Antonella Scorziello



Antonella Scorziello
Antonella Scorziello
Research Scientist, Division of Pharmacology, Department of Neuroscience, School
of Medicine
University of Naples “Federico II” Naples (ITALY)
Laboratory of Cellular and Molecular Pharmacologyy,
Associate Professor in Pharmacology
School of Medicine, Federico II University of Naples
[email protected]
May 1997
October 1997
Student training in Pharmacology, Department of Neuroscience
Division of Pharmacology, University of Naples “Federico II” (Italy).
Degree in Medicine cum laude, University of Naples
“FedericoII” (Italy).
PhD Course in Neuropharmacology, Department of Neuroscience
Division of Pharmacology, University of Naples “Federico II” (Italy).
Residency in Pharmacology, Department of Neuroscience Unit of
Pharmacology, University of Naples “FedericoII” (Italy).
Assistant Professor in Pharmacology, Division of Pharmacology, Dept.
of Neuroscience, School of medicine, Federico II University of Naples.
Associate Professor in Pharmacology, Division of Pharmacology,
Dept. of Neuroscience, School of medicine, Federico II University of
Naples. Italy
AIRC fellowship
Post-doctoral fellowship, Department of Neuroscience Unit of Pharmacology,
University of Naples “FedericoII” (Italy).
Research fellowship, Department of Neuroscience Unit of Pharmacology,
University of Naples “Federico II” (Italy).
Organizer of the following national and International Meetings:
• Meeting of the Italian Society for Neuroscience and Joint Meeting with Swedish
Neuroscientists. Ischia, Napoli (IT). 1-4-Ottobre 2005
• 32° Congresso della Società Italiana di Farmacologia, Napoli, 1-4 Giugno 2005
• National Meeting of PhD Students in Neuroscience, Napoli, 17 Aprile 2009
• International Meeting of PhD Students in Neuroscience, Napoli, 21 Settembre 2009
Sixth International Conference on Sodium Calcium Exchange, Lacco Ameno, Ischia 1-5
October 2011.
Organizer and Chair of the following Symposia:
• Mitochondrial Dysfunction And Oxidative Stress In Neurodegenerative Diseases.
Italian Society of Neuroscience. Verona, Italy 28-30 Settembre, 2007
Neuroscience 1st Joint Meeting with Israel society of Neuroscience . Catania, Italy
19-22 April 2012
Secretary of the Italian Society of Neuroscience (2013-)
Referee of the following National Research Agency:
• Italian Health Research Ministery
• Italian University and Research Ministrery
Referee of the following International Journals:
Brain, J Neuroscience, J Neurochemistry, Molecular Therapy, Stroke, PlosOne,
Neurochemical Research, JBC, Neurological Science, J Neuroscience Research,
International Journal of Molecular Science, Biochemical Pharmacology, EndocrineRelated Cancer , BMC.
1. Characterization of the molecular mechanisms involved in the regulation of
calcium homeostasis in primary colture of neurons and endocrine cell lines
2. Characterization of the molecular mechanisms involved in neurodegeneration
3. Characterization of molecular mechanisms involved in anoxya/reoxygenationinduced neuronal death
4. Characterization of mitochondrial function during Anoxia/reoxygenation
5. Endogenous mechanisms of neuroprotection
1. Scorziello A., Meucci O., Florio T., Fattore M., Forloni G.L., Salmona M. and
Schettini G. “β 25-35 alters calcium homeostasis and induces neurotoxycity in
cerebellar granule cells”. Journal of Neurochemistry, 66: 1995-2003, 1996.
2. Scorziello A., Florio T., Bajetto A., Thellung S. and Schettini G. “TGF-β1 prevents
GP120-induced impairment of Ca2+ homeostasis and recues cortical neurons from
apoptotic death.” Journal Neuroscience Research, 49:600-607, 1997.
3. Florio T., Scorziello A., Thellung S., Salzano S., Berlingieri M.T., Fusco A., and
Schettini G. “Oncogene transformation of PC C13 clonal thyroid cell line induces an
autonomous pattern of proliferation that correlates with a loss of basal and
stimulated phosphotyrosin phosphatase activity.” Endocrinology, 138: 3756-3763,
4. Scorziello A., Pellegrini. C. Forte L., Tortiglione A., Gioielli A., Iossa S., Amoroso S.,
Tufano R. , Di Renzo GF., Annunziato L. “Differential vulnerability of cortical and
cerebellar neurons in primary culture of oxygen glucose deprivation followed by
reoxygenation” Journal Neuroscience Resarch, 63: 20-26, 2001.
5. Scorziello A, Pellegrini C, Secondo A, Sirabella R, Formisano L, Sibaud L, Amoroso
S, Canzoniero LM, Annunziato L, Di Renzo GF. Neuronal NOS activation during
oxygen and glucose deprivation triggers cerebellar granule cell death in the later
reoxygenation phase. Journal Neuroscience Research, 76:812-21, 2004.
6. Pignataro G, Tortiglione A, Scorziello A, Giaccio L, Secondo A, Severino B,
Santagada V, Caliendo G, Amoroso S, Di Renzo G, Annunziato L. Evidence for a
protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by
middle cerebral artery occlusion in male rats. Neuropharmacology, 46:439-448,
7. Matrone M., Pignataro G., Molinaro P., Irace C., Scorziello A., Di Renzo GF.,
Annunziato L. “HIF-1alpha reveals a binding activity to the promoter of iNOS gene
after permanent middle cerebral artery occlusion.”.Journal Neurochemistry,
90:368-78, 2004
8. Panaccione A., Secondo A., Scorziello A., Calì G., Taglialatela M., Annunziato L.
“Nuclear factor-kappaB activation by reactive oxygen species mediates voltagegated K current enhancement by neurotoxic beta-amyloid peptides in nerve growth
factor-differentiated PC-12 cells and hippocampal neurones. Journal
Neurochemistry, 94:572-586, 2005.
9. Magi S., Castaldo P., Carrieri G., Scorziello A., Di Renzo GF., Amoroso S.
“Involvement Of Na+-Ca2+ Exchanger In Intracellular Ca2+ Increase And Neuronal
Injury Induced By Polychlorinated Biphenyls In Human Neuroblastoma Sh-Sy5y
Cells.” Journal Pharmacology Experimental Therapeutics, 315:291-296, 2005.
10. Irace C, Scorziello A, Maffettone C, Pignataro G., Matrone M., Adornetto A.,
Santamaria R., Annunziato L., and Colonna A. “Divergent Modulation of Iron
Regulatory Proteins and Ferritin Biosy nthesis by Hypoxia/Reoxygenation in
Neurons and Glial Cells” Journal Neurochemistry, 95:1331-1331, 2005
11. Livigni A., Scorziello A., Agnese S., Adornetto A. Carlucci A., Garbi C., Castaldo I.,
Annunziato L., Avvedimento EV., Feliciello A. “Mitochondrial AKAP121 Links cAMP
and src Signaling to Oxidative Metabolism”. Molecular Biology of Cell, 17:263-271,
12. Canzoniero LM, Adornetto A, Secondo A, Magi S, Dell'aversano C, Scorziello A,
Amoroso S, Di Renzo G. “Involvement of the nitric oxide/protein kinase G pathway in
polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cells.”
Journal Neuroscience Research., 84:692-697, 2006.
13. Abramov AY, Scorziello A, Duchen MR. “Three distinct mechanisms generate
oxygen free radicals in neurons and contribute to cell death during anoxia and
reoxygenation.” Journal Neuroscience, .27:1129-1138, 2007.
14. Secondo A, Staiano RI, Scorziello A, Sirabella R, Boscia F, Adornetto A, Valsecchi
V, Molinaro P, Canzoniero LM, Di Renzo G, Annunziato L “BHK cells transfected
with NCX3 are more resistant to hypoxia followed by reoxygenation than those
transfected with NCX1 and NCX2: Possible relationship with mitochondrial
membrane potential.” Cell Calcium, . 42:521-35. 2007.
15. Pannaccione A, Boscia F, Scorziello A, Adornetto A, Castaldo P, Sirabella R,
Taglialatela M, Di Renzo G, Annunziato L. Up-regulation and increased activity of
KV3.4 channels and its accessory subunit MIRP2 induced by amyloid peptide is
involved in apoptotic neuronal death. Molecular Pharmacology, . 72:665-673,
16. Scorziello A, Santillo M, Adornetto A, Dell'aversano C, Sirabella R, Damiano S,
Canzoniero LM, Renzo GF, Annunziato L. NO-induced neuroprotection in ischemic
preconditioning stimulates mitochondrial Mn-SOD activity and expression via
Ras/ERK1/2 pathway. Journal Neurochemistry, 103:1472-1480, 2007.
17. Cuomo O, Pignataro G, Gala R, Scorziello A, Gravino E, Piazza O, Tufano R, Di
Renzo G, Annunziato L. Antithrombin reduces ischemic volume, ameliorates
neurologic deficits, and prolongs animal survival in both transient and permanent
focal ischemia. Stroke,.38:3272-3279, 2007.
18. Molinaro P, Cuomo O, Pignataro G, Boscia F, Sirabella R, Pannaccione A, Secondo
A, Scorziello A, Adornetto A, Gala R, Viggiano D, Sokolow S, Herchuelz A,
Schurmans S, Di Renzo G, Annunziato L. Targeted disruption of Na+/Ca2+
exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. Journal
of Neuroscience, 28:1179-1184, 2008.
19. Cuomo O, Gala R, Pignataro G, Boscia F, Secondo A, Scorziello A, Pannaccione A,
Viggiano D, Adornetto A, Molinaro P, Li XF, Lytton J, Di Renzo G, Annunziato L. A
critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in
protection against focal ischemic brain damage. Journal of Neuroscience,
28:2053-2063, 2008.
20. Carlucci A, Adornetto A, Scorziello A, Viggiano D, Foca M, Cuomo O, Annunziato L,
Gottesman M, Feliciello A. Proteolysis of AKAP121 regulates mitochondrial activity
during cellular hypoxia and brain ischaemia. EMBO Journal, . 27:1073-1084, 2008.
21. Pignataro G, Scorziello A, Di Renzo G, Annunziato L. Post-ischemic brain damage:
effect of ischemic preconditioning and postconditioning and identification of potential
candidates for stroke therapy. FEBS J., 276:46-57, 2009.
22. Sirabella R, Secondo A, Pannaccione A, Scorziello A, Valsecchi V, Adornetto A, Bilo
L, Di Renzo G, Annunziato L. Anoxia-Induced NF-kB-dependent upregulation of
NCX1 contributes to Ca2+ refilling into endoplasmic reticulum in cortical neurons.
Stroke. 40: 922-929 2009
23. Boscia F, Gala R, Pannaccione A, Secondo A, Scorziello A, Di Renzo G, Annunziato
L. NCX1 Expression and Functional Activity Increase in Microglia Invading the
Infarct Core. Stroke. 2009 40:3608-3617
24. Valsecchi, V., Pignataro G, Del Prete A., Sirabella R, Matrone M, Boscia F,
Scorziello A, Sisalli MJ, esposito E, Zambrano N, Di renzo GF, Annunziato L. NCX1
Is a Novel Target Gene for Hypoxia-Inducible Factor-1 in Ischemic Brain
Preconditioning. Stroke. 42:754-63. 2011
25. Savoia C, Sisalli MJ, Di Renzo GF, Annunziato L, Scorziello A, “Rosuvastatininduced neuroprotection in cortical neurons exposed to OGD/reoxygenation is due to
nitric oxide inhibition and ERK1/2 pathway activation.” IJPPP,. 3:57-64 2011
26. Molinaro P, Viggiano D, Nisticò R, Sirabella R, Secondo A, Boscia F, Pannaccione
A, Scorziello A, Mehdawy B, Sokolow S, Herchuelz A, Di Renzo GF, Annunziato L.
“Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in
hippocampal long-term potentiation and spatial learning and memory.” J Neurosci.
31:7312-21. 2011
27. Maddalena F, Laudiero G, Piscazzi A, Secondo A, Scorziello A, Lombardi V,
Matassa DS, Fersini A, Neri V, Esposito F, Landriscina M. “Sorcin induces a drugresistant phenotype in human colorectal cancer by modulating Ca(2+) homeostasis.”
Cancer Res. 71:7659-7669. 2011
28. Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nisticò R, Scorziello A, Savoia
C, Garbi C, Annunziato L, Feliciello A. "Control of PKA stability and signalling by the
RING ligase praja2.” Nature Cell Biology. 13:412-22. 2011
29. Pannaccione A, Secondo A, Molinaro P, D'Avanzo C, Cantile M, Esposito A, Boscia
F, Scorziello A, Sirabella R, Di Renzo G, Annunziato L. “A new concept: Aβ1-42
generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12
activation and neuronal death.” J Neurosci. 32:10609-17 2012
30. Molinaro P, Cantile M, Cuomo O, Secondo A, Pannaccione A, Ambrosino P,
Pignataro G, Fiorino F, Severino B, Gatta E, Sisalli MJ, Milanese M, Scorziello A,
Bonanno G, Robello M, Santagada V, Caliendo G, Di Renzo G, Annunziato L.
“Neurounina-1, a Novel Compound That Increases Na+/Ca2+ Exchanger Activity,
Effectively Protects against Stroke Damage.” Mol Pharmacol. 83: 142-156. 2013
31. Pignataro G, Vinciguerra A, Cuomo O, Sirabella R, Di Renzo GF, Scorziello A
“Conjunctival instillation of plasminogen eliminates ocular lesion in B6.129P2Plgtm1Jld transgenic mice, a model of ligneous conjunctivitis”. Pharmacol Res.
74C:45-48. 2013
32. Scorziello A., Savoia C, Sisalli MJ, Adornetto A., Secondo A., Boscia F, Esposito A.,
Polishchuk EV., Polishchuk RS., Molinaro M., Carlucci A., Lignitto L., Di Renzo GF.,
Feliciello A., and Annunziato L., “NCX3 regulates mitochondrial Ca2+ handling
through the AKAP121-anchored signaling complex and prevents hypoxia-induced
cell death”. J Cell Sciences 126(Pt 24):5566-772013
33. Sisalli MJ, Secondo A, Esposito A, Valsecchi V, Savoia C, Di Renzo GF, Annunziato
L,Scorziello A. “Endoplasmic reticulum refilling and mitochondrial calcium extrusion
promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are
determinant for neuroprotection.” Cell Death Differ. 21(7):1142-1149. 2014

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