Presentazione di PowerPoint - ANDI

STILI DI VITA, ALIMENTAZIONE &
SALUTE ORALE.
Stili di vita e di alimentazione come fattori di rischio per la salute
orale e salute orale come fattore determinante della qualità di vita .
ALIMENTAZIONE E SALUTE ORALE
Prof. Michele Davide Mignogna
Oral Cancer and Nutrition
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6 STUDI DI COORTE + 40 STUDI CASO-CONTROLLO
FRUTTA E VEGETALI SONO INVERSAMENTE PROPORZIONALI AL RISCHIO OSCC
RISCHIO CORRELATO ALLA DIETA: 20-25%
RISCHIO CORRELATO ALLA DIETA + FUMO/ALCOOL: 85-95%
FUMATORI E ALCOLISTI RIDUCONO ASSUNZIONE DI FRUTTA E VERDURA
L’AZIONE PROTETTIVA DI FRUTTA E VERDURA E’ ATTRIBUITA ALLA PRESENZA DI
MICRONUTRIENTI E FIBRE CON UNA POTENTE AZIONE ANTIOSSIDANTE
① PIGMENTI VEGETALI (FLAVONOIDI E POLIFENOLI)
② VITAMINE: BETA-CAROTENE, VITAMINA C, VITAMINA E
③ ENZIMI E MINERALI (COENZIMA Q10, SELENIO, ZINCO, RAME)
CEREALI E OSCC: L’ASSUNZIONE DI CEREALI NON RAFFINATI, RICCHI DI FIBRE, E’ INVERSAMENTE
PROPORZIONALE AL RISCHIO DI SVILUPPARE OSCC
I CEREALI INTEGRALI CONDIVIDONO CON LA FRUTTA E VEGETALI
MOLTI MICRONUTRIENTI E MINERALI (ANTIOSSIDANTI)
I CEREALI RAFFINATI VENGONO ASSORBITI MOLTO PIU’ VELOCEMENTE DEI CEREALI INTEGRALI
GLICEMIA
INSULINA
IGF-I : POTENTE AGENTE MUTAGENO IN VITRO
NON C’E’ CONSENSUS IN LETTERATURA SULLA
CORRELAZIONE TRA ASSUNZIONE DI
CARNI ROSSE E MAGGIOR RISCHIO DI SVILUPPARE OSCC
GRASSI, COLESTEROLO, AMINE ETEROCICLICHE
GLOBAL INCIDENCE OF
ORO-PHARYNGEAL CANCER
Sixth most common cancer in the world
Annual incidence: 275,000 for oral cancer
Annual incidence: 130,300 for pharyngeal cancer, excluding nasopharynx
Incidence of Oral Cancer in European
Countries
Highest rates were observed in 3 developing
countries (Pakistan, Brazil, and India) and in 1
developed country (France). A higher proportion of
clinically diagnosed cases is observed in both lowand middle-income countries and in developed
countries in low- and middle-income categories
A study are from population-based cancer registries that participated in the Cancer
Incidence in Five Continents on 108,780 cases of OCC
de Camargo Cancela M, Voti L, Guerra-Yi M, Chapuis F, Mazuir M, Curado MP.
Oral cavity cancer in developed and in developing countries: Populationbased incidence. Head Neck. 2009 Jul 30
The most common anatomic location was oral tongue (n = 44,072; 41%)
followed by floor of mouth and unspecified parts of mouth (21.1% and 20.5%,
respectively). Oral tongue tumors were predominant in all regions except in
South Central Asia, where oral mucosa represents 41% of all tumors. The
highest proportion of tumors of the floor of mouth was observed in Eastern and
Western Europe (31%)
INDIA –SUD EST ASIA
> 30 per 100.000
oral carcinoma represents about
40% of all tumors
WHO-EM/NCD/060/E Towards a strategy for cancer control in the Eastern
Mediterranean Region 2009
BUT…
the majority of oral cancers present at an advanced
stage (III and IV) and the overall percentage of oral
cancers that are localized when diagnosed is very
similar to that of colon cancers (36%), even though
Oral cancer is an
ideal cancer to identify early by screening.
It is frequently preceded by an identifiable pre-malignant lesion
The progression from dysplasia occurs over a period of 2,5-8 years
PMD and diagnostic tools
National Project on Early Detection of Oral Cancer
“5 minuti per salvare una vita”
Prof. Michele D. Mignogna, Dott.ssa Stefania Leuci
UNIVERSITA’ DEGLI STUDI DI NAPOLI “Federico II”
Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche
DAI di Patologia Testa/collo
Unità Operativa Complessa di Medicina Orale
Tobacco is deadly in any form or disguise
Cigarette, cigar, pipe smoking and smokeless tobacco are all
are causes of oral cancer.
On average current smokers have a three-fold increased risk
of oral cancer
GRAZIE PER L’ATTENZIONE
Michele Davide Mignogna