Destinatario / to : - Amik Italia | Cosmetic Department

PRODUCT DATA SHEET
N-BUTYLRESORCINOL
Product code: 9551
Packing: 1/10/25 Kg
INCI name: 4-Butylresorcinol
CAS number: 18979-61-8
EINECS: C.I: Chemical name: 1,3-Dihydroxy-4-n-butyl benzene (4-n-Butyl Resorcinol)
Molecular formula: C10H14O2
Molecular weight: 166.22
OH
OH
C H2C H2C H2C H3
Amik Italia S.p.a -Sede Legale e Amministrativa : Via Fantoli, 5/7 - 20138 Milano - Tel. 02 / 507292.1 - Telefax 02 / 5063361 –
www.amik-cosmetics.com e-mail [email protected]
Cap.soc. € 2.800.000 i.v. - C.C.I.A.A. 943975 - I.T. Milano 170899 Reg.Vol. 5019 - Cod.Fisc. e Partita IVA n.03212480150
Typical properties
Appearance
-
White to yellow powder
Odor
-
Characteristic
Solubility
-
Soluble in most organic solvents; slightly soluble in water
Identification (IR)
-
Matches with standards
Water (by KF)
% w/w
0,1 max
Melting point
°C
~50
Sulphated ash
% w/w
0,5 max
Purity (GC, Area %)
%
98 min
Characteristics of 4- Butylresorcinol
Skin lightener:
- Strong inhibitor of tyrosinase and peroxidase/H2O2
- Effective skin lightener and even-toner for normal skin
- Effective skin lightener for hyper-pigmented skin
- Effective against condition of Melasma.( Acquired hypermelanosis of sun exposed areas)
Skin protectant:
- Has a strong protective effect against H2O2-induced DNA damage.
- Shown to have anti-glycation effect
Amik Italia S.p.a -Sede Legale e Amministrativa : Via Fantoli, 5/7 - 20138 Milano - Tel. 02 / 507292.1 - Telefax 02 / 5063361 –
www.amik-cosmetics.com e-mail [email protected]
Cap.soc. € 2.800.000 i.v. - C.C.I.A.A. 943975 - I.T. Milano 170899 Reg.Vol. 5019 - Cod.Fisc. e Partita IVA n.03212480150
Mechanism of action:
- Tyrosinase plays key role in melanogenesis as it regulates the rate-limiting step of melanogenesis
- 4-n-butylresorcinol has an inhibitory effect on the melanogenesis of cultured B16 melanoma cells by
its direct inhibition of tyrosinase activity, as well as the suppression of tyrosinase synthesis, without
inducing any cytotoxicity.
- Several in vitro studies have demonstrated that 4-n-butylresorcinol inhibits melanin production as well
as the activity of both tyrosinase and tyrosinaserelated protein-1 (TRP-1)
Formulation:
- Suggested use level : 0.5 to 5.0% w/w
Formulation choices:
- Lotion, Cream, Gel, Serum, Spray etc
Formulators’ choice:
- A unique stand alone skin lightening or skin care/protection product
- Complex formulations targeting for Sun care, After sun product, Skin care, Skin protection
Solubility data:
- 1 gm of 4-n-Butylresorcinol is soluble in 5gm of Caprylic capric triglyceride
- 1 gm of 4-n-Butylresorcinol is soluble in 5 gm of PEG 8 caprylic capric glyceride
- 1 gm of 4-n-Butylresorcinol is soluble in 2gm of Ethanol.
- 1gm of 4-n-Butylresorcinol is soluble in 5 gm of IPA.
- 1 gm of 4-n-Butylresorcinol is soluble in 5 gm of Propylene glycol.
- 1 gm of 4-n-Butylresorcinol is soluble in 10 gm of glycerin.
- 1 gm of 4-n-Butylresorcinol is soluble in 10 gm of PPG-15 stearyl ether.
Amik Italia S.p.a -Sede Legale e Amministrativa : Via Fantoli, 5/7 - 20138 Milano - Tel. 02 / 507292.1 - Telefax 02 / 5063361 –
www.amik-cosmetics.com e-mail [email protected]
Cap.soc. € 2.800.000 i.v. - C.C.I.A.A. 943975 - I.T. Milano 170899 Reg.Vol. 5019 - Cod.Fisc. e Partita IVA n.03212480150
- 1 gm of 4-n-Butylresorcinol is soluble in 3gm of 3 polyglyceryl diisostearate.
Oil in water emulsion is the suitable type of emulsion for creams with 4 butyl resorcinol.
In this type of skin cream formulation the active (4-n-Butylresorcinol) is dissolved in a solvent (e.g.
glycerin) then this needs to be added below 45°C in the formulation post emulsification.
Toxicology data
Acute Oral LD50:
The oral LD50 of butyl resorcinol in the rat, rabbit, guinea pig and dog ranged from 550 to >5000 mg/kg
body weight.
Sub acute toxicity:
Oral doses up to 500 mg/kg to mice and rats showed reduced body weight only for male rats. No other
relevant compound- related findings were noted.
Allergenicity/skin irritation/skin sensitization:
Tests in guinea pigs showed that hexylresorcinol was non-sensitizing when applied topically. HRIPT
(1%, 2% & 5% in corn oil, total subjects 240) demonstrates it to be a non-primary irritant and a nonprimary sensitizer. Skin-irritating propensities using 0.1% and 0.5% level on scarified skin: Showed low
irritating potential and compares well with saline control.
Application
- 4-n-Butylresorcinol is safe to use because it is fragrance free and free from color additives.
- 4-n-Butylresorcinol penetrates quickly and reaching deep into the skin.
- 4-n-Butylresorcinol prevents formation of melanin and more effective than other conventional
lightening products.
Amik Italia S.p.a -Sede Legale e Amministrativa : Via Fantoli, 5/7 - 20138 Milano - Tel. 02 / 507292.1 - Telefax 02 / 5063361 –
www.amik-cosmetics.com e-mail [email protected]
Cap.soc. € 2.800.000 i.v. - C.C.I.A.A. 943975 - I.T. Milano 170899 Reg.Vol. 5019 - Cod.Fisc. e Partita IVA n.03212480150
Target products
- Skin whitener/brightener creams,lotions,sprays
- Sunscreen formulations with skin whitener ingredients
- Beauty soaps (skin whitener)
Examples of formulations of N Butyl Resorcinol
Example 1: A depigmenting cream for the skin of oil-in-water emulsion type is prepared, which cream
comprises (% by weight)
Content: N butyl resorcinol 3% Glycerol stearate 2% Polysorbate 60 (Tween 60 from ICI) 1% Stearic
acid 1.4%.sup. Triethanolamine 0.7%.sup.Carbomer 0.4%.sup. Hydrogenated polyisobutene 12%
Perhydrosqualene 12% Glycerol 5% Antioxidant 0.05% Preservative q.s. Water q.s. for 100%
Example 2: A depigmenting gel for the skin is prepared, which gel comprises (% by weight)
Content: N Butyl resorcinol 5% Hydroxypropylcellulose 1% Antioxidant 0.05% Isopropanol 40%
Preservative q.s. Water q.s. for 100%
IMPORTANT SUGGESTION:
The product is very sensitive to light, humidity and oxidation.
When you formulate with n-butylresorcinol it is very imortant to use a powerful anti-oxidant to protect it
(BHT is the best choice, tochopherol could be a suitable alternative, while citric acid is not working).
Is it possible to observe a slight pinkish color of the product, this is normal and it is not compromising
the efficacy; if the color become light brown or brown this means the product is not been stored or
handled in the correct way, it is oxidized and it lost his efficacy.
Amik Italia S.p.a -Sede Legale e Amministrativa : Via Fantoli, 5/7 - 20138 Milano - Tel. 02 / 507292.1 - Telefax 02 / 5063361 –
www.amik-cosmetics.com e-mail [email protected]
Cap.soc. € 2.800.000 i.v. - C.C.I.A.A. 943975 - I.T. Milano 170899 Reg.Vol. 5019 - Cod.Fisc. e Partita IVA n.03212480150