Curriculum del docente

CURRICULUM VITAE ET STUDIORUM
Name: Giulia De Falco
e-mail: [email protected]
EDUCATION
 1993: Degree in Biology, at the University “Federico II” of Naples, Italy, Magna cum
Laude.
 30/6/96-6/7/96: Participated in a lecture course on “Integration of signaling pathways in
the control of the cell fate” - Cividale del Friuli, Italy.
 2000-2004: Ph.D. in Diagnostic and Molecular Pathology at the University of Siena,
Italy.
 21-23/04/2008: GeneSpring Training Course, EMBL Heidelberg, Germany.
 30/09/09-01/10/09: Practical course on high-throughput microRNA profiling, arranged
by Tecan and Exiqon, Salzburg, Austria.
 2011-present: Post-graduate Specialization School in Medical Genetics, at the
University of Siena, Italy.
AWARDS
 1/1/94-31/12/94: Fellowship from CNR (National Council for Research) on the
isolation of opioid from mammalians.
 1995-1997: Three-year fellowship from AIRC (Italian Association for Cancer
Research) to study IL-6 signal transduction.
 2/3/96: Fellowship for cancer research from “Sen Pascale” of Naples, Italy.
 5/1/98-12/31/98: Fellowship from University of Naples (Italy) “Federico II” to study
the cell cycle.
 1998-2000: Two-year fellowship for AIDS research from the Italian Ministry of Health.
 05/2000-11/2000: Fellowship from Science and Technology Park at the Institute of
Farmacology and Toxicology of the Second University of Naples, to study antisense
oligonucleotides with antiproliferative effect.
 2001: UICC Fellowship for Technology Transfer from the International Union against
Cancer.
 2002: Grant for Young Researchers by the University of Siena, Italy.
 2003: Fellowship “Rocco D’Amelio” from SHRO, Temple University, Philadelphia,
PA USA.
 2003: SHRO/Rocco D’Amelio and Family Fellowship for biomedical and cancer
research, at Temple University, Philadelphia PA.
 2005-2007: Post-Doctoral fellowship at the Department of Human Pathology and
Oncology, University of Siena.
 2007-2011: Research Fellowship at the Department of Human Pathology and
Oncology, University of Siena.
PROFESSIONAL EXPERIENCE
 1991/93: Internship at the Organic and Biological Chemistry Department of the Faculty
of MM.FF.NN. Sciences, University Federico II of Naples.
 15/3/1993-14/9/1993: Post degree elective at the Institute of Macromolecule
Biochemistry of the Medical School of the Second University of Naples.
 15/9/93-14/3/94: Post degree elective at the Department of Organic and Biological
Chemistry of the Faculty of sciences of the University “Federico II” of Naples.
 1994-96: Fellow at the University of Naples, Biochemistry Dept., Italy.
 1996-1999: Fellow at the department of “Pathology, Anatomy & Cell Biology”,
Jefferson Medical College, Thomas Jefferson University, Philadelphia PA, USA.
 2000-2004: Ph.D. Student at the University of Siena, Italy.
 2004-2007: Post-Doc at the Department of Human Pathology and Oncology, University
of Siena, Italy.
 2005: Post-Doc at the Institute of Pathology, Charite’, Campus Benjamin Franklin, Free
University of Berlin, Germany.
 2005-2007: Assistant Professor at the Department of Biology, Temple University,
Philadelphia PA, 19122, USA.
 2007- present: Research Assistant at the Department of Human Pathology and
Oncology, University of Siena, Italy.
 2011-present: Post-graduate Specialization School in Medical Genetics, at the
University of Siena, Italy.
 2012-present: Researcher at the Department Medical Biotechnologies, University of
Siena, Italy.
EXPERIENCE ABROAD
1996-1999: Fellow at the Department of “Pathology, Anatomy & Cell Biology”, Thomas
Jefferson University, Philadelphia, PA (USA);
2001: Fellow at the Department of “Pathology, Anatomy & Cell Biology”, Thomas
Jefferson University, Philadelphia, PA (USA);
2003: Fellow at the Department of “Biology”, Temple University, Philadelphia, PA (USA);
2005: Post-Doctoral Fellow at the Institute of “Pathology”, Charitè University, Berlin;
2005-2007: Assistant Professor at the Department of “Biology” Temple University,
Philadelphia, PA (USA);
TEACHING EXPERIENCE
2005-2007: Assistant Professor at the Department of Biology, Temple University,
Philadelphia PA, 19122, USA.
2005-present: Lecturer for Academic Courses of Molecular Pathology of the Medical
College and the Biotechnology Degree, at the University of Siena, Italy.
2007-present: Coordination of undergraduate and PhD students for the Pathology program
of the University of Siena, Italy.
2009-2010: Lecturer for the Molecular Biology Course of the Biotechnology Degree,
University of Siena, Italy.
2012-present: Teacher of the “Nucleic Acid Detection Methods” course, Degree in
Medical Biotechnology, University of Siena.
2013: Teacher at the Master Degree “Tecniche di diagnostica macroscopica, istologica e
molecolare applicate alla anatomia patologica”, University of Siena.
PUBLICATIONS
1. M.R. Ruocco, X. Chen, C. Ambrosino, E. Dragonetti, W. Liu, M. Mallardo, G. De
Falco, G. Franzoso, I. Quinto, S. Venuta and G. Scala. Regulation of HIV-1 Long Terminal
Repeat by interaction of C/EBP (NF-IL6) and NF-kB/Rel Transcription Factors” - (1996) J
Biol Chem 271:22479-22486.
2. V.Giordano, G. De Falco, C. Ambrosino, M.R. Ruocco, I. Quinto, P.G. Pelicci, P. Del
Mastro and G. Scala. Interleuchin-6 induces the association of SHC with gp130 and Jak2
through different tyrosine-binding domains. (1997) J Immunology 158:4097-5103.
3. G. De Falco and A. Giordano. CDK9 (PITALRE): a multifunctional cdc2-related
kinase. (1998) J Cell Physiol, 177:501-506.
4. Romano G., Kasten M., De Falco G., Micheli P. Khalili K. and Giordano A.
Regulatory functions of Cdk9 and of cyclin T1 in HIV Tat transactivation pathway gene
expression. (1999) J Cell Biochem, 75:357-368.
5. G. De Falco, L. Bagella, P.P Claudio, A. De Luca, Y. Fu, B. Calabretta, A. Sala and A.
Giordano: Physical interaction between CDK9 and B-Myb results in suppression of B-Myb
gene autoregulation. (2000) Oncogene, 19:373-379.
6. Zini N., Trimarchi C., Claudio P.P., Stiegler P., Marinelli F., Maltarello M.C., La Sala
D., De Falco G., Russo G., Ammirati G., Maraldi N.M., Giordano A. and Cinti C.
pRb2/p130 and p107 control cell growth by multiple strategies and in association with
different compartments within the nucleus. (2001) J Cell Physiol, 189:34-44.
7. De Falco M, Laforgia V, Fedele V, De Luca L, Cottone G, De Falco G and De Luca A.
Vasoactive intestinal peptide stimulation modulates the expression of Bcl-2 family
members in the adrenal gland of the lizard Podarcis sicula. (2001) Histochem J, 33:639-45.
8. Bellan C., De Falco G., Tosi G.M., Lazzi S., Ferrari F., Morbini G., Bartolommei S.,
Toti P., Mangiavacchi P., Cevenini G., Trimarchi C., Cinti C., Giordano A., Leoncini L.,
Tosi P. and Cottier H. Missing expression of pRb2/p130 in human retinoblastomas is
associated with reduced apoptosis and lesser differentiation. (2002)Invest Ophthalmol Vis
Sci. 43:3602-8.
9. De Falco G. and Giordano A. CDK9: from basal transcription to cancer and AIDS.
(2002) Cancer Biol Ther 1:342-7.
10. Lazzi S., Bellan C., De Falco G., Cinti C., Ferrari F., Nyongo A., Claudio P.P., Tosi
G.M., Vatti R., Gloghini A., Carbone A., Giordano A., Leoncini L. and Tosi P. Expression
of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas:
implications for disease pathogenesis. (2002) Hum Pathol 33:723-31.
11. Simone C., Stiegler P., Bagella L., Pucci B., Bellan C., De Falco G., De Luca A.,
Guanti G., Puri P.L. and Giordano A. Activation of MyoD-dependent transcription by
cdk9/cyclin T2. (2002) Oncogene 21:4137-48.
12. De Falco G., Neri L.M., De Falco M., Bellan C., Yu Z., De Luca A., Leoncini L. and
Giordano A. Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the
receptor of the IL-6 family of cytokines. (2002) Oncogene. 21:7464-70.
13. Bellan C., Lazzi S., De Falco G., Nyongo A., Giordano A., Leoncini L. Burkitt's
lymphoma: new insights into molecular pathogenesis. (2003) J Clin Pathol. 56:188-92.
14. De Falco, G., Bellan, C., Lazzi, S., Claudio, P.P., La Sala, D., Cinti, C., Tosi, P.,
Giordano, A. and Leoncini L. Interaction between HIV-1 Tat and pRb2/p130: a possible
mechanism in the pathogenesis of AIDS-related neoplasms. (2003) Oncogene. 22:6214-9.
15. Bellan C., De Falco G., Lazzi S. and Leoncini L., Pathogenetic aspects of AIDS-related
malignancies. (2003) Oncogene 22:6639-45.
16. Bellan C., De Falco G., Lazzi S., Schuerfeld K., Micheli P., Bartolommei S., Vestri M.,
Nyongo A., Pileri S., Leoncini L., Tosi P. and Giordano A. Cdk9/Cyclin T expression in
reactive lymph nodes and malignant lymphomas. (2004) The Journal of Pathol 203:946952.
17. De Falco G., Bellan C., D’Amuri A., Angeloni G., Giordano A. and Leoncini L.: Cdk9
regulates neural differentiation and its expression correlates with the differentiation grade
of PNET tumors. (2005) Cancer Biol Therapy 4:277-81.
18. Florio P, Torricelli M, Galleri L, De Falco G, Leucci E, Calonaci G, Picciolini E,
Ambrosini G, Linton EA, Petraglia F. High fetal urocortin levels at term and preterm labor.
(2005) J Clin Endocrinol Metab. 90:5361-5.
19. P. Vogiatzi and G. De Falco: Commentary: Gene expression profiles of serous,
endometrioid, and clear cell subtypes of ovarian and endometrial cancer. Zorn KK,
Bonome T, Gangi L, Chandramouli GV, Awtrey CS, Gardner GJ, Barrett JC,Boyd J, Birrer
MJ. Clin Cancer Res 2005; 11:6422-30. (2005) The Women’s Oncology Review, 5:219 –
221.
20. Vogiatzi P, De Falco G, Claudio PP, Giordano A. How Does the Human RUNX3 Gene
Induce Apoptosis in Gastric Cancer? Latest Data, Reflections and Reactions. (2006)
Cancer Biol Ther. 5: 371-4.
21. Florio P, De Falco G, Leucci E, Torricelli M, Torres PB, Toti P, Dell’Anna A,
Santopietro R, Pecciarini L, Leoncini L and Petraglia F: Urocortin expression is
downregulated in human endometrial carcinoma. (2006) J Endocrinol. 190:99-105.
22. Florio P, Torricelli M, De Falco G, Leucci E, Giovannelli A, Gazzolo D, Severi FM,
Bagnoli F, Leoncini L, Linton EA, Petraglia F. High maternal and fetal plasma urocortin
levels in pregnancies complicated by hypertension. (2006) J Hypertens. 24:1831-1840.
23. G De Falco and A Giordano. pRb2/p130: a new candidate in retinoblastoma tumor
formation. (2006) Oncogene, 25:5333-40.
24. G. De Falco, F. Comes and C. Simone: pRb master of differentiation: Coupling
irreversible cell cycle withdraw to induction of muscle-specific transcription. (2006)
Oncogene, 25:5244-9.
25. Leoncini L, Bellan C and De Falco G.: Retinoblastoma gene family expression in
lymphoid tissues. (2006) Oncogene, 25:5309-14.
26. Caracciolo V, Reiss K, Khalili K, De Falco G and Giordano A.: Role of the interaction
between large T antigen and Rb family members in the oncogenicity of JC virus. (2006)
Oncogene, 25:5294-301.
27. Nyagol J, Leucci E, Onnis A, De Falco G, Tigli C, Sanseverino F, Torriccelli M,
Palummo N, Pacenti L, Santopietro R, Spina D, Gichangi P, Muchiri L, Lazzi S, Petraglia
F, Leoncini L, Giordano A. The Effects of HIV-1 Tat Protein on Cell Cycle during Cervical
Carcinogenesis (2006) Cancer Biol Ther, 5:684-90.
28. Roviello F, Corso G, Pedrazzani C, Marrelli D, De Falco G, Berardi A, Garosi L,
Suriano G, Vindigni C, De Stefano A, Leoncini L, Seruca R, Pinto E. Hereditary diffuse
gastric cancer and E-cadherin: Description of the first germline mutation in an Italian
family (2007) Eur J Surg Oncol, 33:448-51.
29. Torricelli M, De Falco G, Florio P, Rossi M, Leucci E, Viganò P, Leoncini L, Petraglia
F: Secretory endometrium highly expresses urocortin mRNA and peptide: possible role in
the decidualization process. (2007) Hum Reprod, 22:92-96.
30. Eleonora Leucci, Anna Onnis, Giulia De Falco, Anna Luzzi, Giovanna Cerino,
Antonio Giordano and Lorenzo Leoncini. Silencing human Rb2/p130 with shRNA. (2007)
Cellular Oncology 29:265-8.
31. Eleonora Leucci, Giulia De Falco, Anna Onnis, Giovanna Cerino, Mario Cocco, Anna
Luzzi, Domenica Crupi, Chiara Tigli, Cristiana Bellan, Piero Tosi, Lorenzo Leoncini and
Antonio Giordano. The role of the Cdk9/Cyclin T1 complex in T cell differentiation.
(2007) J Cell Physiol, 212:411-5.
32. Michela Torricelli, Alessia Giovannelli, Eleonora Leucci, Giulia De Falco, Fernando
M. Reis, Alberto Imperatore, Pasquale Florio and Felice Petraglia. Labor (term and
preterm) is associated with changes in the placental mRNA expression of CRF. (2007)
Reprod Sci. 14:241-5.
33. Michela Torricelli, Alessia Giovannelli, Eleonora Leucci, Pasquale Florio, Giulia De
Falco, Paulo B. Torres, Fernando Reis, Lorenzo Leoncini and Felice Petraglia. Placental
Neurokinin B mRNA expression increases at preterm labor. Placenta, (2007) 28:1020-3.
34. G. De Falco, E. Leucci, D. Lenze, P.P. Piccaluga, P.P. Claudio, A. Onnis, G. Cerino, J.
Nyagol, W. Mwanda, C. Bellan, M. Hummel, S. Pileri, P. Tosi, H. Stein, A. Giordano and
L. Leoncini: Gene expression analysis identifies novel RBL2/p130 target genes in endemic
Burkitt’s lymphoma cell lines and primary tumors. Blood, (2007) 110:1301-7.
35. Bardelli M, Leucci E, Schurfeld K, Bellan C, Passiatore G, Rocchigiani M,
Bartolommei S, Orlandini M, Zagursky J, Lazzi S, De Falco G, Tosi P, Oliviero S,
Leoncini L. VEGF-D is expressed in activated lymphoid cells and in tumors of
hematopoietic and lymphoid tissues. Leukemia & Lymphoma (2007) 48:2014-21.
36. Roviello F, Corso G, Pedrazzani C, Marrelli D, De Falco G, Berardi A, Garosi L,
Suriano G, Vindigni C, De Stefano A, Leoncini L, Seruca R, Pinto E. Family history of
gastric cancer in a high incidente Italian area. Oncology (2007) 72:243-7.
37. G. De Falco, E. Leucci, A. Onnis, C. Tigli, S. Wirths, M. Cocco, C. Bellan, A. De
Luca, A. Lanzavecchia, A. Giordano and L. Leoncini. Cdk9/Cyclin T1 expression during
normal lymphoid differentiation and malignant transformation. J Cell Physiol (2008)
215:276-82.
38. C. Giacinti, A. Musarò, G. De Falco, I. Jourdane, L. Bagella, M. Molinaro, C. Simone
and A. Giordano. Cdk9-55: a new player in muscle regeneration. J Cell Physiol (2008)
216:576-82.
39. Leucci E, Cocco M, Onnis A, De Falco G, van Cleef P, Bellan C, van Rijk A, Nyagol J,
Byakika B, Lazzi S, Tosi P, van Krieken H, Leoncini L. MYC-negative classical Burkitt
Lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation. J
Pathol (2008) 216:440-50.
40. Nyagol J., De Falco G., Palummo N., Shaheen S., Bellan C., Lazzi S., Spina D.,
Leoncini L. HIV-1 Tat increases micro vessels density independently of VEGF expression
in AIDS-related Diffuse Large B-Cell and Burkitt lymphomas. J Hematopathology
(2008),1:3-10.
41. Stefano Lazzi, Cristiana Bellan, Anna Onnis, Giulia De Falco, Shaheen Sayed, Ioannis
Kostopoulos, Monica Onorati, Alessandro D’Amuri, Rosa Santopietro,Carla Vindigni,
Alberto Fabbri, Piero Tosi and Lorenzo Leoncini. Rare Lymphoid Neoplasms Coexpressing B and T-cell Antigens. The Role of Pax-5 Gene Methylation in their
Pathogenesis. Hum Pathol (2009), 40:1252-61.
42. Giulia De Falco, Giuseppina Antonicelli, Anna Onnis, Cristiana Bellan, Stefano Lazzi
and Lorenzo Leoncini. Role of EBV in microRNA dysregulation in Burkitt lymphoma.
Seminars in Cancer Biology 2009, 19:401-6.
43. Leucci E, Onnis A, Cocco M, De Falco G, Costanzo V, Bellan C, Lazzi S and Leoncini
L. Altered hsa-miR-127 expression impairs terminal B cell differentiation in EBV-positive
Burkitt lymphoma. Int J Cancer (2010), 126:1316-26.
44. Alessandro Carugi, Anna Onnis, Giuseppina Antonicelli, Benedetta Rossi, Susanna
Mannucci, Anna Luzzi, Stefano Lazzi, Cristiana Bellan, Gian Marco Tosi, Giulia De Falco
and Lorenzo Leoncini. Geographic variation and environmental conditions as cofactors in
Chlamydia psittaci association with ocular adnexal lymphomas: a comparison between
Italian and African samples. Hematological Oncology (2010), 28:20-6.
45. Paola Indovina, Antonio Acquaviva, Giulia De Falco, Francesca Giorgi, Anna Luzzi,
Anna Onnis, Paolo Toti, Alessandro Carugi and Antonio Giordano. Down-regulation and
aberrant promoter methylation of p16INK4a: a possible novel heritable susceptibility
marker to retinoblastoma. J of Cell Physiol (2010), 223:143-50.
46. Nagaja Capitani, Orso Maria Lucherini, Elisa Sozzi, Micol Ferro, Nico Giommoni,
Francesca Finetti, Giulia De Falco, Emanuele Cencini, Pier Giuseppe Pelicci, Francesco
Lauria, Francesco Forconi, Cosima T. Baldari. Impaired expression of p66Shc, a novel
regulator of B-cell survival, in chronic lymphocytic leukemia. Blood (2010), 115:3726-36.
47. Anna Onnis, Giulia De Falco, Giuseppina Antonicelli, Monica Onorati, Benedetta
Rossi, Cristiana Bellan, Joshua Nyagol, Bessie Byakika and Lorenzo Leoncini. microRNA
altered expression as an alternative mechanism of MYC dysregulation in aggressive B-cell
lymphoma. PloS ONE (2010), 5:piie12960.
48. E. Rogena, S. Lazzi, G. De Falco, M. R. Ambrosio, M. Onorati, B. J. Rocca, C. Bellan,
PP. Piccaluga, P.Pileri and L. Leoncini. Burkitt lymphoma, fifty years plus: the beginning
and the future. Pathologica, (2010), 102:187-188.
49. Cristiana Bellan, Stefano Lazzi, Giulia De Falco, Emily A. Rogena and Lorenzo
Leoncini. Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach.
Hematological Oncology (2010), 28:53-56.
50. Emily Rogena, Giulia De Falco and Lorenzo Leoncini. A review of the trends in
lymphomas: from north to south of the equator. Hematol Oncol (2011), 29:111-115.
51. Pier Paolo Piccaluga, Giulia De Falco, Manjunath Kustagi, Anna Gazzola, Annalisa
Astolfi, Anna Onnis, Eleonora Leucci, Maria Rosaria Sapienza, Valeria Calbi, Michael
Mawanda, Lynnette Tumwine, Claudio Agostinelli, Cristiana Bellan, Stefano Lazzi,
Claudio Tripodo, Martin Ogwang, Andrea Califano, Riccardo Dalla Favera, Stefano A
Pileri and Lorenzo Leoncini. Gene expression analysis uncovers similarity and differences
in endemic and sporadic Burkitt lymphomas molecular profiles. Blood (2011), 117:3596608.
52. Giulia De Falco, Emily Rogena and Lorenzo Leoncini: Infectious agents and
lymphoma. Seminars in Diagnostic Pathology (2011), 28:178-187.
53. Dido Lenze, Lorenzo Leoncini, Michael Hummel, Stefano Volinia, Chang Gong Liu,
Teresa Amato, Giulia De Falco, Jessie Githanga, Heike Horn, Joshua Nyagol, German Ott,
Jeff Pallatini, Michael Pfreundschuh, Emily Rogena, Andreas Rosenwald, Reiner Siebert,
Carlo M Croce, Harald Stein. The different epidemiologic subtypes of Burkitt Lymphoma
share a largely homogenous micro RNA profile distinct from diffuse large B-cell
lymphoma. Leukemia (2011), 25:1869-1876.
54. Martina Cozzi, Francesca Giorgi, Eleonora Marcelli, Francesca Pentimalli, Iris Maria
Forte, Silvia Schenone, Vittorio D’Urso, Giulia De Falco, Maurizio Botta, Antonio
Giordano and Paola Indovina. Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC
kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition.
Cell Cycle (in press).
55. Michela Torricelli, Romina Novembri, Nathalie Conti, Giulia De Falco, Maria De
Bonis, Felice Petraglia. Correlation with placental Kisspeptin in post term pregnancy and
apoptosis. Reproductive Sciences (2012), 19:1133-7.
56. Susanna Mannucci, Anna Luzzi, Alessandro Carugi, Alessandro Gozzetti, Valeria
Malagnino, Lorenzo Leoncini, Cornelia van den Bosch and Giulia De Falco. Euphorbia
tirucalli as a possible cofactor in inducing EBV-driven malignant transformation. Advances
in Heamatology, (2012), 2012:149780.
57. Ambrosio MR, Rocca BJ, Giulia De Falco, Pier Paolo Piccaluga, Onorati M, Ogwang
M, Calbi V, Naresh KN, Doglioni C, Leoncini L, Lazzi S. Adipophilin, a novel marker
useful in the diagnosis of Burkitt lymphoma. PlosONE (2012), 7:e44315.
58. Anna Onnis, Mohsen Navari, Giuseppina Antonicelli, Federica Morettini, Susanna
Mannucci, Giulia De Falco, Elena Vigorito and Lorenzo Leoncini. Epstein-Barr Nuclear
Antigen-1 induces the expression of the cellular microRNA hsa-miR-127 and B-cell
differentiation impairment of EBV-infected memory B cells. New insights in the
pathogenesis of Burkitt Lymphoma. Blood Cancer Journal (2012), Aug 31;2:e84.
59. Maria Teresa Savino, Cristina Ulivieri, Giacomo Emmi, Domenico Prisco, Giulia De
Falco, Barbara Ortensi, Enrico Beccastrini, Lorenzo Emmi, Giuliana Pelicci, Mario Milco
D'Elios, Cosima T. Baldari The Shc family protein adaptor, Rai, acts as a negative regulator
of mouse Th17 cell development. Journal of Leukocyte Biology, J Leukoc Biol. 2013 Jan
23. [Epub ahead of print].
60. A. Onnis, G. De Falco, E. Rogena, F. Morettini, C. Bellan, L. Leoncini. MicroRNA
expression profile identifies a different signature between MYC translocation-positive and
negative Burkitt Lymphoma cases. (Submitted to the Journal of Pathology).
61. Anna Luzzi, Federica Morettini, Anna Onnis, Cristiana Bellan and Lorenzo Leoncini
and Giulia De Falco. microRNA modulation in HIV-associated malignancies. (Submitted).
CAPITOLI DI LIBRI
1. Giulia De Falco, Catherine Soprano and Antonio Giordano. Chapter I: Cdk inhibitors:
Background and introduction. Cell cycle inhibitors in cancer therapy. Humana press.
2. Antonio Giordano, Giulia De Falco, Emanuel Rubin, Raphael Rubin. Chapter VI:
Neoplasia. Rubin’s Pathology (Edition 2007). Lippincott Williams & Wilkins.
3. Giulia De Falco, Donatella Cirillo, Annamaria Rachiglio, Antonio Giordano: I
microRNA nella diagnostica molecolare. (2008). 4° Volume Educazionale GOIM.
4. Giulia De Falco, Cristiana Bellan, Stefano Lazzi and Lorenzo Leoncini. Chapter 17:
HIV-related lymphoma. In Viral Oncology: Basic Science and Clinical Applications, Ed.
Khalili and Jeang KT. John Wiley & Sons (2010).
5. Giulia De Falco, Emily A. Rogena, Kikkeri Naresh, Martine Raphael, Ian Magrath and
Lorenzo Leoncini. Managing lymphomas in the African settings: Improving diagnostic
accuracy and carrying out research projects. INCTR Book.
6. Giulia De Falco and Alessandro Davide Videtta: “Clinical criterion to define familial
gastric cancer” in Springer familial gastric cancer, Springer (in press).
7. Giulia De Falco and Cornelia A. Van den Bosch: “Infectious agents and lymphomas”,
in Aggressive B-celll lymphomas: from molecular biology to target therapy, Research
Signpost (in press).
ABSTRACTS PUBBLICATI SU RIVISTA (2005-ad oggi)
1. De Falco G, Leucci E, Onnis A, Tigli C, Cocco M, Bellan C, Giordano A and Leoncini
L. CDK9/Cylin T1 expression during normal lymphoid differentiation and malignant
transformation. 20th European Congress of Pathology (ECP), Paris, France, September 3-8
2005. Virchows Arch (2005) 447:pag.271.
2. Nyagol J, Leucci E, Castagnini M, Cocco M, Onnis A, Tigli C, De Falco G,
Santopietro R, Giordano A and Leoncini L. New insight into the effect of HIV on HPVinfected cells. 20th European Congress of Pathology (ECP), Paris, France, September 3-8
2005. Virchows Arch (2005) 447:pag.468.
3. G. De Falco, G. Cerino, E. Leucci, J. Nyagol, M. Cocco, A. Onnis, P. Tosi and L.
Leoncini. Role of chromatin remodelling mediated by the HIV-1 Tat protein in the genesis
of HIV-associated malignancies. International Meeting for the 50th anniversary for the
discovery of Burkitt lymphoma, February 25-27 2008 Kampala, Uganda. J.
Hematopathology (2008), 1: pag. 11.
4. Nyagol J, De Falco G, Palummo N, Shaheen S, Bellan C, Lazzi S, Spina D, Giordano
A and Leoncini L. International Meeting for the 50th anniversary for the discovery of
Burkitt lymphoma, February 25-27 2008 Kampala, Uganda. HIV-1 Tat increases micro
vessels density independently of VEGF expression in AIDS-related diffuse large B-cell and
Burkitt’s lymphomas. J. Hematopathology (2008), 1: pag. 11.
5. Leucci E, Cocco M, Onnis A, van Cleef P, Bellan C, van Rijk A, De Falco G, Nyagol J,
Byakika B, Lazzi S, Tosi P, van Krieken J and Leoncini L. International Meeting for the
50th anniversary for the discovery of Burkitt lymphoma, February 25-27 2008 Kampala,
Uganda. C-MYC negative classical Burkitt lymphoma: alternative pathogenetic
mechanisms. J. Hematopathology (2008), 1: pag. 12.
6. Leucci E, De Falco G, Onnis A, Roberti A, Guzzo A, Leoncini L and Giordano A.
International Meeting for the 50th anniversary for the discovery of Burkitt lymphoma,
February 25-27 2008 Kampala, Uganda. Burkitt lymphoma: Role of pRB2/p130
inactivation during lymphomagenesis. J. Hematopathology (2008), 1: pag. 14.
7. Leucci E, Onnis A, Cocco M, Costanzo V, De Falco G, Bellan C and Leoncini L.
International Meeting for the 50th anniversary for the discovery of Burkitt lymphoma,
February 25-27 2008 Kampala, Uganda. Hsa-miR-127 is implicated in B-cell
differentiation and its expression is altered in Burkitt’s lymphoma. J. Hematopathology
(2008), 1: pag. 14.
8. Bellan C, Lazzi S, Cocco M, Amato T, De Falco G, Leucci E, Antonicelli G, Palummo
N, Mannucci S, Tosi P, Piris M and Leoncini L. International Meeting for the 50th
anniversary for the discovery of Burkitt lymphoma, February 25-27 2008 Kampala,
Uganda. expression in endemic Burkitt’s lymphoma. Correlation with EBV status and IGH
mutation pattern. J. Hematopathology (2008), 1: pag. 15.
9. Roberti A, De Falco G, Leucci E, Cerino G, Carugi A, Macaluso M, de Leval L,
Leoncini L and Giordano A. International Meeting for the 50th anniversary for the
discovery of Burkitt lymphoma, February 25-27 2008 Kampala, Uganda. Epigenetic
silencing of p16 and p21 in GAL-01 sporadic Burkitt lymphoma cell line. J.
Hematopathology (2008), 1: pag. 15.
10. Stein H, Bentink S, Spang R, Lenze D, De Falco G, Bellan C, Cocco M, Iriso R,
Leoncini L and Hummel M. International Meeting for the 50th anniversary for the
discovery of Burkitt lymphoma, February 25-27 2008 Kampala, Uganda. Transcriptional
gene expression profiling of sporadic and endemic Burkitt lymphomas in relation to other
types of aggressive B-cell lymphomas. J. Hematopathology (2008), 1: pag. 15.
11. Piccaluga PP, De Falco G, Califano A, Leucci E, Roberti A, Lukande R, Tumwine L,
Iriso R, Lucchetti C, Giordano A, Pileri SA and Leoncini L. International Meeting for the
50th anniversary for the discovery of Burkitt lymphoma, February 25-27 2008 Kampala,
Uganda. RBL2 network in endemic Burkitt lymphoma explored by gene expression
analysis. J. Hematopathology (2008), 1: pag. 16.
12. De Falco G., Cerino G, Leucci E, Nyagol J, Cocco M, Onnis A, Tosi P, Giordano A
and Leoncini L. Role of chromatin remodelling mediated by the HIV-1 Tat protein in the
genesis of HIV-1-associated malignancies. 3rd Intercontinental Congress of Pathology, May
17-22, 2008 Barcelona.Virchows Archiv (2008) Suppl:S1-S286, pag. S-43.
13. De Falco G, Cerino G, Luzzi A, Pasquarella A, Morettini F, Imperatore F, Tosi P and
Leoncini L. Role of chromatin remodelling mediated by the HIV-1 Tat protein in the
genesis of HIV-associated malignancies. XIV Meeting of the European Association for
Haematopathology (EAHP), September 20-25 2008, Bordeaux, France. J. Hematopathol
(2008), 1:75, pag. 184.
14. Carugi A, Onnis A, Luzzi A, Tosi GM, Bellan C, Cocco M, De Falco G, Giordano A
and Leoncini L. Chlamydia infection and the development of the ocular adnexal
lymphomas. XIV Meeting of the European Association for Haematopathology (EAHP),
September 20-25 2008, Bordeaux, France. J. Hematopathol (2008), 1:75, pag. 204.
15. Cocco M, Mannucci S, Antonicelli G, Carugi A, Luzzi A, De Falco G, Leoncini L and
van den Bosch CA. Euphorbia tirucalli as a possible cofactor in inducing EBV-driven
malignant transformation. XIV Meeting of the European Association for
Haematopathology (EAHP), September 20-25 2008, Bordeaux, France. J. Hematopathol
(2008), 1:75, pag. 205.
16. Leucci E, Cocco M, Onnis A, van Cleef P, Bellan C, Van Rijk A, De Falco G, Nyagol
J, Byakika B, Lazzi S, Tosi P, van Krieken H and Leoncini L. MYC translocation-negative
classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving
miRNA deregulation. XIV Meeting of the European Association for Haematopathology
(EAHP), September 20-25 2008, Bordeaux, France. J. Hematopathol (2008), 1:75, pag.
207.
17. Leucci E, Onnis A, Cocco M, De Falco G, Costanzo V, Cerino G, Mannucci S,
Cantisani R, Nyagol J, Mwanda W, Iriso R, Schuerfeld K, Bellan C, Lazzi S and Leoncini
L. B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at the posttranscriptional level by miRNA altered expression. XIV Meeting of the European
Association for Haematopathology (EAHP), September 20-25 2008, Bordeaux, France. J.
Hematopathol (2008), 1:75, pag. 208.
18. Carugi A, Onnis A, Antonicelli G, Rossi B, Mannucci S, Luzzi A, Lazzi S, Bellan C,
Tosi GM, De Falco G and Leoncini L. Geographic variation and environmental conditions
as cofactors in Chlamydia psittaci association with ocular adnexal lymphomas: a
comparison between Italian and African samples. 22nd European Congress of Pathology
(ECP), Firenze, 4-9 Settembre 2009. Virchows Arch (2009) 455 (Suppl 1): S-444.
19. Onnis A, Antonicelli G, Lazzi S, De Falco G and Leoncini L. MYC dysregulation
relies on miRNA altered expression. 22nd European Congress of Pathology (ECP), Firenze,
4-9 Settembre 2009. Virchows Arch (2009) 455 (Suppl 1): S-444.
20. De Falco G, Luzzi A, Morettini F, Onnis A, Bellan C and Leoncini L. MicroRNA
deregulation in HIV-related lymphoid malignancies.22nd European Congress of Pathology
(ECP), Firenze, 4-9 Settembre 2009. Virchows Arch (2009) 455 (Suppl 1): S-445.
21. Leoncini L, Lazzi S, De Falco G, Bellan C, Onnis A and Mourmouras V. New
approaches to molecular classification of lymphomas. Intercongress meeting of the
European Association of Pathology (ESP), August 31- September 3 2010, Krakow, Poland.
Virchows Arch (2010) 457:pag.119.
22. De Falco G, Mannucci S, Carugi A, Luzzi A, Gozzetti A, Leoncini L and van den
Bosch CA. Euphorbia tirucalli as a possibile cofactor in inducine EBV-driven malignant
transformation. XXIII ECP, Helsinki (Finland), 27 August-1 September 2011.Virchows
Arch (2011) 459 (Suppl 1):S1-S329, pag S. 315.
23. De Falco G, Luzzi A, Morettini F, Pennacchio V, Onnis A, Bellan C and Leoncini L.
microRNA-induced DNA methyltransferase up-regulation leads to aberrant
hypermethylation in HIV-positive aggressive B-cell lymphomas. XXIII ECP, Helsinki
(Finland), 27 August-1 September 2011.Virchows Arch (2011) 459 (Suppl 1):S1-S329, pag
S. 315.
INVITED SPEAKERS AT INTERNATIONAL MEETINGS (2002-present)
o XI Meeting European Association for Haematopathology (EAHP), Siena, 26-30
Maggio 2002, con una relazione dal titolo “Cdk9, a member of the cdc2-like family of
kinases, binds to gp130, the receptor of the IL-6 family of cytokines”.
o XII Meeting of the European Association of Hematopathology (EAHP), September,
26 – October, 1, 2004, con una relazione dal titolo “Gene expression analysis of endemic
Burkitt’s lymphoma cell lines and primary tumors”.
o XXXI CONGRESSO Nazionale “L’Oncologia della nuova era: dalla qualità della
ricerca alla ricerca della qualità”, Trieste, 24-26 Novembre 2005.
o “First international Workshop on Viral Oncology Research (ICVOR)”, Padua,
April 27-29 2006, con una relazione dal titolo “Rb family and Cdks: a link between AIDS
and cancer”.
o AIEOP giugno 2007, Policlinico Le Scotte, Siena, con una relazione dal titolo
“pRb2/p130: a new candidate in the genesis of retino blastoma”.
o XXI ECP (European Congress of Pathology), September 8-13, 2007 Istanbul, Turkey,
con una relazione dal titolo “Gene expression analysis identifies novel RBL2/p130 target
genes in endemic burkitt’s lymphoma cell lines and primary tumors”.
o Congresso di Chirurgia Plastica, November 2007, Trieste, con una relazione dal titolo
“Skin Banks and the state of the art of Research in Europe and United States”.
o International Meeting for the 50th anniversary of the discovery of Burkitt
lymphoma. February 25-27 2008, Kampala, Uganda, con una relazione dal titolo “Role of
chromatin remodelling mediated by the HIV-1 Tat protein in the genesis of HIV-associated
malignancies”.
o 3rd Intercontinental Congress of Pathology, May 17-22, 2008 Barcelona, Spain, con
una relazione dal titolo “Role of chromatin remodeling mediated by the HIV-1 tat protein in
the genesis of HIV-associated malignancies”.
o INCTR Meeting, March 22-24 2009, Antalya, Turkey, con una relazione dal titolo
“HIV-1 as an oncogenic virus: host cell microRNA dysregulation in infected individuals”.
o II Mediterranean workshop: “Current Trends and advances in Oncopathology”. June
10-11, Gallipoli, con una relazione dal titolo “Markers and molecular biology: a revolution
in surgical pathology”.
o X Conferencia de Oncologia, June 18-21 2009, Habana Cuba, con una relazione dal
titolo “microRNA modulation in HIV-associated malignancies”.
o Intercongress meeting of the European Association of Pathology (ESP), August 31September 3 2010, Krakow, Poland, con una relazione dal titolo “Interplay between HIV
and microRNAs in AIDS-related lymphomas”.
o Intercongress meeting of the European Association of Pathology (ESP), August 31-
September 3 2010, Krakow, Poland, con una relazione dal titolo “Managing unusual
diseases in unusual settings: Project Uganda and heamatopathology”.
o Intercongress meeting of the European Association of Pathology (ESP), August 31September 3 2010, Krakow, Poland, con una relazione dal titolo “New approaches to
molecular classification of lymphomas”.
o 10th APECSA (East African Division of the International Academy of Pathology)
Conference, September 15-17 2010, Kampala, Uganda, con una relazione dal titolo “HIV
as an oncogenic virus: AIDS-related lymphomas”.
o 10th APECSA (East African Division of the International Academy of Pathology)
Conference, September 15-17 2010, Kampala, Uganda, con una relazione dal titolo “Gene
expression analysis uncovers similarity and differences: Burkitt lymphoma subtypes
molecular profiles”.
o III Mediterranean workshop: “Pathologist and patient safety: new laboratory
quality improvement tools”, Gallipoli, October 8-9, 2010, con una relazione dal titolo
“Biomolecular procedures application in pathology”.
o 16th Congress of the Eurpean Hematology Association (EHA), June 9-122, London
UK, con una relazione sal titolo “The role of EBV in lymphomagenesis”.
o IV Mediterranean Workshop “Molecular Pathology Critical Crossover Role in
Patient Care Team, 30 Settembre-1 Ottobre, Gallipoli (LE), con una relazione dal titolo
“Viral mechanisms of Lymphomagenesis”.
o 2nd Annual World AIDS Day (HIV-2011). December 1-3, 2011, Beijing, China.
o Recenti Acquisizioni per il trattamento delle malattie linfoproliferative – 3^
Edizione // Milano, 24 Gennaio 2013, con una relazione dal titolo °La regolazione di
MYC° nel linfoma di Burkitt.
o Lymphomas: What can we learn from Africa? III Edizione, con una relazione dal
titolo “Viral microRNAs”, 31 Gennaio-2 Febbraio 2013, Mombasa, Kenia.