D, Abdi R, Ricordi C, Sayegh MH, Pileggi A, Fiorina P. Circulation. 2013 Jan 29;127(4):463-75. 12. CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival. D'Addio F, Ueno T, Clarkson M, Zhu B, Vergani A, Freeman GJ, Sayegh MH, Ansari MJ, Fiorina P, Habicht A. PLoS One. 2013 Apr 4;8(4):e60391. 13. Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes. D’Addio F, Maffi P, Vezzulli P, Vergani A, Mello A, Bassi R, Nano R, Falautano M, Coppi E, Finzi G, D’Angelo A, Fermo I, Pellegatta F, La Rosa S, Magnani G, Piemonti L, Falini A, Folli F, Secchi A and Fiorina P. Diabetes Care. 2014 Jan;37(1):267-76. 14. TIM4 regulates the anti-islet Th2 alloimmune response. Vergani A, Gatti F, Lee KM, D'Addio F, Tezza S, Chin M, Bassi R, Tian Z, Wu E, Maffi P, Ben Nasr M, Kim JI, Secchi A, Markmann JF, Rothstein DM, Turka LA, Sayegh MH, Fiorina P. Cell Transplant. 2014 Mar 7. 15. Role of Podocyte B7-1 in Diabetic Nephropathy. Fiorina P, Vergani A, Bassi R, Niewczas MA, Altintas MM, Pezzolesi MG, D'Addio F, Chin M, Tezza S, Ben Nasr M, Mattinzoli D, Ikehata M, Corradi D, Schumacher V, Buvall L, Yu CC, Chang JM, La Rosa S, Finzi G, Solini A, Vincenti F, Rastaldi MP, Reiser J, Krolewski AS, Mundel PH, Sayegh MH. J Am Soc Nephrol. 2014 Mar 27. 16. Autologous non-myeloablative hematopoietic stem cell transplantation in new onset type 1 diabetes: a multicenter analysis. D'Addio F, Valderrama Vasquez A, Ben Nasr M, FraneK E, Zhu D, Li L, Ning G, Snarski E, Fiorina P. Diabetes 2014 Sep;63(9):3041-6. 17. Harnessing the immunological properties of stem cells as a therapeutic option for diabetic nephropathy. D'Addio F, Trevisani A, Ben Nasr M, Bassi R, El Essawy B, Abdi R, Secchi A and Fiorina P. Acta Diabetologica 2014 Jun 4. 2 18. Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens. Kleffel S, Vergani A, Tezza S, Ben Nasr M, Niewczas MA, Wong S, Bassi R, D'Addio F, Schatton T, Abdi R, Atkinson M, Sayegh MH, Wen L, Wasserfall CH, O'Connor KC, Fiorina P. Diabetes. 2014 Sep 3. 19. The rise, fall, and resurgence of immunotherapy in type 1 diabetes. Ben Nasr M, D'Addio F, Usuelli V, Tezza S, Abdi R, Fiorina P. Pharmacol Res. 2014 Aug 6. pii: S1043-6618(14)00118-2. Review. Past research support American Society of Transplantation Basic Science Fellowship Grant 2008-2010 Premio Angela Bertin - Sanofi Aventis 2010-2011 ERA-EDTA (EMBO) Long-Term Fellowship Grant 2010-2012 SISQT Fellowship 2012-2013 Currrent research support ISSNAF-Fondazione Marche PostDoctoral Fellowship 2013-2016 3