Tegoni Matteo

Tegoni Matteo
Date and place of birth: October 17th, 1974 in Reggio Emilia (Italy)
Nationality: Italian
Present position: Research associate at the University of Parma
Work address:
Dipartimento di Chimica, Università di Parma, Parco Area delle Scienze 17A, I 43124 Parma, Italy
Tel. +39 0521 905424 Fax. +39 0521 905557 Email [email protected]
PRESENT POSITION
2002 – Present: Researcher at the University of Parma in Parma, Italy - Faculty of Sciences and
Department of Chemistry
UNIVERSITY EDUCATION
2002 – Ph.D. in Chemical Sciences awarded by the University of Parma (January 31st, 2002).
Thesis title: “Metal complexes with α-amino acid derivatives. Studies in solution and in the
solid state”. Supervisor: Prof. Francesco Dallavalle.
1998 – First Degree in Chemistry awarded by the Faculty of Sciences of the University of
Parma with the grade of summa cum laude.
Thesis title: “Ruthenium(II) and ruthenium(III) complexes with triazoline, triazole and
sulfurated triazole ligands. Synthesis, reactivity and structural characterization”. Supervisor:
Prof. Marina Cingi Biagini.
INTERNATIONAL RESEARCH EXPERIENCE
2010 – 2012: Two six months sabbatical leaves at the University of Michigan in Ann Arbor,
Michigan, USA. De novo designed copper metallopeptides in collaboration with Prof. Vincent L.
Pecoraro.
2008 – 2009: Two three-months sabbatical leave at the University of Michigan in Ann Arbor,
Michigan, USA. Metallacrowns as cation recognition agents in collaboration with Prof. Vincent L.
Pecoraro.
2001: Visiting Ph.D. student at the Technical University of Lisbon (Instituto Superior Tecnico) in
Lisbon, Portugal. Hydroxamates as inhibitors of matrix metalloproteinases supervised by Prof. M.
Amelia Santos Seabra.
1998: Visiting student at the University of Leiden in Leiden, Netherlands. Ruthenium complexes
and new antitumor drugs supervised by Prof. Jan Reedjik and Prof. Jaap Haasnoot.
2003 – FEBS/EU , PRACTICAL TRAINING COURSE, Role of Metals in Biology, Medicine and
the Environment, Louvain-la-Neuve, Belgique, 19-29 May 2003.
FUNDING
-­‐ Grant from the Italian Ministry of Foreign Affairs - Ministero degli Affari Esteri (cofinanced by
the University of Parma) – 2001. Strategic Bilateral Project Italy – USA Coordinator of the project: “De novo Designed Metallopeptides to mimic Structural and Catalytic Copper Sites in Metalloproteins”. (Joint Declaration following the 10th Review Conference on Scientific and Technological Cooperation between Italy and the United States of America for the years 2011-­‐2012) Bilateral Project Italy –
USA 2011/12. (http://www.chim.unipr.it/denovopeptides/De_Novo_Designed_Metallopeptides_IT-­‐
USA/Home.html) €16000
-­‐ Marie Curie IRSES grant from the EU Research Executive Agency (REA) on Metallacrowns-­‐based innovative materials and supramolecular devices (FP7-­‐PEOPLE-­‐2013-­‐IRSES Project Number 611488 Acronym METALLACROWNS). Coordinator of the project -­‐ €194000 -­‐ Funding from the C.I.R.C.M.S.B. Consorzio Interuniversitario di Ricerca dei Metalli nei Sistemi
Biologici through graduate student fellowships granted to Dr. Manuela Bersellini (“Progettazione
“de novo” di metallopeptidi per la realizzazione di rame proteine artificiali”, 2011) and Dr. Luca
Ferretti (“Sintesi, caratterizzazione strutturale e studio termodinamico in soluzione di complessi
di fitochelatine con ioni metallici di rilevanza biologica”, 2005). €40000
-­‐ Grant from MIUR (cofinanced by the University of Parma) – 2004 – “Metal chelates of amino
acids, α-hydroxyacids and peptides synthesized or extracted for animal nutrition” (Chelati
metallici di amminoacidi, α-idrossiacidi e peptidi di sintesi e di estrazione per la nutrizione
animale). €54000
-­‐ Funding from the University of Parma (FIL). €10000
SUMMARY OF SCIENTIFIC ACTIVITIES AND PRODUCTION
- Research interests in the field of bioinorganic and supramolecular chemistry. Study of the
thermodynamic stability of metal complexes which have relevance in biology, pharmacolgy and life
sciences. Aims of establishing the link between the structure with the physico-chemical or
biological properties of the compounds.
- Documented in 40 publications on international peer-reviewed journals and in more than 60
communications presented at national and international conferences and meetings, which include 25
oral communications and 4 oral invitations.
- Served as a member in national and regional scientific associations and boards.
Research projects
- Chemistry of metallacrowns.
In this fiels I contributed to the elucidation of the thermodynamics of self asembly of these
supramolecules, now under study as precursors of functional materials in the field of magnetism
(Single Molecule Magnets) and luminescent bioprobes.
- De novo designed metallopeptides / Artificial metalloproteins.
In this field I contributed to the design and synthesis of the first de novo designed copper redox
metallopeptide with catalytic properties as a model of natural metalloenzymes.
- Copper complexes as antitumor/antiproliferative agents.
In this area I contributed to the elucidation of new biomolecular and signalling cellular pathways
which lead to the programmed cell death named “paraptosis”.
INVITED LECTURES
- “Designing a functional type 2 copper center that has nitrite reductase activity within α-helical
coiled coils”, Closing Symposium of the Blaise Pascal International Chair Professor Vincent
Pecoraro, Université Paris Sud, Paris, France, November 20, 2012.
- “De novo designed Type 2 copper metallopeptide as functional redox model of nitrite reductase”
ArtZymes 2011 – First symposium on Artificial metalloenzymes, Marseille, France, September 2528, 2011.
- “Self-assembly of copper(II) metallacrowns: a thermodynamic approach” – Scientific seminars of
the Department of Biotechnology and Biosciences, University of Milano Bicocca, April 21, 2009.
- “Copper (II) 12- metallacrown -4 of α-, ß- and γ-aminohydroxamic acids: a comparative
thermodynamic study in aqueous solution” - XVIII ISMEC Italian Spanish Congress on
Thermodynamics of Metal Complexes, Cagliari, Italy, June 5-9, 2007 (Keynote lecture).
AWARDS
1998 – award from the Chemistry department for the Best Outcome in the academic year of
1997/98.
MEMBERSHIPS AND AFFILIATIONS
Member of the National Board of the Young Chemists Group of the Italian Chemical Society (SCI,
Società Chimica Italiana). Member and Secretary of the Board of the Regional Section (Emilia
Romagna) of the Italian Chemical Society. Member of the CIRCMSB – Interuniversity Consortium
for Research on Metal Ions in Biological Systems and of the European Group of Thermodynamics
of Metal Complexes.
CONFERENCE COMMITTEES, EVALUATION COMMITTEES AND REVIEWING
DUTIES
Member of the Organizing Committee of International and National Conferences. Member of
evaluation committees for positions of researcher. Reviewer for the international peer-reviewed
journals (ACS Inorganic Chemistry, Dalton Transactions, Journal of Inorganic Biochemistry,
Organic and Biomolecular Chemistry, Chemistry – A European Journal, Inorganica Chimica Acta,
Polyhedron and Journal of Solution Chemistry).
TEACHING ACTIVITIES
2002-present: Teacher of General and Inorganic Chemistry and Laboratory, Physical Methods in
Bioinorganic and Inorganic Chemistry.
- Supervisor for more than 15 undergrad students in Chemistry and Biological Sciences, and four
graduate students and post docs.
- Member of the Doctorate Board of the Ph.D. course in Chemical Sciences since 2008, and
member of the teaching commission for the Degree courses in Chemistry and Industrial Chemistry
since 2012.
PUBLIC EVENTS AND OUTREACH ACTIVITIES
2002-present: Organizer and co-organizer of several public events oriented to divulge Chemistry as
a scientific area to citizenship and schools, and of meetings within the framework of the Italian
Chemical Society (both regional and national).
SELECTED PUBLICATIONS:
• M. Tegoni, M. Remelli. Metallacrowns of copper(II) and aminohydroxamates: Thermodynamics
of self assembly and host–guest equilibria. Coord. Chem. Rev. 256, 2012, 289–315.
• M. Tegoni, F. Yu, M. Bersellini, J.E. Penner-Hahn, V.L. Pecoraro. Designing a functional type 2
copper center that has nitrite reductase activity within α-helical coiled coils. Proc. Natl. Acad. Sci.
U.S.A. 109, 2012, 21234–9.
• M. Tegoni, M. Furlotti, M. Tropiano, C.S. Lim, V.L. Pecoraro. Thermodynamics of Core Metal
Replacement and Self-Assembly of Ca2+ 15-Metallacrown-5. Inorg. Chem. 49(11), 2010, 51905201.
• F. Dallavalle, M. Remelli, F. Sansone, D. Bacco, M. Tegoni. Thermodynamics of Self-Assembly of
Copper(II) 15-Metallacrown-5 of Eu(III) or Gd(III) with (S)-α-Alaninehydroxamic Acid in Aqueous
Solution. Inorg. Chem. 49(4), 2010, 1761-72.
• S. Tardito, O. Bussolati, M. Maffini, M. Tegoni, M. Giannetto, V. Dall'Asta, R. Franchi-Gazzola,
M. Lanfranchi, M.A. Pellinghelli, C. Mucchino, G. Mori, L. Marchio. Thio-amido Coordination in
a Thioxo-1,2,4-triazole Copper(II) Complex Enhances Non-apoptotic Programmed Cell Death
Associated with Copper Accumulation and Oxidative Stress in Human Cancer Cells. J. Med.
Chem. 50(8), 2007, 1916-24.
• M. Tegoni, L. Ferretti, F. Sansone, M. Remelli, V. Bertolasi, F. Dallavalle. Synthesis, Solution
Thermodynamics, and X-ray Study of CuII [12]Metallacrown-4 with GABA Hydroxamic Acid: An
Unprecedented Crystal Structure of a [12]MC-4 with a γ-Aminohydroxamate. Chem. Eur. J. 13(4),
2007, 1300-08.
• M. Gennari, M. Tegoni, M. Lanfranchi, M.A. Pellinghelli, M. Giannetto, L. Marchiò. CuI
Complexes with N,N',S,S' Scorpionate Ligands: Evidence for Dimer-Monomer Equilibria. Inorg.
Chem. 47(6), 2008, 2223-32.
• L. Ferretti, L. Elviri, M. A. Pellinghelli, G. Predieri, M. Tegoni. Glutathione and Nacetylcysteinylglycine: Protonation and Zn2+ complexation. J. Inorg. Biochem. 101(10), 2007,
1442-56.
• M. Tegoni, F. Dallavalle, M. A. Santos. Succinylhydroxamic derivatives of α-amino acids as
MMP inhibitors. Study of complex-formation equilibria with Cu2+, Ni2+ and Zn2+. J. Inorg.
Biochem. 98, 2004, 209-18.
• M. Tegoni, M. Remelli, D. Bacco, L. Marchio, F. Dallavalle. Copper(II) 12-metallacrown-4
complexes of α-, β- and γ-aminohydroxamic acids: a comparative thermodynamic study in aqueous
solution. Dalton Trans. 20, 2008, 2693-2701.
• M. Gennari, M. Tegoni, M. Lanfranchi, M. A. Pellinghelli, L. Marchiò. A New Chiral N,N',ODonor Heteroscorpionate Ligand. Structures of Ni2+, Cu2+, Zn2+ Complexes and Study of Solution
Equilibria by Means of 1H NMR/UV-Vis Titrations and EXSY NMR Spectroscopy. Inorg. Chem.
46(8), 2007, 3367-77.
• M. Gennari, M. Lanfranchi, L. Marchio, M. A. Pellinghelli, M. Tegoni, R. Cammi. Cu(I)
Dinuclear Complexes with Tripodal Ligands vs Monodentate Donors: Triphenylphosphine,
Thiourea, and Pyridine. A 1H NMR Titration Study. Inorg. Chem., 45(8), 2006, 3456-66.
• M. Tegoni, F. Dallavalle, B. Belosi, M. Remelli. Unexpected formation of a copper(II) 12metallacrown-4 with (S)-glutamic-γ-hydroxamic acid: a thermodynamic and spectroscopic study in
aqueous solution. Dalton Trans., 2004, 1329-33.