Europass Curriculum Vitae - Farmacia e Medicina

Europass
Curriculum Vitae
Personal information
First name(s) / Surname(s)
Address(es)
Marco Cippitelli
Dpt. of Molecular Medicine, University of Rome “La Sapienza”,
Via Regina Elena, 291, 00161, Rome, Italy.
Telephone(s)
+0039 0649255152
Fax(es)
+0039 0644340632
E-mail
Nationality
Date of birth
Gender
Mobile:
[email protected]
or
[email protected]
Italian
31-10-1964
Male
Occupational field Teaching and research.
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Work experience
2007/Present: - Study of the molecular mechanisms that regulate the
transcription, expression and function of NK cell-activating ligands by
different chemoterapics, in cancer cells.
2005/2007: - Study of the molecular mechanisms that modulate the
transcription and function of the Rank-L and Trail genes by nuclear receptors
and specific ligands in activated T cells: modulation mediated by activators of
the PPAR-gamma.
2003/2005: - Study of the molecular mechanisms mediated by hyperthermia,
that enhance the transcription of the FasL gene in activated T cells.
2000/2003: - Study of the molecular mechanisms that modulate the
transcription and function of the FasL gene by different nuclear receptors and
specific ligands in activated T cells: modulation mediated by Calcitriol
(Vitamin-D3)/VDR, and by activators of the PPAR-gamma.
- Study of the anti-apoptotic protein Bcl-2, as a molecule able to regulate NFkB transcriptional activity and MMP-9 metallo-proteinase gene expression, in
human breast carcinoma cells.
- Study of the signaling pathways involved in the activation of the IFN-gamma
gene, mediated by integrin receptors, in NK cells.
1996/98: - Study of the molecular mechanisms that modulate the transcription
of the IFN-gamma and IL-12 genes, activated by the nuclear receptor VDR
(vitamin D3/R) in T cells and monocytes/dendritic cells.
1992/95: - Study of the transcriptional events that regulate IFN-gamma, IL-2
and IL-4 genes in activated T cells. Analisys of the role of AP1/CREB-ATF,
NF-AT, NF-kB transcription factors involved in these events. These studies
have given important contributions to understand the intracellular pathways
that regulate these genes in T cells.
Occupation or position held 2007-date Associate Professor General Pathology/Immunology
Main activities and responsibilities Teaching and Research.
Name and address of employer
Sector
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Surname(s) First name(s)
University of Rome “La Sapienza”, Rome, Italy
Dpt. of Molecular Medicine, University of Rome “La Sapienza”,
Via Regina Elena, 291, 00161, Rome, Italy
Med-04
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© European Union, 2004-2010 24082010
Education and training
Dates
2007-Present. Associate Professor - General Pathology (Med-04), Dept. of
Molecular Medicine, University of Rome "La Sapienza".
2000-2007. Research Associate - General Pathology (Med-04), Dept. of
Experimental Medicine and Pathology, University of Rome "La Sapienza".
1996-2000. Research Scientist at the Laboratory of Immunology (Dept.
Experimental Medicine and Pathology) and Laboratory of Pathophysiology,
CRS, Regina Elena, Rome.
1996. PhD University of Rome "La Sapienza".
1992-1995. Visiting Scientist at the "Biological Carcinogenesis and
Development Program, “Molecular Immunology Section" (Laboratory of
Experimental Immunology) National Cancer Institute (NCI) Frederick,
Maryland, USA.
1990. Graduated in Biological Science (summa cum laude), University of
Rome "La Sapienza".
Personal skills and
competences Immunology, Molecular biology, Transcriptional regulation.
Mother tongue(s)
Other language(s)
Self-assessment
Specify mother tongue
Italian.
English
Understanding
Speaking
European level (*)
Listening
Reading
Language
C1
C1
Spoken interaction
Writing
Spoken production
C1
B2
B2
Language
(*) Common European Framework of Reference for Languages
Additional information Include here any other information that may be relevant, for example contact persons, references, etc.
Recieving
Fundings
Page 3/5 - Curriculum vitae of
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Every day, previous appointment.
2001-2002 – Grant Ministero Sanità- Finalizzata/Conv. IFO, Roma.
2005/2007 - Ricerche di Facoltà (ex 60%)
2007/2009 - Ricerca di Ateneo Federato
2009 – Ricerca di Ateneo Federato
2011 - FARI, Ricerche Universitarie "Sapienza".
2011/2013 - Progetto di ricerca scientifica approvato dalla Regione Lazio/Sapienza.
PRIN Grant 2006
PRIN Grant 2008
PRIN Grant 2010/2011
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© European Union, 2004-2010 24082010
Selected Scientific Publications 1) Ricca A., Biroccio A., Del Bufalo D., Mackay AR., Santoni A., and Cippitelli M.
Bcl-2 overexpression enhances NF-kB activity and induces MMP-9 transcription in human MCF7ADR
breast cancer cells.
INT. J. CANCER. (2000) 86, 188 IF: 5.007
2) Ricca A., Biroccio A., Trisciuoglio D., Cippitelli M. and Del Bufalo D.
RelA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells.
BR. J. CANCER. (2001) 85(12), 1914 IF: 4.817
3) Cippitelli M., Fionda C., Di Bona D., Di Rosa F., Lupo A., Piccoli M., Frati L. and Santoni A.
Negative regulation of CD95 ligand gene expression by vitamin D3 in T lymphocytes.
J. IMMUNOL. (2002) 168(3), 1154. IF: 5.362
4) Cippitelli M., Fionda C., Di Bona D., Lupo A., Piccoli M., Frati L. and Santoni A.
The cyclopentenone-type prostaglandin 15-deoxy-delta12,14-prostaglandin J2 inhibits CD95 ligand gene
expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated
receptor-gamma-independent mechanisms.
J. IMMUNOL. (2003) 170(9), 4578. IF: 5.362
5) Cippitelli M., Fionda C., Di Bona D., Piccoli M., Frati L. and Santoni A. Hyperthermia enhances CD95Ligand gene expression in T lymphocytes.
J. IMMUNOL. (2005) 174(1), 223. IF: 5.362
6) Di Bona D., Cippitelli M., Fionda C., Camma C., Licata A., Santoni A., Craxi A.
Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway.
J. HEPATOL. (2006) 45(2), 271. IF: 9.557
7) Fionda C., Nappi F., Piccoli M., Frati L., Santoni A. and Cippitelli M.
15-deoxy-12,14-Prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes:
Role of NF-kB and Early Growth Response transcription factors.
J. IMMUNOL. (2007) 178(7):4039-50 IF: 5.362
8) Cerboni C., Zingoni A., Cippitelli M., Piccoli M., Frati L., Santoni A.
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATRdependent mechanism and become susceptible to autologous NK- cell lysis.
BLOOD. (2007) Jul 15;110(2):606-15. IF: 9.775
9) Fionda C., Nappi F., Piccoli M., Frati L., Santoni A. and Cippitelli M.
Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin
J2 in T lymphocytes.
MOL PHARMACOL. (2007) Nov;72(5):1246-57. IF: 4.120
10) Soriani A., Zingoni A., Cerboni C., Iannitto ML., Ricciardi MR., Di Gialleonardo V., Cippitelli M.,
Fionda C., Petrucci MT., Guarini A., Foa R., Santoni A.
ATM-ATR dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by
therapeutic agents results in enhanced NK cell susceptibility and is associated with a senescent
phenotype.
BLOOD. (2009) 113(15): 3503-3511. IF: 9.775
11) Nappi F., Chiozzini C., Bordignon V., Borsetti A., Bellino S., Cippitelli M., Barillari G., Caputo A., Tyagi
M., Giacca M., Ensoli B.
Immobilized HIV-1 Tat protein promotes gene transfer via a transactivation-independent mechanism
which requires binding of Tat to viral particles.
THE J. OF GENE MEDICINE. (2009) 11(11):955-965. IF: 1.953
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Surname(s) First name(s)
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12) Fionda C., Soriani A., Malgarini G., Iannitto ML., Santoni A., Cippitelli M.
Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligand expression on
multiple myeloma cells and their ability to trigger NK cell degranulation.
J. IMMUNOL. (2009) 183(7):4385-4394. IF: 5.362
13) Angela C. Quinci, Sara Vitale, Elisabetta Parretta, Alessandra Soriani, Maria Luisa Iannitto, Marco
Cippitelli, Cinzia Fionda, Silvia Bulfone-Paus, Angela Santoni, Francesca Di Rosa (2012). IL-15 inhibits
IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.
EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 42, p. 1129-1139. IF: 4.518
14) Cinzia Fionda, Giulia Malgarini, Alessandra Soriani, Alessandra Zingoni, Francesca Cecere, Maria
Luisa Iannitto, Maria Rosaria Ricciardi, V. Federico, Maria Teresa Petrucci, Angela Santoni, Marco
Cippitelli (2013). Inhibition of Glycogen Synthase Kinase-3 Increases NKG2D Ligand MICA Expression
and Sensitivity to NK Cell-Mediated Cytotoxicity in Multiple Myeloma Cells: Role of STAT3.
JOURNAL OF IMMUNOLOGY, vol. 190, p. 6662-6672. IF: 5.362
15) Alessandra Soriani, Cinzia Fionda, Biancamaria Ricci, Maria Luisa Iannitto, Marco Cippitelli, Angela
Santoni (2013). Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic
target in multiple myeloma.
ONCOIMMUNOLOGY, vol. 2, p. e26663-1-e26663-3. IF: 6.283
16) Cristina Cerboni, Cinzia Fionda, Alessandra Soriani, Alessandra Zingoni, Margherita Doria, Marco
Cippitelli, Angela Santoni (2014). The DNA damage response: a common pathway in the regulation of
NKG2D and DNAM-1 ligand expression in normal, infected, and cancer cells.
FRONTIERS IN IMMUNOLOGY, vol. 4, p. art. 508-1-art. 508-7.
17) Alessandra Soriani, Maria Luisa Iannitto, Biancamaria Ricci, Cinzia Fionda, Giulia Malgarini, Stefania
Morrone, Giovanna Peruzzi, Maria Rosaria Ricciardi, Maria Teresa Petrucci, Marco Cippitelli, Angela
Santoni (2014). Reactive Oxygen Species- and DNA Damage Response-Dependent NK Cell Activating
Ligand Upregulation Occurs at Transcriptional Levels and Requires the Transcriptional Factor E2F1.
JOURNAL OF IMMUNOLOGY, vol. 193, p. 950-960. IF: 5.362
18) D. Di Bona, V. Scafidi, A. Plaia, C. Colomba, D. Nuzzo, C. Occhino, A. Tuttolomondo, G.
Giammanco, S. De Grazia, G. Montalto, G. Duro, Marco Cippitelli, C. Caruso (2014). HLA and Killer Cell
Immunoglobulin-like Receptors Influence the Natural Course of CMV Infection.
THE JOURNAL OF INFECTIOUS DISEASES, vol. 210, p. 1083-1089. IF: 5.778
19) C. Fionda, MP. Abruzzese, A. Zingoni, A. Soriani, BM. Ricci, R. Molfetta, R. Paolini, A. Santoni and
M. Cippitelli. (2015). Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple
myeloma cells: role of DNA damage response activation.
BMC CANCER, vol. 15:17. IF: 3.319
20) Zingoni A, Cecere F, Vulpis E, Fionda C, Molfetta R, Soriani A, Petrucci MT, Ricciardi MR, Fuerst D,
Amendola MG, Mytilineos J, Cerboni C, Paolini R, Cippitelli M, Santoni A. (2015) .Genotoxic Stress
Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple
Myeloma Cells.
J IMMUNOL. 2015 Jul 15;195(2):736-48. doi: 10.4049/jimmunol.1402643. IF: 5.362
21) Fionda C, Soriani A, Zingoni A, Santoni A, Cippitelli M. (2015). NKG2D and DNAM-1 Ligands:
Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma.
BIOMED RES INT. 2015;2015:178698. doi: 10.1155/2015/178698. Review. IF: 1.579
22) Fionda C, Abruzzese MP, Zingoni A, Cecere F, Vulpis E, Peruzzi G, Soriani A, Molfetta R, Paolini R,
Ricciardi MR, Petrucci MT, Santoni A, Cippitelli M. (2015) The IMiDs targets IKZF-1/3 and IRF4 as novel
negative regulators of NK cell-activating ligands expression in multiple myeloma.
ONCOTARGET. 2015 Sep 15;6(27):23609-30. IF: 6.359
23) Quatrini L, Molfetta R, Zitti B, Peruzzi G, Fionda C, Capuano C, Galandrini R, Cippitelli M, Santoni A,
Paolini R. Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling
and functions in human NK cells. (2015) SCI SIGNAL. 2015 Oct 27;8(400):ra108. IF: 6.279
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© European Union, 2004-2010 24082010