Nominativo docente: FRANCESCO ORIO Ruolo

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Nominativo docente: RANCESCO RIO
Ruolo: Ricercatore confermato
Area di studio (SS-D): Endocrinologia (MED/13)
Insegnamenti Facoltà Scienze Motorie: Endocrinologia (III anno OPZ, 3 CFU, sede Napoli e Potenza, Classe 33)
Recapiti: DiSIST, via Medina 40, scala A, piano 4° lato sinistro, stanza 11; tel/fax: 081.5474958; cellulare: 338.
6759977; e-mail: [email protected]
ATTIVITÀ DI RICERCA
Azienda Ospedaliera Universitaria “S. Giovanni di Dio e Ruggi d’Aragona” di Salerno
ELENCO DELLE PRINCIPALI LINEE DI RICERCA:
Principali linee di Ricerca sia Clinica che Biologica sono l’Endocrinologia Ginecologica, con particolare riguardo alla
Sindrome dell’Ovaio Policistico, le complicanze metaboliche e cardiovascolari ad essa connessa; l’Endocrinologia dello
Sport e dell’Esercizio Fisico ed i Disturbi del Metabolismo, in particolare l’obesità ed il diabete mellito.
PUBBLICAZIONI SCIENTIFICHE
1.
Articoli (riviste con impact factor)
1. Orio F, Palomba S, Giallauria F, Colao A, Vigorito C. Impaired cardiopulmonary parameters in young women
with polycystic ovary syndrome. Clin Endocrinol 2007 Jan 66:152-153 (I.F. 3.370).
2. Vigorito C, Giallauria F, Palomba S, Cascella T, Manguso F, Lucci R, De Lorenzo A, Lombardi G, Colao A,
Orio F. Beneficial effects of a three-month structured Exercise Training Program on Cardiopulmonary
Functional Capacity in Young Women with Polycystic Ovary Syndrome. J Clin Endocrinol Metab 2007 Apr
92:1379-1384. Epub 2007 Jan 30 (I.F. 5.493).
3. Orio F, Palomba S, Cascella T, Savastano S, Lombardi G, Coalo A. Cardiovascular complication of obesity in
adolescent. J Endocrinol Invest 2007 Jan 30:70-80 (I.F. 2.021).
4. Orio F, Palomba S, Cascella T, Manguso F, Vuolo L, Tafuri D, Lombardi G, Colao A, Vigorito C, Liguori V,
Giallauria F. Lack of electrocardiographic changes in women with polycystic ovary syndrome. Clin Endocrinol
2007 Jul 67:46-50. Epub 2007 Apr 15. (I.F. 3.370).
5. Savastano S, Orio F, Palomba S, Cascella T, Manguso F, Lupoli GA, Formisano P, Lombardi G, Colao A,
Beguinot F, Valentino R. Overexpression of the phospho-protein enriched in diabetes gene product
(PED/PEA15) in women with polycystic ovary syndrome. Clin Endocrinol 2007 Sep 67:557-562. Epub 2007
Jun 21 (I.F. 3.370).
6. Carmina E, Bucchieri S, Esposito A, Del Puente A, Mansueto P, Orio F, Di Fede G, Rini G.B. Abdominal fat
quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin
resistance. J Clin Endocrinol Metab 2007 Jul; 92:2500-2505. Epub 2007 Apr 3. (I.F. 5.493).
7. Palomba S, Falbo A, Russo T, Manguso F, Tolino A, Zullo F, De Feo P, Orio F. Insulin sensitivity after
metformin suspension in normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab 2007
Aug 92:3128-3135. Epub 2007 May 22. (I.F. 5.493).
8. Orio F, Manguso F, Di Biase S, Falbo A, Giallauria F, Labella D, Tolino A, Lombardi G, Colao A, Palomba
S. Metformin administration improves leukocyte count in women with polycystic ovary syndrome: a six-month
prospective study. Eur J Endocrinol 2007 Jul 157:69-73. (I.F. 3.239).
9. Palomba S, Orio F, Zullo F. What is the best first-step therapeutic approach in treating anovulatory infertility
in patients with polycystic ovary syndrome? Questions that are still unanswered. Gynecol Endocrinol 2007
May ; 23:245-247 (I.F. 1.169).
10. Palomba S, Orio F, Falbo A, Russo T, Zullo F, Tolino A, Lombardi G. Clomiphene citrate versus metformin
as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome. J
Clin Endocrinol Metab 2007 Sep; 92:3498-503. Epub 2007 Jun 2 (I.F. 5.493).
11. Nardo LG, Buckett WM, Orio F. Ultrasonography in polycystic ovary syndrome: an update. J Reprod Med
2007 May 52:390-396. (I.F.0.734).
12. Giallauria F, Palomba S, Cascella T, Manguso F, Vitelli A, Maresca L Tafuri D, Lombardi G, Colao A,
Vigorito C, Orio F. Abnormal Heart Rate Recovery after Maximal Cardiopulmonary Exercise Stress Testing
in Young Women with Polycystic Ovary Syndrome.Clin Endocrinol 2008 Jan 68:88-93.Epub 2007 Sep 4 (I.F.
3.370).
13. Palomba S, Falbo A, Orio F, Russo T, Tolino A, Zullo F. Pretreatment with oral contraceptives in infertile
anovulatory patients with polycystic ovary syndrome who receive gonadotropins for controlled ovarian
stimulation. Fertil Steril 2008 Jun 89:1838-1842. Epub 2007 Nov 5 (I.F. 3.168).
1
14. Palomba S, Orio F, Falbo A, Oppedisano R, Tolino A, Zullo F. Tibolone reverses the cognitive effects caused
by leuprolide acetate administration, improving mood and quality of life in patients with symptomatic uterine
leiomyomas. Fertil Steril 2008 Jul 90:165-173. Epub 2007 Nov 14 (I.F. 3.168).
15. Orio F, Giallauria F, Palomba S, Manguso F, Tafuri D, Lombardi G, Colao A, Vigorito C. Metabolic and
cardiopulmonary effects of detraining after a structured exercise training program in young polycystic ovary
syndrome women Clin Endocrinol 2008 Jun 68:976-981. Epub 2007 Nov 2 (I.F. 3.370).
16. Palomba S, Giallauria F, Falbo A, Russo T, Oppedisano R, Tolino A, Vigorito C, Zullo F, Orio F.
Structured exercise training program versus hypocaloric hyperproteic diet in obese polycystic ovary
syndrome patients with anovulatory infertility: a 24-week prospective controlled study. Hum Reprod 2008
Mar 23:642-650. Epub 2007 Dec 23 (I.F. 3.543).
17. Palomba S, Russo T, Orio F, Falbo A, Tolino A, Zullo F. Perifollicular vascularity assessment for selecting
the best oocytes for in vitro fertilization programs in older patients. Fertil Steril 2008 Oct 90:1305-1309. Epub
2007 Dec 31. (I.F. 3.168).
18. Cascella T, Palomba S, De Sio I, Manguso F, Vuolo L, Tafuri D, Giallauria F, Vigorito C, Lombardi G, Colao
A, Carmina E, Orio F. Visceral fat is associated with cardiovascular risk in women with polycystic ovary
syndrome. Hum Reprod 2008 Jan 23:153-159. Epub 2007 Nov 16. (I.F. 3.543).
19. Vitale G, Galderisi M, Colao A, Innelli P, Guerra G, Guerra E, Dini FL, Orio F, Soscia A, de Divitiis O,
Lombardi G. Circulating insulin-like growth factor-I levels are associated with increased biventricular
contractility in top level rowers. Clin Endocrinol 2008 Aug 69:231-236. Epub 2008 Jan 10. (I.F. 3.370).
20. Di Somma C, Angrisani L, Rota F, Savanelli MC, Cascella T, Belfiore A, Orio F, Lombardi G, Colao A,
Savastano S. Growth Hormone and Insulin-Like Growth Factor-I deficiency are associated with reduced
loss of fat mass after laparoscopic- adjustable silicone gastric banding. Clin Endocrinol 2008 Sep 69:393-399.
Epub 2008 Jan 10 (I.F. 3.370).
21. Giallauria F, Cirillo P, Lucci R, Pacileo M, De Lorenzo A, D’Agostino M, Morchella S, Psaroudaki M, Del
Forno D, Orio F, Vitale DF, Chiariello M, Vigorito C. Left ventricular remodeling in patients with
moderate systolic dysfunction after myocardial infarction: favourable effects of exercise training and
predictive role of N-terminal pro-brain natriuretic peptide. Eur J Cardiovasc Prev Rehabil 2008 Feb 15: 113118 (I.F. 2.221).
22. Palomba S, Oppedisano R, Tolino A, Orio F, Zullo F. Outlook: Metformin use in infertile patients with
polycystic ovary syndrome: an evidence-based overview. Reprod Biomed Online 2008 Mar 16:327-335
(I.F. 2.840).
23. Palomba S, Manguso F, Orio F Jr, Russo T, Oppedisano R, Sacchinelli A, Falbo A, Tolino A, Zullo F,
Mastrantonio P. Effectiveness of risedronate in osteoporotic postmenopausal women with inflammatory bowel
disease: a prospective parallel open-label two-year extension study. Menopause 2008 Jul-Aug 15:730-736.
(I.F. 3.672).
24. Di Somma C, Angrisani L, Rota F, Savanelli MC, Cascella T, Belfiore A, Orio F, Lombardi G, Colao A,
Savastano S. GH and IGF-I deficiency are associated with reduced loss of fat mass after laparoscopicadjustable silicone gastric banding. Clin Endocrinol 2008 Sep 69: 393-399. Epub 2008 Jan 10 (I.F. 3.370).
25. Palomba S, Falbo A, Orio F, Tolino A, Zullo F. Efficacy predictors for metformin and clomiphene citrate
treatment in anovulatory infertile patients with polycystic ovary syndrome. Fertil Steril 2009 Jun 91:2557-67.
Epub 2008 Apr 28 (I.F. 3.168).
26. Giallauria F, Palomba S, Maresca L, Vuolo L, Tafuri D, Lombardi G, Colao A, Vigorito C, Orio F. Exercise
training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome
(PCOS). Clin Endocrinol 2008 Nov 69:792-798. Epub 2008 May 23 (I.F. 3.370).
27. Palomba S, Orio F, Falbo A, Oppedisano R, Tolino A, Zullo F. Tibolone reverses the cognitive effects caused
by leuprolide acetate administration, improving mood and quality of life in patients with
symptomatic
uterine leiomyomas. Fertil Steril 2008 Jul 90:165-173 Epub 2007 Nov 12 (I.F. 3.168).
28. Giallauria F, Galizia G,Lucci R, D'Agostino M, Vitelli A, Maresca L, Orio F, Vigorito C. Favourable effects
of exercise-based Cardiac Rehabilitation after acute myocardial infarction on left atrial remodeling.
Int J
Cardiol 2008 Aug 2 [Epub ahead of print] (I.F. 2.878).
29. Palomba S, Pasquali R, Orio F, Nestler J.Clomiphene citrate, metformin or both as first-step approach in
treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of
head- to-head randomized controlled studies and meta-analysis. Clin Endocrinol 2009 Feb 70:311-321. Epub
2008 Aug 7 (I.F. 3.370).
30. Palomba S, Falbo A, Orio F, Zullo F. Insulin sensitizing agents and reproductive function in polycystic
ovary syndrome patients. Current Opinion in Obstetrics and Gynecology 2008 Aug 20:364-373 (I.F. 1.766).
31. Giallauria F, Orio F, Palomba, Lombardi G, Colao A, Vigorito C. Cardiovascular risk in women with
polycystic ovary syndrome. J Cardiovasc Med (Hagerstown) 2008; 9:987-992 (I.F. 1.979).
32. Mason H, Colao A, Blume-Peytavi U, Rice S, Qureshi A, Pellatt L, Orio F, Atkin SL. Polycystic ovary
syndrome (PCOS) trilogy: a translational and clinical review. Clin Endocrinol 2008 Dec; 69:831-844. Epub
2008 Jun 27 (I.F. 3.370).
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33. Palomba S, Falbo A, Orio F, Zullo F. Effect of preconceptional metformin on abortion risk in polycystic ovary
syndrome: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2009 Nov
92:1646-1658. Epub 2008 Oct 19 (I.F. 3.168).
34. Palomba S, Falbo A, Zullo F, Orio F. Evidence-based and potential benefits of metformin in the polycystic
ovary syndrome: a comprehensive review. Endoocr Rev 2009 Feb; 30:1-50. Epub 2008 Dec 4 (I.F. 18.493).
35. Giallauria F, Palomba S, De Sio I, Maresca L, Vuolo L, Savastano S, Lombardi G, Colao A, Vigorito C, Orio
F. Inflammatory markers and visceral fat are inversely associated with maximal oxygen consumption in
women with polycystic ovary syndrome (PCOS). Clin Endocrinol 2009 Mar 70:394-400. Epub 2008 Jun 27
(I.F. 3.370).
36. Savastano S, Di Somma C, Angrisani L, Orio F, Longobardi S, Lombardi G, Colao A. Growth hormone
treatment prevents loss of lean mass after bariatric surgery in morbidly obese patients: results of a pilot, open,
prospective, randomized, controlled study. J Clin Endocrinol Metab 2009 Mar 94:817-826. Epub 2008 Dec 9
(I.F. 5.493).
37. Giallauria F, Palomba S, Vigorito C, Tafuri MG, Colao A, Lombardi G, Orio F. Androgens in polycystic ovary
syndrome: the role of exercise and diet. Semin Reprod Med 2009 Jul 27:306-315. Epub 2009 Jun 15 (I.F.
3.512).
38. Palomba S, Falbo A, Russo T, Tolino A, Orio F, Zullo F. Pregnancy in women with polycystic ovary
syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes. Fertil Steril Oct
94:1805-1811. Epub 2009 Dec 11. (I.F. 3.168).
39. Savastano S, Angrisani L, Di Somma C, Rota F, Savanelli MC, Cascella T, Orio F, Lombardi G, Colao A.
Relationship Between Growth Hormone/Insulin-Like Growth Factor-1Axis Integrity and Voluntary Weight
Loss After Gastric Banding Surgery for Severe Obesity. Obes Surg 2010 Feb 20:211-220. Epub 2009 Jul 28
(I.F. 2.913).
40. Palomba S, Falbo A, Giallauria F, Russo T, Tolino A, Zullo F, Colao A, Orio F. Effects of metformin with or
without supplementation with folate on homocysteine levels and vascular endothelium of women with
polycystic ovary syndrome. Diabetes Care 2010 Feb 33:246-251. Epub 2009 Nov 23 (I.F. 7.851).
41. Palomba S, Falbo A, Russo T, Orio F, Tolino A, Zullo F. Systemic and local effects of metformin
administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response.
Hum Reprod 2010 Apr 25:1005-1013. Epub 2010 Jan 26 (I.F. 3.543).
42. Palomba S, Falbo A, Russo T, Battista L, Tolino A, Orio F, Zullo F. Uterine blood flow in pregnant patients
with polycystic ovary syndrome: relationships with clinical outcomes. BJOG. 2010 May;117(6):711-21. Epub
2010 Mar 12. (I.F.3.101).
43. Palomba S, Falbo A, Battista L, Russo T, Venturella R, Tolino A, Orio F, Zullo F. Laparoscopic ovarian
diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with
polycystic ovary syndrome: a randomized controlled trial. Am J Obstet Gynecol 2010 Jun 202:577.e1-8. Epub
2010 Jan 22 (I.F. 3.453).
44. Savastano S, Valentino R, Pizza G, De Rosa A, Orio F, Passaretti F, Formisano P, Lombardi G, Beguinot F,
Colao. Preliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with
polycystic ovary syndrome. J Endocrinol Invest 2010 Jul-Aug 33:446-450 (I.F. 2.021).
45. Palomba S, Falbo A, Giallauria F, Russo T, Rocca M, Tolino A, Zullo F, Orio F. Six weeks of structured
exercise training and hypocaloric diet increases the probability of ovulation after clomiphene citrate in
overweight and obese patients with polycystic ovary syndrome: a randomized controlled trial. Hum Reprod
2010 Nov 25:2783-2791. Epub 2010 Sep 21 (I.F. 3.543).
2.
Volumi, monografie, capitoli di questi
C. Vigorito, F. Giallauria, D. Del Forno, D. Tafuri, A. Grieco, F. Orio. L’esercizio fisico nel sovrappeso e
nell’obesità. Momento Medico Editore. Aggiornamento di Endocrinologia 2007. Salerno 14-15 dicembre
2007.
2. F. Orio, L. Vuolo, A. Grieco, F. Giallauria, G. Goffredi, T. Russo, S. Savastano, G. Lombardi, A. Colao, F.
Zullo, S. Palomba.Dai nuovi criteri diagnostici alle recenti acquisizioni terapeutiche della Sindrome dell’Ovaio
Policistico. Aggiornamento di Endocrinologia 2007. Salerno 14-15 dicembre 2007.
3. S. Palomba, A. Sacchinelli, A. Falbo, R. Oppedisano, C. Grande, T. Russo, A. Grieco, A. Tolino, A. Colao, F.
Orio, F. Zullo. HRT in menopausa: vantaggi e limiti. Aggiornamento di Endocrinologia 2007. Salerno 14-15
dicembre 2007.
4. Endocrinologia e attività motorie. Editori A. Lenzi, G. Lombardi, E. Martino, F. Trimarchi. Coordinatori F.
Orio P. De Feo. Elsevier Masson Maggio 2008
5. F. Orio. I disordini del ciclo mestruale e la sindrome dell’ovaio policistico: ruolo dell’esercizio fisico. Editori
A. Lenzi, G. Lombardi, E. Martino, F. Trimarchi. Endocrinologia ed attività motorie. Elsevier Masson Maggio
2008, cap. 20 pp146-151
6. F. Orio, S. Palomba, L. Vuolo, A. Grieco, G. Goffredi, D. Caggiano, C. Caggiano, C. Materazzo, G. Lombardi,
A. Colao. Inquinanti ambientali e gonade femminile. Memorial Franco Orio. Aggiornamento di
Endocrinologia 2009. Salerno 9-10 ottobre 2009
1.
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7. S. Palomba, A. Falbo, F. Orio, E. Rania, M. Rocca, C. Materazzo, A. Grieco, G. Lombardi, A. Colao, F. Zullo.
Induzione dell’ovulazione nella paziente infertile. Memorial Franco Orio. Aggiornamento di Endocrinologia
2009. Salerno 9-10 ottobre 2009
8. F. Orio, M. Orio, S. Palomba, D. Caggiano, C. Caggiano, G. Goffredi, G. Lombardi, A. Colao. Insulina e
cancro: mito o realtà. Memorial Franco Orio. Aggiornamento di Endocrinologia 2010. Salerno 1-2 ottobre
2010
ALTRI CONTRIBUTI SCIENTIFICI
1.
Relazioni a congressi internazionali e nazionali
1. Policistosi ovarica e sindrome metabolica Seminario Scuola di Specializzazione. Endocrinologia Università di
Ferrara. Ferrara, 15 Febbraio 2007
2. Visceral fat as early marker of cardiovascular disease in women with polycystic ovary syndrome. European
Congress of Endocrinology, Budapest (Ungheria), 30 Aprile 2007
3. Inquadramento clinico e laboratoristico Patologia benigna dell’ovaio, Cetraro (Cosenza), 28 Settembre 2007
4. Le alterazioni cardiovascolari nella PCOS. 2° Convegno “Diagnosi e Terapia dell’iperandrogenismo: dai
presupposti fisiopatologici agli strumenti operativi”, Verona, 23 Novembre 2007
5. PCOS: dai nuovi criteri diagnostici alle recenti acquisizioni terapeutiche XII Corso di Aggiornamento PostSpecialistico in Endocrinologia, Facoltà di Medicina di Salerno, Baronissi (Salerno) 15 Dicembre 2007
6. Cardiovascular implications of Polycystic Ovary Syndrome,. Society for Endocrinology BES (British Endocrine
Society) 2008, Leeds (UK), 8 Aprile 2008
7. Oral Contraceptives and physical exercise effects on cardiovascular and metabolic risk factors in polycystic
ovary syndrome.The Endocrine Society's 90th Annual Meeting, San Francisco (USA), 16 Giugno 2008
8. Incontro con l’esperto: la PCOS, Novita’ di tema di terapia delle malattie endocrine: Memorial prof. Marco
Minozzi 25 anni dopo. Napoli, 11 Luglio 2008
9. Ovaio policistico: aspetti fisiopatologici Le altre alterazioni del ciclo mestruale. Corso di Perfezionamento in
Ginecologia Endocrinologica, Napoli, 23 Settembre 2008
10. Ovaio policistico Il ruolo fisiopatologico degli androgeni ed estrogeni, 4° Corso di Aggiornamento Scuola del
metabolismo, Napoli, 19 Febbraio 2009
11. La PCOS Tavola Rotonda 1 – Sindrome metabolica ed endocrinopatie, Aggiornamento in tema di terapia delle
malattie endocrine, Napoli, 21 Marzo 2009
12. Patologie metaboliche: aspetti endocrionologici Convegno Regionale AOGOI /FESMED/AGITE Campania
2009, Disturbi uro-ginecologici e patologie associate Salerno, 17 Aprile 2009
13. PCOS : phénotypes chez l'adulte Ovaires Polykystiques, Gynactions 2009, Monaco (Francia), 12 Giugno 2009
14. Non classic cardiovascular risk factors in PCOS 5th Special Scientific Meeting Androgen Excess and PCOS
Society, Update on PCOS: Focus on metabolic and cardiovascular risk, Caracovia (Polonia), 2 Ottobre 2009
15. Inquinanti ambientali e gonade femminile, Memorial Franco Orio. XIII Corso di Aggiornamento PostSpecialistico in Endocrinologia 2009. Salerno, 10 Ottobre 2009
16. Obesità e PCOS Obesità e genetica: aspetti endocrino-metabolici, Avellino, 24 Ottobre 2009
17. Insulina e cancro : mito o realtà XIV Corso di Aggiornamento Post-Specialistico in Endocrinologia 2010
Vietri sul Mare (Salerno). Salerno, 2 Ottobre 2010
18. Ovaio policistico (PCOS): clinica ed implicazioni metaboliche Incontri Stabiesi di Endocrinologia 2010.
Workshop politematico di aggiornamento specialistico in endocrinologia clinica. Castellammare di Stabia (NA),
15 Ottobre 2010
2.
Progetti di ricerca
1. Giugno 2008: Vincitore del Premio: “Travel Grant Award” al 90° Annual Meeting dell’Endocrine Society
2008 a San Francisco con l’abstract intitolato: “Oral Contraceptives and Physical Exercise Effects on
Cardiovascular and Metabolic Risk Factors in Polycystic Ovary Syndrome”.
4