ipotiroidismo e ipertiroidismo

PhytoItalia
ipotiroidismo
e ipertiroidismo
gli strumenti
per la regolazione tiroidea
senza ormoni
“Nutrire la tiroide”
TIREOFORCE
Le terapie in casi di ipotiroidismo non possono prendere in considerazione
solo la carenza di ormoni tiroidei e l’obbiettivo dovrebbe essere un riequilibrio
dell’organismo.
In molti casi di ipotiroidismo, specie quando la causa è una carenza nutrizionale o l’alterata funzionalità di
alcuni organi (fegato ecc.), è possibile ottenere dei miglioramenti correggendo questi problemi senza dover
ricorrere all’uso di ormoni tiroidei.
Tireoforce contiene la maggior parte dei cofattori che influiscono positivamente sul corretto funzionamento della Tiroide. Non contiene iodio, in quanto non è sempre indicata la somministrazione soprattutto
nelle prime fasi del trattamento di tiroiditi autoimmuni.
Una capsula contiene:
Vitamina C 200 mg, Zinco gluconato 115 mg, Magnesio carbonato 100 mg, Lievito arricchito al selenio 83 mg, Vitamina E 50% 60 mg, Manganese gluconato 59 mg, Vitamina B3
- 22 mg, Vitamina B2 - 2,4 mg, Vitamina B6 - 2 mg, Vitamina A - 1.2 mg, Cromo chelato
1 mg, Vitamina D3 - 10 µg, Vitamina B12 - 3,75 µg, Gelatina alimentare.
Modo d’uso: da 2 a 3 cps al giorno, secondo il parere del medico curante.
Assumere preferibilmente prima dei pasti.
Stimolare le ghiandole surrenali
Surrenact
È piuttosto frequente che i casi di squilibrio tiroideo siano accompagnati da
una debolezza surrenalica. Per poter riequilibrare efficacemente la funzionalità tiroidea sarà quindi indispensabile stimolare l’attività delle ghiandole surrenali a produrre.
• Glicocorticoidi
• Mineralcorticoidi
La stanchezza surrenalica può indurre un “Pregnenolone steal” detto furto di pregnenolone, inibendo la
sintesi corretta degli ormoni steroidei.
Prima di procedere alla stimolazione della funzionalità tiroidea si suggerisce quindi l’uso, ove
necessario, di Surrenact.
Una capsula contiene:
Lepidium meyenii (radice) totum 100 mg, Schisandra chinensis (foglie) totum 85 mg, Rhodiola
rosea (radice) totum 80 mg, Eleutherococcus senticosus (radice) totum 50 mg, Ocimum sanctum (pianta intera) polvere 30 mg, Zingiber officinalis (radice) totum 30 mg, Ocimum sanctum
(pianta intera) ext 2,5% 25 mg, Gelatina alimentare.
Modo d’uso: da 2 a 3 cps al giorno, secondo il parere del medico curante. Assumere preferibilmente prima dei pasti.
Stimolare la produzione di T4 e la
conversione in T3
T43 CONVERsE
Contrariamente alla terapia ormonale classica che prevede la vicariazione dell’ormone insufficiente nei casi di
ipotiroidismo, l’approccio fisiologico prevede la stimolazione della secrezione di T4 e soprattutto la stimolazione
della sua conversione, a livello epato-renale, in T3.
Le piante medicinali contenute in T43 converse hanno dimostrato scientificamente di:
• Stimolare la produzione di T4
• Stimolare la conversione della T4 in T3
Una capsula contiene: Commiphora mukul (resina) estratto secco 10% 100 mg, Withania
somnifera (radice) estratto secco 1,7% 80 mg, Coleus forskohlii (radice) estratto secco 20% 50
mg, Bacopa monnieri (rizoma) estratto 4:1 25 mg, eccipienti 50 mg, Gelatina alimentare.
Si consiglia di abbinare il T43 converse con un prodotto che stimoli la funzionalità epatica
nei soggetti con deficit accertato: il Desmodio Phytoitalia
Modo d’uso: da 2 a 3 cps al giorno, secondo il parere del medico curante.
Assumere preferibilmente prima dei pasti.
“Diminuire la secrezione di TSH,T4,T3”
AMIOTIROXIN
Nei casi di ipertiroidismo leggero o subclinico e comunque ove necessiti rallentare l’attività della tiroide in soggetti che manifestino sintomatologia correlata, Amiotiroxin è in grado di intervenire efficacemente grazie al contenuto di Lycopus
Europaeus indicato per la sua azione antitireotropa attraverso la riduzione della deiodinazione periferica di
T4, e una riduzione successiva dei livelli di TSH , legandosi all’ormone ed impedendogli di interagire con i
recettori sulla superficie della tiroide e di stimolare l’adenil ciclasi.
Una capsula contiene:
Lycopus europaeus (pianta intera) totum 244 mg, Ovomucoidi da Coturnix
Japonica 16 mg, Gelatina alimentare.
Si consiglia l’uso anche in abbinamento all’amiodarone nei soggetti
a rischio di ipertiroidismo.
Modo d’uso: da 2 a 3 cps al giorno, secondo il parere del medico
curante. Assumere preferibilmente prima dei pasti.
Bibliografia TIREOFORCE
1. J Biol Chem. 2010 Aug 27;285(35):27279-88. Epub 2010 Jun 23. Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8). Kogai T, Liu YY,
Richter LL, Mody K, Kagechika H, Brent GA. Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, the Departments ofMedicine and Physiology, David
Geffen School of Medicine at UCLA, Los Angeles, PMID: 20573951 PMCID: PMC2930727 [Available on 2011/8/27] 2. J Endocrinol. 2010 May;205(2):179-86. Epub 2010 Feb 22. Regulation of
thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway. Christoffolete MA, Doleschall M, Egri P, Liposits Z, Zavacki AM, Bianco AC, Gereben B. Human and Natural Sciences Center, Federal University of ABC, Santo Andre-SP 09210-370, Brazil.PMID: 20176747 3. Langenbecks Arch Surg. 2010 Sep;395(7):919-24. Epub 2010 Aug 19. 25-hydroxy vitamin D deficiency causes parathyroid incidentalomas. Kirkby-Bott J, El-Khatib Z, Soudan B, Caiazzo R, Arnalsteen L, Carnaille B. Service de Chirurgie Général et Endocrinienne, Hôpital Claude Huriez, CHU,
59037 Lille Cedex, France. [email protected]. PMID: 20717694 4. Eur J Endocrinol. 2011 Jan 17. [Epub ahead of print] Selenium status, thyroid volume and multiple nodule formation in
an area with mild iodine deficiency. Rasmussen L, Schomburg L, Köhrle J, Pedersen IB, Hollenbach B, Hög A, Ovesen L, Perrild H, Laurberg P. L Rasmussen, Dept. of nutrition, National Food
Institute, søborg, 2860, Denmark. PMID: 21242171 5. Ann Ist Super Sanita. 2010;46(4):389-99. Selenium status and over-expression of interleukin-15 in celiac disease and autoimmune thyroid
diseases. Stazi AV, Trinti B. Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy. [email protected] PMID: 21169670 6.
Thyroid. 2010 Oct;20(10):1163-73. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG,
Kouvelas D.Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Ring Road, Nea Efkarpia, Thessaloniki, Greece. touliskos@gmail.
com PMID: 20883174 7. PLoS One. 2010 Sep 22;5(9):e12931. Thyroid hormones regulate selenoprotein expression and selenium status in mice. Mittag J, Behrends T, Hoefig CS, Vennström B,
Schomburg L. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. PMCID: PMC2943913 PMID: 20877559 8. J Clin Endocrinol Metab. 2010 Dec;95(12):5180-8.
Epub 2010 Sep 1. Selenium and the thyroid: a close-knit connection. Duntas LH. Endocrine Unit, Evgenidion Hospital, University of Athens, 20 Papadiamantopoulou Street 115 28 Athens, Greece. [email protected] PMID: 20810577 9. Biol Trace Elem Res. 2010 Apr 20. [Epub ahead of print]. Effect of Zinc Supplementation on the Status of Thyroid Hormones and Na, K, and Ca Levels
in Blood Following Ethanol Feeding. Pathak R, Dhawan D, Pathak A. Department of Physiology, Bhojia Dental College, Baddi, India, [email protected]. PMID: 20405336.
Bibliografia SURRENACT
1. Zhonghua Nan Ke Xue. 2009 Feb;15(2):126-9. [Effects of schisandra on the function of the pituitary-adrenal cortex, gonadal axis and carbohydrate metabolism in rats undergoing experimental chronic
psychological stress, navigation and strenuous exercise]. [Article in Chinese] Sun LJ, Wang GH, Wu B, Wang J, Wang Q, Hu LP, Shao JQ, Wang YT, Li J, Gu P, Lu B. Department of Endocrinology, Nanjing
University School of Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing 210002, Jiangsu, China. PMID: 19323371 2. Curr Clin Pharmacol. 2009 Sep;4(3):198-219. Epub 2009 Sep
1. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Panossian A, Wikman G. Swedish Herbal Institute Research and Development,
Spårvägen 2, SE-43296 Askloster, Sweden. [email protected] PMID: 19500070 3.Food Chem Toxicol. 2010 Oct;48(10):2920-4. Epub 2010 Jul 25. Safety and efficacy of Zingiber officinale
roots on fertility of male diabetic rats. Shalaby MA, Hamowieh AR. Pharmacology Department, Faculty of Veterinary Medicine, Giza, PO Box 12211, Egypt. [email protected] PMID: 20667464.
4. 35. Ip SP, Yiu HY, Ko KM. Differential effect of schisandrin B and dimethyl di- phenyl bicarboxylate (DDB) on hepatic mitochrondrial glutathione redox status in carbon tetrachloride-intoxicated mice.
Molecular and Cellular Bio- chemistry, 2000, 205:111–114. 5. Farnsworth NR, ed. NAPRALERT database. Chicago, IL, University of Illinois at Chicago, 10 January 2001 production (an online database
available directly through the University of Illinois at Chicago or through the Scien- tific and Technical Network (STN) of Chemical Abstracts Services).309 Disponible en CIMEF: http://www.femeba.org.
ar/fundacion 6. Ip SP, Yiu HY, Ko KM. Schisandrin B protects against menadione-induced hepatoxicity by enhancing DT-diaphorase activity. Molecular and Cellular Biochemistry, 2000, 208:151–155.
7. Panossian AG et al. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva. Phytomedicine, 1999, 6:17–26. 8. McGuffin M et al., eds. Botanical safety handbook.
Boca Raton, FL, CRC Press, 1997. 9. Bensky D, Gamble A, Kaptchuk T, eds. Chinese herbal medicine: materia medica, rev. ed. Seattle, WA, Eastland Press, 1993. 10. Fedorova MV et al. [Correction
of fetoplacental functional disturbances in pregnant women living in a radionuclide contamination zone and assessment of the efficacy of therapeutic and prophylactic measures.] Rossijskij Vestnik
Perinatologii i Pediatrii, 1994, 39:13–15 [in Russian].
Bibliografia T43 CONVERSE
1. Life Sci. 1999;65(12):PL137-41. Gugulu (Commiphora mukul) induces triiodothyronine production: possible involvement of lipid peroxidation. Panda S, Kar A.School of Life Sciences,
Devi Ahilya University, Vigyan Bhawan, Indore, India. PMID: 10503949. 2. Phytother Res. 2005 Jan;19(1):78-80. Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female
mice.Panda S, Kar A.Thyroid Research Unit, School of Life Sciences, D. A. University, Khandwa Road, Indore-452017 (M.P.), India. Copyright (c) 2005 John Wiley & Sons, Ltd. PMID: 15798994.
3. Life Sci. 1999;65(12):PL137-41. Gugulu (Commiphora mukul) induces triiodothyronine production: possible involvement of lipid peroxidation. Panda S, Kar A.School of Life Sciences, Devi Ahilya
University, Vigyan Bhawan, Indore, India. PMID: 10503949 4. Coleus forskohlii: Origin and botanical traits. www. tnsmpb.tn.gov.in/images [Accessed January 13, 2006] 5. Forskohl’s Coleus - Coleus
forskohlii BRIQ (Lamiaceae) Phytochemicals. http://www. chromadex.com/Phytosearch/Forskolin.htm [Accessed January 13, 2006] 6. Kim HK, Song KS, Chung JH, et al. Platelet microparticles induce
angiogenesis in vitro. Br J Haematol 2004;124:376-384. 7. Han LK, Morimoto C, Yu RH, Okuda H. Effects of Coleus forskohlii on fat storage in ovariectomized rats. Yakugaku Zasshi 2005;125:449-453.
8. FEBS Lett. 2009 Oct 6;583(19):3140-4. Epub 2009 Sep 13. Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1(DSCR1 or Adapt78). Seo SR, Kim SS, Chung KC.
Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200-701, Republic of Korea. [email protected]. PMID: 19755121. 9. Ned Tijdschr Geneeskd. 2005 Nov
19;149(47):2637-8. [Thyrotoxicosis following the use of ashwagandha]. [Article in Dutch] van der Hooft CS, Hoekstra A, Winter A, de Smet PA, Stricker BH. Inspectie voor de Gezondheidszorg, sectie
Geneesmiddelenbewaking, Postbus 16.119, 2500 BC Den Haag. PMID: 16355578. 10. Evid Based Complement Alternat Med. 2009 Sep 29. [Epub ahead of print]. Withania somnifera Improves
Semen Quality in Stress-Related Male Fertility. Mahdi AA, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D. Medical Elementology and Free Radical Biology Lab, Department of
Biochemistry, C.S.M. Medical University, (Formerly King George’s Medical University), Lucknow 226003, India. [email protected], [email protected]. PMID: 19789214. 11. J Ethnopharmacol.
2002 Jul;81(2):281-5. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. Kar A, Panda S, Bharti S. Thyroid Research Unit, School of
Life Sciences, Devi Ahilya University, Vigyan Bhawan, Khandwa Road, Indore 452 017, India. PMID: 12065164. 12. J Ethnopharmacol. 2007 May 22;111(3):671-6. Epub 2007 Jan 30. Effect of Bacopa
monniera on stress induced changes in plasma corticosterone and brain monoamines in rats. Sheikh N, Ahmad A, Siripurapu KB, Kuchibhotla VK, Singh S, Palit G. Division of Pharmacology, Central
Drug Research Institute, Lucknow 226001, Uttar Pradesh, India.PMID: 17321089. 13. J Ethnopharmacol. 2010 Dec 1. [Epub ahead of print]. Bacopa monniera leaf extract up-regulates tryptophan
hydroxylase (TPH2) and serotonin transporter (SERT) expression: Implications in memory formation. Charles PD, Ambigapathy G, Geraldine P, Akbarsha MA, Rajan KE. Department of Animal Science,
School of Life Sciences, Bharathidasan University, Palkalaiperur, Tiruchirappalli 620024, Tamil Nadu, India. 14. Phytother Res. 2009 Aug;23(8):1140-5. Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice. Jatwa R, Kar A. Endocrine Research Unit, School of Life Sciences, Devi Ahilya University, Indore, M.P., India-452001.
[email protected]. PMID: 19170137.
Bibliografia AMIOTIROXIN
1. Phytomedicine. 2008 Jan;15(1-2):16-22. Lycopus europaeus (Gypsywort): effects on the thyroidal parameters and symptoms associated with thyroid function. Beer AM, Wiebelitz KR, Schmidt-Gayk
H.Department of True Naturopathy, Ruhr-University Bochum, Im Vogelsang 5-11, 45527 Hattingen, Germany. [email protected] <[email protected]> PMID: 18083505.
2. Life Sci. 2006 Feb 2;78(10):1063-70. Epub 2005 Sep 16. Extract of Lycopus europaeus L. reduces cardiac signs of hyperthyroidism in rats. Vonhoff C, Baumgartner A, Hegger M, Korte B, Biller A,
Winterhoff H. Department of Pharmacology and Toxicology, Universitätsklinikum Münster, Westfälische Wilhelms-Universität Münster, Domagkstr. 12, 48143 Münster, Germany. vonhoffc@uni-muenster.
de PMID: 16150466 3. J Ethnopharmacol. 2000 Nov;73(1-2):199-207. Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. Kong LD, Cai Y, Huang WW, Cheng CH, Tan
RX. PMID: 11025157. 4. Arzneimittelforschung. 1994 Jan;44(1):41-5. Endocrine effects of Lycopus europaeus L. following oral application. Winterhoff H, Gumbinger HG, Vahlensieck U, Kemper FH,
Schmitz H, Behnke B. Institut für Pharmakologie und Toxikologie, Westfälischen Wilhelms-Universität Münster, Fed. Rep. of Germany. PMID: 8135877. 5. Planta Med. 1992 Feb;58(1):49-50. On the
influence of the sugar moiety on the antigonadotropic activity of luteoline glycosides. Gumbinger HG, Winterhoff H, Wylde R, Sosa A. Centre C.N.R.S.I.N.S.E.R.M. de Pharmakologie Endocrinologie,
Montpellier, France. PMID: 1620743
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