ansari exchange

BIOGRAPHICAL SKETCH
NAME
Francesca D’Addio MD, PhD
POSITION TITLE
Research Associate/ Transplant Medical Consultant
San Raffaele Hospital
Research Associate Nephrology Division Boston Children’s
Hospital-Harvard Medical School
EDUCATION/TRAINING
Liceo Classico G. Nolfi, Fano, Italy
Universita’ Degli Studi Bologna, Italy
Universita’ Degli Studi Bologna, Italy
DEGREE
(if applicable)
B.S.
M.D.
Residency
Universita’ Degli Studi Bologna, Italy
PhD
2009
Harvard Medical School, Boston, USA
PhD/Fellowship
2008
San Raffaele Hospital/
Boston Children's Hospital, Harvard Medical
School, Boston
Research Associate/
Transplant Consultant
2010
INSTITUTION AND LOCATION
MM/YY
1995
2000
2005
FIELD OF STUDY
Medicine
Nephrology
Nephrology and
Transplantation Immunology
Nephrology and
Transplantation Immunology
Immunology in
Transplantation and
Diabetes
Personal Statement
During my education and training at the Medical School of the University of Bologna, Italy, I learned what was the real
meaning of being a physician and how challenging it can be when dealing with clinical patients and their diseases. I have
taken-on this challenge and have committed myself for the betterment of the care of my patients through research and
discovery. Until 2005, all of my training has been based in clinical settings. My training at the Boston Children’s Hospital
and at the San Raffaele Hospital allowed me to expand my research interest to the field of immunobiology and
autoimmune diabetes. My long-term goal is to combine my scientific experience in research with my clinical background in
developing my future career and becoming an independent investigator in the field of diabetes.
Positions and Employment
2000-2005
Residency in Nephrology, S. Orsola Hospital, University of Bologna-Italy
2006- 2010
Nephrology Research Fellow, Boston Children's Hospital, Harvard Medical School, Boston
2008-2010
Basic Science American Society Transplantation Fellowship
2008Scientific Consultant Transplant Immunology, Transplantation Division, OSR-Milan Italy
2010
Scientific Consultant Transplant Immunology, Mario Negri Institute, Bergamo
2010- 2012
ERA EDTA Long Term Fellowship (Department of Transplantation, OSR-Milan Italy
2010Transplantation Medical Consultant,Transplant Medicine Division, OSR-Milan Italy
2012
SISQT-Biotest Fellowship (Società Italiana per la Qualità e Sicurezza dei Trapianti)
2013ISSNAF-Fondazione Marche PostDoctoral Fellowship, Boston Children’s Hospital, Boston
Other Experience and Professional Memberships
2006
American Society of Transplantation Membership
2010
Executive Committee member Annual Scientific Exchange Conference
2013
Academic Editor PLOS ONE
Honors and Prizes
2008 American Society Transplantation Distinguished Fellow, San Diego United States
2008 Basic Science American Society Transplantation Fellowship
2008 Young Investigator Award –ATC Conference Toronto Canada
2009 Young Investigator Award –ATC Conference Boston United States
2009 Young Innovator Award –ASE Orlando United States
2010 Young Investigator Award–ATC Conference San Diego United States
1
2010
2010
2010
2011
2012
2013
ERA-EDTA Long-Term Fellowship
SIN Best Oral Presentation Award in Translational Research, SIN Conference Rimini Italy
Premio di studio in Diabetologia “ANGELA BERTIN”
Biotest ESOT Award – ESOT Conference Glasgow Scotland
SISQT-Biotest Fellowship (Società Italiana per la Qualità e Sicurezza dei trapianti)
Italian Scientists and Scholars North America Foundation-Fondazione Marche Postodctoral Fellowship Grant
Selected peer-reviewed publications (in chronological order, n=19 out of 33, H index=13).
1. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. Yuan X, Paez-Cortez J,
Schmitt-Knosalla I, D'Addio F, Mfarrej B, Donnarumma M, Habicht A, Clarkson MR, Iacomini J, Glimcher LH, Sayegh MH,
Ansari MJ. J Exp Med. 2008 Dec 22;205(13):3133-44.
2. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Yuan X, Ansari MJ,
D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Popoola J, Clarkson M, Yagita H, Akiba H, Freeman
G, Iacomini J, Turka L, Glimcher L, Sayegh MH. Proc Natl Acad Sci USA 2009 Jun 30;106(26):10734-9.
3. A Novel clinically relevant approach to promote regulation in transplantation. D’Addio F, Habicht A, Yuan X , Williams J,
Ruzek M, iacomini J, Najafian N, Sayegh MH, Ansari MJ. Transplantation. 2010 Aug 15;90(3):260-9.
4. A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice. Vergani A,
D’Addio F, Jurewicz M, Watanebe T, Law k, Schuetz C, Orsenigo E, Shaoping D, Rodig S, Staudacher C, Abdi R,
Williams J, Markmann J, Atkinson M, Sayegh MH, Fiorina P. Diabetes. 2010 Sep;59(9):2253-64.
5. Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival
through a PD-L1-mediated mechanism. Fiorina P, Jurewicz M, Vergani A, D’Addio F, Godwin J, Law K, Thoma G,
Kovarik J, La Rosa S, Capella C, Rodig S, Zerwes H, Sayegh MH, and Abdi R. J Immunol. 2010 Nov 1;187(9):4530-41.
6. TIM-3: A Novel Regulatory Molecule of Alloimmune Activation. Boenisch O*, D’Addio F*, Watanabe T, Elyaman W,
Padera RF, Rodig S, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N. J
Immunol. 2010 Nov 15;185(10):5806-19.
7. Kidney-Pancreas Transplantation Is Associated With Near-Normal Sexual Function in Uremic Type 1 Diabetic Patients.
Salonia A, D’Addio F, Gremizzi C, Briganti A, Dehò F, Caldara R, Orsenigo E, Staudacher C, Socci C, Rigatti P, Secchi A,
Montorsi F, Fiorina P. Transplantation. 2011 Oct 15;92(7):802-808.
8. The Link between the PDL1 Costimulatory Pathway and Th17 in Fetomaternal Tolerance. D'Addio F, Riella LV, Mfarrej
BG, Chabtini L, Adams LT, Yeung M, Yagita H, Azuma M, Sayegh MH, Guleria I. J Immunol. 2011.
9. Prolonged, Low-Dose Anti-Thymocyte Globulin, Combined with CTLA4-Ig, Promotes Engraftment in a Stringent
Transplant Model. D'Addio F, Boenisch O, Magee CN, Yeung MY, Yuan X, Mfarrej B, Vergani A, Ansari MJ, Fiorina P,
Najafian N. PLoS One. 2013;8(1):e53797.
10. Effect of the Purinergic Inhibitor Oxidized-ATP in a Model of Islet Allograft Rejection. Vergani A, Fotino C, D'Addio F,
Tezza S, Podetta M, Gatti F, Chin M, Bassi R, Molano RD, Corradi D, Gatti R, Ferrero ME, Secchi A, Grassi F, Ricordi C,
Sayegh MH, Maffi P, Pileggi A, Fiorina P. Diabetes. 2013 Jan 11.
11. Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7. Vergani A, Tezza S,
D'Addio F, Fotino C, Liu K, Niewczas M, Bassi R, Molano RD, Kleffel S, Petrelli A, Soleti A, Ammirati E, Frigerio M,
Visner G, Grassi F, Ferrero ME, Corradi D, Abdi R, Ricordi C, Sayegh MH, Pileggi A, Fiorina P. Circulation. 2013 Jan
29;127(4):463-75.
12. CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival. D'Addio F, Ueno T,
Clarkson M, Zhu B, Vergani A, Freeman GJ, Sayegh MH, Ansari MJ, Fiorina P, Habicht A. PLoS One. 2013 Apr
4;8(4):e60391.
13. Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes.
D’Addio F, Maffi P, Vezzulli P, Vergani A, Mello A, Bassi R, Nano R, Falautano M, Coppi E, Finzi G, D’Angelo A, Fermo I,
Pellegatta F, La Rosa S, Magnani G, Piemonti L, Falini A, Folli F, Secchi A and Fiorina P. Diabetes Care. 2014
Jan;37(1):267-76.
14. TIM4 regulates the anti-islet Th2 alloimmune response. Vergani A, Gatti F, Lee KM, D'Addio F, Tezza S, Chin M,
Bassi R, Tian Z, Wu E, Maffi P, Ben Nasr M, Kim JI, Secchi A, Markmann JF, Rothstein DM, Turka LA, Sayegh MH,
Fiorina P. Cell Transplant. 2014 Mar 7.
15. Role of Podocyte B7-1 in Diabetic Nephropathy. Fiorina P, Vergani A, Bassi R, Niewczas MA, Altintas MM, Pezzolesi
MG, D'Addio F, Chin M, Tezza S, Ben Nasr M, Mattinzoli D, Ikehata M, Corradi D, Schumacher V, Buvall L, Yu CC,
Chang JM, La Rosa S, Finzi G, Solini A, Vincenti F, Rastaldi MP, Reiser J, Krolewski AS, Mundel PH, Sayegh MH. J Am
Soc Nephrol. 2014 Mar 27.
16. Autologous non-myeloablative hematopoietic stem cell transplantation in new onset type 1 diabetes: a multicenter
analysis. D'Addio F, Valderrama Vasquez A, Ben Nasr M, FraneK E, Zhu D, Li L, Ning G, Snarski E, Fiorina P. Diabetes
2014 Sep;63(9):3041-6.
17. Harnessing the immunological properties of stem cells as a therapeutic option for diabetic nephropathy. D'Addio F,
Trevisani A, Ben Nasr M, Bassi R, El Essawy B, Abdi R, Secchi A and Fiorina P. Acta Diabetologica 2014 Jun 4.
2
18. Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet
Autoantigens. Kleffel S, Vergani A, Tezza S, Ben Nasr M, Niewczas MA, Wong S, Bassi R, D'Addio F, Schatton T, Abdi
R, Atkinson M, Sayegh MH, Wen L, Wasserfall CH, O'Connor KC, Fiorina P. Diabetes. 2014 Sep 3.
19. The rise, fall, and resurgence of immunotherapy in type 1 diabetes. Ben Nasr M, D'Addio F, Usuelli V, Tezza S, Abdi
R, Fiorina P. Pharmacol Res. 2014 Aug 6. pii: S1043-6618(14)00118-2. Review.
Past research support
American Society of Transplantation Basic Science Fellowship Grant 2008-2010
Premio Angela Bertin - Sanofi Aventis 2010-2011
ERA-EDTA (EMBO) Long-Term Fellowship Grant 2010-2012
SISQT Fellowship 2012-2013
Currrent research support
ISSNAF-Fondazione Marche PostDoctoral Fellowship 2013-2016
3