INTERNATIONAL SCHOOL OF GERONTOLOGY AND GERIATRICS

THE ENRICO FERMI AND GALILEO GALILEI CELEBRATIONS
A TRIBUTE TO THE "ITALIAN NAVIGATOR", FATHER OF THE WEAK FORCES
AND TO GALILEO GALILEI, FOUNDER OF MODERN SCIENCE
INTERNATIONAL SCHOOL OF
GERONTOLOGY AND GERIATRICS
9th Workshop:
FIRST INTERNATIONAL CONFERENCE ON HEMOPOIESIS AND AGING
III COURSE OF ITALIAN SOCIETY OF ONCOLOGY AND GERIATRICS
ERICE-SICILY: 4 - 10 NOVEMBER 2002
Sponsored by the: • Italian Ministry of Education, University and Scientific Research • Italian Ministry of Health
• Sicilian Regional Government • European Society of Medical Oncology
• International Society of Geriatric Oncology • International Association of Gerontology
• Italian Society of Gerontology and Geriatrics • Italian Association of Medical Oncology
• AUSL 9 Trapani • Sociedad Iberoamericana de Informacion Cientifica
PROGRAMME AND LECTURERS
HEMOPOIETIC STEM CELLS AND AGING
• M. AAPRO, Multidisciplinary Institute of Oncology, Geneva, CH
• M. ACANFORA, IAG, University of Buenos Aires, RA
Hemopoiesis;
• L. BALDUCCI, H. Lee Moffitt Cancer Center, Tampa, FL, USA
Evidence of the Decline in Number of Hemopoiesis Stem Cells;
• M. BARBAGALLO, Chair of Geriatrics, University of Palermo, I
Evidence of the Decline of Stem Cells Proliferative Ability;
• G. BIASCO, Medical Oncology, University of Bologna, I
The Concept of Hemopoietic Stress;
• M. BJÖRKHOLM, Karolinska Hospital, Stockholm, S
Proliferative Senescence and Hemopoietic Stem Cells;
• I. CARRECA, Medical Oncology, University of Palermo, I
• U. CARUSO, Medical Oncology, II Medical School, "La Sapienza"
Age and Plasticity of Hemopoietic Stem Cells.
University, Rome, I
• A. CERAMI, Kenneth S. Warren Laboratory, Tarrytown, NY, USA
HEMOPOIETIC STROMA AND AGING
• A. CERVELLI, Centro Geriatrico ASL RM/B, Rome, I
Aging and Homing;
• G. CHATTA, University of Pittsburg, NJ, USA
Aging and Production of Hemopoietic Growth Factors;
• H. COHEN, Duke University Med. C, Durham, NC, USA
• L. DOGLIOTTI, Medical Oncology, University of Turin, I
Role of Stromal Cells in Stem Cells Plasticity;
• D. DONATI, IOR, Bologna, I
Young Versus Old Stem Cells and Stromal Cells;
• C. EAVES, Terry Fox Lab, British Columbia University, Vancouver, CDN
Aging of the Hemopoietic Stroma.
• W.B. ERSHLER, Inst. for Advanced Studies in Aging and Geriatric
Medicine, Washington, DC, USA
CYTOKINES AGING AND HEMOPOIESIS
• M. FOTI, Chief Executive Officer of A.A.C.R., Philadephia, PA, USA
• C. FRANCESCHI, Dept. of Exp. Pathology, Bologna, I
Cytokine and Aging;
• G. FRANCINI, Medical Oncology, University of Siena, I
Influence of Cytokines on Hemopoiesis;
• L. FRATI, Dean of Med. School, “La Sapienza” University, Rome, I
TNF and MDS;
• A. GIORDANO, Cancer Res. Inst., Temple University, Philadephia, PA, USA
Cytokines and Anemia;
• J. GLASPY, L.A. School of Medicine, Los Angeles, CA, USA
Aging and Responsiveness to Growth Factors;
• F. GUILLÉN LLERA, Chair of Geriatrics, University of Madrid, E
• J. HORTON, Cancer Control, Lee Moffitt Cancer Center, Tampa, FL, USA
Cytokines and Aging Research Issues.
• H. KHALED, Dean of National Cancer Inst., Cairo, EG
• S. KRANZ, VA Medical Center, Nashville, TN, USA
GENERAL LECTURE: NUTRITION, AGE AND HEMOPOIESIS
• D. LIPSCHITZ, Reynolds Dept. of Geriatrics, Little Rock, AK, USA
Metabolic Influence and Hemopoiesis;
• G. MANTOVANI, Medical Oncology, University of Cagliari, I
Vitamin Deficiency, Aging and Hemopoiesis;
• V. MARIGLIANO, Chair of Geriatrics, "La Sapienza" University, Rome, I
• M. PASSERI, IAG’s European Region President, University of Parma, I
Anemia and Malnutrition;
• L. REPETTO, Ist. Naz. Riposo e Cura Anziani, Rome, I
Cytokines and Protein Metabolism;
• J.M. RIBERA CASADO, Chair of Geriatrics, University of Madrid, E
Research Issues on Nutrition, Age and Hemopoiesis.
• G. RIONDINO, Ist. Naz. Riposo e Cura Anziani, Rome, I
• G. ROTHSTEIN, Salt Lake City Veterans Adminstration, Medical
CLINICAL CONSEQUENCES OF AGE ON HEMOPOIESIS
Center, Salt Lake City, UT, USA
•
J. SPIVAK, Johns Hopkins University, Baltimore, MD, USA
Guidelines for the Management of Cancer in Older Persons;
•
A.
VECCHIONE, Dean of II Medical School, "La Sapienza"
Cancer Chemotherapy, Aging and Mielotoxicity: the Case for Guidelines;
University,
Rome, I
The Immunespace of Aging;
• V. ZAGONEL, Medical Oncology, University of Palermo, I
Neutrophil Dysfunction of Aging;
• E. ZANJANI, VA Medical Center, Reno, NV, USA
White Cells and Aging.
• K. ZUCKERMAN, H. Lee Moffitt Cancer Center, Tampa, FL, USA
PURPOSE OF THE WORKSHOP
POETIC TOUCH
Hemopoiesis is a well-defined process that influences all other bodily functions
and is influenced by a complex, multisystem regulatory process. Thus hemopoiesis
affords a unique opportunity to study:
1. Cellular and molecular mechanisms of aging;
2. General influences of aging on cellular and molecular mechanisms, particulary
those related to hemopoiesis.
The focus of our conference will include reduction in hemopoietic stem cell
reserve and productive ability, change in hemopoietic stroma (especially in the homing
capacity), production of hemopoietic growth factors, and quantitative and qualitative
influence of inflammatory cytokines on hemopoiesis.
These studies will provide critical information for two areas of aging:
1. Reversibility of age-related cellular and molecolar changes;
2. Reversibility of physiologic changes of age by improvement in hemopoiesis
including hemoglobin concentration and neutrophil response.
Correlation between age, cancer and management of elderly people with cancer.
According to legend, Erice, son of Venus and Neptune, founded a small town on
top of a mountain (750 metres above sea level) more than three thousand years ago. The
founder of modern history — i.e. the recording of events in a methodic and chronological
sequence as they really happened without reference to mythical causes — the great
Thucydides (~500 B.C.), writing about events connected with the conquest of Troy
(1183 B.C.) said: «After the fall of Troy some Trojans on their escape from the Achaei
arrived in Sicily by boat and as they settled near the border with the Sicanians all
together they were named Elymi: their towns were Segesta and Erice.» This inspired
Virgil to describe the arrival of the Trojan royal family in Erice and the burial of Anchise,
by his son Enea, on the coast below Erice. Homer (~1000 B.C.), Theocritus (~300 B.C.),
Polybius (~200 B.C.), Virgil (~50 B.C.), Horace (~20 B.C.), and others have celebrated
this magnificent spot in Sicily in their poems. During seven centuries (XIII-XIX) the
town of Erice was under the leadership of a local oligarchy, whose wisdom assured a
long period of cultural development and economic prosperity which in turn gave rise to
the many churches, monasteries and private palaces which you see today.
In Erice you can admire the Castle of Venus, the Cyclopean Walls (~800 B.C.)
and the Gothic Cathedral (~1300 A.D.). Erice is at present a mixture of ancient and
medieval architecture. Other masterpieces of ancient civilization are to be found in the
neighbourhood: at Motya (Phoenician), Segesta (Elymian), and Selinunte (Greek).
On the Aegadian Islands — theatre of the decisive naval battle of the first Punic War
(264-241 B.C.) — suggestive neolithic and paleolithic vestiges are still visible: the
grottoes of Favignana, the carvings and murals of Levanzo.
Splendid beaches are to be found at San Vito Lo Capo, Scopello, and Cornino,
and a wild and rocky coast around Monte Cofano: all at less than one hour’s drive from
Erice.
APPLICATIONS
Interested candidates should write to the Directors of the Workshop:
• Professore Mario BARBAGALLO
• Professore Ignazio CARRECA
Cattedra di Geriatria
Università di Palermo
Via Del Vespro, 129
90139 PALERMO, Italy
Tel 39.091.6552885
e-mail: [email protected]
Cattedra di Oncologia Medica
Università di Palermo
Via Del Vespro, 129
90139 PALERMO, Italy
Tel 39.091.6552321
e-mail: [email protected]
also could visit: www.unipa.it/oncology.hemoconference
specifying:
i) date and place of birth together with present nationality;
ii) degree and other academic qualifications;
iii) present position and place of work.
L. BALDUCCI - M. BARBAGALLO - I. CARRECA
DIRECTORS OF THE WORKSHOP
• PLEASE NOTE
Participants should arrive in Erice on November 4, not later than 9 a.m.
More information about the other activities of the Ettore Majorana Centre
can be found on the WWW at the following address:
http://www.ccsem.infn.it
G. BARBAGALLO SANGIORGI
DIRECTOR OF THE SCHOOL
A. ZICHICHI
DIRECTOR OF THE CENTRE