CV Michele Tinazzi Ita - Scienze Neurologiche e del Movimento
Transcript
CV Michele Tinazzi Ita - Scienze Neurologiche e del Movimento
PROF. MICHELE TINAZZI CURRICULUM VITAE Nato a Verona il 05.02.1965 E-mail: [email protected] 1991: Laurea In Medicina e Chirurgia (110/110 e Lode), Università di Verona 1995: Specializzazione in Neurologia (50/50 e Lode), Università di Verona 1999: Dirigente Medico I° Livello presso UO di Neurologia OC Bgo Trento, Az Osp Verona 2003: Dottorato in Neuroriabilitazione, Università di Verona 2003: Idoneità Professore Associato di Neurologia Posizione attuale: Professore Associato di Neurologia (dal 30.12.04) presso il Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Università di Verona Campi di Interesse Clinico: Malattia di Parkinson e Disordini del Movimento; Responsabile dell’ambulatorio dedicato alla Malattia di Parkinson e Disordini del Movimento dal 1997 Malattie cerebrovascolari: Collaboratore all’interno del Gruppo Stroke Unit di Verona Campi di Interesse Scientifico: Disordini del Movimento, Dolore e Plasticità Esperienze lavorative all’estero: Studio dei Potenziali Evocati presso il Functional Neurophysiological Institute of Lyon Hospital (France) nell’anno 1993-1994; Studio Clinico dei Disordini del Movimento presso il National Institute of Neurology, Queen Square, London nel periodo febbraio-aprile 2004. Attività scientifica: autore o coautore di 85 contributi scientifici di cui 71 su riviste internazionali indicizzate; collabora come Referee con diverse riviste di neurologia e di neurofisiologia tra cui Brain, Neurology, Neuroimage, Pain, Experimental Brain Research, European Neuroscience, Neuroscience Letters, Clinical Neurophysiology. ELENCO DELLE PUBBLICAZIONI DEL PROF. MICHELE TINAZZI 1. BONATO C, ZANETTE G, POLO A, BONGIOVANNI G, MANGANOTTI P, TINAZZI M, TEATINI F, FIASCHI A. Cortical output modulation after rapid repetitive movements. Ital J Neurol Sci 1994; 15: 489-494. 2. ZANETTE G, BONATO C, POLO A, TINAZZI M, MANGANOTTI P, FIASCHI A. Recenti prospettive neurofisiologiche per la valutazione della plasticità corticale. Atti del XII Corso di Aggiornamento della Società Italiana di Neurologia, Bari, 25-29 ottobre 1994, pp. 401-406. 3. TINAZZI M, MAUGUIERE F. Assessment of intraspinal and intracranial conduction by P30 and P39 tibial nerve somatosensory evoked potentials in cervical cord, brainstem, and hemispheric lesions. J Clin Neurophysiol 1995; 12: 237-253. 4. ZANETTE G, RIGHETTI C, MANGANOTTI P, POLO A, TINAZZI M, FIASCHI A, TOSI L. Neurophysiological and urodynamic examinations in the functional assessement of the spinal cord below the injury site. European Neurology 1995; 35: 93-98. 5. ZANETTE G, TINAZZI M, MANGANOTTI P, BONATO C, POLO A. Two distinct cervical N13 potentials are evoked by ulnar nerve stimulation. Electroenceph Clin Neurophysiol 1995; 96: 114-120. 6. TINAZZI M, ZANETTE G, POLO A, BONATO C, MANGANOTTI P, FIASCHI A, MAUGUIERE F. Subcortical P30 potential following tibial nerve stimulation: detection and normative data. Ital J Neurol Sci 1995; 16: 623-628. 7. MANGANOTTI P, ZANETTE G, TINAZZI M, POLO A. Dynamic F wave from lower limbs: value and clinical application. Electromyogr Clin Neurophysiol 1995; 35: 323329. 8. ZANETTE G, BONATO C, POLO A, TINAZZI M, MANGANOTTI P, FIASCHI A. Long-lasting depression of motor-evoked potentials to transcranial magnetic stimulation following exercise. Exp Brain Research 1995; 107: 80-86. 9. TINAZZI M, ZANETTE G, FIASCHI A, MAUGUIERE F. Effect of stimulus rate on the cortical posterior tibial nerve SEPs: a topographic study. Electroenceph Clin Neurophysiol 1996; 100: 210-219. 10. TINAZZI M, ZANETTE G, BONATO C, MANGANOTTI P, POLO A, FIASCHI A, MAUGUIERE F. Neural generators of tibial nerve P30 somatosensory evoked potential studied in patients with a focal lesion of the cervico-medullary junction. Muscle & Nerve 1996; 19: 1538-1548. 11. ZANETTE G, TINAZZI M, POLO A, RIZZUTO N. Motor neuron disease with pyramidal tract dysfunction involves the cortical generators of the early somatosensory evoked potential to tibial nerve stimulation. Neurology 1996; 47: 932-938. 12. BONATO C, ZANETTE G, MANGANOTTI P, TINAZZI M, BONGIOVANNI G, POLO A, FIASCHI A. ‘Direct’ and ‘crossed’ modulation of human motor cortex excitability following exercise. Neuroscience Letters 1996; 216: 97-100. 13. TINAZZI M, ZANETTE G, POLO A, VOLPATO D, MANGANOTTI P, BONATO C, TESTONI R, FIASCHI A. Transient deafferentation in humans induces rapid modulation of primary sensory cortex not associated with subcortical changes: a somatosensory evoked potential study. Neuroscience Letters 1997; 223: 21-24. 14. TINAZZI M, ZANETTE G, MANGANOTTI P, BONATO C, POLO A, FIASCHI A, MAUGUIERE F. Amplitude changes of tibial nerve cortical SEPs when using ipsilateral or contralateral ear as reference. J Clin Neurophysiol 1997; 14: 217-225. 15. TINAZZI M, ZANETTE G, LA PORTA F, POLO A, VOLPATO D, FIASCHI A, MAUGUIERE F. Selective gating of lower limb cortical somatosensory evoked potentials (SEPs) during passive and active foot movements. Electroenceph Clin Neurophysiol 1997; 104: 312-321. 16. ZANETTE G, TINAZZI M, BONATO C, DI SUMMA A, MANGANOTTI P, POLO A, FIASCHI A. Reversible changes of motor cortical outputs following immobilization of the upper limb. Electroenceph Clin Neurophysiol 1997; 105: 269-279. 17. FIASCHI A, TINAZZI M, MANGANOTTI P, BONATO C, ZANETTE G. Metodiche Neurofisiologiche di valutazione della plasticità neuronale. Atti del VI Congresso Nazionale di Riabilitazione Neurologica, Napoli, 11-13 dicembre 1997, pp. 1-9. 18. MANGANOTTI P, ZANETTE G, BONATO C, TINAZZI M, POLO A, FIASCHI A. Crossed and direct effects of cutaneous input on transcranial magnetic motor evoked potentials. Electroenceph Clin Neurophysiol 1997; 105: 280-289. 19. DI SUMMA, POLO A, TINAZZI M, ZANETTE G, BERTOLASI L, BONGIOVANNI LG, FIASCHI A. Binocular interaction in normal vision studied by pattern-reversal visual evoked potentials (PR-VEPs). Ital J Neurol Sci 1997; 18: 81-86. 20. MANGANOTTI P, MINIUSSI C, SANTORUM E, TINAZZI M, BONATO C, MARZI CA, FIASCHI A, DALLA BERNARDINA B, ZANETTE G. Influence of somatosensory input on paroxismal activity in benign rolandic epilepsy with extreme somatosensory evoked potentials. Brain 1998; 121: 647-658. 21. TINAZZI M, ZANETTE G. Modulation of ipsilateral motor cortex during unimanual finger movements of different complexities. Neuroscience Letters 1998; 244: 121-124. 22. MANGANOTTI P, MINIUSSI C, SANTORUM E, TINAZZI M, BONATO C, POLO A, MARZI CA, FIASCHI A, DALLA BERNARDINA B, ZANETTE G. Scalp topography and source analysis of interictal spontaneous spikes end evoked spikes by digital stimulation in benign rolandic epilepsy. Electroenceph Clin Neurophysiol 1998; 107: 1826. 23. TINAZZI M, FIASCHI A, MAUGUIERE F, MANGANOTTI P, POLO A, BONATO C, ZANETTE G. Effects of voluntary contraction on tibial nerve somatosensory evoked potentials. Neurology 1998; 50: 1655-1661. 24. TINAZZI M, ZANETTE G, VOLPATO D, TESTONI R, BONATO C, MANGANOTTI P, FIASCHI A. Neurophysiological evidence of neuroplasticity at multiple levels of the somatosensory system in patients with carpal tunnel syndrome. Brain 1998; 121: 17851794. 25. BERTOLASI L, PRIORI A, TINAZZI M, BERTASI V, ROTHWELL JC. Inhibitory action of forearm flexor muscle afferents on the corticospinal outputs to antagonist muscles in humans. J Physiology 1998; 511: 947-956. 26. POLO A, ZAMBITO A, ALDEGHERI R, TINAZZI M, RIZZUTO N. Nerve conduction changes during lower limb lenthening. Somatosensory evoked potentials (SEPs) and Fwave results. Electromyogr Clin Neurophysiol; 1999; 39: 139-144. 27. TINAZZI M, FRASSON E, POLO A, TEZZON F, BOVI P, DEOTTO L, MAUGUIERE F, FIASCHI A, FERRARI G. Evidence for an abnormal cortical sensory processing in dystonia: selective enhancement of lower limb P37-N50 somatosensory evoked potential. Movement Disorders 1999; 14: 473-480. 28. TINAZZI M, FRASSON E, BERTOLASI L, FIASCHI A, AGLIOTI S. Temporal disctimination of somesthetic stimuli is impaired in dystonic patients. Neuroreport 1999; 10: 1547-1550. 29. TINAZZI M. Il management acuto dei pazienti con stroke ischemico. Dialogo sui Farmaci 1999: 6: 218-222. 30. TINAZZI M, FIASCHI A, IDONE D, TEZZON F, ZANETTE G. Parkinson's disease and lower limb somatosensory evoked potentials: apomorphine-induced relief of the akineic-rigid syndrome and vertex P37-N50 potentials. Journal Neurological Sciences 1999; 164: 163-171. 31. AGLIOTI S, BELTRAMELLO A, PERU A, SMANIA N, TINAZZI M. Anomalous double sensations after damage to the cortical somatosensory representation of the hand in humans. Neurocase 1999; 5: 285-292. 32. TINAZZI M, FERRARI G, ZAMPINI M, AGLIOTI S. Neuropsychological evidence that somatic stimuli are spatially coded accord to multiple frames of reference in a stroke patient with tactile extinction. Neuroscience Letters 2000; 287: 133-136. 33. TINAZZI M, PRIORI A, BERTOLASI L, FRASSON E, MAUGUIERE F, FIASCHI A. Abnormal central integration of a dual somatosensory input in dystonia. Evidence for sensory overflow. Brain 2000; 14: 473-480. 34. TINAZZI M, FIASCHI A, ROSSO T, FACCIOLI F, GROSSLERCHER J, AGLIOTI SM. Neuroplastic changes related to pain occur at multiple levels of the human somatosensory system. A SEPs study in patients with cervical radicular pain. J Neuroscience 2000; 20: 9277-9283. 35. TINAZZI M, ROSSO T, FIASCHI A. Il ruolo del feedback somatosensoriale nella distonia: valutazione psicofisica e neurofisiologica mediante potenziale evocati somatosensitivi (PESS). Neurological Sciences 2000; 21 (suppl): S509-513. 36. TINAZZI M, FIASCHI A. Parkinson e parkinsonismi. In problemi neuropsichiatrici. Professione Medico, la clinica. Medicina Clinica; approccio clinico alle patologie internistiche, geriatriche, oncologiche. UTET, 2000 pp 574-580. 37. TINAZZI M, BOVI P. Lo stroke. In problemi neuropsichiatrici. Professione Medico, la clinica. Medicina Clinica; approccio clinico alle patologie internistiche, geriatriche, oncologiche. UTET, 2000 pp 580-587. 38. TAMBURIN S, TINAZZI M, FERRARI G. Il morbo di Parkinson. Dialogo sui Farmaci 2001: 3: 104-115. 39. FRASSON E, PRIORI A, BERTOLASI L, MAUGUIERE F, FIASCHI A, TINAZZI M. Somatosensory disinhibition in dystonia. Mov Disord 2001; 16: 674-682. 40. TINAZZI M, ROSSO T, SMANIA N, FIASCHI A. La neurostimolazione nel trattamento riabilitativo delle sindromi dolorose. Neurological Sciences 2001; 22 (suppl): S283-286. 41. FARINA S, VALERIANI M, ROSSO T, AGLIOTI S, TAMBURIN S, FIASCHI A, TINAZZI M. Transient inhibition of the human motor cortex by capsaicin-induced pain. A study with transcranial magnetic stimulation. Neuroscience Letters 2001; 314; 97-101. 42. FIORIO M, TINAZZI M, PRIOR M, AGLIOTI SM. Discriminazione temporale ed integrazione cross-modale visuo-tattile in pazienti distonici. Giorn Ital Psicologia 2002; 2: 237-243. 43. FACCHINI S, ROMANI M, TINAZZI M, AGLIOTI SM. Time related changes of excitability of the human motor system contingent upon immobilization of the ring and little fingers. Clin Neurophysiol 2002; 113: 367-375. 44. TINAZZI M, FIASCHI A, FRASSON E, FIORIO M, CORTESE F, AGLIOTI SM. Deficits of temporal discrimination in dystonia are independent from the spatial distance between the loci of tactile stimulation. Mov Disord 2002; 17: 333-338. 45. TINAZZI M, ROSSO T, FIASCHI A, GAMBINA G, FARINA S, FIORIO SM, AGLIOTI SM. The role of somatosensory feedback in distonia: a psychophysical evaluation. Neurol Sci 2002; 23: S113-S114. 46. ROSSO T, AGLIOTI SM, ZANETTE G, ISCHIA S, FINCO G, FARINA S, FIASCHI A, TINAZZI M. Functional plasticity in the human primary somatosensory cortex following acute lesion of the anterior lateral spinal cord: neurophysiological evidence of short-term cross-modal plasticity. Pain 2003; 101: 117-127. 47. SMANIA N, CORATO E, FIASCHI A, PIETROPOLI P, AGLIOTI SM, TINAZZI M. Therapeutic effects of peripheral repetitive magnetic stimulation on myofascial pain syndrome. Clin Neurophysiol, 2003; 114: 350-358. 48. TINAZZI M, ROSSO T, FIASCHI A. Role of the somatosensory system 49. in primary distonia (Review), Mov Disord 2003; 18: 605-622. 50. FARINA S, TINAZZI M, LE PERA D, VALERIANI M. Pain-related modulation of the human motor cortex. Neurol Res 2003; 25: 130-142. 51. AGLIOTI SM, FIORIO M, FORSTER B, TINAZZI M. Temporal discrimination of cross-modal and unimodal stimuli in generalized distonia. Neurology 2003; 782-785. 52. FIORIO M, TINAZZI M, BERTOLASI L, AGLIOTI SM. Alterations of temporal processing of visuo-tactile and tactile stimuli in writer’s cramp. Ann Neurol 2003; 53: 630-635. 53. TINAZZI M, FARINA S, TAMBURIN S, FACCHINI S, FIASCHI A, RESTIVO D, BERARDELLI. Task-dependent modulation of excitatory and inhibitory functions within the human primary motor cortex. Exp Brain Res 2003; 222-229. 54. BERTOLASI L, ROMITO S, TINAZZI M, RIZZUTO N, PRIORI A. Impaired heteromymous somatosensory motor cortical inhibition in dystonia. Mov Disord 2003; 18: 1367-1373. 55. VALERIANI M, ARENDT-NIELSEN L, RESTUCCIA D, LE PERA D, ROSSO T, DE ARMAS L, MALESE T, TONALI P, TINAZZI M. Short-term plastic changes of the human nociceptive system following acute pain induced by capsaicin. Clin Neurophysiol 2003; 114: 1879-1890. 56. RESTIVO DA, TINAZZI M, LANZA S. Botulinum Toxin Treatment of Painful Tonic Spasms in Multiple Sclerosis. Neurology 2003; 61: 719-720. 57. TINAZZI M, ROSSO T, ZANETTE G, FIASCHI A, AGLIOTI SM. Rapid modulation of cortical proprioceptive activity induced by transient cutaneous deafferentation: neurophysiological evidence of short-term plasticità across different somatosensory modalities in humans. Eur J Neuroscience. 2003; 18: 3053-3060. 58. SMANIA N, FIASCHI A, MONTAGNANA B, TINAZZI M, CORATO E, SALVATORE M. AGLIOTI. The effect of two different rehabilitation treatments in four patients with cervical dystonia. Func Neurol 2003; 18: 219-225. 59. TINAZZI M, FIORIO M, BERTOLASI L, AGLIOTI SM. Processing of tactile and visuo-tactile stimuli is impaired in patients with cervical dystonia. J Neurol 2004; 251: 85-90. 60. TINAZZI M, VALERIANI M, MORETTO G, ROSSO T, NICOLATO A, FIASCHI A, AGLIOTI SM. Plastic interactions between hand and face cortical representations in patients with trigeminal neuralgia: a somatosensory-evoked potentials study. Neuroscience 2004; 127: 769-776. 61. FARINA S, CASAROTTO M, BENELLE M, TINAZZI M, FIASCHI A, GOLDONI M, SMANIA N. A randomized controlled study on the effect of two different treatments (FREMS AND TENS) in myofascial pain syndrome. Eura Medicophys 2004; 40:293301. 62. VALERIANI M, TINAZZI M, LE PERA D, RESTUCCIA D, DE ARMAS L, MAIESE T, TONALI P, ARENDT-NIELSEN L. Inhibitory effect of capsaicin evoked trigeminal pain on warmth sensation and warmth evoked potentials. Exp Brain Res 2005; 160: 2937. 63. TINAZZI M, ZARATTINI S, VALERIANI M, ROMITO S, FARINA S, MORETTO G, SMANIA N, FIASCHI A, ABBRUZZESE G. Long-lasting modulation of human motor cortex following prolonged transcutaneous electrical nerve stimulation (TENS) of ferearm muscles: evidence of reciprocal inhibition and facilitation. Exp Brain Res 2005; 161; 457-464. 64. TINAZZI M, FARINA S, EDWARDS M, MORETTO G, RESTIVO D, FIASCHI A, BERARDELLI A. Task-specific impairment of motor cortical excitation and inhibition in patients with writer’s cramp. Neuroscience Letters 2005; 378: 55-58. 65. SMANIA N, CORATO E, FIASCHI A, PIETROPOLI P, AGLIOTI SM, TINAZZI M. Repetitive magnetic stimulation: a new therapeutic approach for myofascial pain syndrome. J Neurol 2005; 252: 307-314. 66. TINAZZI M, FARINA S, BHATIA K, FIASCHI A, MORETTO G, BERTOLASI L, ZARATTINI S, SMANIA N. TENS for treatment of writer’s cramp dystonia: a randomized, placebo-controlled study. Neurology 2005; 64: 1946-1948. 67. TINAZZI M, GERSCHLAGER W, BHATIA K. Orthostatic tremor. In Phawa/Lyons eds: Handbook of essential tremor and other tremor disorders, 2006: pp 251-261. 68. MORINI A, BONINSEGNA C, NOSTRO M, SIMONETTI S, ORRICO D, MORETTO G, TINAZZI M. Palatal tremor suppressed by mouth opening: clinical and neurophysiological correlations in two patients. J Neurol 2005; 252: 1335-1340. 69. TOMELLERI G, TINAZZI M, PASQUALIN A, BOVI P, ZANETTE G, MORETTO G. Dural arteriovenous fistulas with aggressive course: clinical and angiographic correlations in two patients: Neurol Sci 2005; 26: 50-54. 70. TINAZZI M, INVERINIZZI P, DEL VESCO C. Pain and neuroplasticity: contribution from neurophysiological studies. In A Lucas Eds: Frontiers in Pain research. Nova science Publishers, New York, 2005: pp 113-133. 71. BONIFATI V, ROHE CF, BREEDVELD GJ, FABRIZIO E, DE MARI M, TASSORELLI C, TAVELLA A, MARCONI R, NICHOLL DJ, CHIEN HF, FINCATI E, ABBRUZZESE G, MARINI P, DE GAETANO A, HORSTINK MW, MAATKIEVIT JA, SAMPAIO C, ANTONINI A, STOCCHI F, MONTAGNA P, TONI V, GUIDI M, DALLA LIBERA A, TINAZZI M, DE PANDIS F, FABBRINI G, GOLDWURM S, DE KLEIN A, BARBOSA E, LOPIANO L, MARTIGNONI E, LAMBERTI P, VANACORE N, MECO G, OOSTRA BA; ITALIAN PARKINSON GENETICS NETWORK. Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. Neurology 2005 12; 65 :87-95. 72. M. TINAZZI, C STANZANI, M FIORIO, N SMANIA, G MORETTO, A FIASCHI, MJ EDWARDS, KP BHATIA, JC ROTHWELL. Temporal discrimination of two passive movements in human: a new psychophysical approach to assess kinaesthesia. Exp Brain Research 2005;166:184-189. 73. MARTINO D, DEFAZIO G, ALESSIO G, ABBRUZZESE G, GIRLANDA P, TINAZZI M, FABBRINI G, MARINELLI L, MAJORANO G, VACCA L, BERARDELLI A. The relationship between eye symptoms and blepharospasm: a multicenter case-control study. Mov Disord 2005; 20: 1564-1570. 74. FIORIO M, TINAZZI M, AGLIOTI SM. Selective impairment of hand mental rotation in patients with focal hand dystonia. Brain 2006; 129: 47-54. 75. GAMBARIN M, ANTONINI A, MORETTO G, BOVI P, ROMITO S, FIASCHI A, TINAZZI M. Pisa syndrome without neuroleptic exposure in a patient with parkinson’s disease: case report. Mov Disord 2006; 21: 270-273. 76. DI FONZO A, TASSORELLI C, DE MARI M, CHIEN HF, FERREIRA J, ROHE CF, RIBOLDAZZI G, ANTONINI A, ALBANI G, MAURO A, MARCONI R, ABBRUZZESE G, LOPIANO L, FINCATI E, GUIDI M, MARINI P, STOCCHI F, ONOFRJ M, TONI V, TINAZZI M, FABBRINI G, LAMBERTI P, VANACORE N, MECO G, LEITNER P, UITTI RJ, WSZOLEK ZK, GASSER T, SIMONS EJ, BREEDVELD GJ, GOLDWURM S, PEZZOLI G, SAMPAIO C, BARBOSA E, MARTIGNONI E, OOSTRA BA, BONIFATI V; ITALIAN PARKINSON'S GENETICS NETWORK. Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. Eur J Hum Genet 2006; 14: 322-333. 77. TINAZZI M, DEL VESCO C, FINCATI E, OTTAVIANI S, SMANIA N, MORETTO G, FIASCHI A, MARTINO D, DEFAZIO G. Pain and motor complications in Parkinson's disease. J Neurol Neurosurg Psychiatry 2006 ;77: 822-825. 78. VALERIANI M, TONALI P, LE PERA D, RESTUCCIA D, DE ARMAS L, DEL VESCO C, MILIUCCI R, FIASCHI A, VIGEVANO F, ARENDT-NIELSEN L, TINAZZI M. Modulation of laser-evoked potentials by experimental cutaneous tonic pain. Neuroscience. 2006; 140: 1301-1310. 79. MARONGIU R, GHEZZI D, IALONGO T, SOLETI F, ELIA A, CAVONE S, ALBANESE A, ALTAVISTA MC, BARONE P, BRUSA L, CORTELLI P, PETROZZI L, SCAGLIONE C, STANZIONE P, TINAZZI M, ZEVIANI M, DALLAPICCOLA B, BENTIVOGLIO AR, VALENTE EM, GARAVAGLIA B; ITALIAN PD STUDY GROUP. Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease. Mov Disord. 2006; 21: 1232-1235. 80. TINAZZI M, FIORIO M, STANZANI C, MORETTO G, SMANIA N, FIASCHI A, BHATIA KP, ROTHWELL JC. Temporal discrimination of two passive movements in writer's cramp. Mov Disord. 2006; 21: 1131-1135. 81. GAMBARIN M, VALENTE EM, LIBERINI P, BARRANO G, BONIZZATO A, PADOVANI A, MORETTO G, FIORIO M, DALLAPICCOLA B, SMANIA N, FIASCHI A, TINAZZI M. Atypical phenotypes and clinical variability in a large Italian family with DYT1-primary torsion dystonia. Mov Disord 2006; 21: 1782-1784. 82. TINAZZI M, ZARATTINI S, VALERIANI M, STANZANI C, MORETTO G, SMANIA N, FIASCHI A, ABBRUZZESE G. Effects of transcutaneous electrical nerve stimulation on motor cortex excitability in writer's cramp: Neurophysiological and clinical correlations. Mov Disord 2006; 21: 1131-1135. 83. GAMBARIN M, TINAZZI M. Reply: Pisa sindrome without neuroleptic exposure in a patient with Parkinson’s disease: A case report. Mov Disord 2006; 21: 2264-2265. 84. MARTINO D, DEFAZIO G, ABBRUZZESE G, GIRLANDA P, TINAZZI M, FABBRINI G, ANIELLO MS, AVANZINO L, COLOSIMO C, MAJORANA G, TROMPETTO C, BERARDELLI A. Head trauma in primary cranial dystonias: A multi centre case control study. J Neurol Neurosurg Psychiatry 2006 Oct 20; [Epub ahead of print]. 85. SMANIA N, AGLIOTI SM, GIRARDI F, TINAZZI M, FIASCHI A, COSENTINO A, CORATO E. Rehabilitation of limb apraxia improves daily life activities in patients with stroke. Neurology. 2006; 67: 2050-2052. 86. OTTAVIANI S, TINAZZI M, PASQUIN I, NOTHDURFTER W, TOMELLERI G, FINCATI E, NORDERA G, MORETTO G, FIASCHI A, SMANIA N, GIORGETTI P, ANTONINI A. Comparative analysis of visual and semi-quantitative assessment of striatal [(123)I]FP-CIT-SPET binding in Parkinson's disease. Neurol Sci. 2006; 27: 397401. 87. DELUCA C, TINAZZI M, BOVI P, RIZZUTO N, MORETTO G. Limb ataxia and proximal intracranial territory brain infarcts: clinical and topographical correlations. J Neurol Neurosurg Psychiatry 2007 Aug;78(8):832-5. Epub 2007 Jan 8 88. FIORIO M, GAMBARIN M, VALENTE EM, LIBERINI P, LOI M, COSSU G, MORETTO G, BHATIA KP, DEFAZIO G, AGLIOTI SM, FIASCHI A, TINAZZI M. Defective temporal processing of sensory stimuli in DYT1 mutation carriers: a new endophenotype of dystonia? Brain. 2007; 130: 134-42. 89. DEFAZIO G, MARTINO D, ABBRUZZESE G, GIRLANDA P, TINAZZI M, FABBRINI G, COLOSIMO C, ANIELLO MS, AVANZINO L, BUCCAFUSCA M, MAJORANA G, TROMPETTO C, LIVREA P, BERARDELLI A Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm: evidence from a multicentre case control study.J Neurol Neurosurg Psychiatry. 2007 Aug;78(8):877-9. Epub 2007 Jun 19. 90. FIORIO M, TINAZZI M, IONTA S, FIASCHI A, MORETTO G, EDWARDS MJ, BHATIA KP, AGLIOTI SM. Mental rotation of body parts and non-corporeal objects in patients with idiopathic cervical dystonia.Neuropsychologia. 2007 Jun 11;45(10):2346-54. Epub 2007 Feb 20. 91. FIORIO M, STANZANI C, ROTHWELL JC, BHATIA KP, MORETTO G, FIASCHI A, TINAZZI M. Defective temporal discrimination of passive movements in Parkinson's disease.Neurosci Lett. 2007 May 7;417(3):312-5. 92. SMANIA N, PAOLUCCI S, TINAZZI M, BORGHERO A, MANGANOTTI P, FIASCHI A, MORETTO G, BOVI P, GAMBARIN M. Active finger extension: a simple movement predicting recovery of arm function in patients with acute stroke.Stroke. 2007 Mar;38(3):1088-90. 93. FIORIO M, VALENTE EM, GAMBARIN M, BENTIVOGLIO AR, IALONGO T, ALBANESE A, BARONE P, PELLECCHIA MT, BRANCATI F, MORETTO G, FIASCHI A, TINAZZI M. Subclinical sensory abnormalities in unaffected PINK1 heterozygotes.J Neurol. 2008 Jul 3. [Epub ahead of print] 94 FIORIO M, GAMBARIN M, DEFAZIO G, VALENTE EM, STANZANI C, MORETTO G, LOI M, SOLIVERI P, NARDOCCI N, ALBANESE A, FIASCHI A, TINAZZI M. Impaired body movement representation in DYT1 mutation carriers.Clin Neurophysiol. 2008 Aug;119(8):1864-9. Epub 2008 Jun 19. 95. 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